TRIBOLOGY INTERNATIONAL
·
2025
·
IF 6.9
Xinqi Zou,Zhenghao Ge,Chaobao Wang,Yuyang Xi
Water lubrication is environmentally benign and widely used in marine stern bearings, but its low viscosity and poor interfacial affinity limit effectiveness on inert polymers like UHMWPE. This study presents a mussel-inspired co-lubrication strategy by integrating polydopamine (PDA) and polyglutamic acid (PGA) into a composite suspension. The PDA–PGA system synergistically enhances interfacial adhesion and hydration lubrication, forming a stable, self-replenishing lubricating film. Tribological tests show a 19.7 % reduction in friction and 21.9 % reduction in UHMWPE wear compared to water. Surface analyses confirm nitrogen-rich film deposition and improved shear resistance. These improvements are attributed to amide bonding, hydrogen bonding, and hydration layer formation. This strategy offers an effective lubrication solution for high-load, submerged UHMWPE–metal systems such as water-lubricated marine bearings.
研究领域:
机械工程
·
材料科学
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摩擦学
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船舶工程
·
表面化学
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产品关联
DOI
高影响因子
Polymers
·
2025
·Vol. 17
·期 1
·100
·
IF 4.9
Ben Liu,Shixiao Wang,Hanling Guo,Huibo Yin,Yuqiu Song,Min Gong,Liang Zhang,Xiang Lin,Dongrui Wang
Poly(glycolic acid) (PGA) is a rapidly degradable polymer mainly used in medical applications, attributed to its relatively high cost. Reducing its price will boost its utilization in a wider range of application fields, such as gas barriers and shale gas extraction. This article presents a strategy that utilizes recycled PGA as a raw material alongside typical carbon nanomaterials, such as graphene oxide nanosheets (GO) and carbon nanotubes (CNTs), to produce low-cost, fully degradable yarns via electrospinning and twisting techniques. The results demonstrate that the tensile strength of the PGA/GO composite yarn increased to 21.36 MPa, and the elastic modulus attained a value of 259.51 MPa with a 3 wt% of GO loading. The addition of an appropriate amount of GO enhances the tensile resistance of the composite yarns to a certain extent. However, excessive application of GO and CNTs can lead to surface defects in the nanofibers, reducing their mechanical properties. Moreover, the integration of both materials could inhibit the degradation process of PGA to some extent, thereby partially addressing the issue of excessive degradation rates associated with the relatively low molecular weight of recycled PGA.
研究领域:
材料科学
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医学工程
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环境科学
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DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2017
·
IF 4.95
Tingting Xu,Bo Chi,Jian Gao,Meilin Chu,Wenlu Fan,Meihui Yi,Hong Xu,Chun Mao
A simple and accurate immune sensor for quantitative detection of α-Fetoprotein (AFP) was developed based on the immobilization of antigen on the surface of Hep-PGA-PPy nanoparticles modified glassy carbon electrodes (GCE). The obtained Hep-PGA-PPy nanoparticles were characterized by fourier transform infrared (FT-IR) spectra and transmission electron microscopy (TEM). And the blood compatibility of Hep-PGA-PPy nanoparticles was investigated by in vitro coagulation tests, hemolysis assay and whole blood adhesion tests . Combining the conductive property of polypyrrole (PPy) and the biocompatibility of heparin (Hep), the Hep-PGA-PPy nanoparticles could improve not only the anti-biofouling effect the electrode, but also improved the electrochemical properties of the immune sensor. Under optimal conditions, the proposed immune sensor could detect AFP in a linear range from 0.1 to 100 ng mL −1 with a detection limit of 0.099 ng mL −1 at the signal-to-noise ratio of 3, and it also possessed good reproducibility and storage stability. Furthermore, the detection of AFP in five human blood samples also showed satisfactory accuracy with low relative errors. Thus, the developed immune sensor which showed acceptable reproducibility, selectivity , stability and accuracy could be potentially used for the detection of whole blood samples directly.
