Nature Communications
·
2025
·Vol. 16
·期 1
·1-13
·
IF 15.7
Liu Jize,Zhao Wei,Ma Zhichao,Zhao Hongwei,Ren Luquan
Polyvinyl alcohol (PVA)/polyethylene glycol (PEG) hydrogels, being low-cost and abundant materials, can demonstrate tremendous potential in applications requiring mechanical robustness by harnessing the enhancements afforded by a structure inspired by articular cartilage (AC). This study presents the fabrication of bioinspired PVA/PEG (BPP) hydrogel, characterized by their high mechanical strength and low friction coefficient. By utilizing a concrete-like structure composed of PVA particles and PVA/PEG fibers, the BPP hydrogel demonstrates notable properties such as high compressive strength (86%, 29.5 MPa), high tensile strength (265%, 10.5 MPa), fatigue resistance, impact resistance, and cut resistance. Moreover, under submerged conditions, it exhibits low coefficient of friction (COF) and minimal wear. The packaged hydrogel sensor demonstrates high sensitivity, high linearity, and fast response time. Ultimately, we endeavor to apply the straightforward yet competent bioinspired strategy to intelligent protective sensing equipment, showcasing extensive prospects for practical applications.
研究领域:
材料科学
·
生物医学工程
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DOI
PubMed
高影响因子
MARINE POLLUTION BULLETIN
·
2023
·
IF 5.8
Chen Zhang,Yuhong Qi,Yarui Guo,Shukun Zhang,Gang Xiong,Kaixuan Wang,Zhanping Zhang
Polystyrene microspheres compounded with polyethylene glycol–based hydrogel (PS-PEG)/polydimethylsiloxane (PDMS) coatings were prepared using the physical blending method. The chemical structure, surface and interface properties, interlayer adhesion, and tensile properties were tested in this paper. Furthermore, the antifouling performance was evaluated through bovine serum albumin fluorescent protein adsorption testing, marine bacteria adhesion testing, and benthic diatom adhesion testing. The results showed that the coating performance was best when 20 wt% PS-PEG hydrogel was added. Its surface energy was only 19.21 mJ/m 2 , the maximum breaking strength was 1.24 MPa, the maximum elongation rate was 675 %, the elastic modulus was 2.53 MPa, and the anti-stripping rate was 100 %. In addition, the coating with added 20 wt% PS-PEG hydrogel bacterial adherence rate was 5.36 % and 2.45 % after rinsing and washing, respectively, and the removal rate was 54.29 %. In the benthic diatom adhesion test , the chlorophyll concentration a-value was only 0.0017 mg/L after washing with added 20 wt% hydrogel, and the protein desorption rate was 84.19 % higher than PDMS in the fluorescent protein adsorption test. This coating has the ‘low adhesion’ and ‘desorption’ characteristics in the three growth stages of biofouling. Meanwhile, the low surface energy of the silicone is stable, and the hydrogel also dynamically migrates to the surface to gradually form a hydration layer, both are synergistic. When 20 wt% PS-PEG hydrogel was added, the coating demonstrated excellent antifouling performance due to its high hydration layer, low surface energy, high elasticity, and high interlayer adhesion. This research is expected to contribute to the practical applications of hydrogel coatings in marine antifouling.
研究领域:
材料科学
·
海洋生物学
·
生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2023
·Vol. 31
·期 8
·3551-3564
·
IF 5.3
Zhang Chen,Qi Yuhong,Zhang Zhanping
Marine biofouling has become the main factor of marine economic loss. In this article, we studied the relationship between the PS-PEG hydrogels properties and the anti-bio adhesive behavior, such as amphiphilic, swelling degree, elastic modulus and roughness. Testing the adhesion behavior of marine bacteria and benthic diatom on PS-PEG hydrogel with different polystyrene microspheres content. Meanwhile, the influence of polystyrene microsphere content on the antifouling performance of hydrogel was emphatically analyzed and proposed the anti-bio adhesive behavior mechanism of PS-PEG hydrogels. The results showed that the antifouling performance of PS-PEG hydrogels was significantly enhanced by adding polystyrene microspheres. In the marine bacterial adhesion behavior, when polystyrene microspheres were added at 14.2 wt.%, the bacterial adhesion rate was respectively 3.85% and 0.01% for rinsing and washing samples, and the bacterial removal rate was 99.74%. In addition, in the benthic diatom adhesion behavior, the chlorophyll concentration a-values after rinsing and washing samples were only 0.019 mg/L and 0.002 mg/L with the same content of polystyrene microspheres, and the removal rate was 89.6%. At the same time, polystyrene microspheres enable PS-PEG hydrogels to exhibit amphiphilic, which could form a hydration layer by surface reorganization in seawater, the hardness and toughness of PS-PEG hydrogel substrate can be increased by adding appropriate polystyrene microspheres, and it also reduced the surface roughness of hydrogels after swelling in seawater. Accordingly, PS-PEG hydrogels can achieve efficient anti-bio adhesive behavior mainly through the synergistic effect of a highly hydrated layer, unstable surface and low roughness.
