The synergistic therapy, the combination of photothermal therapy and chemotherapy, has become a potential treatment in the battles with cancer. Here, we developed a synergistic therapy tool that based on CuS nanoparticles-decorated graphene oxide functionalized with polyethylene glycol (PEG-GO/CuS) for cervical cancer treatment. The as-synthesized PEG-GO/CuS nanocomposites with excellent biocompatibility was revealed to have high storage capacity for anticancer drug of doxorubicin (Dox) and high photothermal conversion efficiency, and were effectively employed for the ablation of tumor. In addition, the therapeutic efficacy of Dox-loaded PEG-GO/CuS (PEG-GO/CuS/Dox) nanocomposites was evaluated in vitro and in vivo for cervical cancer therapy. In vitro cell cytotoxicity tests of PEG-GO/CuS/Dox demonstrate about 1.3 and 2.7-fold toxicity than PEG-GO/CuS and free Dox under 5 min irradiation with NIR laser at 1.0 W/cm 2 , owing to both PEG-GO/CuS-mediated photothermal ablation and cytotoxicity of light-triggered Dox release. In mouse models, mouse cervical tumor growth was found to be significantly inhibited by the chemo-photothermal effect of PEG-GO/CuS/Dox nanocomposites, resulting in effective tumor reduction. Overall, compared with chemotherapy or photothermal therapy alone, the combined treatment demonstrates better therapeutic efficacy of cancer in vitro and in vivo . These findings highlight the promise of the highly versatile multifunctional nanoparticles in biomedical application .
The use of pesticides has made great contributions to agriculture, which ensures the high yield of crop. However, the low efficiency and overuse of pesticide has caused severe problems to the environment. Therefore, the construction of an efficient and environmentally friendly nanopesticide delivery system is of urgent need. In this work, we report PEGylated-graphene oxide (PEG-GO) as a nanocarrier for water-insoluble pesticides (e.g., emamectin benzoate, EB) delivery and investigate its antipest activity. In our strategy, through the simple physical adsorption approach, the hydrophobic EB molecule can be effectively loaded on the PEG-GO nanocarrier, forming a stable EB@PEG-GO nanoformulation. As a high performance carrier, PEG-GO exhibits ultrahigh adsorption capacity for EB (1647.2 mg/g). The as-prepared EB@PEG-GO shows excellent stability during the 2-year storage period, which is a benefit for its practical application. Compared with free EB, the advantages of EB@PEG-GO are (1) greatly improved water solubility (30 mg/mL), (2) pH-response and sustained pesticide release performance, (3) prolonged half-life under UV light irradiation (521.16 h), and (4) sustainable antipest activity. In consideration of its industrialization potential, our current results clearly demonstrate the brilliant future of GO-based nanomaterials in plant protection and agriculture.
危险品化学品经营许可证（带存储）