Extracorporeal Membrane Oxygenation (ECMO) is the most important supporting therapy to rescue patients with respiratory distress syndrome (ARDS), for which the membrane oxygenator offers a place for CO 2 and O 2 exchange. Although Poly (4-methyl-1-pentene) (PMP) has been extensively used as ECMO material, the problems of protein adsorption fouling and the need for anticoagulation remain challenging for clinical applications. Additionally, the challenges associated with the functional modification of PMP material underscore the importance of finding a new material with excellent gas permeability and blood compatibility. On the other hand, Polymers of Intrinsic Microporosity (PIM) has been extensively studied in the field of gas separation due to their unique twisted helical structure and high free volume. However, its hydrophobic nature also raises concerns about its anti-fouling ability and hemocompatibility, which restricts the exploration of PIM in ECMO applications. Herein, we modify the PIM-1 membrane and study the hemocompatibility of PIM-1, carboxylated-PIM-1, and amidoxime-functionalized-PIM-1, and explore their gas permeability by molecular dynamics simulation and experimental verification. The modified PIM membranes exhibit remarkable comprehensive performance, including effective anti-protein adhesion and hemocompatibility, high oxygen permeability, and CO 2 removal rate. Blood oxygenation tests also reveal that the modified membranes prepared in this work fully meet practical requirements, exhibiting great application potential.
Ionic liquids (ILs) are attractive and prospective materials used in membranes due to the nonvolatility, structure tunability, and the ability to tune the interface compatibility. The cobalt IL Bmim 2 Co(NCS) 4 possesses the porphyrin-like N4-coordinated cobalt center which could selectively and reversibly interact with O 2 . Herein the Bmim 2 Co(NCS) 4 as liquid-phase oxygen carrier was used to fabricate thin-film composite (TFC) membrane with the polymer of intrinsic microporosity (PIM-1). The microstructures, properties and gas separation performance of the membrane were compared with the TFC membrane which takes cobalt porphyrin (T(4-Cl)PPCo) as a carrier. We found that the addition of a small amount of T(4-Cl)PPCo can enlarge the d -spacing of packed chains of PIM-1 and significantly increase the fractional free volume (FFV) and the gas permeability of the membrane, but the selectivity is unsatisfactory. It is worth noting that adding Bmim 2 Co(NCS) 4 into the polymer can increase greatly the O 2 /N 2 selectivity which is higher than that of the membrane with T(4-Cl)PPCo. Although the addition of Bmim 2 Co(NCS) 4 decreases the d -spacing of packed chains of PIM-1, resulting in the slight decline of FFV and gas permeability of the membrane, the Bmim 2 Co(NCS) 4 /PIM-1 TFC membranes exhibit better O 2 /N 2 separation performance than the T(4-Cl)PPCo/PIM-1 TFC membranes in consideration of the Robeson upper bound.
Membrane-based separations are of energy-efficient and environmentally benign attributes for biogas energy developments. Membranes from polymers of intrinsic microporosity (PIMs) often suffer from low selectivity. In this study, remarkable enhancements in CO 2 /CH 4 selectivity of PIM-1 membranes are achieved by incorporating nano-sized ZIF-67 (ZIF-S) filler with a larger specific surface area and a better compatibility, thereby fortifying the interactions with PIM-1 matrix and effectively alleviating nonselective interfacial voids. For the resulting PIM-1/ZIF-S membranes, a maximum CO 2 /CH 4 selectivity of 21.1 was acquired with 15 wt% loading of ZIF-S, an increase of 69.40% compared with the pristine PIM-1 membrane, along with an associated CO 2 permeability above 2800 Barrer. To elucidate gas transport behaviors within membranes, a modified Maxwell model is developed and the calculation results match well with the experimental data. The strategy of incorporating framework nanofillers into membranes may find promising applications in enhancing the selectivity of highly permeable polymer membranes.
危险品化学品经营许可证（带存储）