CERAMICS INTERNATIONAL
·
2015
·
IF 2.605
Xuedong Wei,Ruiguang Xing,Bangwen Zhang,Qiwei Zhang,Chaoke Bulin
To achieve high- ε r , low-tg σ polymer composites , a multistep grafting route was designed to coat BaTiO 3 (BT) nanoparticles with polymer PATP and then composite them with epoxy resin. FTIR and TGA were used to evaluate the chemical grafting of BT nanoparticles. TEM and SEM were utilized to characterize the morphology and microstructure of samples. The effects of surface modification and filler fraction on dielectric properties were investigated. The results show BT nanoparticles were successfully encapsulated with a PATP shell of 5–10 nm, which not only improves the dispersion of BT nanoparticles in epoxy resin, but also suppresses the dielectric loss of composites. The obtained composites have high dielectric constant and very low dielectric loss, which can be tailored by surface modification of nano-BT and varying the filler fraction.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2024
·
IF 5.6
Yueshou Zhang,Lichun Yang,Yulin Xu,Haiting Ren,Shi Yin,Yan Sun,Yongjun Hu
Rapid and sensitive detection of phosphate is of great significance for ensuring water safety and preventing eutrophication. In this study, we prepared Au@PATP@Ag NRs core-shell structures using 4-aminothiophenol (PATP) as an internal standard signal molecule to enhance the stability of the SERS signal. Based on the phosphate-induced decomposition of ZIF-8 and the protective effect of ZIF-8 on the internal Au@PATP@Ag NRs, a phosphate SERS sensor (Au@PATP@Ag@ZIF-8) with high sensitivity, selectivity and stability was designed. This method exhibited a good linear range of 0.1–125 μM and a detection limit of 30 nM. Furthermore, the developed sensor (Au@PATP@Ag@ZIF-8) was effectively applied to assess PO 4 3− in tap water samples, achieving recoveries between 97.44% and 104.54%. With its simple, fast and sensitive features, this method of phosphate detection in water provides a direction for the research and practical application of phosphate detection.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2011
·
IF 3.722
Zhihua Wang,Hui Li,Jing Chen,Zhonghua Xue,Bowan Wu,Xiaoquan Lu
A novel electrochemical sensor based on molecularly imprinted polymer film has been developed for aspirin detection. The sensitive film was prepared by co-polymerization of p -aminothiophenol ( p -ATP) and HAuCl 4 on the Au electrode surface . First, p -ATP was self-assembled on the Au electrode surface by the formation of Au–S bonds. Then, the acetylsalicylic acid (ASA) template was assembled onto the monolayer of p -ATP through the hydrogen-bonding interaction between amino group ( p -ATP) and oxygen (ASA). Finally, a conductive hybrid membrane was fabricated at the surface of Au electrode by the co-polymerization in the mixing solution containing additional p -ATP, HAuCl 4 and ASA template. Meanwhile, the ASA was spontaneously imprinted into the poly-aminothiophenol gold nanoparticles (PATP–AuNPs) complex film. The amount of imprinted sites at the PATP–AuNPs film significantly increases due to the additional replenishment of ASA templates. With the significant increasing of imprinted sites and doped gold nanoparticles , the sensitivity of the molecular imprinted polymer (MIP) electrode gradually increased. The molecularly imprinted sensor was characterized by electrochemical impedance spectroscopy (EIS), differential pulse voltammetry (DPV), and cyclic voltammetry (CV). The linear relationships between current and logarithmic concentration were obtained in the range from 1 nmol L −1 to 0.1 μmol L −1 and 0.7 μmol L −1 to 0.1 mmol L −1 . The detection limit of 0.3 nmol L −1 was achieved. This molecularly imprinted sensor for the determination of ASA has high sensitivity, good selectivity and reproducibility, with the testing in some biological fluids also has good selectivity and recovery.
