RSC Advances
·
2017
·Vol. 7
·期 7
·4000-4010
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IF 3.108
Yongjing Xu,Liming Zou,Hongwei Lu,Tingjie Kang
The selection of non-hazardous solvent systems is an important factor that can significantly influence fiber formation during polymer electrospinning. In this paper, poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/polyethylene oxide (PEO) has been electrospun using different solvent systems to investigate the influence of different solution properties on nanofiber morphology and diameter, the thermal and mechanical properties, as well as the degradation kinetics of the electrospun fibers. The morphology, thermal and mechanical properties of PHBV/PEO electrospun fibers were characterized using scanning electron microscopy (SEM), thermogravimetric analysis (TG) and differential scanning calorimetry (DSC), and a universal testing machine, respectively. The results showed that the binary-solvent system (dichloromethane/ethanol DCM/EtOH) gave the finest defect-free fibers, and exhibited the best thermal and mechanical properties of all the single solvents (chloroform (CHL), dichloromethane (DCM)). Therefore, the effect of DCM/EtOH in different ratios on PHBV/PEO electrospun fibers was studied in detail. In brief, the DCM/EtOH solvent system was considered to be the best candidate for PHBV/PEO for electrospinning.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2020
·
IF 2.69
Hua Jiao,Sen Song,Kang Zhao,Xinyuan Zhang,Yufei Tang
The biodegradable material poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) scaffold has good biodegradability, but poor biocompatibility limits its application in the biological field. And it can effectively improve its biological activity by compounding with the bone conduction activity material of Barium titanate (BT). The PHBV and piezoelectric material BT were prepared into porous composite scaffolds with porosity of 45–50%. The mechanical properties and electrical properties of BT/PHBV scaffolds were systematically studied. The results showed that the piezoelectric coefficient d33 was 0.2–1.5 pC/N. Moreover, the compressive strength and elastic modulus were 1.0–2.0 MPa and 100–200 MPa, respectively. The results of degradation and mineralization showed that BT/PHBV scaffolds had good degradation and mineralization performance which was indicated that the materials had good biological activity.
研究领域:
生物医学工程
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材料科学
·
骨组织工程
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DOI
PubMed
高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2016
·Vol. 25
·期 2
·156-164
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IF 1.969
Liu Huifang,Gao Zhaoying,Hu Xueyan,Wang Zhanyong,Su Tingting,Yang Lei,Yan Song
Poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV) is a biodegradable polymer synthesized in microorganisms. The application of PHBV is limited by certain material disadvantages. Poly(ε-caprolactone) (PCL) possesses excellent thermodynamic and mechanical properties and was used to modify PHBV in the presence of triethyl citrate (TEC) and dicumyl peroxide (DCP), which was used as plasticizer and grafting agent, respectively. The effects of PCL and additive agents on the mechanical, thermal, amphipathic and degradability behaviors of the blends were investigated. The results showed that the mechanical properties of the PHBV blends improved by PCL incorporation and improved even further after TEC and DCP addition. The addition of DCP could not induce an increase in crystallization temperature but improved the crystallization degree of the blends. The presence of hydrophilic groups in TEC leads to an apparent increases in the hydrophilicity of the PHBV blends. A PHBV/PCL blend (40/60) with TEC (20 wt.%) and DCP (0.5 wt.%) was chosen for its good mechanical properties and hydrophilicity. The chosen ratio of the blends was also shown a preferable degradation activity by biodegradation assay using Pseudomonas mendocina. The addition of TEC and DCP has no conspicuous negative effect on the biodegradation.
