PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2021
·
IF 6.158
Junyuan Guo,Chongrui Yuan,Ziyu Zhao,Qianlan He,Hengbing Zhou,Ming Wen
Washing is one of the most practical remediation methods for heavy metals contaminated soil, however, conventional washing agents always cause soil acidification and salinization and bring about other negative impacts on soil microbes and plants. This study selected glutamate-N,N-diacetic (GLDA) and polyaspartic (PASP) as biodegradable chelators to remove Cd, Pb and Zn from contaminated farmland soil. The residual metals’ leachability , bioaccessibility , environmental risk and the properties of the soil were investigated after the polluted soil was washed with GLDA and PASP. Results showed that 93.8% of Cd, 87.9% of Pb and 91.9% of Zn were washed out when the concentration of GLDA was 50 mmol/L, pH was 5.5, S/L ratio was 1:10 and contact time was 90 min. Meanwhile, compared with the original soil, the leachability and bioaccessibility of the residual metals were decreased and the stability was increased after washing by GLDA or PASP. The environmental risks of metals were decreased as well by decreasing their bioaccessible concentrations. Moreover, the activity of the soil enzyme was improved after leaching. To sum up, this study provided a theoretical and scientific basis for the treatment of soil heavy metals pollution with biodegradable chelator.
研究领域:
环境科学
·
土壤学
✓ 已验证
DOI
高影响因子
Regenerative Biomaterials
·
2021
·Vol. 8
·期 3
·
IF 6.353
Wang Qiaoying,Wu Changqiang,Li Xiaoting,Yang Dixiao,Shi Liangjun
We have designed and developed an effective drug delivery system using biocompatible polymer of poly (ethylene glycol)-polyaspartic acid (mPEG-PAsp) for co-loading the chemotherapy drugs paclitaxel (PTX) and cisplatin (CP) in one nano-vehicle. This study aimed to improve the anti-cancer efficacy of combinations of chemotherapy drugs and reduce their side effects. mPEG-PAsp-(PTX/Pt) nano-micelles disperse well in aqueous solution and have a narrow size distribution (37.8 ± 3.2 nm) in dynamic light scattering (DLS). Drug release profiles found that CP released at pH 5.5 was significantly faster than that at pH 7.4. MPEG-PAsp-(PTX/Pt) nano-micelles displayed a significantly higher tumor inhibitory effect than mPEG-PAsp-PTX nano-micelles when the polymer concentrations reached 50 μg/mL. Our data indicated that polymer micelles of mPEG-PAsp loaded with the combined drug exert synergistic anti-tumor efficacy on SKOV3 ovarian cells via different action mechanisms. Results from our studies suggested that mPEG-PAsp-(PTX/Pt) nano-micelles are promising alternatives for carrying and improving the delivery of therapeutic drugs with different water solubilities.
研究领域:
药学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Energies
·
2024
·Vol. 17
·期 13
·3195
·
IF 3
WenLong Gao,LiWei Sun,Miao Li,XiAn Ye,QingChun Gao,DongLiang Kong,JunPu An,KuoBo Wang,Fan Yang
This paper focuses on the selection and application of scale inhibitor by studying the problem of pipeline scaling in geothermal well development. Adding scale inhibitor can effectively reduce the treatment cost and achieve a good scale resistance effect, but the commonly used polyaspartic acid scale inhibitor has problems such as poor scale inhibition effect and large use limitations. Therefore, a new modified polyaspartic acid scale inhibitor (His-Tyr-SA-PASP) was prepared using polysuccinimide (PSI) as the raw material and histidine (His), tyrosine (Tyr), and sulfonic acid (SA) as the modification reagent. When the dosage of His-Tyr-SA-PASP was 8 mg/L, the scale inhibition rate of CaCO3was 94.40%. In addition, the scale inhibition effect of His-Tyr-SA-PASP on CaCO3was better than that of PASP. At the same time, under the condition of a static experiment at 75 °C, according to the ion concentration of water samples in different scale zones, this paper also identified the ratio of four composite scale inhibitors. When the dosage of compound scale inhibitor was 100 mg/L, Sodium of Polyaspartic Acid–Diethylene Triamine Penta (Methylene Phosphonic Acid)–2-Phosphonobutane-1,2,4-Tricarboxylic Acid–Amino Trimethylene Phosphonic Acid–Copolymer of Maleic and Acrylic Acid = (10:10:5:1:9), (15:10:5:2.5:2.5), (12.5:5:10:1:6.5), and (15:5:10:4:1) and the scale inhibition rate was more than 95%. Under the condition of a dynamic experiment, the optimized composite scale inhibitor still showed a scale inhibition rate of more than 90%. It provides a useful reference for the practical application of water treatment in geothermal wells and has the prospect of industrial application.