研究领域:
生物医学工程
·
分析化学
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2025
·
IF 3.9
Weiqiang Han,Xia Liao
Constructing a stable interfacial adhesion morphology of polymer blends remains an ongoing challenge in terms of the intrinsic instability of phase morphology. Herein, we obtained poly(ethylene 2,5-furandicarboxylate)/poly(glycolic acid) (PEF/PGA) blends with stable interface adhesion morphology and excellent physical properties by a two-step reactive blending method with the assistance of 2,2-bis(hydroxymethyl)-2,2,2-nitrilotriethanol (BIS-TRIS) and reactive elastomer (EGMA). Due to the formation of bonding points and branched/cross-linked structures, the interfacial morphology and melt strength of blends are significantly improved, leading to obviously enhanced foaming properties, thermostability, and mechanical properties. Specifically, when EGMA content was less than 20%, the blends still maintained tensile strength similar to that of neat PEF but with excellent toughness. Furthermore, all blend foams possess thin-walled cells with relatively uniform morphology, and the expansion ratio is more than 10-fold and shows greater compressive strength than commercial PET foams. Moreover, when the PEGMA foam was immersed in water for 2 weeks, the compression strength of the foam decreased by more than 70%, which makes it potentially useful in the field of temporary support.
研究领域:
高分子材料科学
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生物可降解材料
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反应性加工
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泡沫材料
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聚合物共混
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2023
·
IF 7
Chuang Hu,Haoran Ji,Yan Gong,Xuhui Yang,Yunxuan Jia,Yuanhao Liu,Guangyu Ji,Xiansong Wang,Mingsong Wang
Following the global COVID-19 pandemic, the incidence of tracheal epithelial injury is increasing. However, the repair of tracheal epithelial injury remains a challenge due to the slow renewal rate of tracheal epithelial cells (TECs). In traditional nebulized inhalation treatments, drugs are enriched in the lungs or absorbed into the blood, reducing drug concentration at the tracheal injury site. In this study, we prepared an epidermal growth factor (EGF)-loaded gamma-polyglutamic acid (γ-PGA)/epsilon-poly-L-lysine (ε-PLL) (PP) hydrogel (EGF@PP) to promote the repair of tracheal epithelial injury. Epidermal growth factor promotes the proliferation of TECs and enhances vascularization, thereby accelerating injury repair. The PP hydrogel exhibits outstanding wet adhesion, slow drug release, and antibacterial and anti-inflammatory properties, making it suitable for application in the airways and creating an environment conducive to epithelial repair. Here, we established a rabbit model of tracheal injury using a laser to destroy the tracheal epithelium and delivered EGF@PP powder to the injury site under fiberoptic bronchoscopy guidance. Our findings revealed that this was an effective therapeutic strategy for accelerating the repair of tracheal epithelial injury.
研究领域:
生物医学工程
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药学
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组织工程
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再生医学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xiao Jiang,Yutao Jian,Yuan Zhang,Juan Zhong,Qiulan Li,Xiaodong Wang,Xiaoshi Jia,Xiangnan Wu,Ke Zhao,Yitong Yao
The successful filling of bone defects remains challenging due to the incongruity between bone graft materials and the dynamic process of bone healing. Developing multifunctional materials matching the dynamic process of bone healing offers a viable solution to the current dilemma. Lines of evidence have shown that engineering osteoimmunomodulatory biomaterials can modulate the function of immune cells and thus promote bone regeneration. Herein, we utilized silk fibroin (SF) and polyglycolic acid (PGA) to create a PGA-SF core–shell fibrous scaffold, incorporating interleukin-4 (IL-4) and tricalcium phosphate (TCP) as a codelivery system (PGA/TCP-SF/IL-4), aiming to achieve an initial rapid release of IL-4 and sustained release of TCP. The PGA/TCP-SF/IL-4 scaffold mimicked the native bone structure and showed superior tenacity in the wetting regime. In vitro studies demonstrated that the PGA/TCP-SF/IL-4 scaffold significantly reduced the inflammatory response by upregulating the M2 macrophages, created a favorable microenvironment for osteogenesis, and facilitated osteogenic differentiation and mineralization. Implantation of the PGA/TCP-SF/IL-4 scaffold into the rat skull defect model notably increased the formation of new bones. IL-4 and TCP acted synergistically in attenuating inflammation and enhancing osteogenic differentiation. Overall, this multifunctional scaffold comprehensively considers the various demands in the bone defect region, which might have a significant potential for application in bone reconstruction.
