Chemistry-An Asian Journal
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2017
·Vol. 12
·期 17
·2304-2310
·
IF 4.083
Wei Su,Kui Zhou,Fanglin Cai,Cheng Chen,Bibimaryam Mousavi,Somboon Chaemchuen,Francis Verpoort
Graphical Coordination configuration matters : A Ru dimer, [Ru(NC NHC O)(pic) 2 ] 2 2+ ( 2 ), which transforms to two single-site Ru-OH 2 species to initiate water oxidation, was prepared and fully characterized. Complex 2 could catalyze water oxidation electrochemically, chemically and photochemically, exhibiting an excellent reactivity and stability. A dinuclear ruthenium complex [Ru II (NC NHC O)(pic) 2 ] 2 2+ ( 2 ) was firstly prepared and characterized spectroscopically and electrochemically. Instead of the conventional ligand exchange, complex 2 dissociates in situ to afford two single-site Ru aqua complexes, [Ru II (OH 2 )(NC NHC O)(pic) 2 ] + , which mediates water oxidation through proton-coupled electron transfer events. In electrokinetic studies, complex 2 demonstrated a TOF of 150.3 s −1 comparable to those state-of-the-art catalysts at neutral conditions. TONs of 2173 and 217 were attained in chemical and photochemical water oxidation when 2 was used as a catalyst, exhibiting good stability. Notably, a TOF of 1.3 s −1 was achieved at CAN-driven water oxidation, which outperformed most of the reported single-site Ru complexes, indicating that complex 2 is one of most active water oxidation catalysts (WOCs) to date. The unique coordination configuration and outstanding catalytic performance of complex 2 might shed light on the design of novel molecular WOCs.
研究领域:
无机化学
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催化化学
·
能源化学
✓ 已验证
DOI
PubMed
高影响因子
Advanced Science
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2025
·
IF 14.1
Tongge Li,Shihui Wang,Qianhui Ling,Junyi Sun,Ning Yang,Zhanglei Fu,Zhaoyuan Zhang,Si Chen,Yanfei Wang,Ni Yu,Yafei Wang,Zhexuan Ding,Haodong Liu,Yanwei Jia,Yifang Wang,Xingcai Zhang
Phototherapy integrated chemotherapy (PIC) offers a promising cancer treatment strategy as single chemotherapy approaches are less effective due to tumor heterogeneity and drug resistance, and phototherapy often involves harmful radiation, and the potential of mild phototherapy to enhance chemotherapy remains underexplored. Cancer cells, as key drivers of tumor metastasis, are crucial targets, but current methods for visualizing their response to theranostics are slow. Here, nondestructive real-time impedance spectroscopy to monitor cancer cell response, identifying an optimal light exposure time of 60 min and defined cell viability and resistibility through impedance measurements, achieving high correlation (92.45% and 99.82%) with standard methods is used, and it is demonstrated that mild phototherapy significantly enhance chemotherapy, especially with Lenvatinib in liver cancer cell treatments. Through an in-depth study, the “more light-aiding, less bonding (LALB) mechanism,” meaning less conjugated chemical bonding within the excitation threshold, results in more pronounced light-aiding properties, is proposed. This photochemical interaction mechanism confirms that combining phototherapy and chemotherapy offers significant benefits with higher targeting and lower toxic side effects in cancer and disease treatments, providing a new strategy of photochemical interaction and coupling for drug screening and mild phototherapy integrated chemotherapy (mild-PIC) treatment evaluation, and further promotes the development of other advanced biomedical applications.
