查找使用阿拉丁产品的科研文献

Tailor-made PEG-DA-CuS nanoparticles enriched in tumor with the aid of retro Diels–Alder reaction triggered by their intrinsic photothermal property

Jie Sheng,Beibei Ma,Qian Yang,Chao Zhang,Zhongying Jiang,Entomack Borrathybay

In situ embedding of glucose oxidase in amorphous ZIF-7 with high catalytic activity and stability and mechanism investigation

Siyuan Liu,Jingxing Liu,Zefen Wang,Zhiqi Wu,Yiliang Wei,Pengru Liu,Xiongdiao Lan,Yexin Liao,Ping Lan

Glucose oxidase (GOx) has a great application potential in the determination of glucose concentration. However, its sensitivity to the environment and poor recyclability limited its broader application. Herein, with the assistance of DA-PEG-DA, a novel immobilized GOx based on amorphous Zn-MOFs (DA-PEG-DA/ [email protected] /PDA) was developed to impart excellent properties to the enzyme. SEM, TEM, XRD, and BET analyses confirmed that GOx was embedded in amorphous ZIF-7 with ∼5 wt% loading. Compared with free GOx, DA-PEG-DA/ [email protected] /PDA exhibited enhanced stability, excellent reusability, and promising potential for glucose detection. After 10 repetitions, the catalytic activity of DA-PEG-DA/ [email protected] /PDA can maintain 95.53 % ± 3.16 %. In understanding the in situ embedding of GOx in ZIF-7, the interaction of zinc ion and benzimidazole with GOx was studied by using molecular docking and multi-spectral methods. Results showed that zinc ions and benzimidazole had multiple binding sites on the enzyme, which induced the accelerated synthesis of ZIF-7 around the enzyme. During binding, the structure of the enzyme changes, but such changes hardly affect the activity of the enzyme. This study provides not only a preparation strategy of immobilized enzyme with high activity, high stability, and low enzyme leakage rate for glucose detection, but also a more comprehensive understanding of the formation of immobilized enzymes using the in situ embedding strategy.

A novel photonic crystal hydrogel inverse opal fluorescence enhancement platform for highly sensitive immunoassay of tumor markers

Wenyun Su,Peng Dai,Xiaotian Xu,Zhaokun Xian,Dong Xing,Chaowen Zheng,Xiaohua Fang,Cuimin Sun,Hui You

Cancer is a significant global health issue, necessitating early detection for effective diagnosis and treatment. We presented a novel method for detecting tumor markers using fluorescence-enhanced photonic crystal hydrogel inverse opal (PC-GELIO) membranes. We efficiently fabricated large-area, low-crack photonic crystal membranes using a homemade microfluidic chip. Composed of PEG-DA and PEG, the hydrogel replicated the photonic crystal structure, yielding photonic crystal hydrogel inverse opal membranes with a unique photonic band gap and inverse opal porous structure. These properties afford the PC-GELIO platform several advantages: Firstly, the high stability of the internal nanostructure in the large-area, low-crack photonic crystals film, prepared using the homemade microfluidic chip, is crucial for preserving the platform's exceptional fluorescence-enhanced sensing capabilities. Secondly, the peak wavelength emitted by fluorescent molecules aligns with the photonic band gap (PBG), significantly enhancing the fluorescence signal through the low-photon effect. Lastly, the high specific surface area provides numerous binding targets for biomolecule modification, and the hydrogel offers a uniform liquid environment conducive to biomolecule binding. We evaluated the fluorescence-enhanced sensing performance of the platform using alpha-fetoprotein (AFP). The limit of quantification (LOQ) for AFP was determined to be as low as 23 pg/mL, representing an order of magnitude improvement compared to non-enhanced platforms (0.29 ng/mL and 0.25 ng/mL). Consequently, this novel fluorescence-enhanced photonic crystal hydrogel inverse opal platform holds significant potential as a straightforward and efficient method for biomolecular detection.

High performance printed organic electrochromic devices based on an optimized UV curable solid-state electrolyte

Chenchao Huang,Zishou Hu,Yuan-Qiu-Qiang Yi,Xiaolian Chen,Xinzhou Wu,Wenming Su,Zheng Cui

Manufacturing cost is a major concern for electrochromic device (ECD) applications in smart windows for energy saving and low-carbon economy. Fully printing instead of a vacuum-based chemical vapor deposition (CVD) process is favored for large-scale fabrication of ECDs. To adapt to the screen printing process, a UV curable solid-state electrolyte based on lithium bis(trifluoromethane-sulfonyl) imide (LiTFSI) was specially formulated. It contains poly(ethylene glycol) diacrylate (PEG-DA), LiTFSI, water, and ethyl acetate. The optimized ECDs have achieved a 0.6 s bleaching time at 0.6 V and a 1.4 s coloring time at −0.5 V. The ECDs also exhibited excellent stability, which could endure 100 000 cycles of color switching while still maintaining 35% of transmittance change at a 550 nm wavelength. A demo ECD has been fabricated with a screen printed electrolyte, exhibiting stable switching between the clear state and patterned color state.

Pt Single-Atom Catalyst on Co3O4 for the Electrocatalytic Detection of Glucose

Yong Zhang,Xin Zeng,YiYi Liu,Cuncun Wang,Changpeng Jin,Jingzhou Hou,Mei Yang,Danqun Huo

Developing an accurate, reliable, and stable glucose detection sensor poses a formidable challenge for the food industry. In this study, hydrothermal and wet chemical methods were employed to fabricate a Pt single-atom catalyst on Co3O4 (Co3O4/Pt SAs), where dispersed Pt atoms collaboratively catalyze the electrochemical reaction on the electrode surface. Subsequently, the integration of the microelectrode with polyethylene glycol diacrylate (PEG-DA) hydrogel and a dual-channel microfluidic chip facilitated continuous and rapid glucose detection. The addition of 5% PEG-DA hydrogel served to eliminate interference and expedite glucose detection, while the design of the dual-channel microfluidic chip generated microscale vortices, providing ample reaction opportunities for the target glucose while preventing interference from the mixing of previous and current reaction solutions. The research exhibited a favorable linear detection range from 1 to 800 μM, with a detection limit of 0.84 μM. Furthermore, validation of the device’s feasibility in real samples demonstrated a glucose recovery rate ranging from 94.9 to 104.4% in beverages.