EUROPEAN POLYMER JOURNAL
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2021
·
IF 4.598
Yajun Ren,ZhuanZhuan Zhang,Wenlong Xia,Qifeng Zhou,Xiaofeng Song
Poly(L-lactide) (PLLA) was one of the most well-known biodegradable polyesters. Although its thermo-responsive shape memory (SM) function has been studied by proper program, high transformation temperature is not suitable in some biomedical applications. Water-responsive SM polymer is an alternative choice and exhibits great potential because it is harmless to the cells and tissues of organisms. In the work, a novel PCL-(PMVS- s -PAA)-PCL-PTMG-PCL-(PMVS- s -PAA)-PCL copolymer was devised as an additive to endow PLLA with water-responsive SM capability. The incorporated PLLA was characterized by cross-section, water contact angle, differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA). Inserted PTMG segment and assisted ambient temperature were contributed to its SM behaviors. The shape fixation ratio and shape recovery ratio were 92.0% and 94.2%, respectively. The schematic diagram between internal microstructures and macroscopic properties was proposed. At the same time, the incorporated PLLA showed excellent toughness. So the obtained SM material would be promising for medical and biomimetic fields.
研究领域:
材料科学
·
生物医学工程
·
高分子科学
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产品关联
DOI
高影响因子
Biomedical Materials
·
2021
·Vol. 16
·期 3
·035006
·
IF 3.715
Yuecheng Cui,Ronghua Jin,Yang Zhou,Meirong Yu,Yun Ling,Li-Qun Wang
Temperature-sensitive hydrogels with mild gel-forming process, good biocompatibility and biodegradability have been widely studied as bioinks and biomaterial inks for 3D bioprinting. However, the hydrogels synthesized via copolymerization of aliphatic polyesters and polyethylene glycols have low mechanical strength and cannot meet the needs of 3D printing. In this paper, we propose a strategy of enhancing the strength of hydrogels by introducing crystallization between blocks to meet the requirements of 3D bioprinting inks. A series of polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) triblock polymers were prepared by ring-opening polymerization, of which the strong crystallinity of polycaprolactone blocks improved the printability and enhanced the mechanical properties of the ink. It was found that the resulted hydrogels were temperature-responsive, and the PCL blocks could form a crystalline phase in the state of the hydrogel, thereby significantly increasing the modulus of the hydrogel. Moreover, the mechanical strength of the hydrogel could be adjusted by changing the composition ratio of each block of the copolymer. The 3D printing results showed that the PCL-PEG-PCL hydrogel with crystallinity can not only be extruded and printed via temperature adjustment, but also the three-dimensional structure can be effectively maintained after 3D printing. The gels demonstrated good cell compatibility, and the cell survival rate was maintained at a high level.
研究领域:
材料科学
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生物医学工程
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聚合物化学
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3D打印
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产品关联
DOI
PubMed
高影响因子
IONICS
·
2017
·Vol. 24
·期 3
·787-795
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IF 2.062
Wang Ping,Zhang Di,Zhou Yiyang,Li Yu,Fang Huagao,Wei Haibing,Ding Yunsheng
A novel biodegradable 1,2,3-triazolium-functionalized PEG- b -PCL copolymer (TAPEC) was synthesized by the “click” coupling of methoxypolyethylene glycol azide and α-propargyl-ω-hydroxyl-poly(ε-caprolactone), followed by the quaternization of the 1,2,3-triazole moiety with iodomethane. All the intermediates and TAPEC were characterized by 1 H NMR, FT-IR, and gel permeation chromatography (GPC). Taking advantage of the characteristics of ionic liquid and block copolymer, this ion-containing diblock copolymer is expected to be used as a novel compatibilizer in mixed biopolyester for regulating the interface and crystallization behaviors. Hence, the TAPEC was evaluated as a compatibilizer and an interface emulsifier in the blends of polylactic acid (PLA) and poly(ε-caprolactone) (PCL). Non-isothermal crystallization experimental results showed that the TAPEC with the higher amount of ε-caprolactone units induces a plasticization and nucleate effect that increased the crystallization ability of the PLA phase; meanwhile, in the PCL phase, the agminated ionic cluster acting as a nucleating agent significantly increased the crystalline of PCL.
