Materials
·
2024
·Vol. 17
·期 2
·509
·
IF 3.1
Shuya Ning,Shuo Wang,Zhihui Liu,Naming Zhang,Bin Yang,Fanghui Zhang
Magnetic–plasmonic nanoparticles (NPs) have attracted great interest in many fields because they can exhibit more physical and chemical properties than individual magnetic or plasmonic NPs. In this work, we synthesized Au- or Ag-decorated Fe3O4nanoparticles coated with PEI (Fe3O4-PEI-M (M = Au or Ag) NPs) using a simple method. The influences of the plasmonic metal NPs’ (Au or Ag) coating density on the magnetic and plasmonic properties of the Fe3O4-PEI-M (M = Au or Ag) NPs were investigated, and the density of the plasmonic metal NPs coated on the Fe3O4NPs surfaces could be adjusted by controlling the polyethyleneimine (PEI) concentration. It showed that the Fe3O4-PEI-M (M = Au or Ag) NPs exhibited both magnetic and plasmonic properties. When the PEI concentration increased from 5 to 35 mg/mL, the coating density of the Au or Ag NPs on the Fe3O4NPs surfaces increased, the corresponding magnetic intensity became weaker, and the plasmonic intensity was stronger. At the same time, the plasmonic resonance peak of the Fe3O4-PEI-M (M = Au or Ag) NPs was red shifted. Therefore, there was an optimal coverage of the plasmonic metal NPs on the Fe3O4NPs surfaces to balance the magnetic and plasmonic properties when the PEI concentration was between 15 and 25 mg/mL. This result can guide the application of the Fe3O4-M (M = Au or Ag) NPs in the biomedical field.
研究领域:
纳米材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yali Gao,Weisheng Yang,Wenbo Yi,Shuzhen Ni,Yingjuan Fu,Menghua Qin,Fengshan Zhang
In recent years, researchers have put much attention on the improvements and upgrades of novel wet strength agent in the papermaking fields, especially in the usage of household paper. Herein, PEI M -KH560 by polyethyleneimine (PEI) and γ-glycidyl ether propyl trimethoxysilane (KH560) was synthesized with five molecular weights (Mw) of PEI at 600, 1800, 10,000, 70,000 and 750,000. Results showed that the molecular weight greatly influenced the physicochemical properties of PEI-KH560, such as the size and thermal stability. The intrinsic cationic charge of PEI-KH560 provided the bonding sites with the paper fibers, forming strengthened fiber-fiber joints. It was shown that the dry, wet strength and hydrophobicity of cellulosic paper sheets were obviously improved. When the m (PEI):m(KH560) is 1:2, the strength of papers after sizing by Mw of PEI at 600 and 1800 is the most obvious, with the dry strength increased by 227.9 % and 187.5 %, and the wet strength increased by 183.8 % and 207.8 %, respectively. The maximum hydrophobicity was found at the PEI 1800 -KH560 with the contact angle value of 130.6°. The resultant environmental-friendly agent (PEI-KH560) obtained in this work provides valuable significance for the preparation of household and food packaging paper.
研究领域:
制浆造纸工程
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Qu Zhengquan,Zhang Baozhong,Liu Xihong,Cui Xiaoying,Zhao Ke,Li Ying,Xie Lingling,Zhu Huina,Chen Hanyu,He Baoshan
Fumonisin B1 (FB1) is a secondary metabolite generated by Fusarium verticillioides , which can widely contaminate crops. Herein, an electrochemical aptamer sensor with high sensitivity and selectivity was constructed for FB1 detection, leveraging the specific recognition capability of aptamers. Polyethylenimine-functionalized cerium dioxide-supported platinum nanoparticles (PEI-CeO 2 @PtNPs) were used for the modification of electrodes. The nanocomposite enhanced electrical conductivity on the electrode, and provided more attachment sites to increase the loading capacity of aptamer chains. Additionally, polyethylenimine-functionalized melamine-cyanuric acid condensation polymers (PEI-MCA) were used as carrier for the signal probe. Because of the unique porous structure and abundant functional groups on the surface of MCA, the loading efficiency of methylene blue (MB) was significantly enhanced, and the complementary DNA (cDNA) strand of aptamers was effectively loaded on PEI-MCA by strong electrostatic interaction to construct signal probes. The cDNA was captured by aptamers through complementary base pairing, and PEI-CeO 2 @PtNPs amplified electrical responses cooperatively with PEI-MCA. In the presence of FB1, the aptamers preferentially bound to FB1, and the signal probes were detached from the electrode surface, resulting in a decrease in the electrochemical response. Under optimal conditions, the dynamic range of the constructed aptasensor was 1 × 10 −1 to 1 × 10 4 pg/mL, with a detection limit of 89 fg/mL. Additionally, the sensor had high selectivity, reproducibility, and stability, and could detect FB1 in milk and corn flour samples.