研究领域:
肿瘤学
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药理学
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生物医学工程
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光化学
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细胞生物学
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癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELL BIOCHEMISTRY AND FUNCTION
·
2023
·
IF 3.6
Jing Luo,Yijue Deng,Yi Ding,Chenguang Tang,Mengqing Wang
This study aimed to determine the effects of Xiebai Zengye decoction (XBZY) on airway inflammation and respiratory function in rats with postinfectious cough (PIC), and its regulatory effects on the extracellular signal-regulated kinase (ERK) signaling pathway. Compared with the normal group, the rats from the PIC group had significantly shortened expiratory time (TE) and enhanced pause (EEP), increased resistance (RT), and enhanced pause (Penh), along with increased levels of serum interleukin-4 (IL-4) and IL-6, and decreased levels of IL-10. The lung and colon tissues of rats from the PIC group showed histopathological changes, including inflammatory cell infiltration, damaged mucosal epithelium, and crypt structure, with significantly increased ERK mRNA and protein expression levels. Treatment with XBZY and montelukast sodium (MAS) improved the respiratory function and serum cytokine levels, reduced tissue inflammation, and decreased ERK mRNA and protein expression levels in the lung and colon tissues. In the lung tissues, XBZY treatment significantly decreased the expression of phosphorylated-ERK (p-ERK) protein, as well as p-MEK1/2, p-ERK1/2, and p-c-Fos proteins, while in the colon tissues, XBZY significantly decreased the expression of p-ERK1/2 and p-c-Fos proteins. However, MAS treatment only showed significant improvement in the lung tissue inflammation score, and the expression level of p-ERK protein in the lung tissue was decreased. In conclusion, the present study suggests that XBZY has a potential therapeutic effect on PIC by improving respiratory function and attenuating inflammation, and this effect may be associated with the inhibition of the ERK signaling pathway. These findings could provide a new direction for the development of treatments for PIC. However, further research is needed to elucidate the underlying molecular mechanisms of XBZY and to confirm its safety and efficacy in clinical trials. Significance statement Postinfectious cough (PIC) accounts for 21.73% of the causes of chronic cough in Chinese children and has a higher incidence rate in preschool children. This study aims to observe the effects of Xiebai Zengye decoction (XBZY) on airway inflammation and reactivity in young rat model of PIC cough, and to explore its regulatory effects on the ERK signaling pathway, to preliminarily elucidate the mechanism of XBZY in treating PIC.
研究领域:
药理学
·
呼吸病学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2013
·
IF 5.371
Jie Ren,Yanxin Zhang,Ju Zhang,Hongjun Gao,Gan Liu,Rujiang Ma,Yingli An,Deling Kong,Linqi Shi
Herein, a series of biocompatible, robust, pH/sugar-sensitive, core-cross-linked, polyion complex (PIC) micelles based on phenylboronic acid–catechol interaction were developed for protein intracellular delivery. The rationally designed poly(ethylene glycol)-b-poly(glutamic acid-co-glutamicamidophenylboronic acid) (PEG-b-P(Glu-co-GluPBA)) and poly(ethylene glycol)-b-poly(l-lysine-co-ε-3,4-dihydroxyphenylcarboxyl-l-lysine) (PEG-b-P(Lys-co-LysCA)) copolymers were successfully synthesized and self-assembled under neutral aqueous condition to form uniform micelles. These micelles possessed a distinct core-cross-linked core–shell structure comprised of the PEG outer shell and the PGlu/PLys polyion complex core bearing boronate ester cross-linking bonds. The cross-linked micelles displayed superior physiological stabilities compared with their non-cross-linked counterparts while swelling and disassembling in the presence of excess fructose or at endosomal pH. Notably, either negatively or positively charged proteins can be encapsulated into the micelles efficiently under mild conditions. The in vitro release studies showed that the release of protein cargoes under physiological conditions was minimized, while a burst release occurred in response to excess fructose or endosomal pH. The cytotoxicity of micelles was determined by cck-8 assay in HepG2 cells. The cytochrome C loaded micelles could efficiently delivery proteins into HepG2 cells and exhibited enhanced apoptosis ability. Hence, this type of core-cross-linked PIC micelles has opened a new avenue to intracellular protein delivery.