研究领域:
材料科学
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高分子化学
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产品关联
DOI
高影响因子
CHEMICAL PAPERS
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2019
·Vol. 74
·期 5
·1377-1382
·
IF 1.246
Zhang Xue,Wang Yanhe,Zhang Zhuanzhuan,Xia Wenlong,Song Xiaofeng,Ma Liwei
Resveratrol which is a natural polyphenol with good biological activity is mainly used in medicine, but it has poor photostability in vitro and short plasma half-life in vivo. Multi-armed poly( ε -caprolactone) (PCL) has attracted great attention because the increased number of terminal group broadens the polymeric flexibility in biomedical application. In the work, six-armed PCL was coupled with resveratrol through the hydrolysable ester bond to solve its disadvantage and realize protection for more resveratrol. The synthesized product was characterized with 1 H NMR, GPC and DSC. The molecular weight of the designed polymer was less than the experimental, and the polymeric distribution of molecular weight was narrow. In addition, resveratrol changed the physical form of six-armed PCL. The resveratrol coupling with six-armed PCL presented better photostability compared to original resveratrol. The concentration curve of the coupled resveratrol extended to the plain terrain after 80 min of irradiation, while the original resveratrol continued to decline. They were 72.10% and 52.35% at 2 h, respectively. Moreover, six-armed PCL could effectively protect resveratrol in vivo, and buy time for reaching the target site. The in vitro released amount of the original resveratrol was 52.89% within 3 h, while the coupled resveratrol was only 6.28%. Then this study provides a promising strategy for efficient usage of resveratrol.
研究领域:
药学
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高分子化学
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生物医学工程
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产品关联
DOI
高影响因子
MACROMOLECULES
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2022
·
IF 6.057
Yuanyuan Dou,Nan Tian,Zhenbo Ning,Ni Jiang,Zhihua Gan
Polyesteramides have attracted much attention due to their intriguing properties. However, the synthesis of di- or triblock polyesteramides based on polyamide 6 (PA6) remains challenging owing to their harsh reaction conditions. In this work, we introduced a new strategy to synthesize poly(ε-caprolactone)-block-PA6-block-poly(ε-caprolactone) (PCL-b-PA6-b-PCL) in a mild way. A series of well-designed copolymers were characterized by gel permeation chromatography, 1H, DOSY, and 13C NMR, and their crystallization and melting behavior, degradation rate, and compatibilization effect on PA6/PCL blends were found to be strongly composition dependent. Interestingly, the copolymers exhibited diverse spherulite morphologies, including curving stems and banded spherulites, which also correlated with the different relative content of PA6. Besides, PA6 nanodomains could act as physical cross-linking points to improve the tensile strength and Young’s modulus of PCL. This work fills the synthesis gap of well-defined PA6-based triblock polyesteramides, providing new materials for material modification and elucidation of some basic scientific questions.
研究领域:
高分子科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
MATERIALS LETTERS
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2016
·
IF 2.437
Xinyu Peng,Yixin Zhang,Ying Chen,Sai Li,Bin He
A well-defined miktoarm star copolymer (μ-PEG-PCL-PLLA) was synthesized and the crystallization behavior of the copolymers was investigated. The structure of copolymer was confirmed by 1 H NMR, the molecular weight and molecular weight distribution were studied by GPC . XRD and POM were used to study the crystallization behavior of the miktoarm star copolymers. The XRD spectra showed that the miktoarm star copolymer showed low crystallinity for the joint of terminal, which limited the mobility of polymeric chains. The POM photographs revealed that PCL segments formed spherulites with PLLA crystalline grains as nucleus due to the good compatibility between PCL and PLLA.