研究领域:
分析化学
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食品安全
·
生物传感器
·
纳米材料
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xiaoyu Wang,Hanlin Shao,Zhihao Chen,Xiaoshuang Yin,Yun Chen,Ying Liu,Wenzhong Yang
Herein, we presented a facile method for enhanced boron removal based on PEI-grafted defective MOF-808 (D-MOF-808/PEI). The rich Zr OH bonds, amino-functionalized surface, and exposed metal defects of D-MOF-808/PEI endow it with the high adsorption capacity of boron. Due to the ligand exchange at metal defects and boron-imine/amine groups complexation, D-MOF-808/PEI exhibits exceptional selectivity for boron with the saturation adsorption of 95.30 mmol·g −1 at 45 °C. Additionally, negligible interference from other coexistent ions and excellent reusability promote the application of D-MOF-808/PEI practically for the rapid and high selectivity removal of boron from complex environmental samples. This work furnishes a promising strategy for boron contamination and expands the application potential of defective MOF-based adsorbents for environmental remediation.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2017
·
IF 3.887
Aijie Guo,Yun Wang,Shaohui Xu,Xiao Zhang,Min Li,Qing Liu,Yuanyuan Shen,Derong Cui,Shengrong Guo
Because the surface of the cationic polymer gene complex is positively charged, it can result in problems such as poor blood stability and cytotoxicity. Therefore, reducing the positive charge of the cationic gene complex without affecting its transfection efficiency is crucial. To achieve this objective, a pH -responsive charge-convertible ternary complex was developed in this study. Modified plyethylenimine (PEI) with two different degrees of substitution of NH 2 (plyethylenimine-1,2-cyclohexanedicarboxylic anhydride, PEI-CCA, and folic acid-plyethylenimine-1,2-cyclohexanedicarboxylic anhydride, FA-PEI-CCA) were first obtained by a chemical graft reaction. PEI-CCA and FA-PEI-CCA have significantly lower cytotoxicities and much better blood compatibilities than PEI does, and the former have an undifferentiated compression capability of DNA . The zeta potential values of the as-prepared ternary complexes (PEI-CCA/PEI/DNA and FA-PEI-CCA/PEI/DNA) were negative at pH 7.4 and positive at pH 6.5, with particle sizes of approximately 150 nm. MTT assays demonstrated the significantly lower cytotoxicities of the ternary complexes compared to that of PEI/DNA. Moreover, the cytotoxicities of the ternary complexes were lower at pH 7.4 than pH 6.5. Transfection experiments in vitro revealed that the mean fluorescence intensities and transfection efficiencies of the ternary complexes were lower than for PEI/DNA at pH 7.4 but were almost the same at pH 6.5. The ternary complex with a FA group had significantly higher mean fluorescence intensity and transfection efficiency than did the ternary complex without it. In addition, the transfection experiment in 293T cells preliminarily validated the targeting function of the FA group of the ternary complex.
研究领域:
分子生物学
·
基因治疗
·
药物递送
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产品关联
DOI
PubMed
高影响因子
BioNanoScience
·
2025
·Vol. 15
·期 2
·1-10
·
IF 3.2
Cai He-Qing,Han Lu,Xue Xin-Yu,Zhang Kou,Wang Tian-Hao,Pan Fu-Hong,Sun Zhi-Cheng,Liu Ru-Ping,Hu Kun,Wei Yen
Gold nanocages (AuNCs) exhibit tunable local surface plasmon resonance (LSPR) properties and exceptional drug loading and releasing capabilities, attributes stemming from their hollow interiors and ultra-thin porous walls. These features underscore their promising applications in the biomedical field. In this study, we fabricated AuNCs with LSPR peaks at 810 nm via chemical etching of Ag nanocube templates with sharp edges using a precisely controlled volume of chloroauric acid. To impart gene-loading functionality, we chemically anchored thiol-modified polyethyleneimine (PEI) onto the surfaces of AuNCs through robust Au–S bonds, generating a novel gene carrier, AuNCs-PEI. Subsequently, we evaluated its photothermal efficacy using a femtosecond laser and assessed cytotoxicity via MTT assay. The binding affinity of AuNCs-PEI for EGFP plasmids was characterized by gel retardation assays. Furthermore, the gene delivery efficiency of AuNCs-PEI was examined in 293 T cells by quantifying green fluorescence protein signals using inverted fluorescence microscopy. These findings demonstrate that engineered AuNCs-PEI not only facilitates gene loading for therapeutic applications but also enables photothermal therapy (PTT).