研究领域:
化学工程
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Yuedan Xu,Dongni Shen,Zihuai Zhou,Yi Sun,Xinni Pan,Wei Liu,Chun Hung Chu,Ling Zhang,Matthias Hannig,Baiping Fu
Remineralized dentin with an antibacterial ability is still a significant challenge in dentistry. Previously, a polyelectrolyte-calcium complexes pre-precursor (PCCP) process is proposed for rapid collagen mineralization. In the present study, the expansion concept of the PCCP process is explored by replacing the calcium with other cations, such as strontium. The results of transmission electron microscopy (TEM), 3D stochastic optical reconstruction microscopy, energy-dispersive X-ray analysis, Fourier transform infrared spectroscopy, and high-resolution TEM with selected area electron diffraction demonstrate that biomimetic mineralization of collagen fibrils and demineralized dentin could be fulfilled with Sr&F-codoped hydroxyapatite (HAp) after they are treated with poly-aspartic acid-strontium (PAsp-Sr) suspension followed by a phosphate&fluoride solution. Moreover, dentin remineralized with Sr&F-codoped HAp exhibits in vitro and in vivo antibacterial ability against Streptococcus mutans . The cytotoxicity and oral mucosa irritation tests reveal excellent biocompatibility of mineralization mediums (PAsp-Sr suspension and phosphate&fluoride solution). The demineralized dentin's mechanical properties (elastic modulus and microhardness) could be restored almost to that of the intact dentin. Hence, the expansion concept of the PCCP process that replaces calcium ions with some cationic ions along with fluorine opens up new horizons for generating antibacterial remineralized dentin containing ions-doped HAp with excellent biocompatibility via biomimetic mineralization technology.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Dong-Ni Shen,Yue-Dan Xu,Cheng He,Zi-Huai Zhou,Hai-Hua Zhu,Ying Shi,Meng-Fei Yu,Jian Hu,Bai-Ping Fu
Magnesium ions are highly enriched in early stage of biological mineralization of hard tissues. Paradoxically, hydroxyapatite (HAp) crystallization is inhibited significantly by high concentration of magnesium ions. The mechanism to regulate magnesium-doped biomimetic mineralization of collagen fibrils has never been fully elucidated. Herein, it is revealed that citrate can bioinspire the magnesium-stabilized mineral precursors to generate magnesium-doped biomimetic mineralization as follows: Citrate can enhance the electronegativity of collagen fibrils by its absorption to fibrils via hydrogen bonds. Afterward, electronegative collagen fibrils can attract highly concentrated electropositive polyaspartic acid-Ca&Mg (PAsp-Ca&Mg) complexes followed by phosphate solution via strong electrostatic attraction. Meanwhile, citrate adsorbed in/on fibrils can eliminate mineralization inhibitory effects of magnesium ions by breaking hydration layer surrounding magnesium ions and thus reduce dehydration energy barrier for rapid fulfillment of biomimetic mineralization. The remineralized demineralized dentin with magnesium-doped HAp possesses antibacterial ability, and the mineralization mediums possess excellent biocompatibility via cytotoxicity and oral mucosa irritation tests. This strategy shall shed light on cationic ions-doped biomimetic mineralization with antibacterial ability via modifying collagen fibrils and eliminating mineralization inhibitory effects of some cationic ions, as well as can excite attention to the neglected multiple regulations of small biomolecules, such as citrate, during biomineralization process.
