Journal of Orthopaedic Surgery and Research
·
2021
·Vol. 16
·期 1
·1-9
·
IF 2.359
Zhang Hongxia,Wu Guangsheng,Feng Junjian,Lu Xiaohong,Liu Ping
Background This study aimed to investigate the effects of STOML2 and the relationship between STOML2 and PAI-1 in the development of multiple myeloma (MM). Methods Cell proliferation was tested using CCK-8 assay and cell colony formation assay. Glucose consumption, lactate production and ATP level were measured using commercial kits. The mRNA and protein expression were assessed using quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting, respectively. Results Both mRNA and protein expression of STOML2 were upregulated in MM patients compared to healthy volunteers. CCK-8 and colony formation assays demonstrated that STOML2 silencing inhibited cell proliferation in MM cells. Knockdown of STOML2 reduced glucose consumption, lactate production and ATP/ADP ratios. STOML2 silencing by shSTOML2 led to reduced PAI-1 expression. Overexpression of PAI-1 reversed the inhibitory effects of shSTOML2 on MM cell growth. Conclusion Results from this study demonstrated that STOML2 silencing inhibits cell proliferation and glycolysis through downregulation of PAI-1 expression, suggesting a new therapeutic target for MM.
研究领域:
肿瘤学
·
分子生物学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2020
·
IF 7.094
Xueyu Yuan,Jing Jiang,Huawei Wei,Chengce Yuan,Mingqiang Wang,Dawei Zhang,Li Liu,Yudong Huang,Guo-Lin Gao,Zaixing Jiang
Thermoplastic resins have contributed more and more to the field of fiber reinforced composites . The ability to fabricate fiber reinforced thermoplastic resin composites with excellent and functional interface performances has so far been elusive. Herein, we use a polyamide-imide (PAI)/Ti 3 C 2 T x MXene sizing to enhance the interfacial performance of CF reinforced polyetheretherketone (PEEK) composites. The composite sizing makes the composite with high interfacial adhesion and electromagnetic interference (EMI) shielding performances. Our results indicate that traditional composite materials can improve performance and increase functionality through interface treatment.
研究领域:
材料科学
·
复合材料
·
高分子科学
·
电磁干扰
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2020
·Vol. 10
·期 9
·1806
·
IF 4.324
Dawei Li,Huizhong Liu,Ying Shen,Huiping Wu,Feng Liu,Lanlan Wang,Qingsheng Liu,Bingyao Deng
Electrospun nanofiber, showing large specific area and high porosity, has attracted much attention across various fields, especially in the field of air filtration. The small diameter contributes to the construction of filters with high-filtration efficiency for fine particulate matter (PM), however, along with an increase in air resistance. Herein, composited nanofiber aerogels (NAs), a truly three-dimensional (3D) derivative of the densely compacted electrospun mat, were constructed with the blocks of polytetrafluoroethylene–polyamideimide (PTFE–PAI) composite nanofiber and polyimide (PI) nanofiber. PI/PTFE–PAI NAs with hierarchically porous architecture and excellent mechanical properties have been obtained by thermally induced crosslink bonding. Results indicated that sintering at 400 °C for 30 min could complete the decomposition of polyethylene (PEO) and imidization of polyamic acid (PAA) into PI, as well as generate sufficient mechanical bonding between adjacent nanofibers in the NAs without extra additive. The well-prepared PI/PTFE–PAI NAs could withstand high temperature up to 500 °C. In addition, the filtration tests illustrated that the composite NAs had an excellent performance in PM filtration. More importantly, the filtration behavior could be adjusted to meet the requirements of various applications. The excellent thermal stability and high-filtration efficiency indicated its great potential in the field of high-temperature air filtration.Keywords:nanofiber-based aerogels;PTFE–PAI nanofiber;high-efficiency filter;PM2.5;hierarchical porous architecture
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER COMPOSITES
·
2024
·
IF 4.8
Dingyuan Zhao,Sisi Liu,Jun He,Ziheng Zhao,Shuohui Yin
The carbon nanotubes (CNTs) were chemically grafted onto carbon fibers (CFs) to prepare a CNTs-CF multiscale reinforcement. The tungsten disulfide/polyamide-imide (WS 2 /PAI) composite coating, with PAI as the binder and WS 2 as the lubricant filler, was prepared. The enhancement mechanism of CNTs-CF on the high-temperature tribological performance of WS 2 /PAI composite coating was analyzed. The addition of CNTs-CF was found to increase the temperature of the 10% mass loss of PAI by 14.2°C, indicating its ability to improve the thermal stability of the coating. The hardness of the CNTs-CF-modified WS 2 /PAI composite coating was measured to be 17.9% higher than that of the WS 2 /PAI substrate. The incorporation of CNTs-CF significantly improved the tribological performance of the WS 2 /PAI composite coating. Particularly at 200°C, the friction coefficient and wear rate of CNTs-CF modified WS 2 /PAI composite coating were only 0.095 and 8.92 × 10 −5 mm 3 /(N·m), respectively, which decreased by about 70.3% and 62.2% compared to the WS 2 /PAI substrate. Further analysis revealed that CNTs-CF is firmly embedded within the WS 2 /PAI composite coating through the synergistic mechanism of mechanical interlocking and molecular adsorption. Furthermore, CNTs-CF formed a stable lubricating film, ensuring the excellent friction and wear performance of the coating. Highlights The CNTs-CF can mitigate the thermal degradation of PAI. The high-temperature wear resistance of the coating was noticeably improved. The problem of CF easily detaching from the coating was resolved. The main components of the transfer film were analyzed.