研究领域:
材料科学
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海洋生物学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Xiaorong Gou,Meiling Zheng,Yuanyuan Zhao,Xianzi Dong,Feng Jin,Jinfeng Xing,Xuanming Duan
Two-photon polymerization (TPP) microfabrication is an advanced technology to fabricate precise three-dimensional (3D) hydrogel micro/nanostructure. 3D hydrogel microstructures fabricated by TPP with sophisticated details and appropriate stiffness are able to effectively simulate the microenvironment used in tissue engineering and drug delivery. The mechanical property of the microstructures, for instance, the Young’s modulus is crucial to achieve the microstructures with high fidelity. In this study, the mechanical property of the poly(ethylene glycol) (PEG) 3D microstructures fabricated with various laser powers, writing speeds and layer distances in the air was investigated by characterizing the Young’s modulus. Meanwhile, the Young’s modulus of the microstructure with different layer distances in water was determined as 3.50–6.52 MPa. Furthermore, 3D PEG microstructures simulating red blood cell morphology of different postures and sizes were successfully fabricated.
研究领域:
生物材料学
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组织工程
·
药物递送
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Chunyou Lai,Yunchao Yang,Pengfei Wei,Guangming Xiang,Guan Wang,Shasha Liu,Li Zeng,Guanghong Du,Ke Yang,Maozhu Yang,Xueying Zhang,Yunhuan Li,Xueqiao Yu,Bo Zhao,Yutong Yao
Pancreaticojejunostomy presents significant challenges due to the high risk of complications such as pancreatic leakage and poor tissue regeneration. However, current approaches to enhance surgical outcomes are often limited by issues related to biocompatibility, tissue repair efficacy, and inflammation modulation. Here, we report the potential of an adhesive polyethylene glycol (PEG) hydrogel incorporating M2 macrophage-derived exosomes (PEG/Exo M2 ) for improving tissue repair in pancreaticojejunostomy. M2 macrophage-derived exosomes exhibit potent anti-inflammatory properties and pro-angiogenic effects, making them ideal candidates for tissue regeneration. The PEG/Exo M2 hydrogel demonstrates excellent mechanical strength and strong antibacterial activity. In vitro assays reveal that the PEG/Exo M2 hydrogel promotes angiogenesis and cell migration while modulating inflammatory responses. In animal models, the PEG/Exo M2 hydrogel effectively reduces fibrosis and inflammation in a subcutaneous implantation model, and significantly improves tissue regeneration. In a pancreaticojejunostomy model, the PEG/Exo M2 hydrogel facilitates wound sealing, lowers the risk of pancreatic leakage, and enhances anastomotic repair, outperforming conventional sutures. These results highlight the PEG/Exo M2 hydrogel as a promising biomaterial for tissue repair and regeneration, with strong potential for clinical applications in surgical wound healing.
研究领域:
生物材料学
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再生医学
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外科手术
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DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Chen Wang,Yun Xie,Zhanchi Zhu,Zhaojun Wang,Jiawei Li,Zhaoming Song,Jing Hong,Jingqi Li,Hanmo Zhu,Ying Hao,Guosheng Cheng,Liqiang Luo
Central nervous system (CNS) diseases, characterized by irreversible neuronal damage, pose global health challenges with limited therapeutic options. Stem cell therapy, particularly using neural stem cells (NSCs), is promising with some constraints related to poor microenvironmental simulation. This study presents a composite scaffold integrating three-dimensional graphene foam (3D-GF), GelMA-PEG hydrogel, and mesenchymal stem cell derived small extracellular vesicles (sEVs) to mimic the brain's mechanical and electrical microenvironment while delivering bioactive factors. The hydrogel (<3 kPa) matches brain elasticity (0.5–5 kPa), 3D-GF provides a conductive neural network-like structure, and sEVs enhance neuronal differentiation. In vitro experimental results demonstrated that the NSCs in the composite scaffolds exhibited a proliferation efficiency approximately 7-fold (43.82 ± 2.34 %) higher than that of the control group while the differentiation efficiency was enhanced by 3-fold (49.56 ± 7.80 %). The scaffold's design facilitates mechanical support, electrical signal transduction, and molecular regulation, effectively offering a biomimetic microenvironment. This multi-modal scaffold overcomes traditional limitations, presenting a biomimetic strategy for CNS repair in degenerative diseases.
