Polymers
·
2023
·Vol. 15
·期 8
·1906
·
IF 5
Xinxin Liu,Dengbang Jiang,Yuyue Qin,Zhihong Zhang,Mingwei Yuan
With the increasing environmental pollution caused by disposable masks, it is crucial to develop new degradable filtration materials for medical masks. ZnO-PLLA/PLLA (L-lactide) copolymers prepared from nano ZnO and L-lactide were used to prepare fiber films for air filtration by electrospinning technology. Structural characterization of ZnO-PLLA by H-NMR, XPS, and XRD demonstrated that ZnO was successfully grafted onto PLLA. An L9(43) standard orthogonal array was employed to evaluate the effects of the ZnO-PLLA concentration, ZnO-PLLA/PLLA content, DCM(dichloromethane) to DMF(N,N-dimethylformamide) ratio, and spinning time on the air filtration capacity of ZnO-PLLA/PLLA nanofiber films. It is noteworthy that the introduction of ZnO is important for the enhancement of the quality factor (QF). The optimal group obtained was sample No. 7, where the QF was 0.1403 Pa−1, the particle filtration efficiency (PFE) was 98.3%, the bacteria filtration efficiency (BFE) was 98.42%, and the airflow resistance (Δp) was 29.2 Pa. Therefore, the as-prepared ZnO-PLLA/PLLA film has potential for the development of degradable masks.
研究领域:
材料科学
·
环境科学
·
医学
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS LETTERS
·
2016
·
IF 2.437
Xinyu Peng,Yixin Zhang,Ying Chen,Sai Li,Bin He
A well-defined miktoarm star copolymer (μ-PEG-PCL-PLLA) was synthesized and the crystallization behavior of the copolymers was investigated. The structure of copolymer was confirmed by 1 H NMR, the molecular weight and molecular weight distribution were studied by GPC . XRD and POM were used to study the crystallization behavior of the miktoarm star copolymers. The XRD spectra showed that the miktoarm star copolymer showed low crystallinity for the joint of terminal, which limited the mobility of polymeric chains. The POM photographs revealed that PCL segments formed spherulites with PLLA crystalline grains as nucleus due to the good compatibility between PCL and PLLA.
研究领域:
材料科学
·
高分子化学
·
生物医学材料
✓ 已验证
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2017
·Vol. 29
·期 1
·442-450
·
IF 1.907
Suchen Jiang,Huanchao Liu,Xue Zhang,Yajun Ren,Xinxiang Cui,Xiaofeng Song
Electrospun biodegradable fiber mesh is a promising alternative scaffold for delivering progenitor cells for repairing damaged or diseased tissue, but its cripple mechanical stability has not met the requirement of tissue engineering yet. In this work, the well-defined poly(ε-caprolactone)-branched poly(methyl methacrylate- co -hydroxyethylmethacrylate) (PCL-PMH) has been successfully synthesized to toughen electrospun poly( l -lactide) (PLLA) fiber membrane. Characterization of the obtained nanofibrous meshes indicates that PCL-PMH and PLLA can be well blended to make smooth fibers, and fibrous diameter vary little with blending PCL-PMH. The aggregation state of two macromolecules is closely correlated with blend ratio, molecular structure, and molecular weight of PCL-PMH, and only when PCL-PMH and PLLA form good interfacial adhesion can PMH give full play to its potential for toughening the fiber membrane. The tensile strength and elongation at break of the blend are 6.20 MPa and 63.40% under the optimal conditions, respectively, and it also exhibits the representative feature of toughness materials. The blending fiber membrane is as no cytotoxic as original PLLA. This work will provide a new way for toughness of electrospun fiber membrane in practice.
研究领域:
生物材料学
·
组织工程学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Hui Su,Yucheng Qiu,Jing Luo,Fei Liu,Jun Yang,Xiaofeng Sui,Yue Zhang,Yumei Zhang,Xianyu Zhou
Vascular anastomosis is the cornerstone in microsurgery. To assist complicated microvascular anastomosis with diameters <0.6 mm, nonsuture cuff technique was developed. However, cuff tube made from polyamide is not degradable, and their long-term retention in the body may cause stiffness in blood vessels at the anastomotic site. Thus, development of a biodegradable cuff tube would greatly enhance surgical operability and biosafety. In this study, biocompatible poly-L-lactic acid (PLLA) was chosen as the raw material to prepare cuff tube for nonsuture cuff technique. A customized ‘C’ shaped nozzle was adopted during the melting extruding process, and then was subjected to a water-cooling bath to maintain the round shape and inner diameter of 582 μm ± 20 μm. Its crystallization behavior was controlled through the cooling procedure to achieve the expected mechanical properties and operability. Its good hemocompatibility and genotoxicity were validated by various in vitro assays. Consequently, a PLLA cuff tube with a radial tensile strength of 12 MPa and an elastic modulus of 1685 MPa was prepared and used to assist establishing a rat orthotopic hindlimb transplantation model, which indicated that our PLLA cuff tube was suitable for microvascular anastomosis in organ or tissue repair.