研究领域:
材料科学
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微生物学
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产品关联
DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 21
·3748
·
IF 4.329
Yuandong Wu,Weishuang Zheng,Yinan Xiao,Beining Du,Xingru Zhang,Min Wen,Chen Lai,Yi Huang,Liyuan Sheng
The limitations of hydrophilicity, strength, antibacterial activity adsorption performance of the biobased and biocompatible polymer materials, such as polyhydroxyalkanoates (PHAs), significantly restrict their wider applications especially in medical areas. In this paper, a novel composite membrane with high antibacterial activity and platelet adsorption performance was prepared based on graphene oxide (GO), MXene and 3-hydroxybutyrate-co-hydroxyvalerate (PHBV), which are medium-chain-length-copolymers of PHA. The GO/MXene nanosheets can uniformly inset on the surface of PHBV fibre and give the PHBV—GO/MXene composite membranes superior hydrophilicity due to the presence of hydroxyl groups and terminal oxygen on the surface of nanosheets, which further provides the functional site for the free radical polymerization of ester bonds between GO/MXene and PHBV. As a result, the tensile strength, platelet adsorption, and blood coagulation time of the PHBV—GO/MXene composite membranes were remarkably increased compared with those of the pure PHBV membranes. The antibacterial rate of the PHBV—GO/MXene composite membranes against gram-positive and gram-negative bacteria can reach 97% due to the antibacterial nature of MXene. The improved strength, hydrophilicity, antibacterial activity and platelet adsorption performance suggest that PHBV—GO/MXene composite membranes might be ideal candidates for multifunctional materials for haemostatic applications.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
MACROMOLECULAR RESEARCH
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2022
·Vol. 30
·期 5
·325-333
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IF 2.127
Ting Zhou Xin,Yan Liu Jin
Acetylation of bacterial cellulose whisker (BCW) with acetic anhydride can effectively improve the thermal stability of BCW and the dispersion of interface compatibility with PHBV. The influence of the modified cellulose whiskers on the crystallization and mechanical properties of the PHBV matrix was studied using differential scanning calorimetry (DSC), polarization optical microscopy (POM), and XRD. The results show that ABCW has heterogeneous nucleation and hindrance effect on the PHBV matrix simultaneously. With the increase of ABCW content, PHBV gradually decreases from large spherulite and then increases, and the crystallinity decreases. When the content of ABCs is 1.2%, ABCW has the best strengthening effect on PHBV, and the bending strength and bending modulus are 44.7% and 34.5% higher than PHBV.
研究领域:
材料科学
·
生物材料学
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产品关联
DOI
高影响因子
MATERIALS & DESIGN
·
2025
·
IF 7.9
Hongyu Lv,Siyuan Wang,Mou He,Xue Zhu,Peng He,Ruochen Sun,Zitong Jia,Ziming Wang,Wenwen Zhao,Zhangfeng Zhong,Yantao Han
The development of innovative wound dressings that can accelerate diabetic wound healing and alleviate hypertrophic scar has aroused intensive attraction in the clinics. In this study, the nanofibrous wound dressings constructed with a blend of silk fibroin (SF) and poly-3-hydroxybutyric acid-co-3-hydroxyvaleric acid (PHBV) were designed and fabricated. Meanwhile, berberine (BBR) were loaded in the SF/PHBV nanofibers to enhance the pharmacological effects. Firstly, material characterisation and biological characteristics of SF/PHBV-BBR dressings were investigated. The addition of BBR didn’t change the mechanical properties and biocompatibility of SF/PHBV nanofiber dressings. Then in vitro experiment proved that SF/PHBV-BBR nanofiber dressings obviously decreased the releases of inflammatory factors TNF-ɑ and IL-6, inhibited inflammatory proteins COX-2 and iNOS expression, and also suppressed oxidative stress responses of activated macrophages. Subsequently, in vivo study showed that SF/PHBV-BBR nanofiber dressings with high dose of BBR significantly promoted the healing of diabetic wounds in mice by significantly enhancing wound closure rates, accelerating angiogenesis, and improving collagen matrix deposition. Additionally, SF/PHBV-BBR obviously alleviated scar hyperplasia in rabbit by inhibiting fibroblast activation mediated by transforming growth factor-β1 (TGF-β1)/Smad3 pathway. Our study offered a promising alternative dressing materials for the treatment of hard-to-heal diabetic wounds and hypertrophic scars.