研究领域:
神经科学
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生物材料
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组织工程
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干细胞治疗
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纳米技术
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产品关联
DOI
高影响因子
Gels
·
2024
·Vol. 10
·期 4
·278
·
IF 5
Chao Zhou,Mengdi Sun,Danni Wang,Mingmei Yang,Jia Ling Celestine Loh,Yawen Xu,Ruzhi Zhang
Repairing damaged tissue caused by bacterial infection poses a significant challenge. Traditional antibacterial hydrogels typically incorporate various components such as metal antimicrobials, inorganic antimicrobials, organic antimicrobials, and more. However, drawbacks such as the emergence of multi-drug resistance to antibiotics, the low antibacterial efficacy of natural agents, and the potential cytotoxicity associated with metal antibacterial nanoparticles in hydrogels hindered their broader clinical application. In this study, we successfully developed imidazolium poly(ionic liquids) (PILs) polymer microspheres (APMs) through emulsion polymerization. These APMs exhibited notable antibacterial effectiveness and demonstrated minimal cell toxicity. Subsequently, we integrated the APMs into a gelatin methacryloyl (GelMA)—polyethylene glycol (PEG) hydrogel. This composite hydrogel not only showcased strong antibacterial and anti-inflammatory properties but also facilitated the migration of human skin fibroblasts (HSF) and human umbilical vein endothelial cells (HUVECs) and promoted osteogenic differentiation in vitro.
研究领域:
组织工程
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生物医用材料
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抗菌研究
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Xiang Wu,Fuxiao Wang,Ruiyang Li,Biao Yu,Tianhang Qi,Yunpeng Li,Xiao Chen,Jian Wang,Zhen Geng,Peiran Song,Long Bai,Dongyang Zhou,Hou-Feng Zheng,Qin Zhang,Jiacan Su
Conventional hydrogel drug delivery systems are limited in recapitulating the natural spatiotemporal progression of bone regeneration due to their passive release mechanisms. Here, an enzyme-responsive deoxyribonucleic acid (DNA)-polyethylene glycol (PEG) hydrogel is developed to actively coordinate the sequential processes of angiogenesis, osteogenesis, and mineralization through rational material design. The hydrogel integrates matrix metalloproteinase (MMP)-cleavable peptide-crosslinked PEG networks conjugated with actin-stabilized vascular endothelial growth factor (VEGF)-binding DNA strands, enabling spatiotemporally controlled therapeutic release. Upon implantation, MMPs trigger the hydrogel degradation, releasing VEGF to induce angiogenesis while simultaneously promoting osteogenic differentiation. The actin-stabilized DNA framework maintains structural integrity during this stage, preventing premature phosphate release. Subsequent matrix remodeling liberates nuclease that catalyzes DNA to generate phosphate ions, which synergize with peptides in hydrogels and endogenous calcium to drive mineralization. Molecular dynamics simulations reveal the underlying mechanism of hydrogel-mediated mineralization, demonstrating enhanced calcium phosphate formation. Such temporally controlled cascade significantly improves vascular density, osteogenic marker expression, and mineral deposition compared to controls. This work establishes a bioresponsive platform that dynamically interacts with the biological microenvironment to orchestrate multi-phase bone regeneration, offering new possibilities for complex tissue repair.