研究领域:
生物材料
·
药物递送
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
INORGANICA CHIMICA ACTA
·
2017
·
IF 2.002
Jie Chai,Yanfei Liu,Jinglong Dong,Bin Liu,Binsheng Yang
The worldwide use of chromium(III) picolinate Cr(pic) 3 as nutrition additives has aroused more and more controversies. To reevaluate the safety and validity of Cr(pic) 3 , seven new derivatives Cr(R-pic) 3 (pic = picolinic acid, R = H ( 1 ), 5-Br ( 2 ), 5-CF 3 ( 3 ), 4-Cl ( 4 ), 5-COOH ( 5 ), 3-CH 3 ( 6 ), 5-OH ( 7 ), 3-OH ( 8 )) were synthesized and characterized by X-ray crystal diffraction, ESI-MS, IR and elemental analysis. It was found that different substituent group affected physicochemical activities of the complex such as the Fenton-like reaction and oxidation reaction. Especially, –OH group derivatives lose their hydroxyl radical-generation and Cr(VI)-generation abilities comparing with halogen group in tube experiment. Even so, these differences in chemistry properties may be ignored in live cells and animal tests: no obvious cellular damage (MTT assay) and tissue injury (acute toxicity study) were observed for both Cr(pic) 3 and its derivatives. In addition, hypoglycemic activity study indicated that these Cr(III) complexes have no significant influence than CrCl 3 salt on the blood glucose, serum insulin, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein of diabetic mice through two months’ study. Therefore, these substituent group is unable to improve the biological activities of Cr(pic) 3 obviously and the validity of Cr(pic) 3 used as a nutrition additives is doubted.
研究领域:
无机化学
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生物化学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULES
·
2019
·
IF 5.997
Leilei Huang,Yi Ding,Yajie Ma,Lei Wang,Qizhou Liu,Xinhua Lu,Yuanli Cai
Block copolymer nanoparticles have been widely used for advanced materials. However, the stabilization is challenging. Herein, we present a method for convenient yet reliable synthesis of stabilized polyion complex (PIC) nanometer-sized spheres and micrometer-sized ultrathin lamellae and vesicles by taking advantage of the wavelength orthogonality of UV-induced disulfide exchange and visible light-initiated polymerization-induced electrostatic self-assembly (PIESA). Disulfide-containing PIC vesicles are synthesized at scale using this PIESA, undergoing a small sphere-to-larger sphere-to-lamella-to-vesicle transition. As such, surface-neutralized and surface-charged micrometer-sized vesicles can be achieved. UV irradiation of the vesicles (5.0 mg/mL in water) in ambient air induces very fast exchange reaction of locally confined/enriched disulfide motifs, leading to cross-linking, shape transition, and cystamine salt release in 4 min. As such, cross-linked PIC spheres, lamellae, and vesicles can be achieved, in one pot, from one single vesicle precursor. The wavelength orthogonality is evident from disabled PIESA synthesis under UV light and ineffective postpolymerization functionalization under visible light. The cross-linked PIC spheres and micrometer-sized ultrathin lamellae and vesicles show outstanding shape/size stability and high reversibility in the solution-adaptive electrostatic hierarchical self-assembly and disassembly upon adding ethanol into aqueous dispersion and subsequent dialysis.
研究领域:
材料科学
·
化学
·
纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Chunli Liu,Lei Zhu,Yixin Zhang,Wanwan Hu,Yongqian Shen,Haize Jin,Haiyan Wang,Wenqing Niu
The trade-off between membrane permeance and solute rejection is a persistent challenge in membrane filtration, where higher permeance typically compromises rejection performance. To overcome this limitation, we developed a one-step fabrication method for an integrally skinned asymmetric tight ultrafiltration membrane via a polyion complex reaction-assisted non-solvent induced phase separation process (PIC-assisted NIPS). A reactive hydrolyzed polyacrylonitrile (H-PAN) matrix was used to prepare the dope solution, while an aqueous solution of polyethyleneimine (PEI)/graphene oxide (GO) soluble complexes served as the coagulation bath. During phase separation, the PEI/GO complex further participates in polyelectrolyte complexation with H-PAN, resulting in the formation of a dense selective layer composed of HPAN/PEI/GO on membrane surface, enabling simultaneous high permeance and rejection. Subsequent crosslinking with glutaraldehyde further stabilized the membrane structure. The PEI content and molecular weight in the complexes critically influenced the skin layer thickness and separation performance. The optimal membrane, fabricated with 0.4 wt% PEI-10000 in the coagulation bath, exhibited exceptional performance: a water permeance of 226.1 ± 0.4 L·m −2 ·h −1 ·bar −1 , 99.8 ± 0.1 % rejection of Congo Red, and 3.2 ± 0.3 % NaCl rejection. This study presents a facile and efficient strategy for fabricating high-performance tight ultrafiltration membranes for dye removal from wastewater.