研究领域:
生物材料
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组织工程
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骨愈合
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免疫学
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再生医学
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DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2021
·
IF 7.328
Ling Zhu,Jiajie Chen,Xuan Mao,Shunqing Tang
Injectable hydrogels, of which the cover area and volume can be flexibly adjusted according to the shape and depth of the wound, are considered to be an ideal material for wound dressing. Konjac glucomannan (KGM) is a natural polysaccharide with immunomodulatory capability, while γ-polyglutamic acid (γ-PGA) is a single chain polyamino acid with moisturizing, water-retention and antibacterial properties. This work intended to combine the advantages of the two materials to prepare an injectable hydrogel (P-OK) by mixing the adipic acid dihydrazide (ADH) modified γ-PGA with oxidized KGM. The chemical structures, the physical and chemical properties, and the biological properties of the P-OK hydrogel were evaluated. The optimal conditions to form the P-OK hydrogel were fixed, and the cytotoxicity, qPCR, antibacterial and animal experiments were performed. Results showed that the P-OK hydrogel had a fast gelation time, good water-retention rate, little cytotoxicity, good immunomodulating and antibacterial capabilities, and could shorten the healing period in the rat full-thickness defect model, which makes it a potential candidate for wound repair dressing.
研究领域:
生物材料
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伤口愈合
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生物医学工程
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药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
GREEN CHEMISTRY
·
2023
·Vol. 25
·期 23
·9998-10009
·
IF 9.8
Yong Wang,Liang Wen,Jiajian Liu,Chuncheng Li,Zijian Zhang,Yaonan Xiao,Tian Yin,Shaohua Wu,Zhikui Jiang,Bo Zhang
The emergence of biodegradable polymers has brought hope for solving the problem of plastic pollution. Chemical recovery of biodegradable polymers not only avoids CO2 emissions from polyester degradation, but also enables sustainable utilization of feedstocks. In this study, biodegradable PGA-PBC-PGA triblock copolymers with chemical recovery characteristics were synthesized using ring-opening polymerization (ROP) of glycolide (GL). The Tonset of the triblock copolymers was higher than 315 °C. Mechanical tests showed that the tensile strengths of the copolymers were in the range of 27.5–98.2 MPa, and the elongations at break were in the range of 9.2–409%. The gas permeation test showed that the triblock copolymers had excellent O2 and CO2 barrier performance, which was better than PBS, PBAT and PLA. Besides, the triblock copolymers have excellent degradation properties under both enzymatic and non-enzymatic conditions. What's more, the triblock copolymers were allowed to recover GL by thermal depolymerization. Among them, PGA-PBC-PGA60 could recover GL in 82% yield at 240 °C in 3 hours. The recovered GL could be reused for the next polymerization after recrystallization and purification. The performances of the copolymers after re-polymerization were comparable to that of the original copolymer, successfully completing the closed-loop process from a monomer to a polymer and then to a monomer.
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DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
·
IF 5.518
Jian Peng,Wei Sun,Haisheng Han,Leming Ou,Jianhua Chen,Yuanjia Luo
Herein, a new and environmentally friendly process scheme containing PGA as depressant and Z200 as collector for chalcopyrite-molybdenite bulk flotation and STG as depressant for chalcopyrite/molybdenite separation flotation was applied to the separation of pyritic Cu-Mo sulfide ore from Daye, Hubei Province, China. The flotation results showed that the new process scheme not only can efficiently achieve the flotation separation of chalcopyrite and molybdenite, but also can reduce the dosage of STG in chalcopyrite/molybdenite separation compared with the traditional process combining CaO and BX. The closed-circuit flotation experiment results further demonstrated this preferable result. Besides, the differences in the adsorption of STG on the chalcopyrite (112) surface in the presence of Z200 and BX were investigated by first-principles calculations at the atomic level. The calculation results showed that the STG adsorption on chalcopyrite (112) surface in the presence of Z200 was easier than that in the presence of BX, and the STG adsorption weakened the Z200 adsorption on chalcopyrite (112) surface, which provides atomic-scale explanations to the less STG dosage in chalcopyrite/molybdenite separation. This new reagent scheme has environmental advantages and great reference value for the separation of other pyritic copper-molybdenum sulfide ores.