研究领域:
生物材料学
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药理学
·
医学工程
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产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2020
·
IF 4.244
Somia Yassin Hussain Abdalkarim,Yanyan Wang,Hou-Yong Yu,Zhaofeng Ouyang,Rabie A.M. Asad,Mengya Mu,Yujun Lu,Juming Yao,Lianyang Zhang
In this work, cellulose nanocrystals (CNCs) incorporated with supermagnetic iron oxide nanoparticles (Fe 3 O 4 NPs) as ( M CNC) hybrids by the co-precipitation method have developed. High-performance nanocomposite films consisting of poly(3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) and M CNC hybrids have prepared through a simple solution casting method. The addition of CNCs in M CNC-5% hybrids improved the surface hydrophilicity of PHBV, and displayed a reduction in water vapor permeability by 68.1 %, compared with pristine PHBV. The results prove that the addition of M CNC hybrids can be acted like a sensor to detect voltage change of the nanocomposites as functions of water vapor. The existence of CNCs in the M CNC-5% hybrids caused an increase in tensile strength and Young’s modulus by 74.6 % and 120.2 %, respectively. The addition of CNCs could enhance cell-matrix interactions and thus cytocompatibility of PHBV nanocomposites. The PHBV/ M CNC-5% exhibited saturation magnetization (Ms) values of 1.5 emu g −1 and displayed almost a regular and operative voltage response signal with real-time monitoring of water vapor. This work provides sustainable smart packaging materials with high sensitivity for water vapor and excellent biocompatibility.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Somia Yassin Hussain Abdalkarim,Hou-Yong Yu,Mei-Li Song,Ying Zhou,Juming Yao,Qing-Qing Ni
Fabrication and characterization of bbiodegradable nanocomposites based on poly (3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) matrix reinforced with cellulose nanocrystal (CNC)-ZnO nanohybrids via simple solution casting for possible use as antibacterial biomedical materials is reported. The obtained nanocomposites exhibited an excellent antibacterial ratio of 95.2–100% for both types of bacteria namely S. aureus and E. coli and showed 9–15% degradation after one week. The addition of CNC-ZnO showed a positive effect on hydrophilicity and barrier properties. More significantly, the nanocomposites with 10 wt% CNC-ZnO showed enhancement in tensile strength (140.2%), Young’s modulus (183.1%), and the maximum decomposition temperature (T max ) value increased by 26.1 °C. Moreover, this study has provided a possible mechanism for using such nanofillers on the hydrolytic degradation of PHBV, which was beneficial to obtain the high-performance nanocomposites with modulated degradation rate for antibacterial biomaterials.
研究领域:
生物医学材料
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材料科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
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2016
·
IF 2.437
Peng Zou,Hairong Liu,Yongsheng Li,Jiying Huang,Yao Dai
The proliferation of bone marrow-derived mesenchymal stem cells (BMSCs) in vitro is a key challenge for cartilage tissue engineering and their clinical applications. In this study, novel dextran grafting PHBV (PHBV-DEX) fibrous scaffolds were fabricated via surface modification. Compared with the electrospun PHBV fibrous scaffolds, dextran modified ones exhibited significantly enhanced surface hydrophilicity and bioactivity. The water contact angle (WCA) of those scaffolds was reduced from 117.3±4.30° to 56.03±1.13° after dextran modification. PHBV-DEX scaffold significantly promoted the growth of BMSCs compared with unmodified one, suggesting that it can be potentially applied in tissue engineering.
研究领域:
生物材料学
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组织工程学
·
再生医学
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产品关联
DOI
高影响因子
Materials Today Bio
·
2023
·
IF 8.2
Dengming Zhou,Wenxiang Zhu,Hairong Liu,Feng Zhang,Xiaoyu Zhou,Xinyue Zhang,Yang Zhao,Yuting Huang,Xuanchu Duan
Trabeculectomy is the primary surgical approach used to treat glaucoma, but scarring of the filtering passage (filtering bleb) after surgery often leads to treatment failure. To address this issue, we have developed a drug release system called RSG/Pd@ZIF-8 PHBV film. This system enables the sustained release of an anti-fibrosis drug, aiming to prevent scarring. In vitro , the film has the function of continuous Rosiglitazone (RSG) release, with accelerated release after laser irradiation. The antibacterial experiments revealed that the film exhibited antibacterial rates of 87.0 % against E.coli and 97.1 % against S.aureus, respectively. Moreover, we confirmed its efficacy in a rabbit eye model undergoing trabeculectomy. After implantation of the film, we observed a prolonged postoperative period for reducing intraocular pressure (IOP), increased survival rate of filtering blebs, and improved long-term surgical outcomes in vivo . Additionally, the film exhibited excellent biosafety. In summary, the designed sustained-release film in this study possesses the aforementioned functionalities, allowing for the regulation of anti-scarring drug release without causing harm post-surgery. This personalized and precise anti-scarring strategy represents a significant advancement.