研究领域:
材料科学
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摩擦学
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2021
·Vol. 14
·期 21
·6376
·
IF 3.623
Haiyang Yang,Duxin Li,Jun Yang,Jin Wang,Shunchang Gan
In this paper, 4,4′-diaminodiphenyl ether and 2,2′-bis (trifluoromethyl)-4,4′-diaminophenyl ether are selected for molecular structure design, and PAI materials are synthesized by acyl chloride method. 2,2′-bis (trifluoromethyl)-4,4′-diaminophenyl ether has the same main chain structure as 4,4′-diaminodiphenyl ether, but the side chain contains two trifluoromethyl groups, which has high fluorine content. PAI terpolymers were prepared by compounding two diamine monomers, and the effects of trifluoromethyl on heat resistance, friction and wear properties, hydrophobic properties and mechanical properties of PAI materials were studied. The results showed that with the increase of trifluoromethyl content, the Tg of PAI material first increased and then changed little, and the Td5%would decrease and the tensile properties would also decrease. The wear mechanism of PAI varied with the content of trifluoromethyl. With the increase of the amount of fluorinated diamine monomer, the adhesive wear degree of PAI materials gradually increased, and reached the maximum when the molar ratio of the two monomers was 5:5, and then decreased gradually. Different trifluoromethyl content had little effect on friction coefficient, and the friction coefficient increased slightly when the molar ratio of 4,4′-diaminodiphenyl ether to 2,2′-bis (trifluoromethyl)-4,4′-diaminophenyl ether is 1:9. With the increase of trifluoromethyl content, the wear of PAI material would increase. With the increase of the amount of trifluoromethyl, the water absorption of PAI material decreased and the water contact angle increased, which indicated that the hydrophobic property of PAI material was improved. To sum up, the results of this study showed that the introduction of trifluoromethyl into the side chain provided an effective way to prepare PAI materials with low water absorption. Considering the comprehensive properties such as heat resistance, friction and wear, tensile properties, etc., the appropriate addition amount is 10–30%.Keywords:polyamide-imide (PAI);4,4′-diaminodiphenyl ether;2,2′-bis (trifluoromethyl)-4,4′-diaminophenylether
研究领域:
材料科学
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化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Evidence-based Complementary and Alternative Medicine
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2022
·
IF 2.65
Fei Kong,Meng Zhao
Myocardial ischemia/reperfusion (MI/R) injury is a common clinical problem after myocardial infarction without effective therapy. Loureirin B (LrB) is a kind of flavonoid with anti-inflammatory and antifibrotic activities. However, the effect of LrB on MI/R and its underlying mechanism remains elusive. In the present study, a mouse model of MI/R was established by coronary artery occlusion. Administration of LrB (0.5 mg/kg or 1 mg/kg) for 4 weeks effectively improved left ventricular (LV) function and reduced myocardial infarction in MI/R mice. MI/R-induced expression of IL-6, TNF-α, and IL-1β in the hearts was reduced by LrB treatment. Histological analysis showed that LrB attenuated myocardial collagen deposition. LrB downregulated fibronectin, collagen I, collagen III, and α-SMA expression. Notably, LrB inhibited the expression of profibrotic plasminogen activator inhibitor-1 (PAI-1), transforming growth factor (TGF)-β1, TGF-β1R, and p-Smad2/3. Consistently, LrB inhibited the activation of TGF-β1/Smad signaling pathway and the expression of fibrosis-related proteins in angiotensin (Ang) II-treated cardiac fibroblasts (CFs). Overexpression of PAI-1 abolished the effects of LrB on Ang II-treated CFs, suggesting that LrB may function through regulating PAI-1. These results indicated that LrB may alleviate MI/R-induced myocardial fibrosis by inhibiting PAI-1/TGF-β1/Smad signaling pathway. Thus, LrB may be a potential drug in the treatment of MI/R injury.
