POLYMER ENGINEERING AND SCIENCE
·
2023
·Vol. 63
·期 7
·2084-2092
·
IF 3.2
Gaoyuan Ye,Tongfei Gu,Boyuan Chen,Hongjie Bi,Yingcheng Hu
To improve the toughness of polylactic acid (PLA), in this research, a tough polymer polycaprolactone (PCL) was combined with PLA to prepare blends, and a compatibilizer of glycidyl methacrylate grafted PLA (PLA-g-GMA) was produced to enhance the compatibility of PLA/PCL blend. Compared with PLA/PCL blend, the compatibilized blend exhibited a lower melting temperature and greater thermal stability. The tensile test indicates that the addition of compatibilizer greatly improved the toughness of the PLA/PCL blend. Particularly, the elongation at break of PLA/PCL blend with 6 wt% PLA-g-GMA increased to 370% and reached about 66 times of neat PLA. In addition, compatibilized blends have good shape memory performance. The research provides a simple and feasible method to overcome the brittleness of PLA, supplying a new strategy to modify PLA.
研究领域:
材料科学
·
高分子科学
·
工程学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER SCIENCE SERIES A
·
2019
·Vol. 61
·期 3
·317-324
·
IF 0.984
Ting Gu,Zhu Dayong,Lu Yue,Lu Shengjun
Abstract Polylactic acid (PLA) and poly(butylene adipate- co -terephthalate) (PBAT) were blended in a twin-screw extruder with a compatibilizer of PLA grafted using glycidyl methacrylate (PLA- g -GMA), providing PLA- g -GMA/PLA/PBAT composites. The chemical structures of the composites were determined using Fourier-transform infrared spectroscopy (FTIR). The effects of the PLA- g -GMA amount on the thermal properties, rheological performance, and mechanical behavior of the composites were studied through differential scanning calorimetry (DSC) using an advanced rheometer and material testing machine. The results revealed that the reaction between the PLA/PBAT and epoxy groups within the PLA- g -GMA promotes an entanglement between molecular chains, which increases the glass transition temperature T g , cold crystallization temperature T c , and melting temperature T m of the samples. Moreover, the PLA- g -GMA/PLA/PBAT composites show higher tensile and notch impact strengths than PLA/PBAT.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR PHARMACEUTICS
·
2013
·
IF 4.57
Wenjing Li,Xinru Li,Yajie Gao,Yanxia Zhou,Shujin Ma,Yong Zhao,Jinwen Li,Yan Liu,Xinglin Wang,Dongdong Yin
The present study aimed to investigate the effect of monomethoxy poly(ethylene glycol)-block-poly(d,l-lactic acid) (mPEG-PLA) on the activity of P-glycoprotein (P-gp) in Caco-2 cells and further unravel the relationship between PLA chain length in mPEG-PLA and influence on P-gp efflux and the action mechanism. The transport results of rhodamine 123 (R123) across Caco-2 cell monolayers suggested that mPEG-PLA unimers were responsible for its P-gp inhibitory effect. Furthermore, transport studies of R123 revealed that the inhibitory potential of P-gp efflux by mPEG-PLA analogues was strongly correlated with their structural features and showed that the hydrophilic mPEG-PLA copolymers with an intermediate PLA chain length and 10.20 of hydrophilic–lipophilic balance were more effective at inhibiting P-gp efflux in Caco-2 cells. The fluorescence polarization measurement results ruled out the plasma membrane fluidization as a contributor for inhibition of P-gp by mPEG-PLA. Concurrently, mPEG-PLA inhibited neither basal P-gp ATPase (ATP is adenosine triphosphate) activity nor substrate stimulated P-gp ATPase activity, suggesting that mPEG-PLA seemed not to be a substrate of P-gp and a competitive inhibitor. No evident alteration in P-gp surface level was detected by flow cytometry upon exposure of the cells to mPEG-PLA. The depletion of intracellular ATP, which was likely to be a result of partial inhibition of cellular metabolism, was directly correlated with inhibitory potential for P-gp mediated efflux by mPEG-PLA analogues. Hence, intracellular ATP-depletion appeared to be possible explanation to the inhibition mechanism of P-gp by mPEG-PLA. Taken together, the establishment of a relationship between PLA chain length and impact on P-gp efflux activity and interpretation of action mechanism of mPEG-PLA on P-gp are of fundamental importance and will facilitate future development of mPEG-PLA in the drug delivery area.
