REACTIVE & FUNCTIONAL POLYMERS
·
2016
·
IF 2.725
Guiyou Wang,Lingmei Zhang
In this study, well-defined double-hydrophilic triblock copolymers , consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly( N , N -diethylamino-2-ethylmethacrylate) (PDEAEMA), were synthesized and characterized. The molecular weights of the copolymers were controllable. In the basic environments, the copolymers can self-assemble into the PDEAEMA core and PEG corona micelles in aqueous solution with an average size of 40–180 nm. The low critical micelle concentration (CMC, about 10 − 3 mg mL − 1 ) of copolymers investigated in pH 7.4 aqueous solution confirmed the adequate thermodynamic stability of their self-assembly. As shown in the cytotoxicity assay, the copolymers have good biocompatibility. Doxorubicin (DOX) was encapsulated into the triblock copolymer micelles . The drug loading efficiency and entrapment efficiency values of DOX-loaded micelles reached 8.14% and 88.6%, respectively. The DOX release of the drug-loaded micelles depends on the pH values. These phenomena indicated that the double-hydrophilic PDEAEMA – PEG – PDEAEMA triblock copolymers have a potential application in the drug delivery.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 3.9
Xin Luo,Zhuqing Wang,Mengxia Yan,Jianhui Xin,Yongqi Yang,Longpo Zheng,Haijun Zhang
CO 2 -responsive based separation membranes are attractive in the field of membrane separation, not only for their ability to modulate the pore size of the membrane in response to CO 2 stimulation, but also for their ability to facilitate the removal of contaminants from the membrane surface. However, the introduction of CO 2 -responsive polymers by simple blending often results in membranes that are not responsive enough to last. In this study, we synthesized a hooked triblock copolymer and used it as an additive to prepare CO 2 -responsive PVDF membranes. The modified membrane combines the advantages of the PVDF material with the CO 2 response of the triblock copolymer. It not only has good CO 2 responsiveness, but also removes organic contaminants from the membrane surface well. The water flux of the hybrid membranes is 4 to 11 times higher than that of pure PVDF membranes, indicating that the triblock copolymer also has some porogenic ability. Surprisingly, the static contact angle on the membrane surface increased from 67° to 86° with the increase of the triblock copolymer content in the PVDF membrane. This suggests that modified PVDF membranes have some potential in the field of switchable oil–water separation. Graphical
研究领域:
膜科学
·
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2023
·Vol. 25
·期 17
·12458-12468
·
IF 3.3
Chufen Yang,Delin Wang,Wenyao Liu,Zexiong Yang,Teng He,Fang Chen,Wenjing Lin
Aiming at achieving the concurrent performances of high loading, well controlled release and active targeted delivery, folate (FA) modified dual pH/reduction-responsive mixed polymeric micelles were rationally assembled using FA-PEG-PDEAEMA and PEG-SS-PCL by dissipative particle dynamics (DPD) simulations. The optimized polymers PEG112-PDEAEMA40, FA-PEG112-PDEAEMA40, and PEG112-SS-PCL70 were synthesized and characterized using 1H NMR, FT-IR and GPC, and their mixed micelles were applied for doxorubicin (DOX) delivery. The drug loading capacity (LC) and encapsulation efficiency (EE) values of the MIX1 (FA-PEG112-PDEAEMA40/PEG112-SS-PCL70) at a DOX/polymer feeding ratio of 15 mg/30 mg were 20.22% and 50.69%, which were higher than those of single polymer micelles and MIX2 (PEG112-PDEAEMA40/PEG112-SS-PCL70). Particle size distributions, mesoscopic morphologies, DPD simulations and in vitro drug release profiles all confirmed the well-controlled release performance of the DOX-loaded micelles formed by MIX1: slow DOX release with a cumulative release of 20.46% in the neutral environment and accelerated release with a cumulative release of 74.20% at pH 5.0 + 10 mM DTT within 120 h, which were similar to those of MIX2. Cytotoxicity assay found that both MIX1 and MIX2 blank micelles were biocompatible, and a superior inhibitory effect of the FA-modified DOX-loaded micelles MIX1 on HepG2 cells was found compared to that of free DOX and non-FA-modified DOX-loaded micelles MIX2. All of these confirmed the superiority of MIX1 micelles with high loading capacity, well controlled release, and enhanced inhibitory effects on HepG2 cells, which might be a prospective candidate for anticancer drug delivery.