研究领域:
心脏病学
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药理学
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分子生物学
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病理生理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2022
·
IF 14.903
Jingwen Dong,Chenfei Zhu,Ying Huang,Quanhao Li,Jing Li,Zheng Wang,Yixin Wang,Zhanwei Zhou,Minjie Sun
Fibrosis is one of the key factors that lead to the immune exclusion of solid tumors. Although degradation of fiber is a promising strategy, its application was still bottlenecked by the side effects of causing metastasis, resulting in the failure of immunotherapy. Here, we developed an antimetastatic polymer (HPA) for the delivery of chemo-drug and antifibrotic siPAI-1 to form the nano-permeator. Nano-permeator shrank after protonation and deeply penetrated into the tumor core to down-regulate the expression of PAI-1 for antifibrosis, and further promoted the sustained infiltration and activation of T cells for killing tumor cells. Moreover, metastasis after fiber elimination was prevented by multivalent CXCR4 antagonistic HPA to reduce the attraction of CXCL12 secreted by distant organs. The administration of stroma-alleviated immunotherapy increased the infiltration of CD8 + T cells to 52.5% in tumor tissues, inhibiting nearly 90% metastasis by HPA in distant organs. The nano-permeator reveals the mechanism and correlation between antifibrosis and antimetastasis and was believed to be the optimizing immunotherapy for solid fibrotic tumors.
研究领域:
癌症生物学
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免疫治疗
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药学
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Clinical and Translational Hepatology
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2022
·
IF 5.065
Feng-Yong Liu,Ming Shi,Xin Li,Hong-Jun Yuan,Xiao-Mei Tian,Yi-Mao Xia,Min Zhou,Fu-Sheng Wang
Background and Aims Stem cell transplantation is a potential treatment option for liver cirrhosis (LC). Accurately and noninvasively monitoring the distribution, migration, and prognosis of transplanted stem cells using imaging methods is important for in-depth study of the treatment mechanisms. Our study aimed to develop Au-Fe 3 O 4 silica nanoparticles (NPs) as tracking nanoplatforms for dual-modal stem cell imaging. Methods Au-Fe 3 O 4 silica NPs were synthesized by seed-mediated growth method and co-precipitation. The efficiency and cytotoxicity of the NPs-labeled bone marrow-derived mesenchymal stem cells (BM-MSCs) were evaluated by Cell Counting Kit-8 assays, ICP-MS, phenotypic characterization, and histological staining. The biodistribution of labeled BM-MSCs injected through different routes (the hepatic artery or tail vein) into rats with LC was detected by magnetic resonance imaging (MRI), photoacoustic imaging (PAI), and Prussian blue staining. Results Synthesized Au-Fe 3 O 4 silica NPs consisted of a core (star-shaped Au NPs) and an outside silica layer doped with Fe 3 O 4 NPs. After 24 h coincubation with 2.0 OD concentration of NPs, the viability of BM-MSCs was 77.91%±5.86% and the uptake of Au and Fe were (22.65±1.82) µg/mL and (234.03±11.47) µg/mL, respectively. The surface markers of labeled BM-MSCs unchanged significantly. Labeled BM-MSCs have osteogenic and adipogenic differentiation potential. Post injection in vivo , rat livers were hypointense on MRI and hyperintense on PAI. Prussian blue staining showed that more labeled BM-MSCs accumulated in the liver of the hepatic artery group. The severity of LC of the rats in the hepatic artery group was significantly alleviated. Conclusions Au-Fe 3 O 4 silica NPs were suitable MRI/PAI dual-modal imaging nanoplatforms for stem cell tracking in regenerative medicine. Transhepatic arterial infusion of BM-MSCs was the optimal route for the treatment of LC.
研究领域:
医学成像
·
再生医学
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纳米技术
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干细胞生物学
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肝病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2022
·
IF 6.064
Yingjian Ma,Jing Mao,Haojie Qin,Pan Liang,Wenpeng Huang,Chenchen Liu,Jianbo Gao
The multifunctional theranostic nanoplatforms, which can realize changing the contrasts of medical images and enhance cancer therapies simultaneously, have attracted tremendous attention from chemists and medicine in past decades. Herein, a nanoscale metal–organic framework-based material was first synthesized and then decorated with platinum (NMOF545@Pt) successfully for multimodal imaging-guided synergistic cancer therapy. The obtained NMOF545@Pt is advantageous in shortening the longitudinal relaxation time (T1), enhancing photoacoustic effects, and elevating X-ray absorption efficiently. Thus, the enchantments of tripe imaging modalities, computed tomography (CT)/magnetic resonance imaging (MRI)/photoacoustic imaging (PAI), were realized with NMOF545@Pt administration simultaneously and can be cleared from the mice. Meanwhile, in vitro and in vivo experiments demonstrate that the synthesized NMOF545@Pt can dramatically increase photothermal therapy (PTT) and radiotherapy (RT) efficacy. Convincing evidence proves that tumor growth can be wholly inhibited without noticeable side effects or organ damage. The results demonstrated the promise of multifunctional nanocomposites NMOF545@Pt to improve biomedical imaging and synergistic tumor treatments.
