Polymer Chemistry
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2025
·
IF 3.9
Nan Qin,Na Li,Xiang Gao
Photoacid generators (PAGs) play an important role in chemically amplified resists (CARs), but small molecule PAGs have low solubility and limited compatibility with resins, which may lead to various problems. One of the important solutions is to bound PAG to polymer chains but differences in monomer reactivity can lead to an uneven distribution of molecular chain sequences between different polymer chains during polymerization, potentially impacting the lithographic performance. In this work, PAG units were incorporated into the photoresist resin polymer backbone via reversible addition-fragmentation chain transfer (RAFT) polymerization to synthesize methyl methacrylate polymer with different PAG loadings. The lithographic properties of the PAG bound polymer resist and the PAG blend polymer resist were studied and compared. The direct incorporation of PAG functionality into the polymer showed lower sensitivity, shorter acid diffusion length, and better compatibility. By observing the lithography results through AFM and SEM, the lithography lines of the PAG bound polymer photoresist synthesized via RAFT polymerization exhibited improved morphology and narrower line edge roughness (LER).
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
LANGMUIR
·
2015
·
IF 4.457
Ruidong Cheng,Min Tian,Sujuan Sun,Chenghui Liu,Youpeng Wang,Zhaotie Liu,Zhongwen Liu,Jinqiang Jiang
The amphiphilic random copolymer of P(NVP-co-NHPSS) with photocleavable N–O sulfonate side groups has been prepared to investigate the light-triggered disruption of copolymer micelles. Methods of absorption and emission spectra, solution transmittance, dynamic light scattering (DLS), and transmission electron microscopy (TEM) were applied. It was found that P(NVP-co-NHPSS) could form polymeric nanoaggregates in aqueous solution. And the photocleavage of the N–O bond within copolymer micelles upon 365 nm UV light could be conveniently controlled by changing the irradiation intensity, leading to the disruption of copolymer micelles and the photocontrolled release of Nile red encapsulation. And by encapsulating NaLuF4:Gd/Yb/Tm UCNPs inside copolymer micelles, the response of the photocleavable N–O bond to the 980 nm laser was much weaker than the response to 365 nm light; however, the photocontrolled release of Nile red could still be effectively triggered by the NIR light of the 980 nm laser.
研究领域:
材料科学
·
化学
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产品关联
DOI
PubMed
高影响因子
VETERINARY RESEARCH
·
2023
·Vol. 54
·期 1
·1-12
·
IF 4.4
Fu Shaodong,Wang Zhenglei,Han Xiangan,Xu Yuanyuan,Miao Jinfeng
Macrophages play a pivotal role in the inflammatory response to the zoonotic pathogen E. coli, responsible for causing enteric infections. While considerable research has been conducted to comprehend the pathogenesis of this disease, scant attention devoted to host-derived H2S. Herein, we reported that E. coli infection enhanced the expression of CSE in macrophages, accompanied by a significantly increased inflammatory response. This process may be mediated by the involvement of excessive autophagy. Inhibition of AMPK or autophagy with pharmacological inhibitors could alleviate the inflammation. Additionally, cell model showed that the mRNA expression of classic inflammatory factors (Il-1β, Il-6), macrophage polarization markers (iNOS, Arg1) and ROS production was significantly down-regulated after employing CSE specific inhibitor PAG. And PAG is capable of inhibiting excessive autophagy through the LKB1-AMPK-ULK1 axis. Interestingly, exogenous H2S could suppress inflammation response. Our study emphasizes the importance of CSE in regulating the macrophage-mediated response to E. coli. Increased CSE in macrophages leads to excessive inflammation, which should be considered a new target for drug development to treat intestinal infection.