研究领域:
矿物学
·
材料科学
·
环境科学
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产品关联
DOI
高影响因子
Sustainable Materials and Technologies
·
2023
·
IF 9.6
Pei Feng,Saipu Shen,Yang Shuai,Shuping Peng,Cijun Shuai,Shijie Chen
The interfacial interaction between poly (l-lactic acid) (PLLA) and poly (glycolic acid) (PGA) is poor although the blending of PLLA and PGA may combine the advantages of both, which seriously affects the mechanical properties of PLLA/PGA bone scaffold. In this study, PLLA chains were grafted onto graphene oxide (GO) by ring-opening polymerization reaction, and the modified GO was used as nanofiller to increase the interfacial interaction for PLLA/PGA scaffold fabricated by selective laser sintering (SLS). The result indicated that GO grafted with PLLA chains reduced the interfacial tension between GO and PLLA from 24.09 mN/m to 3.74 mN/m, thus drawing GO from PGA phase to the interface between PLLA and PGA. The GO at the interface hindered the coalescence of PGA phase through the repulsive forces and facilitated the breakup of the PGA phase, which increased the contact surface area between PLLA and PGA, and thereby enhancing the interfacial interaction. Consequently, the tensile and compressive strength of the PLLA/PGA scaffold containing 1 wt% the PLLA-grafted GO, on which L-LA ring-opening polymerized for 24 h, were increased by 44.64% and 69.65%, respectively, compared with PLLA/PGA scaffold. Besides, the cell adhesion and fluorescence experiments demonstrated that the bone scaffold had good cytocompatibility for cell adhesion, migration and proliferation.
研究领域:
生物材料学
·
组织工程学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Xueli Zuo,Qi Hao,Weiyi Su,Jiahui Ding,Jun Liang,Honghai Wang,Chun Yang,Jianxin Chen,Peng Guo,Yanjun Jiang
In the context of the severe global carbon emission crisis, green and sustainable enzymatic reactions are garnering widespread attention in the industry. However, these processes still face numerous challenges, such as limitations imposed by reaction equilibrium, product decomposition, and inhibition. Product removal via crystallization has the potential to address these issues. More importantly, crystal product properties can be directly manipulated during enzymatic reactive crystallization (ERC), such as polymorphic purity, size, and morphology in a single batch. In the synthesis of cefaclor catalyzed by penicillin G acylase (PGA), primary and secondary hydrolysis greatly limited the efficiency of the reaction. Thus, ERC was performed to combine the advantages of green enzymatic reactions and controllable direct crystallization. Initially, a supersaturated solution of the substrate was established, and cefaclor crystals were seeded to the enzymatic reaction system at a proper time. Subsequently, operating parameters were adjusted to facilitate selective crystallization of cefaclor. It is noteworthy that both immobilized and free enzymes were examined in our research. Ultimately, cefaclor crystals with purity exceeding 99% were obtained directly. The yield of cefaclor reached as high as 88%. It is believed that this method held significant promise for the green and efficient production of high-purity cefaclor and demonstrated considerable potential for application in more similar pharmaceutical scenarios.
研究领域:
药物化学
·
绿色化学
·
生物催化
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Yazhou Chen,Li Zhang,Yingjie Liu,Shiming Tan,Ruidan Qu,Zirong Wu,Yue Zhou,Jing Huang
Poly-γ-l-glutamic acid (PGA) is an outstanding drug carrier candidate owning to its excellent biodegradability and biocompatibility. The PGA carrier may shield toxic drugs from the body and enable the delivery of poorly soluble or unstable drugs and thereby minimize the side effects and improve drug efficacy. However, the limitation of PGA as a drug carrier is low drug loading efficiency (DLE), which is usually below 30%. In this study, we reported a chemical modification method using l-phenylalanine ethyl ester (PAE). PGA–PAE construct was amphiphilic, which could form micelles in aqueous solution. Cisplatin (CDDP), a commonly used chemotherapy drug whose side effect is well-known, was used as a model molecule to test the drug-loading efficiency of PGA–PAE. In this paper, two sizes of CDDP-loaded PGA–PAE micelles (M(Pt)-1 and M(Pt)-2) were prepared, the average diameter of M(Pt)-1 was 106 ± 6 nm and M(Pt)-2 was 210 ± 9 nm. The DLE of M(Pt)-1 and M(Pt)-2 was 52.8 ± 2.2 and 55.8 ± 1.2%, respectively. Both exhibited excellent biocompatibility, stability, and drug-retaining capability in physiological condition. The in vitro accumulative drug-releasing profile, IC50 for different tumor cell lines HeLa, A549, and HCCC9810, and in vivo pharmacokinetics were similar between these two micelles; however, M(Pt)-1 showed higher tumor tissue retention and longer efficient cancer cell internalization time (up to 20 d). Our results suggested PGA–PAE micelle carriers reduced the toxicity of CDDP and its size at around 100 nm was the better for CDDP high-efficacy.
研究领域:
药理学
·
肿瘤学
·
纳米技术
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）