INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Yifan Yun,Ying Guan,Yongjun Zhang
Patterned hydrogel films are attractive for the generation of 3D multicellular spheroids, a new in vitro cell model. Traditional methods for their synthesis, such as photolithography and micromolding, usually require a template and are difficult to fit into commercial cell culture plates. Here a simple method to synthesize patterned poly(2-hydroxyethyl methacrylate) (PHEMA) films were developed. First PHEMA films were synthesized in situ in the wells of cell culture plates by bulk redox polymerization of the monomer. Films with a corrugated surface were usually obtained. Fortunately a narrow range of initiator concentration was identified in which smooth films could be obtained. Then water was added to swell the films and wrinkling patterns were produced spontaneously. The shape and size of the patterns can be controlled by adjusting cross-link density and film thickness. Under optimized conditions, films with regular hexagonal patterns were obtained successfully. The patterned PHEMA films were further used to generate multicellular spheroids. The resulting spheroids exhibit high viability and narrow size distribution.
研究领域:
生物材料学
·
细胞生物学
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2022
·
IF 5.122
Sheng-Tong Wu,Fan Yang,Chun-Qin Zhao,Lai-Di Xu,Xue-Lian Han,Ping Chen,Shou-Nian Ding
Traditional photonic crystal microspheres have internal pores and can only be fabricated by self-assembly of colloidal nanoparticles . Therefore, their internal vulnerability to contamination and poor structural stability limit their further application. Therefore, we proposed a new method of photonic crystal composite microsphere fabrication by combining polymerisation with the self-assembly process. The droplets composed of colloidal nanoparticles, monomer , and initiator in continuous phase are obtained by a Shirasu porous glass (SPG) membrane emulsification undergo polymerised and self-assembled to obtain organic-inorganic photonic crystal composite microspheres. Since the self-assembled colloidal nanoparticles are immobilized in the polymer cross-linked network, the composite microspheres exhibit high structural stability. Based on this, we fabricated SiO 2 -PHEMA photonic crystal composite microspheres by polymerisation and self-assembly process. Compared with the pure SiO 2 photonic crystal microspheres fabricated by the same method, the composite microspheres exhibit high structural stability, color saturation, and good hydrophobicity due to the self-curling of the material driven by hydrogen bonding during polymerisation. In addition to the potential applications as dyes, biosensors, and in light, these composite microspheres overcome the difficulty of bulk generation of traditional photonic crystal microspheres and have the potential for industrialized mass production.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Jingfang Li,Jiaqi Liu,Jiajun Wang,Wen Li,Fang Wang
Wearable electrochemical sensors for glucose analysis hold significant potential for non-invasive monitoring of sweat biomarkers. However, the complex and expensive preparation process has limited the application of these sensors. In this study, we proposed an electrochemical glucose biosensor based on poly (2-hydroxyethyl methacrylate) (PHEMA) hydrogel initiated via iron ion and phenol hydroxyl groups. Copper nanoparticles are then incorporated into the hydrogel, enhancing the conductivity and electrocatalytic performance of the hydrogel electrode. The composite hydrogel, characterized by its rich metal coordination and hydrogen bonds, demonstrated remarkable cyclic adhesion properties, stretchability, and self-healing capability. Subsequently, this hydrogel is modified onto a screen-printed electrode (SPE) to create an in vitro skin patch for glucose detection in human sweat. The biosensor exhibits a wide linear range for glucose concentration of 0–0.2 mM and 0.2–4 mM, with low detection limit of 9.99 μM. The sensor exhibits good stability, selectivity and flexibility, and demonstrates a strong correlation with glucose measurements obtained from real sweat using a glucose assay kit. This sweat sensor holds great development potential, providing broad prospects for future non-invasive detection applications.
研究领域:
生物医学工程
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2016
·
IF 2.725
Rong Ren,Yanhua Wang,Weilin Sun
Metal coordinated micelles based on the diblock copolymer PHEMA 82 -b-HQ 78 were synthesized. The block PHQ with 8-hydroxyquinoline groups can coordinate with metal ions to form the crosslinked core for micellization , while the other block PHEMA in the shell of the micelle improves its solubility. The morphological characteristics and the coordinating interaction between the metal ions and the core segment were characterized by DLS and TEM . The magnetic measurement found that the Curie-Weiss temperature T θ of the metalized micelle was 56 K and its hysteresis loop exhibited the typical ‘S’ shape with low H c and M r at 5 K, indicating that this micelle had the properties of soft ferromagnetic materials .