研究领域:
医学
·
生物材料学
·
外科手术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Shuhua Chang,Miaoran Zhao,Wenxia Gao,Jun Cao,Bin He
Injectable subcutaneous fillers are used in medical aesthetics primarily to correct skin wrinkles. The limitations of collagen fillers include rapid degradation, lack of collagen regeneration effects and high-frequency injections. The regenerative filler of Sculptra (Aesthetic) offers prolonged regenerative effects; however, the slow collagen regeneration results in prolonged waiting time for the filling effects. Herein, we report a facile strategy to fabricate dermal fillers with rapid collagen regeneration. Crosslinked collagen was swollen in a weak acidic solution and coated onto the surface of poly(L-lactic acid) (PLLA) microspheres. The collagen@PLLA composite microspheres (Col@PLLA) were dispersed in an aqueous solution of sodium carboxymethyl cellulose (CMC) to form a porous sponge after lyophilization. In vitro studies verified the good safety and fibroblast affinity of the Col@PLLA fillers. The fillers were subcutaneously injected to evaluate the effects of collagen regeneration in vivo. Compared to the single collagen and PLLA microspheres, the Col@PLLA composite fillers showed significant collagen regeneration after injecting for 5 days. The regenerated type III and type I collagens of Col@PLLA maintained high levels after 4 months post-implantation. The inflammation response further validated the regenerative mechanism and long-lasting potential of this product. The Col@PLLA fillers achieved a significant enhancement in collagen regeneration.
研究领域:
医学美学
·
生物材料学
·
组织工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2019
·Vol. 37
·期 11
·1152-1161
·
IF 2.804
Shi Lei,Zhang Ruo-Yu,Ying Wu-Bin,Hu Han,Wang Yu-Bin,Guo Ya-Qian,Wang Wen-Qin,Tang Zhao-Bin,Zhu Jin
Thermoplastic poly(ether-ester-urethane)s were synthesized from poly(L-lactide) diols (PLLA diols), polytetrahydrofuran diol (PTMG diols), 4,4′-dicyclohexylmethane diisocyanate (HMDI), and 1,4-butanediol (BDO) by a two-step reaction, and the morphology and property of the resultant TPU could be adjusted by varying the PLLA contents. The soft segment was composed of PLLA and PTMG diols. By controlling the percentage of PLLA in the soft segment, the glass transition temperature and mechanical properties of the polyurethanes could be regulated. Based on the FTIR spectrum, we found that two kinds of hydrogen bonding existed individually in soft matrix and hard domain. The hydrogen bonding in soft matrix was unstable, which could be destroyed during elongation. With in situ stretching WAXS and SAXS experiments, we found that the PLLA crystal was destroyed and the PLLA domain oriented along the stretch direction. Finally, we proposed a schematic model to illustrate the microstructures of these elastomers before and after stretch.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Ruixian Lian,Dong Zhou,Lan Xiao,João Rodrigues,Ruilong Sheng,Zhishan Bai,Yulin Li,Changsheng Liu
Poly(lactic acid) (PLA) possesses excellent biocompatibility and biodegradability for the construction of biomaterials. However, its limited crystallinity largely restricts practical application. In this study, four poly(l-lactic acid) (PLLA) copolymers were synthesized by incorporating two different molecular weights of PEG/mPEG (1K and 2K) chains with l-lactide via ring-opening polymerization (ROP). The impact of PEG/mPEG chains on the hydrophilicity and mechanical properties of the resulting copolymers, their crystallization kinetics, and activation energy was also examined. The results demonstrate that introducing PEG/mPEG chains could significantly improve the hydrophilicity, crystallinity, and crystallization rate and reduce the maximum crystallization temperature of the copolymer materials. Among the PLLA copolymers, PLLA-mPEG (2K) exhibits the most remarkable improvements in polymer crystallinity, crystallization rate, and reduction of the maximum crystallization temperature. The advancements in copolymer material properties were anticipated to significantly expand the potential applications for PLLA-based polymer materials, which also greatly improved the applicability as sustainable and controllable biopolymer materials.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yuwei Zhou,Ke Hu,Zhaobin Guo,Kun Fang,Xing Wang,Fang Yang,Ning Gu
In this study, composite antibacterial microcapsules combining of two antibacterial agents: chlorhexidine acetate and silver nanoparticle were prepared. The chlorhexidine acetate was encapsulated inside of the microcapsules and nano-sized silver particles were modified on the surface of microcapsules by electrostatic adsorption methods. Results show that this method decreases the silver usage dramatically, and promises a sustained antibacterial effect > 30 days. These microcapsules can also be modified on the surface of polymer films easily, which demonstrated the potential in functionalizing the implanted materials with antibacterial property.