研究领域:
生物医学工程
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纳米技术
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癌症研究
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医学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AUSTRALIAN JOURNAL OF CHEMISTRY
·
2021
·Vol. 74
·期 9
·632-639
·
IF 1.321
Haiyang Yang,Duxin Li,Jun Yang,Jin Wang,Shunchang Gan,Yufeng Liu,Kaikai Cao
In this paper, diamine monomers with ether bonds in the main chain are selected for molecular structure design, and four polyamide-imide (PAI) materials are prepared by the acyl chloride method. A diamine monomer containing an ether group can reduce the friction coefficient and improve the wear performance of PAI material. The wear mechanism of PAI material can also change due to ether linkages. PAI synthesized using m-phenylenediamine without an ether bond has the highest friction coefficient and abrasion loss, and the wear mechanism is mainly adhesive wear. With the increase of the number of ether bonds in the diamine monomer structure, the friction coefficient of the material decreases from 0.5445 to 0.4216 (22.57 %). The abrasion loss of the PAI material synthesized using 4,4′-diaminodiphenyl ether is the smallest, which is 84.4 % lower than m-phenylenediamine. The wear mechanism is abrasive wear and slight adhesion wear. With the increase of the number of ether bonds, the heat r esistance of PAI decreases slightly, while the hydrophobic property increases and the water absorption decreases. To summarise, PAI material synthesized using 4,4′-diaminodiphenyl ether has a low friction coefficient, the best wear resistance, the highest tensile strength and elongation at break, and the best comprehensive properties of the materials reported here.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR RESEARCH
·
2021
·Vol. 29
·期 10
·727-734
·
IF 2.227
Yang Haiyang,Li Duxin,Yang Jun,Wang Jin,Gan Shunchang,Cao Kaikai,Liu Yufeng
Polyamide-imide (PAI) materials with good heat resistance, excellent friction, wear properties, and low water absorption were prepared by acyl chloride process with diamine monomer containing trifluoromethyl in the side chain. The results showed that PAI prepared from 2,2′-bis(trifluoromethyl)-[1,1′-biphenyl]-4,4′-diamine without flexible hinge group had the best heat resistance, with T g as high as 302.6 °C and T d5% as 490.1 °C. With the increase of the proportion of flexible hinge groups in diamine monomer, the thermal properties of PAI materials would decrease. The wear mechanism of PAI prepared from 2,2′-bis(trifluoromethyl)-[1,1′-biphenyl]-4,4′-diamine was mainly adhesive wear. With the increase of the proportion of flexible hinge groups in diamine monomer, the wear mechanism would change from abrasive wear, slight adhesive wear to severe adhesive wear. The friction coefficient and wear loss of PAI prepared by 1,4-bis(4-amino-2-trifluoromethylphenoxy)benzene were the smallest, which were 0.4706 and 3.5, respectively. PAI synthesized by diamine monomer containing trifluoromethyl had low water absorption and high water contact angle. With the increasing flexibility of monomer containing trifluoromethyl diamine, the elongation at break and tensile strength of the material increased gradually.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xuzheng Feng,Xing Li,Zhuoxin Li,Yufei Xue,Xianggang Chen,Xiaoxu Sun,Jixiang Tang,Shuyi Liu,Zishuo Wang,Yuhang Xie,Rui Jia,Songyuan Dai,Guoping Gao,Molang Cai
Wide-bandgap perovskite solar cells (WBG PSCs) have been receiving increasing focus due to the ideal application in tandem photovoltaics. Nonetheless, WBG perovskites tend to form high-density trap states, causing serious nonradiative recombination and phase segregation, which is detrimental to the efficiency and stability of WBG PSCs. In this work, a dual-field passivation strategy facilitated by isopropylamine hydroiodide (i-PAI) is introduced, in effect, showing both the molecular dipole field passivation and interface electric field passivation. This strategy reduces the charge trap density of WBG perovskite and suppresses the phase segregation, which is supported by the analysis of the experimental data and simulation results. Moreover, the dual functional passivation mitigates the open-circuit-voltage (VOC) deficit of the WBG (1.65 eV) PSCs to 0.39 V and increases the efficiency to a competitive value of 22.21%. The device also exhibits excellent photostability, maintaining 84.2% of the initial efficiency after 1080 h of illumination under 1-sun white LED. This work showcases a pivotal pathway to defect passivation that can markedly enhancing both the efficiency and stability of wide-bandgap perovskite solar cells.
研究领域:
材料科学
·
能源技术
·
光伏研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）