研究领域:
药学
·
纳米技术
·
癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 9
·10008-10014
·
IF 1.338
Jiang Ping,Wu Yiqiang,Wu Zhipin,Zhou Gang,Luo Weihua,Xu Lijian
Self-supporting pH-responsive porous membranes of ethyl cellulose graft poly(2-(diethylamino)) ethyl methacrylate (EC-g-PDEAEMA) were prepared via the Non-Solvent-Induced Phase Separation (NIPS) process from mixtures of THF and DMF. The pH-responsive polymers (EC-g-PDEAEMA)
were synthesized via Atom Transfer Radical Polymerization (ATRP) and evidenced by 1H NMR spectroscopy and FT-IR spectra. The morphologies of the porous films were investigated by scanning electron microscopy (SEM) and polarized optical microscopy. These results indicated that the
size and the number of pores in the membranes as well as the flux values were larger along with the decrease of THF content and “Open time.” The optimum preparation conditions for microfiltration membrane were obtained.
研究领域:
高分子科学
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材料科学
·
膜技术
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响应性材料
·
化学工程
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2012
·
IF 3.628
Xiaoyun Qiu,Xueqin Ren,Shuwen Hu
An independently temperature- and pH-responsive membrane was developed by simultaneously grafting poly( N -isopropylacryamide) (PNIPAAm) and poly[(2-(diethylamino)ethyl methacrylate] (PDEAEMA) from different sides of a crosslinked cellulose membrane. The synthesis was simplified by using surface-initiated activators regenerated by electron transfer for atom-transfer radical polymerization in a diffusion device. The grafted membrane was heterostructured. The grafted polymer layer thickness was linearly related to reaction time. The wettabilities of the double-membrane sides responded individually and reversibly to temperature and pH. The surface grafted with PNIPAAm shifted from hydrophilicity to hydrophobicity above the lower critical solution temperature. The PDEAEMA side was hydrophilic in acidic aqueous solution and hydrophobic under basic conditions. This dual-response cellulose membrane has potential applications in water treatment, separations, and other membrane applications.
研究领域:
材料科学
·
化学工程
·
膜技术
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2025
·
IF 14.3
Huiling Su,Zhikun Wang,Jianqiang Zhang,Nannan Cui,Fengting Li,Miantuo Li,Wentao Qu,Xupeng Li,Jiaqi Feng,Songqing Hu
Responsive nanocontainers have dual functions in targeted delivery of corrosion inhibitors and emulsion development of shale oil in oil and gas fields, exhibiting potential for simultaneously achieving metal protection and efficient oil and gas development from a material perspective. Here, we propose the preparation of a pH-responsive nanocontainer, HMSNs- g -PDEAEMA (poly [2-(N, N-diethyl amino)-ethyl-methacrylate] (PDEAEMA) grafted onto hollow mesoporous spherical silica (HMSNs)), to integrate the delivery of 2-mercaptobenzothiazole (MBT)) for targeted corrosion inhibition and the emulsification of oil as Pickering emulsifiers. Under acidic conditions (reduced pH value caused by localized corrosion or high concentration acidic gases), PDEAEMA chains are protonated and extended by electrostatic repulsion, exposing pores on HMSNs surface and allowing the controlled release of loaded MBT molecules. Once transforming into a neutral or alkaline environment, the responsive release of the MBT process is inhibited. After the fluid passes through the wellbore and enters the shale layer, the HMSNs- g -PDEAEMA nanocontainers act as Pickering emulsifiers to achieve emulsification. The emulsified oil can be extracted onto the ground more efficiently, and a following pH-responsive demulsification process can be achieved. Overall, through a pH-responsive nanocontainer material, the dual function of corrosion inhibition and emulsification in oil and gas development is possible to be simultaneously achieved.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2010
·Vol. 84
·期 1
·195-202
·
IF 3.167