研究领域:
生物医学工程
·
纳米医学
·
基因治疗
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Yi-Ping Cao,Yu-Pei Xia,Xiao-Fei Gu,Li Han,Queting Chen,Gao-Ying Zhi,Dong-Hao Zhang
Here, PEI@PMMA microspheres were prepared by grafting polyethyleneimine (PEI) on poly(methyl methacrylate) (PMMA) magnetic microspheres and successfully used to immobilize lipase. The results showed that PEI@PMMA microspheres had strongly adsorbed lipase (49.1 mg/g microsphere) via electrostatic attraction. To prevent lipase shedding, the adsorbed lipase was further crosslinked with PEI on microspheres using glutaraldehyde as crosslinker. Consequently, PEI-crosslinked lipase (2.14 U/mg) exhibited 2.6 times and 1.4 times higher activity respectively than the directly covalent lipase (0.82 U/mg) and the crosslinked lipase aggregates (1.57 U/mg), which was close to the activity of adsorbed lipase (2.20 U/mg). Conformational analysis from FTIR spectroscopy showed that PEI-crosslinked lipase retained its natural structure well. And the α-helix structure seemed to play a key role in enhancing lipase activity. Furthermore, the effects of various parameters on crosslinking reaction were investigated. Also, PEI-crosslinked lipase revealed higher pH and thermal stability. The Michaelis constant ( K m ) was increased and the optimum temperature of lipase was widened observably after crosslinking with PEI on PEI@PMMA magnetic microspheres.
研究领域:
生物化学
·
酶工程
✓ 已验证
DOI
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Chen Zhao,Yiheng Wang,Nianping Wang,Ruilin Chen,Rui Yin,Xiangxi Li
The in-situ growth of ZnO is often used to modify membrane surface for enhanced hydrophilic and antibacterial properties due to significant modification effect, simple process and low cost. Nonetheless, some polymer membranes (such as PVDF membrane) lack active sites for ZnO growth on their surfaces, resulting in a small number of particles and unstable binding. This study utilized PDA/PEI to modify PVDF membranes for adequate active sites to capture Zn 2+ ions via the chelation action. Thereafter, nano ZnO can be synthesized easily via the alkalization reaction and thermal breakdown of Zn 2+ . Upon improving the modification conditions, ZnO particles were evenly distributed on the PVDF membrane's surface, leading to a reduction in membrane pore size from 0.38 nm to 0.29 nm. The water contact angle of the ZnO/PDA-PEI modified membrane dropped from 130° to 19°, indicating a significant enhancement in hydrophilicity. The modified membrane demonstrated enhanced anti-fouling performance in the oil/water separation experiment, achieving a steady permeance of 298 L·m −2 ·h −1 ·bar −1 , which was sixfold that of the original membrane. In the antibacterial experiment, the modified membrane exhibited significant antibacterial efficacy against both E. coli and S. aureus .
研究领域:
材料科学
·
环境工程
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2018
·
IF 4.816
Ya-Ping Xiao,Ji Zhang,Yan-Hong Liu,Ju-Hui Zhang,Qing-Ying Yu,Zheng Huang,Xiao-Qi Yu
Fluorinated biomaterials have been reported to have promising features as non-viral gene carriers. In this study, a series of fluorinated polymeric gene carriers were synthesized via Michael addition from low molecular weight polyethyleneimine (PEI) and fluorobenzoic acids (FBAs)-based linking compounds with different numbers of fluorine atoms . The structure-activity relationship (SAR) of these materials was systematically investigated. SAR studies showed that fluorine could screen the positive charge of these polymers. However, this shielding effect of fluorine would endow fluorinated polymers with good balance between DNA condensation and release. In vitro transfection results suggested that these fluorinated polymers could mediate efficient gene delivery. Flow cytometry and confocal microscopy studies demonstrated that more efficient cell uptake could be achieved by fluorinated materials with more fluorine atoms. Cytotoxicity assays showed that these fluorinated materials exhibited very low cytotoxicity even at high mass ratios. This study demonstrates that FBA-based fluorinated biopolymers have the potential for practical application.