研究领域:
眼科
·
药学
·
生物材料
·
外科研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Regenerative Biomaterials
·
2024
·
IF 5.6
Wang Qiuyu,Zhang Sai,Jiang Jiayi,Chen Shaojuan,Ramakrishna Seeram,Zhao Wenwen,Yang Fan,Wu Shaohua
A dressing patch made of radially oriented poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers was successfully manufactured with a modified electrospinning strategy. The as-electrospun PHBV radially oriented nanofiber dressing patch exhibited uniform and bead-free nanofibrous morphology and innovative radially oriented arrangement, which was demonstrated to possess obviously improved mechanical property, increased surface hydrophilicity, and enhanced biological properties compared to the PHBV nanofiber dressing patch control with traditionally randomly oriented pattern. Interestingly, it was found that the radially oriented pattern could induce the cell migration from the periphery to the center along the radially oriented nanofibers in a rapid manner. In order to further improve the bio-function of PHBV radially oriented nanofiber dressing patch, berberine (Beri, an isoquinoline alkaloid) with two different concentrations were encapsulated into PHBV nanofibers during electrospinning, which were found to present a sustained drug release behavior for nearly one month. Importantly, the addition of Beri could impart the dressing patch with excellent anti-inflammatory property by significantly inhibiting the secretion of pro-inflammatory factors of M1 macrophages, and also showed an additive influence on promoting the proliferation of human dermal fibroblasts (HDFs), as well as inhibiting the growth of E. coli, S. aureus, and C. albicans, compared with the Beri-free dressing patch. In the animal studies, the electrospun PHBV radially oriented nanofiber dressing patch loading with high Beri content was found to obviously accelerate the healing process of diabetic mouse full-thickness skin wound with shortened healing time (100% wound closure rate after 18 days’ treatment) and improved healing quality (improved collagen deposition, enhanced re-epithelialization and neovascularization, and increased hair follicles). In all, this study reported an innovative therapeutic strategy integrating the excellent physical cues of electrospun PHBV radially oriented nanofiber dressing patch with the multiple biological cues of Beri for the effective treatment of hard-to-heal diabetic wounds.
研究领域:
生物医学工程
·
材料科学
·
伤口愈合
·
药学
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2016
·Vol. 51
·期 12
·5695-5711
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IF 2.302
Xu Yongjing,Zou Liming,Lu Hongwei,Wei Yizhi,Hua Jianbing,Chen Shuyun
Abstract
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV)/polyethylene oxide (PEO) mats were fabricated by electrospinning in different weight ratios (i.e., 100/0, 90/10, 80/20, 70/30, 60/40, 50/50, 0/100). In this paper, dichloromethane (DCM) has been used as potential solvent for electrospinning. In order to evaluate the influence of PEO and DCM on the final properties of PHBV mat, the following characterization techniques were employed: scanning electron microscopy, Fourier transform infrared attenuated total reflectance spectroscopy, X-ray diffraction analysis, thermogravimetric analysis, differential scanning calorimetry, and the test of mechanical properties, water contact angle, porosity analysis, swelling properties, water–vapor transmission rate (WVTR) and in vitro degradation behavior. All PHBV/PEO electrospun mats consist of randomly oriented and distinctly separated fibers. The average fiber diameters and the porosity were 738–1098 nm and 80–90 %, respectively. The water contact angle, swelling ratio, WVTR, and in vitro degradation behavior of PHBV/PEO electrospun mats were 124°–55°, 265–436 %, 1977–2610 g m −2 day −1 , and 17–50 %, respectively. Besides, the crystallinity degree of PHBV/PEO electrospun mats has decreased with the increasing of PEO content. Therefore, PEO imparted PHBV/PEO electrospun mats on better properties, improving the nature defects of PHBV. In particular, PHBV/PEO 70/30 electrospun mat with optimizing performance, was considered the best candidate for potential scaffold in skin tissue engineering.
研究领域:
材料科学
·
生物医学工程
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）