INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Xiaoci Cui,Yingying Zhang,Zhiyuan Chen,Huining Xiao,Ranhua Xiong,Chaobo Huang
Water and soil pollution caused by Cu 2+ is not conducive to sustainable development of environment and could cause damage to environment and even human body. Currently, fluorescent sensor solutions analysis method has been used for Cu 2+ detection, but they also suffer from drawbacks including easy leakage, difficult storage, and inaccurate. Herein, a green solid-state biomass fluorescence platform (NBU-CDs) consisting of xylan-derived carbon dots (U-CDs) and polylactic acid/polycaprolactone (PLA/PCL) was designed by using in situ electrospinning technology. The prepared NBU-CDs fluorescence platform showed good fluorescence effect and can be served as fluorescence sensor for detecting Cu 2+ with high sensitively, selectively and low detection limit (LOD = 0.83 μM). The practical applications of NBU-CDs exhibited high specificity for Cu 2+ detection in zebrafish, water samples (school lake, Xuanwu Lake and Yangtze River) with high recovery rates of 97 %–104 % and soil (pond soil, grassland soil and bamboo soil) samples, respectively. The developed fluorescence platform was utilized to predict water and soil safety by monitoring Cu 2+ concentration and provides a new strategy for Cu 2+ detection.
研究领域:
环境科学
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材料科学
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分析化学
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生物技术
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产品关联
DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2023
·Vol. 63
·期 7
·2084-2092
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IF 3.2
Gaoyuan Ye,Tongfei Gu,Boyuan Chen,Hongjie Bi,Yingcheng Hu
To improve the toughness of polylactic acid (PLA), in this research, a tough polymer polycaprolactone (PCL) was combined with PLA to prepare blends, and a compatibilizer of glycidyl methacrylate grafted PLA (PLA-g-GMA) was produced to enhance the compatibility of PLA/PCL blend. Compared with PLA/PCL blend, the compatibilized blend exhibited a lower melting temperature and greater thermal stability. The tensile test indicates that the addition of compatibilizer greatly improved the toughness of the PLA/PCL blend. Particularly, the elongation at break of PLA/PCL blend with 6 wt% PLA-g-GMA increased to 370% and reached about 66 times of neat PLA. In addition, compatibilized blends have good shape memory performance. The research provides a simple and feasible method to overcome the brittleness of PLA, supplying a new strategy to modify PLA.
研究领域:
材料科学
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高分子科学
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工程学
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产品关联
DOI
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
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2025
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IF 4.7
Junqin Mao,Yutong Zhang,Tao Shen,Qiuyu Zeng,Wanli Zhang,Xinyu Zhang,Qiang Liu,Heng Zheng,Guoyu Lv
As gastric ulcers remain a significant clinical challenge, this study presents the development of a flexible microneedle system based on cerium/zinc-doped bioactive glass (CeZnBG) and a PCL/PLA matrix for targeted ulcer therapy. The design leverages the synergistic antioxidant and antibacterial properties of CeZnBG, combined with the localized drug delivery capability of microneedles, to enhance ulcer healing. CeZnBG was synthesized via high-temperature sintering at various temperatures (950 °C, 1050 °C, 1150 °C, and 1250 °C), and subsequently incorporated into PCL/PLA microneedles (PCMN) at doping concentrations of 0.5 %, 1.5 %, and 2.5 % to form composite materials. The structural and physicochemical characteristics of the CeZnBG-PCMN, were investigated using X-ray diffraction (XRD), scanning electron microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), mechanical properties, differential scanning calorimetry (DSC), and X-ray photoelectron spectroscopy (XPS). In vitro assays, including ROS scavenging and cytocompatibility, were used to assess the bioactivity of the composites. The results demonstrated that PCMN containing 1.5 % CeZnBG maintained excellent cytocompatibility (with relative cell viability exceeding 80 %) while exhibiting notable antibacterial performance, indicating promising potential for targeted gastric ulcer repair.
研究领域:
生物医学工程
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药剂学
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组织工程
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纳米医学
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消化病学
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材料科学
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转化医学
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产品关联
DOI
高影响因子
MATERIALS & DESIGN
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2022
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IF 9.417
Ting Zhang,Hao Xu,Yonggang Zhang,Siruo Zhang,Xia Yang,Yan Wei,Di Huang,Xiaojie Lian
Ideal wound dressings provide optimal microenvironment for the reconstruction of damaged tissue. In this work, we fabricated a bilayer asymmetric dressing to mimic gradient structure of epidermis and dermis of skin by combining electrostatic spinning and 3D printing method with properties including surface hydrophilic and hydrophobic, porosity, mechanical as well as antibacterial properties. The outer layer was prepared by optimized PCL/PLA (PP) via electrostatic spinning to mimick epidermis with water repellency and against bacterial penetration, which has a tensile modulus of 19.69 ± 0.66 MPa. While, the inner layer was 3D printed by optimized sodium alginate/polyvinyl alcohol/chitosan quaternary ammonium salt (SPH). The tensile modulus of SPH with a porosity of 70–90% is 0.82 ± 0.01 MPa, and the water content can be achieved above 85%. The antibacterial efficacy of inner layer was tested against Staphylococcus aureus indicating forming inhibition zone with a diameter of 1.61 ± 0.35 cm. In addition, Cell Counting Kit-8 and Live/Dead assay was used to test the viability of human dermal fibroblasts (HFBS), which showed that PP/SPH with 6% PVA had not significant cytotoxic effects. The double-layer asymmetric dressing meets the requirements of skin mechanical properties and provides an effective repair strategy for clinical skin trauma.
研究领域:
生物医学工程
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材料科学
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组织工程
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伤口愈合
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）