研究领域:
材料科学
·
生物材料
·
生物矿化
·
牙科材料
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 13.2
Shan Zhang,Mi Zhang,Xinye Zhou,Xuewen Li,Yangyang Ye,Zeyuan Chen,Kaining Yu,Qingyi Yang,Hui Sun,Min Li,Wenguang Liu,Xu Zhang
The composition and physical architecture of bone play vital roles in bone defect repair. Non-vascularized autografts are constrained by limited bone availability and unpredictable resorption. In this study, we synthesized artificial lamellar bone (ALB) by mimicking the physical structure of natural lamellar bone, integrating structure, properties, and function. Based on the principles of macromolecular crowding and charge shielding in regulating the hierarchical assembly of collagen, our strategy utilized the co -assembly of concentrated collagen with polyaspartic acid-Ca 2+ complexes (PAsp-Ca) to guide collagen ordered assembly and cross-linking, thereby fabricating a biomimetic organic scaffold. During assembly, abundant PAsp-Ca was embedded within the collagen, priming the dense collagen block for deep mineralization. The resulting mineralized ALB closely matched the structure, properties of natural bone and exhibited superior osteogenic performance to autograft in rat critical-sized mandibular defect models. The synergistic effect between new bone formation and material resorption persisted until ALB was completely replaced. This strategy establishes a new paradigm for enhancing the overall performance threshold of osteogenic materials.
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2018
·Vol. 24
·期 52
·13830-13838
·
IF 5.16
Xiangming Li,Yihe Zhang,Zequn Ma,Meng Fu,Qi An
Graphical The heat is on : A facile and efficient approach for the preparation of pH responsive self-assembled (electrostatic interactions) rGO-polymer-DOX nanocomposites for photothermal and chemical therapy is reported (see figure). The development of well-controlled drug carriers that are stable and highly effective for the delivery of anticancer agents is challenging. Herein, we report a novel pH-controlled drug delivery system, utilizing reducing graphene oxide (rGO)-polymer self-assembly films as carriers, for the preparation of effective drug nanorods and nanoparticles. In this system, the rGO-polymer carriers were constructed by the alternating assembly of poly- l -lysine (PLL) and polyaspartic acid (PASP) around the rGO sheets. Furthermore, the rGO-polymer cores, which possess a positively charged surface as the desired template, could assemble with negatively charged doxorubicin (DOX) via electrostatic interactions. The DOX embedding efficiency and the morphology of the drug nanocomposites could be controlled by the number of rGO-polymer bilayers and concentration of the rGO-polymer bilayers and the initial DOX concentration. Importantly, the release of DOX could be regulated by controlling the pH and by using a NIR laser. Under acidic conditions, the interactions between the PASP layer and DOX molecules can be broken, resulting in gradual release of the DOX molecules. Upon NIR irradiation, the release of DOX could be further accelerated and a photothermal effect from rGO induced. Cellular uptake and cytotoxicity experiments indicate that the drug nanocomposites possess effective anticancer activity. Thus, in this work, we present a useful strategy for the fabrication of pH-responsive drug nanocomposites for combined photothermal and chemical therapy. The nanocomposite can be used as a potential drug delivery system for practical cancer treatment.
