JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Jiayao Wang,Jingguo Li,Shaokui Cao,Yingliang Liu,Jun Shi
In recent years, the remotely multi-responsive chitosan (CS) hydrogel has been garnering extensive attention owing to its remarkable potential in biomedical applications. Meanwhile, it presents a wide range of uses in the realm of controlled drug delivery and photothermal chemical combination therapy. In this paper, the CS/β-glycerophosphate disodium salt (β-GP) physical crosslinked network was employed as the framework to encapsulate near-infrared (NIR) responsive hollow copper sulfide (CuS)/polydopamine (PDA) nanoparticles, and the NIR/pH synergistic responsive CS/CuS/PDA hydrogel was fabricated. The negatively charged β-GP, along with the hollow CuS/PDA nanoparticles, played a key role in promoting the creation of abundant electronegative cavities. As a result, the hybrid hydrogel achieved an impressively high DOX loading rate, reaching up to 95.5%. The CS/CuS/PDA hydrogel exhibits excellent pH responsiveness, which could be attributed to the disintegration of the CS/β-GP network under acidic buffer solution. In addition, hollow CuS/PDA nanoparticles embedded in the hydrogel endow the hydrogel with excellent NIR photothermal responsiveness, which significantly promotes the release of DOX. Consequently, the CS/CuS/PDA hydrogel reveals excellent synergistically enhanced NIR, pH, and thermal triple-responsiveness, indicating its tremendous promise in the field of controlled drug release.
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
·
2022
·
IF 4.383
Wenlong Li,Ludan Shang,Dafei You,Hao Li,Han Wang,Lijuan Ma,Xinna Wang,Yanwei Li,Yanhui Li
In this paper, we synthesized a core-shell structured Fe 3 O 4 @Ti-PDA nanoparticles as photocatalyst by a facile method in environmental friend mild reaction conditions without organic solvent . Firstly, Fe 3 O 4 was synthesized by solvothermal method, and Fe 3 O 4 @PDA was formed by dopamine (DA) self-polymerization to encapsulate Fe 3 O 4 to form polydopamine (PDA) lager. Then, the surface of Fe 3 O 4 @PDA was wrapped by coordinating bis(2-hydroxypropionic acid) diammonium dihydroxide(Ti-BALDH) with DA combined DA self-polymerizing to obtain Fe 3 O 4 @Ti-PDA. As control, we synthesized another photocatalyst Fe 3 O 4 @PDA@TiO 2 . Compared with Fe 3 O 4 @PDA@TiO 2 (band gap 3.0 eV), Fe 3 O 4 @Ti-PDA had a narrower band gap (2.5 eV) and a wider light absorption range (from ultraviolet to visible light to near-infrared light), as a photocatalyst, which can make full use of sunlight to improve photocatalytic efficiency. Meanwhile, magnetic core of Fe 3 O 4 @Ti-PDA made it was easy to separate from aqueous solution for convenient recovery. Using methylene blue (MB) as model pollutant, the degradation efficiency of Fe 3 O 4 @Ti-PDA on MB reached to 92.4% under visible light irradiation for 120 min without cocatalyst, while for Fe 3 O 4 @PDA@TiO 2 only to 32.5%. The result indicated Fe 3 O 4 @Ti-PDA enabled photocatalytic oxidation and rapid separation when photogenerated electron-hole pairs were generated. After three recycles, the degradation efficiency of Fe 3 O 4 @Ti-PDA on MB still remained at 86.47%, showing good recycle stability.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Tiantian Chen,Zhihan Zhang,Xiaohu Zhou,Zhiyue Zhang,Jun Liu,Qirui Gong,Tengda Ma,Abulimiti Dilihumaer,Yuhang Zhan,Zhizhong Xie,Lihong Fan,Yue Zhang,Shengxiang Tao,Yingying Chu
Osteochondral defects are common orthopedic conditions that can lead to osteoarthritis and severe joint pain. Recently, smart biohydrogels have been widely applied in osteochondral repair and regeneration, owing to their 3D structural resemblance to osteochondral tissues and their remarkable responsiveness to external stimuli. Glucosamine hydrochloride (GH) has been proved to stimulate the proliferation and chondrogenic differentiation of bone mesenchymal stem cells (BMSC), thereby accelerating wound healing and tissue regeneration. Herein, double-crosslinked smart hydrogels SPA 5 -Mg/GH/FP are fabricated using sodium alginate, acrylamide and N-Isopropylacrylamide (NIPAM) as the substrates. Simultaneously, the incorporation of Mg 2+ and Polydopamine (PDA)-coated Fe 3 O 4 NPs into the system further enhanced its properties. The results emphasized the favorable microenvironment created by the 3D architecture of the hydrogel, which effectively facilitated tissue repair and regeneration of the defects. Notably, the controlled release of GH aligned with the repair process is achieved through the responsiveness of Fe 3 O 4 @PDA NPs to near-infrared light. Moreover, in vivo assessments have demonstrated the effectiveness of the smart hydrogel in repairing osteochondral defects, highlighting its structural similarities to native tissue. This promising outcome underscores the potential of SPA 5 -Mg/GH/FP as a sophisticated solution for addressing the challenges associated with osteochondral repair.