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2019
·Vol. 10
·期 35
·4844-4851
·
IF 4.76
Yu Wang,Qianbing Chen,Mao Chen,Ying Guan,Yongjun Zhang
Swelling-induced mechanical instability is ubiquitous for substrate-attached hydrogel films, which results in a coarse surface and should be avoided in most applications. To test if the undesired instability patterns can be self-healed by the introduction of reversible covalent crosslinks, poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogel films crosslinked with disulfide bonds were synthesized. 2-Acetylthioethyl methacrylate (ATEMA), a monomer containing a protected thiol group, was first synthesized from HEMA and thioacetic acid. Linear P(HEMA-ATEMA) copolymers were then synthesized by free-radical polymerization. To avoid the hydrolysis of ester bonds, the thioester protecting groups were cleaved by reaction with dithiothreitol in the presence of a catalytic amount of a base, and linear PHEMA polymers with pendant thiol groups, i.e., P(HEMA-MEMA) were obtained. PHEMA films crosslinked with disulfide bonds were obtained by exposing P(HEMA-MEMA) films to H2O2 vapor. Like ordinary hydrogel films, the crosslinked films also undergo mechanical instability when swelling in an ethanol/water mixture, because unidirectional expansion generates compressive stress within the film. Interestingly, the instability patterns could be self-healed, and the gel surface returned to be flat. In contrast, the instability patterns on a PHEMA film crosslinked with ordinary covalent bonds were permanent. The transient network in films crosslinked with dynamic disulfide bonds allows the relaxation of the swelling-induced compressive stress in the films, therefore, the undesired instability patterns can be self-healed.
研究领域:
材料科学
·
聚合物化学
·
软物质物理
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Mengnan Xu,Zhiyuan Zhang,Jiajun Tao,Yan Nai,Chenglong Su,Shan Jiang
In this paper, the rare earth europium complex Eu(FTFA) 3 TPPO 2 (EuFT) was synthesized by using europium as the central ion, 4-trifluoro-1-(2-furanyl)-1,3-butanedione (FTFA) as the first ligand, and triphenylphosphine oxide (TPPO) as the second ligand. The structure was characterized by Fourier transform infrared spectroscopy (FTIR), and the photoluminescence process was investigated by UV and fluorescence spectra. The luminescent film was prepared by adding EuFT and the compatibilizer POE- g -PHEMA into the POE matrix, which can convert the UV light to the red light, and improve the photovoltaic conversion efficiency while reducing the effect of UV aging on the cell. Experimental results show that the complex can absorb UV light (200–400 nm) and emit red light (612 nm), the luminescent film also maintains good luminescence performance. The peel strength of POE/POE- g -PHEMA/EuFT film achieves 23.9 N cm −1 ，while that of POE film is 12.8 N cm −1 . The silicon cell prepared by POE/POE- g -PHEMA/EuFT film also showed higher EQE in UV region, and its current density–voltage (J–V) curve revealed that J sc increased from 33.05 to 34.25 mA/cm 2 , the conversion efficiency increased from 12.99% to 13.39%, and the relative efficiency increased by 3.08%. The rare earth europium complex effectively improved the photoelectric conversion efficiency of solar cells.
研究领域:
材料科学
·
光伏技术
·
光电技术
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 127
·104907-104914
·
IF 3.84
Kunlin Chen,Shuxue Zhou,Limin Wu
Durability of nonfouling coatings is a critical problem to be solved for their practical application. In this paper, self-repairing nonfouling polyurethane (PU) coating was fabricated by spraying of a triblock copolymer of polyethylene glycol (PEG), 2-hydroxyethyl methacrylate (HEMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) on pre-cured acrylic-based PU coatings. The triblock copolymer was synthesized through living radical polymerization mediated by an atom transfer radical polymerization. Anchoring of the copolymer took place both on the surface and in the interior (namely, 3D-grafting) of PU coatings through the diffusion of the copolymer and subsequently the chemical reaction between the pendent hydroxyl group of the copolymer and the remaining isocyanate groups in the pre-cured PU coatings. This 3D grafting procedure is rather simple and favorable for large-area application. The 3D-grafted PU coating has higher hydrophilicity (water contact angle: 33°). In contrast, if the triblock copolymer was used as an additive in PU coatings, the hydrophilicity of the PU coating did not obviously change. The 3D-grafted PU coating effectively inhibited the adhesion of protein and human platelet cells due to the synergistic effect of PEG and MPC. Moreover, after the coatings were detached and mechanically damaged, the surfaces can restore their hydrophilicity and possess better long-term anti-fouling ability than the control surface-grafted coatings underwater.