研究领域:
药学
·
药理学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Shu Sun,Jing Qin,Yifu Zhuang,Pengfei Cai,Xiao Yu,Hongsheng Wang,Xiu-Mei Mo,Jinglei Wu,Mohamed El-Newehy,Meera Moydeen Abdulhameed,Mingyue Fan,Wenhao Qian,Binbin Sun
Clinically, gingival tissue repair is challenging due to the complex oral microbial environment and inflammation. The development of gingival membranes using tissue engineering techniques offers a promising solution to this issue. This study focuses on developing the nanofibrous gingival membrane, combining polylactic acid (PLA), decellularized extracellular matrix (dECM), and magnesium oxide (MgO) nanoparticles. Electrospinning was used to fabricate membranes with varying ratios of PLA, dECM, and MgO, and their mechanical, antibacterial, and cell-proliferation properties were evaluated. NIH-3T3 and rat gingival fibroblasts (RGF) cells were cultured on the membranes to assess biocompatibility. A rat model with gingival defects was used to test in vivo tissue regeneration. It was indicated that the antibacterial nanofibrous membranes with MgO showed enhanced antibacterial effects, reduced inflammation, and promoted gingival tissue repair.
研究领域:
生物材料学
·
组织工程学
·
口腔医学
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS & DESIGN
·
2025
·
IF 7.9
Ruichao Zu,Wenzheng Chen,Yicang Huang,Yujie Chen,Chengzhen Du,Qunfu Fan,Hua Li,Hezhou Liu
Commercially available thermoplastic polyurethane (TPU) materials for 3D printing often exhibit inadequate damping properties, limiting their application in damping scenarios. However, 3D printing TPU filaments specifically engineered for enhanced damping performance frequently lack sufficient stiffness, causing printing continuity issues. To address these challenges, this study investigates the rational design of TPU composites by regulating TPU molecular structure and incorporating polylactic acid (PLA) to enhance both damping performance and stiffness. The results reveal that a prepolymer curing coefficient of 2.0, combined with a chain extender ratio of Dimethyl thio-toluene diamine (DMTDA) to 1,4-Butanediol (BDO) at 5:5, optimizes the damping and mechanical properties of the TPU material. Furthermore, by incorporating 30 wt% PLA particles into the TPU matrix, the obtained TPU7/PLA3 composite filament has excellent printability and admirable damping properties with a peak damping value of 0.60 around room temperature and an effective damping temperature range exceeding 100 °C. A lattice structure resembling Kelvin foam was successfully fabricated using the TPU/PLA filaments, demonstrating superior damping performance compared to commercial TPU filaments and underscoring its potential for energy absorption applications.
研究领域:
材料科学
·
工程学
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2019
·Vol. 11
·期 2
·306
·
IF 3.164
Tobias Standau,Chunjing Zhao,Svenja Murillo Castellón,Christian Bonten,Volker Altstädt
Polylactide (PLA) is known as one of the most promising biopolymers as it is derived from renewable feedstock and can be biodegraded. During the last two decades, it moved more and more into the focus of scientific research and industrial use. It is even considered as a suitable replacement for standard petroleum-based polymers, such as polystyrene (PS), which can be found in a wide range of applications—amongst others in foams for packaging and insulation applications—but cause strong environmental issues. PLA has comparable mechanical properties to PS. However, the lack of melt strength is often referred to as a drawback for most foaming processes. One way to overcome this issue is the incorporation of chemical modifiers which can induce chain extension, branching, or cross-linking. As such, a wide variety of substances were studied in the literature. This work should give an overview of the most commonly used chemical modifiers and their effects on rheological, thermal, and foaming behavior. Therefore, this review article summarizes the research conducted on neat and chemically modified PLA foamed with the conventional foaming methods (i.e., batch foaming, foam extrusion, foam injection molding, and bead foaming).Keywords:polylactide (PLA);biofoams;chemical modification;foam extrusion;batch foaming;foam injection molding;bead foaming;rheology;crystallization;density reduction
研究领域:
材料科学
·
环境科学
·
高分子化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Zhiliang Huang,Jinming Qian,Qingyuan Li,Lijuan Zhu,Shanshan Nie,Qianqian Ju,Tingguo Liu
