CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Qingcong Wei,Ziming Jin,Weiwei Zhang,Yanfei Zhao,Yaxing Wang,Yixing Wei,Xing He,Guanglei Ma,Yuming Guo,Yuqin Jiang,Zhiguo Hu
Bacterial infection, oxidative stress and inflammation are the main obstacles in wound healing. Hydrogels with moist and inherent properties are beneficial to wound healing. Here, we fabricated a honokiol-laden micelle-crosslinked hyaluronate-based hydrogel by simply mixing honokiol-laden PF127-CHO micelles, 3,3′-dithiobis(propionohydrazide) grafted hyaluronic acid and silver ions. PF127 could not only effectively load hydrophobic small molecules but also be macromolecular crosslinker for preparing hydrogels. Hyaluronic acid plays an essential role in wound healing processes including regulating macrophage polarization towards M2 phenotype. The chemical dynamic acylhydrazone crosslinking and physical crosslinking among PF127-CHO micelles constructed hydrogel's networks, which endowed hydrogel with excellent self-healing properties. PF-HA-3 hydrogel also exhibited outstanding antioxidant and antibacterial capabilities. In a full-thickness skin defect model, this degradable and biocompatible hydrogel could promote wound healing by remodeling wound tissues, regulating M2 polarization and angiogenesis . In summary, this inherent multifunctional hydrogel will provide a promising strategy for designing bioactive compounds-based wound dressings.
研究领域:
材料科学
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生物医学工程
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药剂学
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组织工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2018
·Vol. 18
·期 12
·8070-8077
·
IF 1.354
Zhao Hongli,Sun Shanshan,Wang Zhaodong,Hong Yayun,Shi Lulu,Lan Minbo
In this work, a novel combination of drug therapy and cryotherapy for tumor treatment was developed. Pluronic F127 modified with poly(acrylic acid) at two terminals (denoted as PAA-PF127-PAA) was used as carriers for doxorubicin (DOX) delivery. Due to the pH-sensitive property endowed
by PAA, the DOX-loaded PAA-PF127-PAA micelles released DOX faster in the slightly acidic physiological environment of the tumor site than that in the neutral physiological environment. Three-group rats bearing Walker 256 carcinosarcoma were respectively treated with cryotherapy, combination
of DOX-loaded micelles and cryotherapy, and saline injection to investigate the effect of the combined therapy. The apoptosis rate of TdT-mediated dUTP nick-end labeling (TUNEL) slices indicated that compared with cryotherapy alone, the DOX-loaded PAA-PF127-PAA micelles combining with cryotherapy
showed increased apoptosis. Thus, the combination of drug therapy and cryotherapy can be used as an effective technique for tumor treatment.
研究领域:
肿瘤学
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药学
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生物医学工程
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DOI
PubMed
高影响因子
NANOTECHNOLOGY
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2014
·Vol. 25
·期 29
·295103
·
IF 3.672
Jun Chen,Xiao-Quan Yang,Yuan-Zheng Meng,Huan-Huan Huang,Meng-Yao Qin,Dong-Mei Yan,Yuan-Di Zhao,Zhi-Ya Ma
Probe bismuth sulfide modified with Pluronic F127 (Bi2S3-PF127), which has high biocompatibility and dispersibility, is synthesized using triblock copolymer Pluronic F127 to modify hydrophobic Bi2S3 nanoparticles that are prepared by a hot injection method. TEM results show that most of the probe has a length of about 14.85 ± 1.70 nm and a breadth of about 4.79 ± 0.63 nm. After injected into the tail vein of a mouse, the probe has obvious CT contrast enhancement capability from x-ray CT imaging results. Meanwhile, the probe's in vivo toxicity is also studied. It is found that hematoxylin and eosin stains of major organs have no change. A biochemical analysis (alanine aminotransferase and aspartate aminotransferase) prove the probe has no adverse effects. The results of a blood analysis (white blood cell count, red blood cell count, hemoglobin, and platelet count) are also normal. The biological distribution of Bi by ICP-AES shows that most of nanoparticles are cleaned out after injection 48 h, and the circulation half-life of the probe is 5.0 h, suggesting that Bi2S3-PF127 has a long circulation and indicating that the Bi2S3-PF127 probe has good biocompatibility and safety.
