查找使用阿拉丁产品的科研文献

Activatable MRI-monitoring gene delivery for the theranostic of renal carcinoma

Meilin Shi,Shan Wang,Shaohui Zheng,Pingfu Hou,Lina Dong,Meijuan He,Chen Wu,Xiuli Zhang,Fengmei Zuo,Kai Xu,Jingjing Li

Multifunctional nanocarriers, which can be used for molecular imaging and drug delivery simultaneously, favor the fabrication of theranostic platforms in a less cost- and time-consuming way. Polyethylene glycol (PEG)-modified manganese dioxide (MnO 2 ) nanosheets (PEG-MnO 2 ), used as two-dimensional nanomaterials, not only possess the high surface-to-volume ratio necessary for drug delivery but also display a redoxable property in the tumor microenvironment, producing Mn 2+ ions for magnetic resonance imaging (MRI). In this study, we constructed a PEG-MnO 2 -OPN siRNA nanocomplex via a modular streptavidin bridge for the theranostic treatment of renal carcinoma in vitro and in vivo . This strategy of utilizing PEG-MnO 2 nanosheets for OPN siRNA delivery showed effective tumor growth inhibition of 786-O tumor-bearing mice, and such a process could be monitored by the activated T 1 -weight MRI, illustrating the promising potential of PEG-MnO 2 nanosheets for the fabrication of an MRI-based theranostic system.