研究领域:
纳米医学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2025
·
IF 4.5
Wenjun Lv,Guangli Chen,Kangwei Zhang,Yuxuan Zhang,Zaosheng Lv,Yanfen Huang
Hydrogels have attracted significant attention due to their high hydrophilicity and low viscosity. However, the poor mechanical properties of most hydrogels have limited their applications. By incorporating a semi-interpenetrating polymer network (semi-IPN) into polyaspartic acid (PASP)/polyvinyl alcohol (PVA) hydrogels, both physical and chemical cross-linking have enhanced the mechanical properties of the hydrogels. The stainless steel mesh coated with the hydrogel exhibits super hydrophilicity and underwater super oleophobicity (the underwater oil contact angle is approximately 157°), and can stably separate oil-water mixtures in various oil phases and complex environments (acidic, alkaline, and saline). The removal efficiency remains above 98% even after 20 cycles of separation. Furthermore, the PASP/PVA semi-IPN hydrogel can effectively adsorb copper ions, and the hydrogel is biodegradable in the environment after use. These results demonstrate that the PASP/PVA semi-IPN hydrogel has promising prospects in wastewater treatment.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 30
·75681-75693
·
IF 5.8
Kang Fei,Lv Qilin,Fan Jingbiao,Zhang Yun,Song Yuling,Ren Xueqin,Hu Shuwen
Soil acidification is a worldwide eco-environmental problem detrimental to plant growth and threatening food security. In this study, calcium poly(aspartic acid) (PASP-Ca) and calcium poly-γ-glutamic acid (γ-PGA-Ca) were obtained through cation exchange and used to mitigate soil acidity owing to high solubility and complexing capability. Three rates at 6.7, 13.4, and 20.1 g kg −1 , denoted as PASP-Ca1, PASP-Ca2, and PASP-Ca3, and γ-PGA-Ca (7.4 g kg −1 ) were surface-applied and compared with conventional lime (CaCO 3 , 2.5 g kg −1 ) along with control in two soil layers (top soil 0–10 cm, subsoil 10–20 cm). After leaching, various soil properties and aluminum fractions were measured to assess their ameliorative performance and mechanisms. Although lime achieved the highest soil pH (6.91) in the topsoil followed by PASP-Ca and γ-PGA-Ca (pH: 5.57–6.33), it had less effect on subsoil increase (5.3) vs. PASP-Ca and γ-PGA-Ca (pH: 5.44–5.74). Surface-applied PASP-Ca demonstrated efficiency in elevating soil pH and reducing exchangeable acidity, mainly as exchangeable Al 3+ , whereas γ-PGA-Ca addition superiorly improved soil pH buffering capacity (pHBC). Moreover, PASP-Ca and γ-PGA-Ca addition improved organic carbon by 34.4–44.9%, available P by 4.80–20.71%, and cation exchange capacity (CEC) by 6.19–29.2%, thus greatly enhanced soil fertility. Ca 2+ from polyAA-Ca promoted the displacement of exchangeable Al 3+ or H + from soil colloid, which were subsequently complexed or protonated and facilitated leaching. Additionally, the transformation into stable organo-aluminum fractions via complexation inhibited further hydrolysis. Under PASP-Ca or γ-PGA-Ca addition, the saturation of aluminum in cation exchange complex was reduced 2.91–7.81% compared to the control without addition amendments. Thus, PASP-Ca and γ-PGA-Ca can serve as potent ameliorants to alleviate soil acidity and aluminum toxicity for sustainable agricultural development.
研究领域:
农业科学
·
环境科学
·
土壤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Zhifang Wu,Xiaokan Wang,Zhe Wang,Changyu Shao,Xiaoting Jin,Leiqing Zhang,Haihua Pan,Ruikang Tang,Baiping Fu
Lab biomineralization should be carried out in an actual clinical practice. This study evaluated self-etch adhesive as a carrier for amorphous calcium phosphate (ACP) nanoprecursors to continuously deliver biomimetic remineralization of self-assembly type I collagen and demineralized dentin. Si-containing ACP particles (Si-ACP) stabilized with polyaspartic acid (PAsp) were synthesized and characterized by transmission electron microscopy (TEM), scanning electron microscopy–energy-dispersive X-ray spectroscopy, Fourier transform infrared analysis, X-ray powder diffractometry, and X-ray phototelectron spectroscopy. The biomimetic remineralization of single-layer reconstituted type I collagen fibrils and demineralized dentin was analyzed by using two one-bottle self-etch dentin adhesives (Clearfil S3 Bond (S3), Kurraray-Noritake; Adper Easy One (AEO), 3 M ESPE) as a carrier loaded (or not, in the case of the control) with 25 wt % of Si-ACP particles. In vitro cytotoxicity assessed by the Cell Counting Kit-8 indicated that the Si-ACP particles had no adverse effect on cell viability. The capacity for Ca and P ions release from cured Si-ACP-containing adhesives (S3, AEO) was evaluated by inductively coupled plasma-atomic emission spectrometry, revealing the successively increasing release of Ca and P ions for 28 days. The intra- and extrafibrillar remineralization of type I collagen and demineralized dentin was confirmed by TEM and selected-area electron diffraction when the adhesives were used as a carrier loaded with Si-ACP particles. Therefore, we propose self-etch adhesive as a novel carrier for ACP nanoprecursors to continuously deliver biomimetic remineralization.