研究领域:
生物材料学
·
基因治疗
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Greenhouse Gases-Science and Technology
·
2024
·
IF 2.7
Lanxin Li,Zhibo Luo,Wei Zou,Shengke Liang,Hong Wang,Chen Zhang
Amine-functionalized porous polymers have been considered as a prominent chemical adsorption material for carbon capture and storage (CCS) process, because of their large adsorption capacity and high selectivity. By comparison, the low energy-consumption for desorption and high recyclability are the advantages of the physical adsorption approach. In this work, an amine-functionalized hierarchical porous polymer was prepared by HIPE (high internal phase emulsions) template and amine impregnation strategy, and applied as CO 2 adsorbent to realize chemical adsorption and physical adsorption simultaneously. First, a hierarchical porous matrix of poly(styrene-glycidyl methacrylate) was prepared by the HIPE method. The formed meso/micropores in the typical porous polymer matrix could attract CO 2 molecules, where the physical adsorption was achieved. Subsequently, PEI (polyethyleneimine) was impregnated into the porous polymer with abundant macropores, and the numerous of amino groups provided the reaction sites, where the chemical adsorption was achieved. As a result, an effective CO 2 adsorption material was obtained via controlling the porous structure by changing the volume fraction of dispersive phase, impregnation condition and amine loading. Aided by the chemical adsorption of amino groups, the CO 2 adsorption capacity of the obtained adsorbent reached 3.029 mmol/g. Moreover, the CO 2 adsorption thermodynamics confirmed the physicochemical synergistic adsorption, and then the Q st reduced to 31–42 kJ/mol and a good cyclic stability was obtained. As conclusion, the porous adsorbent showed a good industrial application prospect. © 2024 Society of Chemical Industry and John Wiley & Sons, Ltd.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Chaojian Zhang,Tianrui Yang,Junsheng Liu,Qianqian Duan,Jiahui Song,Youjun Yin,Hansong Wang
Novel poly(ethylene imine) (PEI) modified chitosan-based hybrid membranes (PMCHMs) were created via a soft chemistry method, in which unmodified chitosan (CS) firstly reacted with PEI to produce a CS-PEI precursor. Later, such CS-PEI precursor was blended with silicone to create the membrane solution of PMCHMs. Finally, PMCHMs could be obtained via phase-inversion process. Multi-component sorption of Pb 2+ , Cu 2+ and Ni 2+ on PMCHMs in metal mixed solutions, such as, Pb 2+ &Cu 2+ and Pb 2+ &Ni 2+ binary, Pb 2+ , Cu 2+ and Ni 2+ ternary, as well as Pb 2+ , Cu 2+ , Ni 2+ , Cd 2+ and Cr 3+ quintuple mixed solutions, was inspected. The calculation of effective diffusion coefficients, distribution coefficients and selectivity coefficients showed that Pb 2+ sorption on PMCHMs had excellent selectivity in these mixed multi-metal solutions. While, the calculation of activation energy proved that Pb 2+ , Cu 2+ and Ni 2+ sorption on PMCHMs was a physic-sorption process Also, mechanism insight reveals that Pb 2+ sorption on PMCHMs could be depicted via Lagergren pseudo-2nd-order kinetic model and Langmuir or Freundlich isotherm equation. Exclusively, intra-particle diffusion process was discussed in detail. Desorption testing verified that HCl is a good desorbent for metals sorption on PMCHMs and the cycle time of membranes can arrive at 6 times. These results demonstrate that PMCHMs can be used to preferentially eradicate Pb 2+ from metal mixture solutions, showing prospective applications in the treatment of metal mixture wastewater from waste vehicle power-battery and other various metal-bearing polluted water.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 5
·1-10
·
IF 6.408
Ding Jinglei,Zhang Wenqi,Xue Fengying,Sun Yu,Yan Quizhu,Chen Yanwei,Shan Guiye
Gold nanoclusters (AuNCs) are widely used in the fluorescence detection of biomolecules in human serum due to their good fluorescence properties, low toxicity, and better biocompatibility. However, the weak fluorescence intensity of AuNCs limits the fluorescence detection of molecules within a wide concentration range. It is reported that coating AuNCs in ZIF-8 with adjustable pore size can effectively improve the fluorescence intensity of AuNCs and broaden the detection range. And the AuNCs wrapped in the gaps of ZIF-8 can prevent the fluorescence quenching caused by the aggregation of AuNCs. However, ZIF-8 has high crystallinity, poor dispersion, and easy deposition, which reduces the fluorescence stability of the detection system and affects the detection. Based on the above research, the highly hydrophilic polymer PEI was modified to the surface of ZIF-8, and a kind of nanocomposite material AuNCs/ChOx@ZIF-8/PEI was obtained by co-encapsulating AuNCs prepared with glutathione as a ligand and cholesterol oxidase (ChOx) into ZIF-8 modified with PEI. The composite material emits strong red light at 650 nm under the excitation of 395-nm light, and the system can sensitively detect cholesterol (Chol) in human serum. Compared with other materials, the PEI-modified composite has better solubility and stability, so the detection effect of Chol is better. Encapsulation of ChOx in the ZIF-8 shell can protect the enzyme and increase the local concentration of ChOx, thereby speeding up the reaction rate. Compared with free AuNCs/ChOx, the quenching rate of AuNCs/ChOx@ZIF-8/PEI system is doubled. Secondly, the addition of Fe 2+ to the detection process results in higher quenching rate and detection sensitivity. The system can detect Chol in the concentration range 0.1–2.4 μM, with a detection limit of 0.073 μM. The determination is a fast and sensitive strategy. In addition, the practicability of this assay in the detection of Chol in human serum has been verified. Due to its selectivity and sensitivity, it has potential application value in clinical diagnosis. Graphical abstract
研究领域:
生物化学
·
医学诊断
·
纳米材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）