研究领域:
电分析化学
·
传感器与生物传感器
·
纳米材料
·
分子印迹技术
·
环境与生物医学分析
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 2
·1-11
·
IF 5.833
Li Jingxian,Jiang Ding,Shan Xueling,Wang Wenchang,Ou Guofu,Jin Haozhe,Chen Zhidong
A novel aptasensor has been fabricated based on the resonance energy transform (RET) system from MoS 2 QDs-PATP/PTCA (donor) to NH 2 -UiO-66 (acceptor). The electrochemiluminescence (ECL) signal of PTCA was greatly amplified due to the decoration of MoS 2 QDs-PATP, and the NH 2 -UiO-66 was utilized to label the signal probe DNA (pDNA), which hybridizes with the exposed aptamer anchored on the surface of MoS 2 QDs-PATP/PTCA. With the target acetamiprid, the specific binding of acetamiprid to aptamer causes the connection between the donor and the acceptor to be interrupted and produce an “on” ECL signal. Thus, an “off-on” ECL sensing platform for sensitive and selective acetamiprid assay was designed. Under the optimal condition, the ECL signal of the aptasensor was found to be linearly related to the logarithm of the acetamiprid concentration ranging from 0.1 fM to 0.1 μM with a detection limit of 0.064 fM. More importantly, the recovery rate of the ECL aptasensor was calculated to be 98.7 ~ 106% with a RSD lower 5.1% for the residual acetamiprid assay in real food samples, which indicated that the aptasensor has high potential for practical applications. Graphical abstract
研究领域:
分析化学
·
环境科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Xunlong Ji,Hui Chen,Zijin Hong,Jingjing Du,Zhenli Sun
Accurate measurement of aerosol pH is crucial for understanding atmospheric processes and mitigating haze pollution. However, online detection of aerosol pH is challenging due to the complex composition of single-particle matter and trace components. This study develops a sensitive and selective sensor for the online detection of aerosol pH using surface-enhanced Raman spectroscopy (SERS). A novel Fe3O4@SiO2@Au-p-aminothiophenol (FA-pATP) sensor was fabricated using a layer-by-layer self-assembly method, achieving enhanced uniformity and increased density of SERS-active hotspots. Magnetic aggregation was employed to further amplify the Raman signal. This sensor was integrated into a 3D-printed microfluidic device to facilitate online monitoring of aerosol pH. The FA-pATP sensor exhibited a significant increase in peak intensity ratio with rising pH, demonstrating high sensitivity and responsiveness due to structural changes in the −NH2 groups of pATP under different pH conditions. The sensor demonstrated a linear pH response ranging from 5 to 11. The 3D-printed microfluidic device, coupled with the FA-pATP sensor, demonstrated notable performance in various environmental media, indicating strong anti-interference capabilities. The proposed sensor shows great promise for real-time online monitoring of aerosol pH, with broad applications in environmental monitoring.
研究领域:
环境科学
·
分析化学
·
材料科学
·
大气化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Zhe Wu,Yingjie Wang,Yufei Wang,Kaining Zhang,Yongchao Lai
Malondialdehyde (MDA) is an endogenous genotoxic product of lipid peroxidation and its accumulation in the human body is associated with various diseases. To accurately understand the role of MDA in physiological and pathological processes, it is of great significance to develop a robust and reliable method for rapid detection of MDA. Hence, we proposed a surface-enhanced Raman spectroscopy (SERS) based method for MDA analysis, which employed 4-aminophenylthiophenol (PATP) as a SERS microprobe to recognize and quantify MDA. Qualitative analysis of MDA was performed using the fingerprint Raman spectrum of MDA adducts, and quantitative analysis of MDA was conducted using the characteristic peak of PATP at 1083 cm −1 as the internal standard. MDA detection can be performed in a mild reaction environment and the detection limit was below 0.50 μM. The proposed method successfully detected MDA in fresh blood samples and found satisfactory recovery rates in spiked samples. The proposed method allows reliable detection of endogenous toxic compounds in blood plasma, which is of great significance for monitoring oxidative stress indicators, such as lipid peroxidation rate and intensity, potential antioxidant capacity, and the degree of tissue peroxidation damage.
研究领域:
分析化学
·
生物化学
·
医学诊断
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Pengbo Huang,Achen Shang,Deguo Liu,Jun Xi
Glycinin is an important storage protein in soybean, but it can also lead to allergic reactions in humans. In this study, based on a low-cost, simple, rapid and portable lateral flow immunoassay test strip, combined with high sensitivity surface enhanced Raman spectroscopy (SERS) technology, a sandwich lateral flow immunochromatographic test strip for rapid detection of soybean allergen glycinin is established. In the experiment, colloidal gold was covalently conjugated with rabbit-derived polyclonal antibodies of glycinin and Raman probe molecule 4-aminothiophenol(4-PATP) to prepare the immunoprobe. The respective optimal PATP and optimal antibody labeling amounts of colloidal gold solution were 1.05 × 10 -2 mol/L and 4.6 × 10 -8 mol/L. The detection limit of the test strip for glycinin was 4.87 ng/mL. The recovery rate ranged from 91 to 107 % and the CV was between 3 and 10 %. The test strip underwent no cross-reaction with β-conglycinin, sesame protein, peanut protein, wheat protein or whey protein. The results of the experiment showed that this method exhibits high sensitivity and specificity.