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULES
·
2023
·
IF 5.5
Jie Cai,Xiyu Wang,Yuanyuan Liu,Caihui Luo,Xinhua Lu,Yuanli Cai
We herein report a site-specific polymerization-induced electrostatic self-assembly (PIESA) that enables the precision synthesis of highly charged salt-tolerant nanoreactors. Site-specific PIESA is achieved using an anionic aromatic–aliphatic sulfonate block copolymer in photoinitiated reversible addition-fragmentation chain transfter (photo-RAFT) polymerization of a cationic monomer in water at 25 °C. Preferential complexation of cationic growing chains to the aromatic sulfonate block results in not only site-specific molecular recognition but also unique salt-tolerant PIC nanoparticles. Neutral block incorporation leads to ultrafast reaction of very dilute monomer (2.0% w/w) and exclusive formation of more salt-tolerant smaller spheres or 4 nm fibril-structured 10 nm ultrathin lamellae. The ultrathin lamellae can induce a sequence-controllable ultrafast copolymerization of oppositely-charged dilute monomers with perfect shape/size preservation up to 100% conversions, and thus can be viewed as a nanoreactor. This work opened up an avenue for the precision synthesis of highly charged salt-tolerant PIC functional nanoparticles, providing a versatile platform for easy access to structural and functional complexity from simple mixtures.
研究领域:
聚合物化学
·
材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF NEUROSCIENCE
·
2024
·
IF 4.4
Jing Chen,Yuan Gao,Shu-Ting Bao,Ying-Di Wang,Tao Jia,Cui Yin,Cheng Xiao,Chunyi Zhou
The comorbidity of chronic pain and depression poses tremendous challenges for the treatment of either one because they exacerbate each other with unknown mechanisms. As the posterior insular cortex (PIC) integrates multiple somatosensory and emotional information and is implicated in either chronic pain or depression, we hypothesize that the PIC and its projections may contribute to the pathophysiology of comorbid chronic pain and depression. We show that PIC neurons were readily activated by mechanical, thermal, aversive, and stressful and appetitive stimulation in naïve and neuropathic pain male mice subjected to spared nerve injury (SNI). Optogenetic activation of PIC neurons induced hyperalgesia and conditioned place aversion in naïve mice, whereas inhibition of these neurons led to analgesia, conditioned place preference (CPP), and antidepressant effect in both naïve and SNI mice. Combining neuronal tracing, optogenetics, and electrophysiological techniques, we found that the monosynaptic glutamatergic projections from the PIC to the basolateral amygdala (BLA) and the ventromedial nucleus in the thalamus (VM) mimicked PIC neurons in pain modulation in naïve mice; in SNI mice, both projections were enhanced accompanied by hyperactivity of PIC, BLA and VM neurons, and inhibition of these projections led to analgesia, CPP, and antidepressant-like effect. The present study suggests that potentiation of the PIC-BLA and PIC-VM projections may be important pathophysiological bases for hyperalgesia and depression-like behavior in neuropathic pain, and reversing the potentiation may be a promising therapeutic strategy for comorbid chronic pain and depression.Significance Statement Treatment of chronic pain is quite challenging because of the involvement of central sensitization and emotional disorders. It is keenly demanding to search for brain circuits commonly or separately contributing to hyperalgesia and emotional dysfunction in chronic pain. The PIC is involved in both pain and emotional processing. But, the relationship between the malfunction in the PIC and the comorbidity of chronic pain and depression has not been elucidated. Here, we demonstrate that in chronic pain, PIC neurons became hyperactive, and their projections to the BLA and the VM of the thalamus were augmented; these alterations may confer hyperalgesia and depression-like behaviors in chronic pain. Therefore, these pathways may be potential therapeutic targets for comorbid chronic pain and depression.
研究领域:
神经科学
·
疼痛研究
·
行为神经科学
·
神经回路
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）