研究领域:
材料科学
·
聚合物化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Zhao Wang,Xiaomei Wang,Yao Zhou,Xiaojuan Zhang,Yong Bian,Qing Lin,Yujie Wang,Ruilong Sheng
Ocular bacterial infections are typically associated with elevated levels of reactive oxygen species (ROS). Nevertheless, for treating ocular bacterial keratitis (BK), broad-spectrum antibiotics in eye drops or ointments are unable to inhibit ROS and encounter swift clearance and reduced bioavailability. This work developed antibiotic levofloxacin (LEV)-loaded hollow ceria nanoparticles (hCe NPs, ROS scavengers), which were embedded into poly-hydroxyethyl methacrylate (pHEMA) hydrogels to prepare dual-functional contact lenses (LEV@hCe-pHEMA), enabling extended ocular drug delivery and enhanced bioavailability. The integration of LEV@hCe NPs within pHEMA contact lenses preserved good optical transmittance (> 90.0 %), fortified UV-blocking capacities (200–400 nm), achieved controllable LEV release (84.2 % within 120 h), and enhanced ROS scavenging-antioxidative potential (78.4 % within 60 min). In vitro cytotoxicity evaluations revealed low cytotoxicity (cell viability >95.0 %) of the hCe-pHEMA contact lenses and affirmed their good biocompatibility. Notably, LEV@hCe-pHEMA exhibited significant antibacterial efficacy against S. aureus ATCC29213 (89.8 %) and E. coli ATCC25922 (94.2 %), demonstrating their therapeutic potential. In vivo safety evaluations in rabbit models showed no ocular irritation or pathological changes during a 7-day wearing period, confirming the good biocompatibility of the hCe-pHEMA lenses. LEV@hCe-pHEMA contact lenses could be utilized to treat rabbit BK model induced by S. aureus . It could near-completely remove the keratitis (within 7 days), reducing corneal edema and further recovering corneal transparency. The results suggested that LEV@hCe-pHEMA contact lenses could be employed as promising dual-functional smart ocular drug delivery systems for non-invasive ocular therapy.
研究领域:
药学
·
材料科学
·
眼科医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Fang Wang,Jingfang Li,Huiting Xia,Jiaqi Liu
Non-invasive, continuous monitoring of sweat biomarkers using flexible sensors enables real-time tracking of indicators such as glucose, electrolytes, and lactate, facilitating early disease detection and improved health management. In this paper, a flexible screen-printed electrode (labeled as Cu@PHEMA/SPE) based on a Cu 2+ doped poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogel was prepared by a simple free radical polymerization method, which is used for glucose and ascorbic acid detection in sweat. This hydrogel exhibits excellent mechanical properties (184 kPa and 346 %), self-healing capabilities and recycled self-adhesive performance. Cyclic voltammetry (CV) and chronoamperometry techniques were employed to investigate the electrochemical properties of the hydrogel electrode in an alkaline solution and the flexible electrode in a neutral solution, with respect to glucose and ascorbic acid. The flexible electrode demonstrated a wide linear range, high sensitivity, and a low detection limit. Specifically, glucose detection ranged from 0 to 2 mM, exhibiting sensitivities of 122.24 and 24 μA/mM/cm 2 , with a detection limit of 4.5 μM. Moreover, it can detect ascorbic acid in the range of 0–220 μM, with sensitivities of 799.85 and 201.94 μA/mM/cm 2 , and a detection limit of 0.96 μM. Furthermore, the electrode displayed good selectivity for interfering substance such as uric acid (UA), dopamine (DA), lactic acid (LA), sodium chloride (NaCl), and potassium chloride (KCl), and it maintained performance despite external deformation. Notably, real sweat samples analysis demonstrated strong concordance with the results obtained using commercially available kits. These results indicate that this flexible electrode has great potential for application in wearable devices.