研究领域:
生物医学工程
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组织工程
·
药物递送系统
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生物材料
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再生医学
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产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2020
·
IF 4.032
Siju Liu,Hong Cao,Renqi Guo,Heling Li,Cuifen Lu,Guichun Yang,Junqi Nie,Feiyi Wang,Nianguo Dong,Jiawei Shi,Feng Shi
A series of enzymatically degradable PEG hydrogels with tunable degradability were prepared by changing the proportions of two cross-linkers, enzymatically degradable cross-linker matrix metalloproteinase (MMP) degradable peptide and non-degradable cross-linker PEG-dithiol, and the effects of the proportion of two cross-linkers on the other properties of PEG hydrogels were also investigated. As the content of the degradable cross-linker increased, their mechanical properties decreased, but their swelling rate gradually increased. LIVE/DEAD cell staining and CCK-8 assay indicated that PEG hydrogels have high biocompatibility and low cytotoxicity, and as the content of the degradable cross-linker increased, the proliferation of cells is more favorable. Furthermore, adipogenic differentiation and osteogenic differentiation assays showed that BMSCs 3D-capsulated in PEG hydrogels can proliferate and then differentiate into osteoblasts or adipocytes, and as the content of degradable cross-linker increased, calcium nodules and the number of fat cells increased. These results demonstrate that the proportions of two cross-linkers have an effect on the physical, chemical and biological properties of PEG hydrogels, and these PEG hydrogels could be used as tissue engineering scaffold materials.
研究领域:
生物材料
·
组织工程
·
生物医学工程
·
细胞生物学
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产品关联
DOI
高影响因子
Biomaterials Science
·
2020
·Vol. 9
·期 3
·882-891
·
IF 6.183
Zecong Xiao,Xinyao Zheng,Ying An,Kangning Wang,Junwen Zhang,Huacheng He,Jiang Wu
Growth factors (GFs) have been well known for their therapeutic effects on wound healing. Due to their vulnerable biostability, biomaterial carriers are usually used to deliver GFs to maintain their bioactivity. Among the carriers, PEG hydrogels are the most widely applied. But the uncontrolled release of GFs and their immunogenicity dramatically retard the application of PEG hydrogels as carriers of GFs. Herein, FGF2 loaded zwitterionic sulfobetaine methacrylate (SBMA) hydrogels were developed, and it was revealed that these hydrogels were more effective in delivering FGF2 for wound healing than were PEG hydrogels. In vitro studies demonstrated that SBMA hydrogels could successfully prolong the release of FGF2, which effectively maintained the bioactivity of FGF2. Further in vivo investigation showed that SBMA hydrogels could efficiently accelerate wound regeneration by promoting granulation tissue formation, collagen deposition, cell proliferation and migration, reepithelialization and angiogenesis. All results validated that SBMA hydrogels were promising substituents of PEG hydrogels for delivering FGF2 for wound regeneration.
研究领域:
生物材料
·
组织工程
·
伤口愈合
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2019
·
IF 5.256
Lina Wu,Yingfei Wang,Rong He,Yue Zhang,Yuling He,Chao Wang,Zhenda Lu,Ying Liu,Huangxian Ju
Despite the great success of fluorescence sensing array application in bioanalysis , the photo-quenching problem accompanied with high surface fluorophore density has become the bottleneck for its further sensitivity improvement. Herein, a fluorescence polyethylene glycol (PEG) hydrogel array was developed for highly sensitive microRNA detection based on interfacial cation exchange amplification coupled with DNA hybridization chain reaction (HCR). The carboxylate PEG hydrogel array was fabricated on glass slide via photo polymerization and modified with miRNA capture probe, target miRNA binding triggered HCR in hydrogel with biotin labelled DNA probes to generate numerous DNA polymer chains where biotinylated CdS QDs were subsequently conjugated with a streptavidin bridge. Interfacial cation exchange amplification was triggered in hydrogel upon the introduction of Ag + and Rhod-5N, and abundant Cd 2+ was released from CdS to bind with Rhod-5N for substantial fluorescence enhancement. The aqueous-like environment of hydrogel eliminated the fluorescence quenching and simplified experiment process by performing cation exchange reaction at interface with direct result. The linear range for model target miRNA-21 was 1 fM to 500 pM with a detection limit of 0.835 fM. Taking advantage of the nonfouling property of PEG hydrogel, direct quantification of miRNA-21 was achieved from crude cancer cell lysates with a detection limit down to 10 equivalent cells. The expressions of circulating miRNA-21 in clinical serum samples were also assessed with comparable results from RT-PCR. The developed hydrogel array provides a universal platform for highly sensitive fluorescence sensing, and would benefit clinical non-invasive disease diagnosis.
研究领域:
生物化学
·
生物技术
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分析化学
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分子生物学
·
临床诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）