研究领域:
分析化学
·
免疫学
·
食品科学
·
过敏学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Tongtong Duo,Chenchen Wang,Diantao Chen,Shan Liu,Xiujuan Xu,Chunqiang Yang,Yong Wang,Wei Wei
Background Polyphenols, as the predominant natural antioxidants in fruits, are key indicators of nutritional value. However, conventional polyphenol assays involve complex pretreatment and rely on their reducing properties, making them susceptible to interference and limiting sensitivity. Therefore, it is crucial to develop a simple and sensitive method for polyphenols detection. Results Herein, core-shell metal-organic framework nanomaterials (AuNR/PATP@ZIF-8) were constructed by in situ growth of zeolitic imidazolate framework-8 (ZIF-8) on gold nanorods/p-aminothiophenol (AuNRs/PATP). Surface-Enhanced Raman Scattering (SERS) was obtained utilizing the enrichment effect of ZIF-8 on small molecules and the chemical enhancement effect of ZIF-8 on gold nanorods (AuNRs). The polyphenols were sensitively detected based on the coordination of polyphenols with Zn 2+ using SERS. Gallic acid (GA), tannic acid (TA) and piceatannol (PIC) were detected as model polyphenols. The limit of detection (LOD) of GA, TA and PIC were 0.69 nM, 0.48 nM and 0.64 nM, and their linear ranges were 1 × 10 −9 - 2 × 10 −6 M, 1 × 10 −9 - 2 × 10 −6 M and 1 × 10 −9 - 1 × 10 −5 M, respectively, which was better than most of the previously reported works. Moreover, the method showed good reproducibility, stability and selectivity and was successfully applied to the evaluation of total polyphenols in grapes. Significance This method enables highly sensitive detection of polyphenols without complex pretreatment. This method was applied to the detection of total polyphenols in grapes with a wider linear range and higher sensitivity than that of the traditional folin-ciocalteu (F–C) detection, which has great potential in the trace detection of total polyphenols in fruits.
研究领域:
食品化学
·
分析化学
·
纳米材料
·
光谱学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Sirui Han,Min Fan,Guichan Xu,Wenting Liu,Jingbo Chen,Yudong Lu,Shangyuan Feng,Ruiyun You
As a marker of cellular senescence and abnormal apoptosis, overexpression of β-galactosidase (SA-β-gal) is currently associated with many cancers, Alzheimer’s disease, cataracts, osteoporosis, and other diseases related to cellular senescence. SA-β-gal detection using surface-enhanced Raman scattering (SERS) is increasingly in the spotlight because of its acuteness and efficiency. This study aims to construct a sandwich-structure SERS substrate that can detect SA-β-gal in a sensitive, accurate, and cost-effective way, with a limit of detection of 4.79 × 10–5 U·mL–1. First, gold nanostars (Au NSs) were self-assembled on glass sheets, forming a monolayer gold surface, and the resulting substrate was defined as a gold nanoflake (Au-NF). Then 4-mercaptophenylboronic acid (PMBA) molecules were assembled on it. Lactose molecules served as a bridge between the substrate and SERS tags and were formed by Au NSs modified by PMBA and 4-aminothiophenol (PATP). When SA-β-gal came in contact with the functionalized Au-NF, with the SERS intensity at 1437 cm–1, the characteristic peak of 4,4′-dimercaptoazobenzene (DMAB) formed by PATP through laser irradiation decreased, indicating SA-β-gal activity. This structure allows the use of highly SERS-enhanced Au NSs while creating more hot spots between the SERS tags and substrate and improving the signal intensity without losing reproducibility and has potential in serum testing in the future.