研究领域:
生物医学工程
·
电化学传感
·
可穿戴设备
·
即时检测
·
代谢物监测
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Yang Wang,Si Sun,Lin Shi,Pengcheng Gao,Yingying Wei,Chuan Zhang,Yong Jiang
A facile and energy-efficient synthesis of Fe 3 O 4 @SiO 2 -PHEMA complex and its application as adsorbent for removal of Cu 2+ from aqueous solution were investigated. Fe 3 O 4 @SiO 2 -PHEMA was synthesized by mixing Fe 3 O 4 @SiO 2 and HEMA monomer and then initiating the polymerization of HEMA monomer by H 2 O 2 under Fe 2+ catalyzing at room temperature . As adsorbent, the maximum sorption capacity of Fe 3 O 4 @SiO 2 -PHEMA for Cu 2+ was calculated to be 20.7 mg/g at pH 6.0. And the efficient enrichment of Cu 2+ on Fe 3 O 4 @SiO 2 -PHEMA depended on its multiple carbonyl groups and the electrostatic interaction between carboxyl groups and Cu 2+ . The carboxyl groups were from slow hydrolysis of partial ester bonds of PHEMA under acidic conditions. The possible hydrolysis process of ester bonds was facilitated to avoid sorption capacity of Cu 2+ decreasing caused by other ions sorption (like Fe 2+ ) during the synthesis of the adsorbent. The adsorption of Cu 2+ on Fe 3 O 4 @SiO 2 -PHEMA coincided with Langmuir model. The Fe 3 O 4 @SiO 2 -PHEMA had good dispersity in water and it could be easily collected from wastewaters by a magnet. The results showed that Fe 3 O 4 @SiO 2 -PHEMA was a promising adsorbent in wastewater treatment.
研究领域:
环境科学
·
材料科学
·
化学工程
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Siyuan Zhang,Xinjian Cheng
Developing water-soluble fluorescent probes has important scientific and practical significance. In this work, coumarin derivatives bearing -OH were obtained through the classical Knoevenagel reaction firstly. Secondly, -C C- on allyl bromide was introduced into coumarin by Williamson ether formation method. Thirdly, hydrazine hydrate was added to the coumarin derivatives, a polymerizable small molecular coumarin fluorophore containing probe was obtained successfully. And, the -COOH on di-thioester underwent an esterification reaction with –OH groups on β-cyclodextrin(β-CD) to prepare oligomer based reversible addition-fragmentation chain transfer(RAFT) reagents. Finally, three copolymer probes β-CD-PMAA-Coumarin, β-CD-PMAm-Coumarin, and β-CD-PHEMA-Coumarin were prepared via RAFT polymerization , in which C C-coumarin was used as the functional monomer and methacrylamide(MAm)/methacrylic acid (MAA)/hydroxyethyl methacrylate (HEMA) as the main monomers. The MALDI-TOF mass tests showed that the macromolecular level probes were successfully prepared. These polymer probes have molecular weights up to 5.4 kDa and have narrow molecular weight distributions (PDI≤1.31). With the assistance of water-soluble long-chained PMAm/PMAA/PHEMA and hydrophilic β-CD, the coumarin containing macromolecular fluorescent probes could be dissolved in water readily. These water soluble polymer fluorescent probes could recognize Fe 3+ /Fe 2+ and Cu 2+ ions with high sensitivity. The detection limit of Fe 3+ could be as low as 0.34 μM. This study successfully developed a promising technique for producing highly selective, fully water-soluble fluorescent macromolecular probes.
研究领域:
化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 33
·27301-27312
·
IF 3.289
Wang Delong,Ma Weibin,Jia Mingchen,Yang Zhonglin,Feng Juntao,Zhang Xing
Plant-based insect repellents are environmentally-friendly and play a practical and economic role in preventing the transmission of diseases to humans. Preformed 2-hydroxyethyl methacrylate-co-ethylene glycol dimethacrylate (pHEMA) hydrogels were functionalized with pedant triazinyl-β-cyclodextrin (T-β-CD) with the aim of improving the ability to host and release plant-based repellents. The structural and thermal properties were investigated by FTIR and thermogravimetric analysis, respectively. The most potent mosquito repellents, geraniol, methyl salicylate and trans-cinnamaldehyde, were screened from 35 plant-based compounds through Y-tube olfactometer assay. Pendant T-β-CDs did not affect the swelling of the hydrogels and exhibited low cytotoxicity towards mouse embryo fibroblasts, and no skin irritation or allergy was observed on human skin treated with modified hydrogels loaded with repellents. The physicochemical properties of the repellent and its affinity to form complexes determined the role played by the CDs in the loading and release. Methyl salicylate possessed an optimal stability constant KS (232.19 M−1) and thus it got a longer protection duration with higher repellent activity. Increasing the crosslink density resulted in decreases in the degree of swelling, the amount of T-β-CDs bonded to hydrogels, and the duration of complete repellency. Additionally, pHEMA hydrogels with pendant T-β-CDs showed good recyclability. The new hydrogel formulation loaded with plant-based repellents may provide a suitable, eco-friendly and safe approach to achieve protection against mosquitoes.
研究领域:
材料科学
·
药学
·
环境科学
·
生物技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）