查找使用阿拉丁产品的科研文献

Industrial-Scale hot embossing of PLA microneedles enabled by sheet processing and PEG Plasticization: Synergy of energy efficiency and mechanical Adaptability

Zhi Wei Luo,Ren Hui Liao,Shi Ming Du,Kang Xun Zhao,Xiao Ping Cao,Li Juan Chen,Xue Qiu You

This study resolves PLA microneedle production bottlenecks via sheet-based hot embossing and PEG plasticization. Replacing granules with sheets reduced energy by 40 % using TC4 molds (>200 cycles). Orthogonal tests prioritized pressure (F = 76.8), achieving 82 % yield at 200 ± 5°C/190 ± 10 s/0.2 MPa. PEG (60 wt%) enhanced flexibility via hydrogen bonds, maintaining 92 % skin penetration and 95 % drug release. Resultant microneedles matched commercial hollow efficacy (p > 0.05) with 82 % lower pain (0.6 g vs. 3.4 g). The revealed flow-degradation mechanism guides scalable manufacturing.