研究领域:
材料科学
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高分子化学
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生物医学材料
✓ 已验证
DOI
高影响因子
Materials Research Express
·
2021
·Vol. 8
·期 5
·055402
·
IF 1.62
Lu Pang,Peixin Sun,Xufeng Dong,Tao Tang,Yi Chen,Qiang Liu,Min Qi
Articular cartilage has limited self-repair capacity due to the lack of vascularization, innervation and lymphatic networks. Biomimetic scaffolds with features of the extracellular matrix (ECM) of cartilage are advantageous to repair the injured cartilage tissue, but it remains a challenge to regulate its shear viscoelasticity to meet the needs of applications as articular cartilages. Fiber reinforced hydrogel is of great significance for their clinical application as cartilage tissue engineering scaffolds, especially for repairing the fibrocartilage tissue like meniscus or temporomandibular joint disc. In order to promote the shear viscoelasticity of alginate hydrogels, which was seldom studied, electrospinning PCL nanofiber layers were added into the alginate hydrogels to prepare PCL nanofibers reinforced alginate hydrogel composites (PNRAHCs). Compared with neat alginate hydrogel scaffolds, the PNRAHCs presented coral-like structure and spider web-like structure, and some PCL nanofibers form reinforced fiber bundles. Those special structures make the PNRAHCs have higher porosity, higher shear storage modulus and higher shear loss modulus than the neat alginate hydrogels, indicating better shear mechanical properties. They have the potential to be applied as the scaffolds to repair fibrocartilage tissues.
研究领域:
生物材料学
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组织工程学
·
再生医学
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DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2017
·Vol. 29
·期 1
·442-450
·
IF 1.907
Suchen Jiang,Huanchao Liu,Xue Zhang,Yajun Ren,Xinxiang Cui,Xiaofeng Song
Electrospun biodegradable fiber mesh is a promising alternative scaffold for delivering progenitor cells for repairing damaged or diseased tissue, but its cripple mechanical stability has not met the requirement of tissue engineering yet. In this work, the well-defined poly(ε-caprolactone)-branched poly(methyl methacrylate- co -hydroxyethylmethacrylate) (PCL-PMH) has been successfully synthesized to toughen electrospun poly( l -lactide) (PLLA) fiber membrane. Characterization of the obtained nanofibrous meshes indicates that PCL-PMH and PLLA can be well blended to make smooth fibers, and fibrous diameter vary little with blending PCL-PMH. The aggregation state of two macromolecules is closely correlated with blend ratio, molecular structure, and molecular weight of PCL-PMH, and only when PCL-PMH and PLLA form good interfacial adhesion can PMH give full play to its potential for toughening the fiber membrane. The tensile strength and elongation at break of the blend are 6.20 MPa and 63.40% under the optimal conditions, respectively, and it also exhibits the representative feature of toughness materials. The blending fiber membrane is as no cytotoxic as original PLLA. This work will provide a new way for toughness of electrospun fiber membrane in practice.
研究领域:
生物材料学
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组织工程学
✓ 已验证
DOI
高影响因子
Applied Materials Today
·
2021
·
IF 10.041
Yu Chen,Yi Lu,Danrong Hu,Jinrong Peng,Yao Xiao,Ying Hao,Meng Pan,Liping Yuan,Zhiyong Qian
Colorectal cancer is the third most frequently diagnosed cancer in men and the second most frequent in women, with a mortality of approximately half the incidence. Currently, there is no specific consensus regarding standard treatments for colorectal cancer, and new and effective treatment regimens are yet to be developed. Cabazitaxel (CTX), a derivative of paclitaxel, has better anticancer activity than paclitaxel and docetaxel, and has low structural affinity with the MDR1 efflux pump, which offers the advantage of overcoming multidrug resistance. However, the adverse effects and poor stability impede its clinical applications; therefore, we synthesized a new block copolymer (MPEG 2k -PCL 10k ) to prepare CTX nanoparticle formulations to enhance its biocompatibility and bioavailability. Compared with the CTX preparation Jevtana®, the drug loading, stability and antitumor efficacy of the nanoparticles were significantly improved, while the cytoxicity was notably reduced. The results indicate that CTX-MPEG 2k -PCL 10k nanoparticle preparations have high security and excellent anti-tumor effects, and has great application potential in the colorectal cancer therapy.
