Controlling the Biological Activity and Mechanical Properties of Sol–Gel Synthesized PEG–CaO–SiO2–P2O5 Hybrid Materials for Bone Tissue Engineering
In this study, PEG–CaO–SiO2–P2O5 hybrid materials were synthesized by the triethosysilane-propyl end caped polyethylene glycol (PEG), teraethylorthosilicate (TEOS), triethyl phosphate and calcium nitrate tetrahydrate using a two-step method. The telechelic PEG was first synthesized by the reaction of PEG with isocyanatopropyl triethoxysilane (IPTS). Then, PEG–CaO–SiO2–P2O5 hybrid materials were synthesized by using sol–gel method. Transmission electron microscopy (TEM) revealed that the phase structure of the hybrid material changed from organic dominated to inorganic dominated when the PEG content decreased. The size of the dispersed phase is about several microns observed by TEM. Bioactivity tests employed by soaking the specimen in simulated body fluid (SBF) indicated that hydrophilic polymer contents have no adverse effect on the hydroxyapatite formation. After soaking the hybrid samples in SBF for 2 days, the deposition with the characteristic diffraction peaks of hydroxyapatite was presented on the hybrid material. It's also noticed the deposition amounts increased with the inorganic contents increasing in the hybrid materials. Mechanical tests displayed no brittle cracks were developed in all the hybrid material samples. The compressive strength of the hybrid materials increased while the elastic deformation decreased with the polymer contents reduction in the hybrid materials.
危险品化学品经营许可证（带存储）