This study presents the development of a biodegradable composite scaffold designed to address the limitations associated with conventional bone repair materials. 3D-printing filaments were developed using fish scale powder (FSP) or fish scale-derived hydroxyapatite (HAP), polylactic acid (PLA), and polycaprolactone (PCL), with a focus on the optimal effect of 5 wt% HAP on the mechanical properties of PLA. Composite scaffolds were further prepared by integrating 3D-printed grid scaffolds with chitosan/gelatin composite hydrogels through vacuum freeze-drying. The properties of the composite scaffolds were evaluated through mechanical property tests, thermal analysis (including DSC and TGA), absorption rate assessments (conducted via immersion experiments in various solutions), and surface morphology analyses (utilizing SEM and EDS). The results show that the addition of HAP significantly improves the mechanical properties of 3D-printed filaments. The high absorption rate exhibited by the HAP/PLA composite scaffold suggests improved biocompatibility and its potential for in vivo tissue fluid absorption. The HAP/PLA composite scaffold showed visible surface mineralization and degradation after 10 days of immersion in simulated body fluid (SBF), highlighting its potential for bone repair and regeneration.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL PAPERS
·
2021
·Vol. 75
·期 12
·6399-6406
·
IF 2.097
Yao Lihui,Wang Yajuan,Li Ya,Jiang Zhiqiang,Qiu Dan
A series of Fe 3 O 4 /PLA composites are controllably prepared using consecutive reaction route. The neat PLA and its composites are characterized by FT-IR, WAXRD and XPS for composition analysis. The performances of PLA and Fe 3 O 4 /PLA composites are, respectively, determined by SEM, VSM, CAM, POM, DSC and TG. Fe 3 O 4 particles are a good dispersion in the PLA matrix, and the saturation magnetization values of PLA have increased from 0.33 to 5.06 emu/g. When PLA is transformed into composites, the mean thickness of composites has decreased and water contact angle of composites has increased due to heavy and hydrophobicity Fe 3 O 4 . After addition of Fe 3 O 4 particles, the 50 k, 100 k and 200 k PLA’s crystallization rate is severally increased to 1.84, 1.56 and 1.44 times. It is concluded that the Fe 3 O 4 particles are the efficient crystallization nucleating agent of PLA and faster accelerate the crystallization of low molecular weight PLA in comparison with high molecular weight PLA. The melting points of Fe 3 O 4 /PLA composites slightly have decreased compared with the neat PLA, which is in accord with the melting point of the mixture that is lower than that of the pure substance. By introducing 5 mass% of Fe 3 O 4 particles to PLA, the initial decomposition temperatures reached to higher temperatures as compared to the neat PLA, and the final char yield is about 4.60%. The well dispersion of the particles in the PLA matrix is thought to be an effective barrier to the permeation of heat, which would improve the thermal stability.
研究领域:
材料科学
·
聚合物工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2023
·
IF 8.4
Ruizhe Li,Xuhai Zhu,Fuyan Peng,Fang Lu
The effective use of agricultural lignocellulose resources in biodegradable bioplastics has become the focus of people’s attention due to the inappropriate disposal of agricultural waste and plastic materials. However, the repulsive smell and uncontrollable color of agricultural lignocellulose-based materials limit their potential to replace common consumer plastics. In this study, when the corn stover (CS) meal enforced the PLA/PBAT matrix using the melt blending method, the lignin and hemicellulose components were shown to substantially impact the color darkening and unsavory odor release for the resultant bioplastic; therefore, an optimized scalable alkaline hydrogen peroxide oxidation that can be performed using traditional pulp and paper production lines was used to modify CS on a large scale (LCS) to enhance the properties of bioplastics fabricated with the PLA/PBAT matrix. As a result, the appearance color and odor character of the bioplastic enforced by LCS have been significantly improved compared to those of natural CS. In addition, the bioplastic (LCS/PLA/PBAT) exhibited good tensile strength (9.7 MPa), flexural strength (18.1 MPa), elongation at break (61.8%), and surface hydrophobicity with a contact angle value of 91.6°, which could meet the requirement of the Chinese National Standard for Packaging. The reinforcing effect of LCS on these performances lay in its rigid structure with a strong fiber network, high content of cellulose crystalline, and hydrophobic nature of lignin after treatment, as proven by FTIR, XRD, and SEM results. Therefore, our bioplastics filled with treated agricultural waste are attractive appearance-wise, economically competitive, and biodegradable, making them a sustainable alternative to common consumer plastics.