研究领域:
纳米技术
·
癌症研究
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Deshan Cheng,Yali Zhang,Changwang Yan,Zhongming Deng,Xiaoning Tang,Guangming Cai,Xin Wang
Surface-enhanced Raman scattering (SERS) spectroscopy as an effective method in sensitive detection applications has attracted more and more attentions recently. In this work, polydopamine was taken to achieve the modification of PET film surface for in-situ growth of three-dimensional (3D) ZnO/Ag nanocomposites. Ag nanoparticles on cluster-like ZnO nanorods surface were applied as Raman hot spots for target molecules detection. SEM, XPS, and XRD were used to characterize the microstructures and morphologies of 3D SERS substrates. pATP molecules were selected to measure the sensitivity, uniformity, and durability, the surface-enhanced enhancement mechanism of Raman scattering was analyzed by finite difference time domain (FDDT) simulation method. Malachite green (MG) was further used as the demonstrative pesticide residue, and the catalytic activity was studied by the deoxidization of 4-nitrophenol (4-NP). This work has indicated that SERS substrates exhibited the advantages of facile fabrication process, low cost, high sensitivity, good stability and excellent uniformity, which can be used for the rapid Raman enhanced spectroscopy analysis of environmental pollutants.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Siqi Wei,Ling Li,Lichen Gou,Li Wu,Xiandeng Hou
Acrylamide (AA) is a carcinogen mainly ingested through food and drinking water, making its accurate determination crucial for both food safety and environmental protection. Herein, we proposed a derivatization-based ratiometric surface-enhanced Raman scattering (SERS) method for the quantification of AA. High density Au NPs were anchored to the surface of Cu-TCPP MOF nanosheets (MOFNs) to form the SERS sensor. The abundant Raman “hot spots” at the nanogaps generated by the Au NPs and the internal standard (IS) signal provided by Cu-TCPP MOFNs improved the sensitivity and quantitative accuracy of the method. Following the thiol-ene click derivatization reaction between p-aminothiophenol (PATP) and AA, the Raman peak intensity ratio (I 1080 /I 395 ) was employed to quantify AA. The linear range was 0.1 nM to 10 μM, and the limit of detection (LOD) was as low as 0.08 nM. Trace amounts of AA in food and water samples were successfully determined using this method.
研究领域:
分析化学
·
环境科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Photonics Research
·
2020
·Vol. 8
·期 4
·548-563
·
IF 6.099
Bin Wang,Chen Zhao,Huanyu Lu,Tingting Zou,Subhash C. Singh,Zhi Yu,Chaonan Yao,Xin Zheng,Jun Xing,Yuting Zou,Cunzhu Tong,Weili Yu,Bo Zhao,Chunlei Guo
Localized surface plasmon resonance (LSPR) of nanostructures and the interfacial charge transfer (CT) of semiconductor materials play essential roles in the study of optical and photoelectronic properties. In this paper, a composite substrate of Ag2S quantum dots (QDs) coated plasmonic Au bowtie nanoantenna (BNA) arrays with a metal–insulator–metal (MIM) configuration was built to study the synergistic effect of LSPR and interfacial CT using surface-enhanced Raman scattering (SERS) in the near-infrared (NIR) region. The Au BNA array structure with a large enhancement of the localized electric field (E-field) strongly enhanced the Raman signal of adsorbed p-aminothiophenol (PATP) probe molecules. Meanwhile, the broad enhanced spectral region was achieved owing to the coupling of LSPR. The as-prepared Au BNA array structure facilitated enhancements of the excitation as well as the emission of Raman signal simultaneously, which was established by finite-difference time-domain simulation. Moreover, Ag2S semiconductor QDs were introduced into the BNA/PATP system to further enhance Raman signals, which benefited from the interfacial CT resonance in the BNA/Ag2S-QDs/PATP system. As a result, the Raman signals of PATP in the BNA/Ag2S-QDs/PATP system were strongly enhanced under 785 nm laser excitation due to the synergistic effect of E-field enhancement and interfacial CT. Furthermore, the SERS polarization dependence effects of the BNA/Ag2S-QDs/PATP system were also investigated. The SERS spectra indicated that the polarization dependence of the substrate increased with decreasing polarization angles (θpola) of excitation from p-polarized (θpola=90°) excitation to s-polarized (θpola=0°) excitation. This study provides a strategy using the synergistic effect of interfacial CT and E-field enhancement for SERS applications and provides a guidance for the development of SERS study on semiconductor QD-based plasmonic substrates, and can be further extended to other material-nanostructure systems for various optoelectronic and sensing applications.
研究领域:
光学
·
光子学
·
材料科学
·
纳米技术
·
光谱学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）