研究领域:
免疫学
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微生物学
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药理学
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DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2017
·Vol. 295
·期 2
·371-378
·
IF 1.723
Wang Youpeng,Li Guo,Cheng Ruidong,Zhang Xuan,Jiang Jinqiang
Amphiphilic random copolymer micelle of P(NVP- co -NHPM) that responds to both UV and NIR light was designed and investigated. N -hydroxyphthalimide methacrylate — bearing a photoacid generator functional group was synthesized and used to construct the hydrophobic segment of P(NVP- co -NHPM); the N–O bond can be photocleaved when exposing the polymer aqueous solution to 310 nm UV light irradiation, inducing the micellar dissociation and delivery of loaded substances. Dynamic light scattering (DLS), atomic force microscope (AFM), and transmission electron microscopy (TEM) were used to characterize the micellar dissociation and controlled release processes. Moreover, the upconverting nanoparticles (NaLuF 4 :Gd/Yb/Tm) that can effectively absorb NIR light and convert it into visible and UV light were coloaded into polymer micelles to activate the micellar dissociation and the delivery of loaded cargoes via 980 nm NIR light.
研究领域:
材料科学
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生物医学工程
·
纳米技术
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Liyan Zhang,Zeikai Jin,Yuwen Shao,Chenfei Wang,Meisi Chen,Bo Fu
The growing issues of environmental pollution and energy consumption have spurred extensive research into the development of renewable heat-insulation materials. This study proposes a facile and cost-effective strategy to fabricate biodegradable chitosan(CS) aerogels by incorporating a phosphorus-based flame retardant (PAG), which was synthesized through the esterification of biomass-derived phytic acid and mannitol. Experimental results shows that the composite aerogels CS-PAG exhibit intrinsic flame-retardant performance, outstanding thermal insulation and mechanical properties. Compared to pure CS aerogels, the thermal conductivity of CS-PAG decreased to 0.0307 W/(m·K), while the compressive modulus increased to 697.41 kPa. This improvement is attributed to an optimized porous network formed by covalent and hydrogen bonding interactions between PA and CS. Remarkably, the modified aerogels exhibited a limited oxygen index of 41.1 % and achieved the V-0 rating in the UL-94 vertical burning test. Meanwhile, the total heat release and the peak heat release rate values were significantly reduced by 24.9 % and 58.2 %, respectively. The bio-based chitosan aerogel, endowed with superior flame-retardant properties, demonstrates significant potential as an innovative and sustainable material for thermal insulation applications.
研究领域:
材料科学
·
高分子科学
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消防工程
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可持续能源
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绿色化学
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产品关联
DOI
高影响因子
Scientific Reports
·
2015
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IF 5.578
Ailin Xiao,Hongjuan Wang,Xin Lu,Jianchun Zhu,Di Huang,Tonghui Xu,Jianqiang Guo,Chuanyong Liu,Jingxin Li
H2S is produced mainly by two enzymes:cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), using L-cysteine (L-Cys) as the substrate. In this study, we investigated the role of H2S in gastric accommodation using CBS(+/-) mice, immunohistochemistry, immunoblot, methylene blue assay, intragastric pressure (IGP) recording and electrical field stimulation (EFS). Mouse gastric fundus expressed H2S-generating enzymes (CBS and CSE) and generated detectable amounts of H2S. The H2S donor, NaHS or L-Cys, caused a relaxation in either gastric fundus or body. The gastric compliance was significantly increased in the presence of L-Cys (1 mM). On the contrary, AOAA, an inhibitor for CBS, largely inhibited gastric compliance. Consistently, CBS(+/-) mice shows a lower gastric compliance. However, PAG, a CSE inhibitor, had no effect on gastric compliances. L-Cys enhances the non-adrenergic, non-cholinergic (NANC) relaxation of fundus strips, but AOAA reduces the magnitude of relaxations to EFS. Notably, the expression level of CBS but not CSE protein was elevated after feeding. Consistently, the production of H2S was also increased after feeding in mice gastric fundus. In addition, AOAA largely reduced food intake and body weight in mice. Furthermore, a metabolic aberration of H2S was found in patients with functional dyspepsia (FD). In conclusion, endogenous H2S, a novel gasotransmitter, involves in gastric accommodation.
研究领域:
胃肠病学
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药理学
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生理学
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产品关联
DOI
PubMed
高影响因子
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