研究领域:
牙科材料
·
生物材料
·
生物矿化
·
修复牙科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2021
·Vol. 5
·期 11
·4202-4213
·
IF 6.482
Mengying Jiang,Li-Ye Chen,Qian Zou,Siwei Xiong,Peigen Fu,Jing-Gang Gai
Reverse osmosis (RO) membrane technology, as an effective and eco-friendly method, has been widely used for seawater desalination and sewage treatment. However, RO membranes inevitably suffer serious organic and biological fouling during operation. Herein, we fabricated a hydrophilic anti-fouling layer on the RO membrane surface through the synergistic effect of covalent bonds and coordination bonds. Polyethyleneimine (PEI) and polyaspartic acid (PASP) are assembled onto the RO membrane surface successively. Fe(III) is utilized to induce further cross-linking for fabricating the PEI/PASP/Fe layer. The modified membranes exhibit superior hydrophilicity, whose water contact angle declines from 86.7° to 23.6°. In addition, the water flux of the PEI/PASP/Fe membrane increases by 45.8% with an excellent desalting property. Long-term, multi-cycle membrane fouling experiments demonstrate that the modified membrane manifests not only a lower flux loss rate (DRt) but also a higher flux recovery rate (FRR). This means that the hydrophilic layer modified membranes show excellent separation performance even under severe environments, which is expected to boost the anti-fouling research in the membrane field.
研究领域:
环境科学
·
材料科学
·
化学工程
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 11
·期 10
·2200053
·
IF 11.092
Shaohua Wu,Yiran Li,Caidan Zhang,Litao Tao,Mitchell Kuss,Jung Yul Lim,Jonathan Butcher,Bin Duan
3D heterogeneous and anisotropic scaffolds that approximate native heart valve tissues are indispensable for the successful construction of tissue engineered heart valves (TEHVs). In this study, novel tri-layered and gel-like nanofibrous scaffolds, consisting of poly(lactic- co -glycolic) acid (PLGA) and poly(aspartic acid) (PASP), are fabricated by a combination of positive/negative conjugate electrospinning and bioactive hydrogel post-processing. The nanofibrous PLGA-PASP scaffolds present tri-layered structures, resulting in anisotropic mechanical properties that are comparable with native heart valve leaflets. Biological tests show that nanofibrous PLGA-PASP scaffolds with high PASP ratios significantly promote the proliferation and collagen and glycosaminoglycans (GAGs) secretions of human aortic valvular interstitial cells (HAVICs), compared to PLGA scaffolds. Importantly, the nanofibrous PLGA-PASP scaffolds are found to effectively inhibit the osteogenic differentiation of HAVICs. Two types of porcine VICs, from young and adult age groups, are further seeded onto the PLGA-PASP scaffolds. The adult VICs secrete higher amounts of collagens and GAGs and undergo a significantly higher level of osteogenic differentiation than young VICs. RNA sequencing analysis indicates that age has a pivotal effect on the VIC behaviors. This study provides important guidance and a reference for the design and development of 3D tri-layered, gel-like nanofibrous PLGA-PASP scaffolds for TEHV applications.
研究领域:
组织工程
·
生物材料
·
心血管研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）