研究领域:
生物材料学
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再生医学
·
骨科
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2020
·
IF 3.644
Bi Yanhong,Wang Zhaoyu,Tian Yaoqi,Fan Haoran,Huang Shuo,Lu Yihui,Jin Zhengyu
The immobilization of Thermomyces lanuginosus lipase on polydopamine-functionalized Fe3O4 magnetic nanoparticles (Fe3O4@PDA-TLL) as a nanobiocatalyst was successfully performed for the first time, and the Fe3O4@PDA-TLL was used for regioselective acylation of natural hyperoside with vinyl decanoate. The effects of several crucial factors, such as the reaction solvent, substrate molar ratio, temperature, and immobilized enzyme dosage, were investigated. Under optimum conditions, the reaction rate, 6″-regioselectivity, and maximum substrate conversion were as high as 12.6 mM/h, 100%, and 100%, respectively. An operational stability study demonstrated that the immobilized enzyme could maintain 90.1% of its initial maximum conversion even after reusing it five times. In addition, further investigations on the kinetic parameters, like Vmax, Km, Vmax/Km, and Ea, also revealed that the biocompatible Fe3O4@PDA could act as an alternative carrier for the immobilization of different enzymes.
研究领域:
生物化学
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纳米生物学
·
酶工程
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2024
·Vol. 14
·期 4
·2778-2791
·
IF 3.9
Ying Wei,Junhua Fu,Enrui Liu,Junru Gao,Yaqing Lv,Zhenlu Li
The difficulty of wound healing due to skin defects has been a great challenge due to the complex inflammatory microenvironment. Delayed wound healing severely affects the quality of life of patients and represents a significant economic burden for public health systems worldwide. Therefore, there is an urgent need for the development of novel wound dressings that can efficiently resist drug-resistant bacteria and have superior wound repair capabilities in clinical applications. In this study, we designed an adhesive antimicrobial hydrogel dressing (GMH) based on methacrylic-anhydride-modified gelatin and oxidized hyaluronic acid formed by Schiff base and UV-induced double cross-linking for infected wound repair. By inserting PDA nanoparticles into the hydrogel (GMH/PDA), the hydrogel has the capability of photothermal conversion and exhibits good photothermal antimicrobial properties under near-infrared (NIR) light irradiation, which helps to reduce the inflammatory response and avoid bacterial infections during the wound healing process. In addition, GMH/PDA hydrogel exhibits excellent injectability, allowing the hydrogel dressings to be adapted to complex wound surfaces, making them promising candidates for wound therapy. In conclusion, the multifunctional injectable GMH/PDA hydrogel possesses high antimicrobial efficiency, antioxidant properties and good biocompatibility, making them promising candidates for the treatment of infected skin wounds.
研究领域:
生物医学工程
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材料科学
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伤口愈合
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纳米技术
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光热疗法
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2024
·
IF 5.4
Miao Yu,Yuhang Wang,Yihan Liu,Yanxia Wang,Yunfeng Qiu,Zhuo Ma,Youshan Wang,Shaoqin Liu
Solar absorbers play a crucial role in interfacial solar steam generation (ISSG) technology, facilitating efficient steam generation and sterilization. Nonetheless, limitations in solar conversion efficiency and water transport effects, coupled with challenges in outdoor portability of traditional installations, have hindered the progress in steam sterilization technology. In this work, based on Cu8S5/PDA nanoparticles (NPs) and sodium alginate (SA) hydrogel, a solar steam sterilization absorber with superior photothermal conversion and antibacterial properties was developed. The Cu8S5/PDA@SA hydrogel synthesized via in situ deposition demonstrated remarkable full-spectrum absorption performance and stable photothermal conversion ability (37.56%), capable of effectively destroying bacterial structure and metabolic functions through multiple therapeutic mechanisms: photothermal therapy via thermal effect of high temperature and chemodynamic and photodynamic therapies via oxidation of reactive oxygen species and depletion of intracellular glutathione, achieving 100% steam antibacterial efficiency and presenting excellent antibacterial potential under low irradiation conditions. This study proposes a promising avenue for the development of environmentally friendly and easy-to-use solar steam sterilizers for off-grid conditions.
研究领域:
材料科学
·
纳米技术
·
环境科学
·
生物医学工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）