研究领域:
医学影像学
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纳米医学
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毒理学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Lei Nie,Xiaoyue Ding,Yingsong Zhao,Peng Ding,Meili Zhao,Yuanna Sun,Yanfang Sun,Guohua Jiang
Multifunctional hydrogel dressings, with their robust antibacterial and anti-inflammatory properties, represent a great potential in biomaterials for wound care. Injectable and self-healing hydrogels that mimic the natural extracellular matrix of tissues offer a promising strategy for effective wound repair. This study designs a hydrogel based on the formation of a dynamic cross-linking network within the hydrogel matrix through the Schiff base reaction between the synthesized polymers L-hydroxyproline-conjugated chitosan (LHCS) and oxidized pullulan (OPL). The fabricated LP hydrogels preserve the porous interconnected microstructure, excellent self-healing capacity, and injectability, suitable swelling capability, robust mechanical strength, and outstanding tissue adhesion. Moreover, curcumin was encapsulated in Polyether F127 (Pluronic F127) micelles to obtain curcumin loaded PF127 (Cur-PF127) micelles and then incorporated into LP hydrogel to fabricate the composite hydrogels. The composite hydrogels exhibit effective antibacterial properties and antioxidant abilities, admired hemostatic effect and hemocompatibility, excellent cytocompatibility and cell pro-migration ability. In addition, in vivo evaluation confirmed that curcumin loaded hydrogels could facilitate the regeneration of epithelial and hair follicles, increase the collagen production, alleviate the inflammatory response via the downregulation of the tumor necrosis factor-α (TNF-α), and reduce the fibrosis, thus promote the wound repair process. This work offers a promising facile approach for the development of the composite hydrogel as wound dressing in wound healing applications.
研究领域:
生物材料
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伤口愈合
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药物递送
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高分子科学
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组织工程
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纳米医学
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产品关联
DOI
PubMed
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2023
·
IF 10.2
Yu Tang,Lanfang Zhang,Rui Sun,Baiyi Luo,Yu Zhou,Yan Zhang,Yuqi Liang,Bo Xiao,Chenhui Wang
The mucosal barrier remains a major barrier in the pulmonary drug delivery system, as mucociliary clearance in the airway accelerates the removal of inhaled nanoparticles (NPs). Herein, we designed and developed the inhalable Pluronic F127-modified silk fibroin NPs loading with quercetin (marked as QR-SF (PF127) NPs), aiming to solve the airway mucus barrier and improve the cancer therapeutic effect of QR. The PF127 coating on the SF NPs could attenuate the interaction between NPs and mucin proteins, thus facilitating the diffusion of SF(PF127) NPs in the mucus layer. The QR-SF (PF127) NPs had particle sizes of approximately 200 nm with negatively charged surfaces and showed constant drug release properties. Fluorescence recovery after photobleaching (FRAP) assay and transepithelial transport test showed that QR-SF (PF127) NPs exhibited superior mucus-penetrating ability in artificial mucus and monolayer Calu-3 cell model. Notably, a large amount of QR-SF (PF127) NPs distributed uniformly in the mice airway section, indicating the good retention of NPs in the respiratory tract. The mice melanoma lung metastasis model was established, and the therapeutic effect of QR-SF (PF127) NPs was significantly improved in vivo . PF127-modified SF NPs may be a promising strategy to attenuate the interaction with mucin proteins and enhance mucus penetration efficiency in the pulmonary drug delivery system.
研究领域:
药学
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纳米技术
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癌症研究
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2026
·
IF 6.2
Jinghan Wang,Gang He,Jinying Zhao,Min Chen,Zheng Pan,Chong Zhang,Decheng Wu,Wen Sui
Oral ulcers remain difficult to treat owing to the mechanically dynamic and microbially rich oral environment, where constant shear forces, microbial challenge, and oxidative stress collectively impede mucosal repair. Here, we report a versatile injectable self-healing bioadhesive hydrogel sealant (F127-AG) based on dynamic Schiff-base crosslinking between aldehyde-modified Pluronic F127 (PF127-CHO) and amine-functionalized gelatin (AG), enabling rapid in situ gelation, strong wet tissue adhesion, and intrinsic self-healing. Kaempferol was incorporated into the hydrogel matrix, and the resulting Kae@FG hydrogel exhibited antioxidant and antibacterial activities. In vitro, Kae@FG exhibited excellent hemocompatibility and cytocompatibility, promoted fibroblast migration, and degraded favorably in artificial saliva. Additionally, it effectively scavenged reactive oxygen species and displayed potent bactericidal activity against both E. coli and S. aureus. In a rat oral ulcer model, Kae@FG accelerated wound closure, enhanced epithelial regeneration, improved collagen deposition, and promoted neovascularization, outperforming the commercial GENGIGEL®. Mechanistically, Kae@FG exerted an immunomodulatory effect by attenuating local inflammation, reducing neutrophil and M1 macrophage infiltration, and promoting M2 macrophage polarization, thereby supporting a pro-regenerative microenvironment. Overall, the F127-AG platform represents a versatile therapeutic delivery system with substantial potential for promoting regeneration of oral and other soft tissues.