研究领域:
材料科学
·
微生物学
·
生物医学工程
✓ 已验证
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2023
·
IF 8.7
Menghan Xu,Yongxian Wen,Fukun Niu,Quanling Yang,Chuanxi Xiong,Zhuqun Shi
Herein, PLLA/ZnO oriented fibers were prepared via orientation electrospinning towards a piezoelectric generator, omitting polarization and stretching postprocesses. The composite fibers achieved macroscopic orientation and molecular alignment, as well as higher crystallinity and more polar phase for PLLA. Collectively, the resulting generator exhibited dramatic and stable piezoelectric signals over 1000 s, boosting the open-circuit voltage to 7.9 V, nearly 4.6 times larger than that of the random neat device. With the same changing tendency, the simulated results confirmed oriented fibers and ZnO induced stress concentration, imparting better piezoelectricity. Furthermore, the generated electricity from the generator with a short-circuit current of 286nA and an output power density of 1.25 mW cm −3 charged a 10 μF capacitor up to 2 V at 210 s then illuminated a LED. Encouragingly, high flexibility and sensitivity allowed this device to function as a wearable self-powered sensor for differentiating human movement and monitoring human health.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 8
·1071
·
IF 4.7
Qian Zhang,Qiang Liu,Weidong Xue,Yong Xiang,Xiaoran Hu
In the present study, poling−free PLLA/VB2piezoelectric composites are fabricated to achieve synchronous sound recognition and energy harvesting. The addition of VB2can interact with PLLA by intermolecular hydrogen bonding, inducing the dipole orientation of C=O in PLLA. Meanwhile, VB2can promote crystallization of PLLA through heterogeneous nucleation. The combination of the two strategies significantly improves the piezoelectric performance of PLLA/VB2composites. The PLLA/VB2can detect the sound frequency with an accuracy of 0.1% in the range of 0–20 kHz to recognize characteristic sounds from a specific source. PLLA/VB2can also convert sound into electrical energy synchronously with an energy density of 0.2 W/cm−3to power up LEDs. Therefore, PLLA/VB2shows great potential in the field of information and energy synchronous collection.
研究领域:
材料科学
·
能源技术
·
声学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2019
·Vol. 297
·期 10
·1321-1330
·
IF 1.906
Chen Jun,Ding Amin,Zhou Yifeng,Chen Pengpeng,Xu Ying,Nie Wangyan
Star-shaped copolymers based on star-shaped poly (L-lactide) (s-PLLA) and tocopheryl polyethylene glycol 1000 succinate (TPGS) (s-PLLA-TPGS) were synthesized with structural variation on arm numbers in order to investigate the relationship between the arm numbers of s-PLLA-TPGS copolymers and their micelle properties. The structure and M w of s-PLLA-TPGS were characterized with 1 H NMR, GPC, DSC, and XRD. The indometacin(IMC)-loaded s-PLLA-TPGS micelles were obtained by dialysis method. The effects of arm numbers of s-PLLA-TPGS copolymers on surface morphology, particle size, zeta potential, drug loading content (LC), drug encapsulation efficiency (EE), and in vitro drug release behavior of prepared micelles were studied. The results indicated that the average diameters, LC, and EE of IMC-loaded s-PLLA-TPGS micelles gradually increased in the order of 4-arm, 5-arm, and 6-arm s-PLLA-TPGS copolymers. The in vitro release studies showed that the IMC accumulative release can be decreased by increasing the arm numbers of the s-PLLA-TPGS copolymers, and the release profiles of IMC from the s-PLLA-TPGS copolymers followed the Baker-Lonsdale model equation. The results suggest that the arm number regulation of s-PLLA-TPGS copolymers can provide a new strategy for designing drug carriers of high efficiency.
Graphical abstract
研究领域:
药剂学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2015
·
IF 3.005
Tiankui Qiao,Ping Song,Huiling Guo,Xiaofeng Song,Baochang Zhang,Xuesi Chen
Biodegradable polymeric fiber membranes produced by electrospinning have been candidate for tissue engineering, but they sometimes lack the necessary mechanical stability. In the work, electrospun poly ( l -lactide) fiber membranes are chemically crosslinked by adding dicumyl peroxide (DCP) and triallylisocyanurate (TAIC). Their corresponding properties such as morphology, thermodynamics, mechanics, degradation and cytotoxicity are investigated. Morphology of PLLA fiber is maintained after crosslinking, but its crystallization and melting temperature is influenced by chemical crosslinking. The membranous tensile strength and modulus not only climb with TAIC concentration increasing, but also depend strongly on crosslinked temperature which the best is 140 °C. Compared to neat PLLA, degradation rate of the crosslinked PLLA membrane is slower. At the same time, it is also non-cytotoxic. The results suggest that the chemical crosslinking improves the mechanical properties of PLLA fiber membrane and keeps its mechanical stability longer, making it more suitable for tissue engineering.
研究领域:
材料科学
·
生物材料
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）