研究领域:
材料科学
·
环境科学
·
农业科学
✓ 已验证
DOI
高影响因子
POLYMER TESTING
·
2014
·
IF 1.816
Ya-nan Wang,Yun-xuan Weng,Lei Wang
The applicability of bamboo flour (BF) blended with polylactic acid (PLA) to improve the properties of PLA for widespread use as an environmentally friendly, biodegradable polymer is limited by the poor compatibility of these materials. Therefore, as a potential compatibilizer for PLA/BF composites, PLA-g-glycidyl methacrylate (GMA) was synthesized by grafting GMA onto PLA using benzoyl peroxide and tert-butyl peroxy benzoate as initiators. GMA grafting onto PLA was confirmed by infrared testing and elemental analysis . Then, PLA/BF biocomposites were prepared by blending PLA (85 wt%) and BF (15 wt%) with different concentrations of PLA-g-GMA. The phase morphology, thermal stability and mechanical properties of the composites prepared with PLA-g-GMA were improved over those of PLA/BF composites without compatibilizer, as characterized by scanning electron microscopy, thermogravimetric analysis and using a universal materials tester, respectively. Specifically, the thermal decomposition temperature , tensile strength and tensile modulus of PLA/BF biocomposites prepared with 15 hpr PLA-g-GMA were increased.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2024
·
IF 6.3
Yitong Ding,Mingjiao Li,Wenjing Dong,Ze Kan,Zhibo Li
Chemically synthesized poly(4-hydroxybutyrate) (P4HB) serves as an alternative material for toughening poly(lactic acid) (PLA), but the two materials exhibit poor compatibility, and most compatibilizers fail to localize at the phase interface, resulting in inefficient toughening. In this study, a phase interface-located reactive compatibilizer, poly (glycidyl methacrylate) (PGMA), is synthesized to enhance the interfacial adhesion between PLA and P4HB, thereby improving their compatibility. The PGMA compatibilizer demonstrates a tendency to selectively disperse at the phase interface of PLA and P4HB supported by thermodynamic calculations. Compared to the PLA/P4HB blend, the PLA/P4HB/PGMA blend exhibits enhanced molecular chain entanglement and a blurrier phase interface. Consequently, the mechanical and shape memory behavior of the PLA/P4HB/PGMA blend are improved. For example, the elongation at break of the PLA/P4HB/PGMA blend increased from 20.8 % to 265.1 %, marking an increase of 12.7 times compared to the PLA/P4HB blend. Due to its small molecular weight, the T o n e s e t (onset degradation temperature) of PGMA is only 180.3 °C. Fortunately, the T o n e s e t of the PLA/P4HB/PGMA system exceeds 220 °C after the chain expansion reaction, indicating a significant improvement in thermal stability. Thus, the phase interface-located chain expansion reaction offers an effective approach to improving the compatibility of PLA/P4HB blends while maintaining their high thermal stability.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
Coatings
·
2024
·Vol. 14
·期 1
·115
·
IF 2.9
Suzhan Shi,Xun Xu,Xuzhao He,Siyuan Fan,Pengruofeng Liu,Chengwei Wu,Kui Cheng
Electroactive biomaterials can influence the microenvironment between cells and a material’s surface by controlling surface electrical signals, thereby affecting cellular physiological activities. As the most commonly used ferroelectric polymer, Poly(vinylidene fluoride-trifluoroethylene) (PVTF) has attracted widespread attention due to its good stability, biocompatibility and mechanical properties. However, it has limitations such as non-degradability. In this study, PVTF nanoparticles (PVTF NPs), prepared using a phase separation method, were compounded with polylactide (PLA) to prepare PVTF NPs/PLA composite membrane (PN/PLA), which simultaneously achieved electroactivity and degradability. PVTF NPs containing ferroelectric β phase were evenly distributed on the PLA substrate, forming negative potential spots through corona polarization. The PLA substrate gradually degraded in a simulated body fluid environment. The negative surface potential provided by PVTF NPs in PN/PLA enhanced the adhesion, proliferation, and early-stage osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). The electrical bioactivity and degradability could be joined together in this study, which is promising for tissue regeneration biomaterials, such as guided bone regeneration membrane.
研究领域:
生物材料学
·
组织工程
·
细胞生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）