ANALYTICA CHIMICA ACTA
·
2016
·
IF 4.712
Xi Dai,Zhi-Fang Du,Li-Hong Wang,Jun-Ying Miao,Bao-Xiang Zhao
We have designed and synthesized a simple but effective fluorescent probe for sensing glutathione (GSH) by PET process based on coumarin and quinone , which worked as fluorophore and reaction site, respectively. The probe could discriminate GSH from cysteine and homocysteine within 1 min in PBS-buffered solution. The sensing mechanism was confirmed by density functional theory (DFT), viscosity test, fluorescence spectrum analysis and HRMS , respectively. The probe has a low limit of detection (0.1 μM) and finally been used in cell imaging successfully.
研究领域:
生物化学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
Analytical Methods
·
2019
·Vol. 11
·期 19
·2579-2584
·
IF 2.378
Dongjian Zhu,Xiaowei Yan,Aishan Ren,Wen Cai,Zhenhua Duan,Yanghe Luo
A novel ratiometric fluorescent probe 1 based on boranil derivatives modulated by ICT and PET processes was designed and synthesized for the first time. Upon addition of Cys, the emission peak of 1 changed from 461 nm to 474 nm, accompanied by a fluorescence color change from dark blue to blue under illumination with a 365 nm UV lamp. 1 exhibited a fast response (within 9 min), high sensitivity (detection limit of 95.1 nM) and excellent selectivity toward Cys over Hcy and GSH owing to a specific conjugate addition–cyclization reaction between Cys and the acrylate moiety. Furthermore, 1 was successfully implemented for monitoring Cys in living cells.
研究领域:
分析化学
·
生物医学
✓ 已验证
DOI
高影响因子
ANALYTICAL SCIENCES
·
2019
·Vol. 35
·期 12
·1341-1345
·
IF 1.618
Xu Wenzhi,Li Xue,Yin Jiwei,Liu Weiyan,Yang Yutao,Li Wei
Hydrazine is an important catalyst and chemical raw material. But it is highly toxic and potentially carcinogenic. We designed a new hydrazine probe based on a synergistic effect by introducing acetate and phthalimide into 2-phenylbenzimidazole (PBI). Comparative experiments proved that “the dual position interaction” had a “synergistic effect” on fluorescence enhancement. The fluorescence enhancement caused by the probe (15.0 fold) is much larger than the sum of the fluorescence enhancement of the two monomer compounds (2.6 and 1.4 folds, respectively). A theoretical calculation showed an inhibition of the PET process and a recovery of the ICT process led to a fluorescence enhancement. The probe was specific to hydrazine and showed a linear response to it in the concentrations range of 0.2–200 μM with a LOD of 0.062 μM (1.99 ppb). Moreover, the probe could detect hydrazine in tap water; the recovery of hydrazine from the tap water was between 98.86–103.28%.
研究领域:
分析化学
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环境科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Yujiao Wang,Qingyu Guo,Xingyi Wu,Haixiang Gao,Runhua Lu,Wenfeng Zhou
In this study, a novel FONs-based sensor P-M(w) was synthesized using 1-Pyrenecarboxaldehyde and L-methionine through facile hydrothermal strategy. The fluorescence emission peaks of the acquired P-M(w) would show specific changes after the addition of Hg 2+ due to interfering the PET process and inducing nano-structure conformational rigidification of P-M(w). Notably, the water-soluble FONs-based sensor was firstly used to detect Hg 2+ in tea samples providing a new material choice for the fluorescence sensor construction of metal ion detection. Besides, the qualitative and quantitative analysis of Hg 2+ could be carried out with P-M (w) at a very low concentration (1 μg/mL) meaning that the acquired P-M(w) synthesized by few grams of reactants may satisfy the detection of approximate fifty thousand samples.
研究领域:
分析化学
·
环境科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Chunxia Liu,Caixia Shi,Haixia Li,Weiwei Du,Zhanxian Li,Liuhe Wei,Mingming Yu
A 8-hydroxyquinoline-based derivative was designed and synthesized, which is shown to act as a highly sensitive fluorescent probe for formaldehyde in aqueous solution. Based on the photo induced electron transfer (PET) process, addition of formaldehyde greatly enhanced the fluorescence of the probe. Formaldehyde can be detected quantitatively in the concentration range from 900 nM to 1.3 × 10 −4 M and the detection limit on fluorescence response of the probe can be as low as 900 nM. The proposed method was successfully employed for preliminary application in several commercially available foods. Moreover, it has been successfully blended with a host polymer polyvinyl alcohol and the polymer containing the probe has been made in nanofiber form via electrospinning. The fluorescence of the nanofibers could also be enhanced after they were immersed into water solution of formaldehyde.
研究领域:
分析化学
·
材料科学
·
环境监测
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Lina Guo,Xiaochao Chen,Ruijun Xie,Limin Han,Ning Zhu
4-Phenyl-2-(2′-pyridyl) quinoline ( L1 ) was synthesized by a three-component reaction of aniline, phenylacetylene and pyridine-2-aldehyde catalyzed by trifluoromethanesulfonic acid (TfOH). Its structure was confirmed by FT-IR, MS, NMR and X-ray single crystal diffraction analysis. L1 was investigated as a probe for the detection of Fe 3+ and Fe 2+ ions, which displayed fluorescence enhancement by Fe 3+ and fluorescence quenching by Fe 2+ . This unique fluorescence switching property of L1 was used to identify Fe 2+ and Fe 3+ with high selectivity and sensitivity. The detection limit of Fe 2+ was 8.772 × 10 −9 mol/L and that of Fe 3+ was 1.912 × 10 −9 mol/L. Mechanism investigation revealed that the fluorescence quenching of probe L1 was caused by ferrous-induced PET process and the fluorescence enhancement was due to the combinational effect of ferric-induced PCT enhancement and PET inhibition. In addition, the cyclic voltammetry curves demonstrated that both the Fe 2+ complexes and the Fe 3+ complexes displayed reversible redox process, indicating that the Fe 2+ and Fe 3+ complexes can be reversibly converted into each other upon electrical stimulation. The reversible “On” and “Off” of the fluorescence emission of iron complexes upon electrochemical stimulation could potentially be used in information recording and erasing.
研究领域:
分析化学
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
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