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DOI
PubMed
高影响因子
BIOMEDICINE & PHARMACOTHERAPY
·
2024
·
IF 6.9
Ya-wei Zhang,Xiaoyang Pang,Yan Yang
Background A new spray adhesive (KYNA-PF127) was established through the combination of thermosensitive hydrogel (Pluronic F127) and KYNA, aimed to investigate the effect of KYNA-PF127 on multi-territory perforator flaps and its possible molecular mechanism. Materials and methods 36 SD male rats with 250–300 g were randomly divided into 3 groups (n = 12): control group, blank glue group and KYNA-PF127 group. KYNA-PF127 hydrogel was prepared and characterized for its morphology and properties using scanning electron microscopy. CCK-8 assay, scratch wound assay, transwell assay, tube formation assay and Ki67 staining were used to study the effect of KYNA-PF127 on the proliferation, migration, and tube formation of HUVECs. VEGF and FGF2 were measured by qPCR to evaluate the angiogenesis capacity of HUVECs in vitro. In vivo, the effect of each group on the survival area of the cross-zone perforator flap was evaluated, and angiogenesis was evaluated by HE and immunofluorescence (CD31 and MMP-9). The effect of inflammation on skin collagen fibers was assessed by Masson. Immunohistochemistry (SOD1, IL-1β, TNF-α) was used to evaluate the effects of oxidative stress and inflammatory factors on multi-territory flaps. Results KYNA-PF127 has good sustained release and biocompatibility at 25% concentration. KYNA-PF127 promoted the proliferation, migration, and angiogenesis of HUVECs in vitro. In vivo, the survival area of multi-territory perforator flaps and angiogenic capability have increased after KYNA-PF127 intervention. KYNA-PF127 could effectively reduce the oxidative stress and inflammation of multi-territory perforator flaps. Conclusion KYNA-PF127 promotes angiogenesis through its antioxidant stress and anti-inflammatory effects, and shows potential clinical value in promoting the survival viability and drug delivery of multi-territory perforator flaps.
研究领域:
生物医学工程
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组织工程
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药学
·
分子生物学
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DOI
PubMed
高影响因子
DESALINATION
·
2021
·
IF 9.501
Yang Li,Tian-Hui Chen,Chun-Yang Yu,Tao Wu,Xue-Ting Zhao,Jie-Feng Pan,Li-Fen Liu
The integrity and uniformity of polyamide (PA) layer have a great influence on the separation performance of thin-film composite (TFC) polyamide reverse osmosis (RO) membrane. In this work, three kinds of micelles including the neutral macromolecule Pluronic F127 (PF127), anionic surfactant sodium dodecyl sulfate (SDS) and the PF127/SDS mixed micelles (PSMM), were proposed to be introduced in the aqueous phase to regulate the interfacial polymerization (IP) process with the purpose of constructing a more integrated and uniform PA separation layer of the RO membrane for seawater desalination . Compared to the single PF127 and SDS, the PSMM-1 (0.05 wt% PF127/0.05 wt% SDS) in the aqueous solution exhibited special advantages including unique three-dimensional (3D) spherical structure, lower solution viscosity and water-Isopar G interface tension (IFT), which sped up m -phenylenediamine (MPD) to homogeneously diffuse to the water-Isopar G interface and further regulated the interfacial polymerization reaction between MPD and trimesoyl chloride (TMC). Ultimately, the regulated RO membrane via PSMM-1 had more uniform PA layer and thus exhibited better comprehensive separation performances including higher salt rejection (more than 99.5%) and ideal water flux (about 35 L·m −2 ·h −1 ). This study provides a facile method of PA microstructure adjustment via micelles to fabricate higher-performance TFC RO membrane for seawater desalination.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
Materials Today Communications
·
2026
·
IF 4.9
Lei Nie,Xinran Li,Jingyu Li,Yanfang Sun,Guohua Jiang
Nanoparticle-reinforced composite hydrogels have been widely used for tissue engineering and biomedicine. In particular, hydrogels with multiple functionalization, such as self-healing, antibacterial, and cytocompatible properties, can facilitate their use in wound-healing and bio-adhesive applications. In this work, the multifunctional composite hydrogels were fabricated using silk fibroin (SF) and gelatin methacrylate (GelMA), incorporating silver-doped reduced graphene oxide (Ag@rGO) nanosheets and curcumin-loaded PF127 (PF127-Cur) micelles. The obtained hydrogels possessed an interconnected microstructure, good swelling properties (250–350%), and strong adhesion to the surface of different matrices, including rubber, metal, glass, plastic, wood, and finger skin. In addition, the hydrogels demonstrated self-healing, injectability, and electrical conductivity. Furthermore, the designed composite hydrogels demonstrated good antibacterial properties against the typical bacteria, Gram-positive S. aureus and Gram-negative E. coli . CCK-8 assay, fluorescent images, and cell scratch assay confirmed that the composite hydrogels exhibited excellent cytocompatibility and cell pre-migration ability. The obtained data confirmed that the designed hydrogels possessed great potential for biomedical applications, such as wound healing and bio-adhesives.