Deqian Wang,Junjun Tan,Hongliang Kang,Lin Ma,Xin Jin,Ruigang Liu,Yong Huang
The pH-responsive ethyl cellulose graft poly(2-(diethylamino) ethyl methacrylate) (EC- g -PDEAEMA) copolymers were synthesized through atom transfer radical polymerization (ATRP). Kinetic analysis confirmed the reaction is living and controllable. The graft copolymers can form micelles in acid aqueous medium. The critical micelle concentration (CMC) of the graft copolymers decreases with the increase of the graft length and graft density. The resultant micelles show the pH-sensitivity. The decrease in the hydrodynamic radius of the micelles at pH 6–6.9 attributes to collapse of the side PDEAEMA chains in the shell of the micelles due to the deprotonation , which was further confirmed by TEM observation. The loading and controlled release of drugs in the micelles was investigated by using rifampicin (RIF) as the model drug. It was found that the cumulant release of RIF in the buffer solution at pH 6.6 is higher than that at pH 7.4.
✓ 已验证
DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2020
·
IF 1.349
Ping Jiang,Hongmin Ji,Gen Li,Shaowei Chen,Linda Lv
To clarify the structure formation in pH-sensitive cellulose based micro porous membrane in non-solvent-induced phase separation process, first, a series of ethyl cellulose-graft-poly(2-(diethylamino)) ethyl methacrylate) (EC-g-PDEAEMA) with different graft density and graft length were synthesized via atom transfer radical polymerization (ATRP). The results of the micelles characterized by UV, Laser particle analysis and TEM indicated that the copolymer had pH responsive behavior and the increase of grafting density and grafting length led to the decrease of critical pH value. Furthermore, the morphology study of micro porous membrane via the NIPS process from mixture of THF and DMF indicated that the pores became smaller and more uniform with the increase of THF content and “open time”, and the most optimal preparation conditions was using EC0.2-g-PDEAEMA32 as the film-forming material and 75%THF/25%DMF (v/v) as solvent with the “open time” 1 min. What’s more, the membrane was responsive to pH stimulus in terms of water flux and demonstrated by scanning electron microscopy.
研究领域:
高分子科学
·
膜技术
·
材料化学
·
智能响应材料
·
分离科学
✓ 已验证
DOI
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Jia Tian,Chao Xiao,Baoxuan Huang,Xiaoze Jiang,Hongliang Cao,Feng Liu,Weian Zhang
Nowadays, multidrug resistance is the main challenge during cancer chemotherapy. Photochemical internalization (PCI) has been demonstrated to be a unique and promising approach to overcome multidrug resistance with light-harnessed activation. Here, an amphiphilic pH-responsive block copolymer with IR780 at the junction point [PEG-IR780-PDEAEMA; PEG, poly(ethylene glycol); PDEAEMA, poly((diethylamino)ethyl methacrylate)] has been designed as a perfect drug release platform as well as a functional macromolecular photosensitizer of PCI. PEG-IR780-PDEAEMA was synthesized by the combination of RAFT polymerization and click chemistry and further self-assembled into spherical micelles in aqueous solution. Notably, IR780 moieties were dispersed regularly around the core of the spherical micelles, which led to the diminishment of the aggregation-caused quenching effect of photosensitizers and high singlet oxygen quantum yield. Confocal laser scanning microscopy results showed that a high amount of doxorubicin (DOX) was translocated into the nucleus with NIR light irradiation through the PCI effect. Moreover, DOX-loaded PEG-IR780-PDEAEMA micelles showed much higher phototoxicity under short-time NIR light irradiation than their dark toxicity. Therefore, this DOX-loaded drug release platform based on pH-sensitive IR780-containing block copolymers has the potential to offer an efficient strategy for addressing drug resistance.
研究领域:
癌症研究
·
聚合物化学
·
药物科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
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