研究领域:
肿瘤学
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药剂学
·
生物医学工程
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产品关联
DOI
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 39
·18857-18868
·
IF 7.233
Haipeng Wang,Wulong Li,Zhanxiong Li
In this study, fluorinated polycaprolactone (PCL) block polymers with different fluorine contents were synthesized via atom transfer radical polymerization (ATRP). An electrospraying technique was used to prepare fluorinated PCL microspheres with different microstructures. In contrast to the golf ball shape of unmodified PCL microspheres displaying porous pits on the surface, block polymer PCL-PTFOA(2 h) and PCL-PTFOA(6 h) microsphere surfaces displayed regular honeycomb-like pore structures. Thermally induced and evaporation-induced phase separations are proposed as the main mechanisms involved in the formation of the porous microstructures. The micro-phase separation between the two blocks of the fluorinated PCL copolymer is another factor that promoted the uniform collapse on the microsphere surface and the formation of its rugged wall. The surface roughness of the porous microspheres significantly improved their hydrophobicity, generating coating contact angles on aluminium foil substrates that measured as high as 162.4 ± 1.5°, which revealed that the surfaces were super-hydrophobic. Lastly, cotton fabric was directly coated with the fluorinated polymer microspheres via electrospraying, resulting in super-hydrophobic surfaces and CAs reaching 160.0 ± 1.3°. The results demonstrate that electrospraying is a simple, innovative and cost-effective method for preparing polymer microspheres with controllable microstructures for fabric coating applications.
研究领域:
材料科学
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纺织工程
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表面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 20
·4259-4271
·
IF 4.726
Chunhuan Shi,Zhiqing Zhang,Fang Wang,Xiaoqing Ji,Zhongxi Zhao,Yuxia Luan
There are two major hurdles for the current anti-cancer drug delivery systems. One is the emergence of multidrug resistance (MDR) and the other is the conflict between long-circulation and cellular uptake. In the present study, the anticancer drug docetaxel (DTX) was successfully loaded into three series of micelles via self-assembly using a mixture of PEO–PPO–PCL and D-α-tocopheryl poly(ethylene glycol) 1000 succinate (TPGS), for the purpose of prolonging the blood circulation time as well as overcoming MDR of DTX. Three series of copolymers with different PCL molecular weights, PEO68–PPO34–PCL9, PEO68–PPO34–PCL18 and PEO68–PPO34–PCL36, were synthesized. The prepared spherical mixed micelles (MM) were found to possess nanoscale size (25–135 nm). The PEO–PPO–PCL/TPGS mixed micelles had a low critical micelle concentration (∼10−6 g mL−1) and a low hemolysis rate (<5%), which has proved that they are safe for use in vivo. Moreover, they had obvious sustained release behavior in vitro and a longer circulation time than free DTX in vivo. The P-gp inhibition assay, cellular uptake and MTT assay in cancer cells exhibited that DTX-loaded MM could overcome MDR, show higher cellular uptake and higher antitumor efficacy than free DTX. The IC50 values demonstrated that the three series of DTX-loaded MM were 69, 82 and 100 fold effective than free DTX after 72 h treatment with MCF-7 cells, respectively. Therefore, these results demonstrated that the prepared DTX-loaded MM provide desirable application in cancer chemotherapy.
研究领域:
药学
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肿瘤学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2013
·Vol. 4
·期 18
·9031-9038
·
IF 2.562
Delin Cheng,Xiaodong Cao,Huichang Gao,Xiaoling Ye,Wenxiu Li,Yingjun Wang
Composite polymer devices have gained considerable interest in biomedical applications. In this work, a composite poly(lactic-co-glycolic acid)/poly(ε-caprolactone) (PLGA/PCL) microsphere with a layered architecture and an island–sea topography was developed. PCL was found to occupy the shell layer of the microsphere, while PLGA constituted surface islands and the internal core. This subtle structure was derived from the different external and internal rates of phase separation between PCL and PLGA. The existence of the PLGA islands enhanced the hydrophilicity of the PCL shell. Mouse mesenchymal stem cells (mMSCs) were cultured and they grew well on the PLGA/PCL microspheres. The surface of the microsphere was microscopically composed of PCL sea and PLGA islands, and the mMSCs showed a trend to attach to the more hydrophilic PLGA islands and bridged between adjacent microspheres. This paper provides a new alternative to design functional microspheres for potential application in tissue repair.
研究领域:
生物医学工程
·
材料科学
·
细胞生物学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）