✓ 已验证
DOI
高影响因子
Advanced Healthcare Materials
·
2023
·
IF 10
Hui Shi,Ru Wang,Hu-Chen Cao,Hai-Yan Guo,Pei Pan,Cheng-Feng Xiong,Lin-Jun Zhang,Qiang Yang,Shuang Wei,Tao Liu
To overcome the limitations of doxorubicin (DOX) chemotherapy, nanomedicines that integrate additional photothermal therapy (PTT) and chemodynamic therapy (CDT) strategies are highlighted as promising alternatives for the treatment of malignant tumors. However, time-consuming preparation processes, biosafety concerns, and the bottlenecks of individual therapeutic modalities often limit the practical applications of this strategy. To address these issues, this work designs an oxygen economizer that additionally serves as a Fenton reaction amplifier through the simple assembly of epigallocatechin gallate (EGCG), pluronic F-127 (PF127), iron (III) ions, and doxorubicin (DOX) for the enhancement of synergistic PTT/CDT/chemotherapy. The resulting nanoformulation, EFPD, can target mitochondria and inhibit cell respiration to reduce O 2 consumption, thus boosting DOX-mediated H 2 O 2 generation for enhanced CDT and simultaneously improving hypoxia-limited DOX chemotherapy efficacy. Moreover, the coordination between EGCG and Fe 3+ provides EFPD with excellent photothermal conversion efficiencies ( η = 34.7%) for PTT and photothermal-accelerated drug release. Experimental results indicate that EFPD-mediated synergistic enhancement of PTT/CDT/chemotherapy can achieve excellent therapeutic outcomes, including enhanced ablation of solid tumors, reduced metastasis and cardiotoxicity, and extended life spans.
研究领域:
纳米医学
·
癌症治疗
·
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Liying Wan,Peijie Li,Meiling Yan,Jianhong Wang,Xibao Li
Conductive hydrogels have attracted much attention in soft electronic devices. However, it is still a challenging to be integrated with outstanding mechanical performance, self-healing, shape memory and conductive capability. Herein, we developed a multifunctional conductive hydrogel via interpenetrating network (IPN) and multiple hydrogen bond interaction. Poly (acrylic acid)-polyaniline (PAA-PANI) and polyvinyl alcohol (PVA) form bones of IPN through chemical and physical double cross-linking. Chemically crosslinking of IPN was obtained by in situ polymerization of acrylic acid and aniline. Physical crosslinking is realized by more multiple hydrogen bonds (N–H···O, O–H···O, O–H···N, N–H···N) interaction among PVA, polydopamine and PF127 diamino oxygen derivatives. PANI forms a conductive path in the IPN to ensure its conductivity. IPN hydrogels with multiple hydrogen bonds has excellent mechanical strength, which is much higher than conventional conductive hydrogels. Moreover, the structure endowed the hydrogel low swelling property, good self-healing and thermal-responsive shape memory effect. The multifunctional IPN conductive hydrogel have potential applications in smart devices including self-healing electronic devices, soft robot, and sensors.
研究领域:
材料科学
·
电化学
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软体机器人
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传感器
·
智能材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）