APPLIED SURFACE SCIENCE
·
2012
·
IF 2.103
Cheng Jiang,Qihua Wang,Tingmei Wang
Thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) was grafted onto the cotton fabric by atom transfer radical polymerization (ATRP). Introducing 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PFDTS) onto the surface, the density of PNIPAAm chains can be adjusted because of the competitive reactions of (3-aminopropyl) triethoxysilane (APS) and PFDTS. With the appropriate ratio of APS and PFDTS, the cotton fabric can be switched from superhydrophilic to superhydrophobic by controlling temperature. The prepared cotton fabric may find application in functional textiles, soft and folding superhydrophobic materials.
研究领域:
材料科学
·
纺织工程
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER ENGINEERING
·
2020
·Vol. 41
·期 1
·65-71
·
IF 1.126
Zhengdong Fei,Dong Zheng,Ping Fan,Feng Chen,Mingqiang Zhong
A triple interpenetrating polymer network (IPN) with dual responses to temperature and pH was constructed based on chemical crosslinking and electrostatic interaction. In this IPN, CaCO 3 microspheres were used as the kernel and PNIPAAM/sodium alginate microcapsules were prepared by the inverse emulsion polymerization method. Research results demonstrated that CaCO 3 kernels were decomposed into Ca 2+ and CO 2 at pH 1.2. Such decomposition facilitated the formation of triple IPN of Ca 2+ crosslinking. Moreover, microcapsules were expanded by tension of CO 2 and the volume increased to 3.55 × 10 5 times that of the original microcapsules, with capsules remaining an intact morphology. These microcapsules loading doxorubicin hydrochloride (DOX) stability and responses to environment were investigated. No drug overflow was observed at pH 7.4, indicating the high stability of microcapsules. However, DOX was released gradually in the simulated human stomach acid with a weak solution of hydrochloric acid (pH 1.2, 37 °C). This showed that the prepared microcapsules were feasible for drug-loaded capsules and the controlled drug release behavior could relieve side effects of drugs to human body. Moreover, it will help to increase the drug utilization and realize accurate treatment.
研究领域:
材料科学
·
药学
✓ 已验证
DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2014
·Vol. 55
·期 1
·223-230
·
IF 1.441
Zhao-Xia Li,Man-Geng Lu,Kun Wu,Yun-Fei Zhang,Lei Miao,Yin-Wen Li,Hui-Long Guo,Jian Zheng
A series of novel thermosensitive macroporous poly (ethylene glycol) (PEG)- co -poly( N -isopropylacrylamide) (PNIPAAm)- co -poly (ε-caprolactone) (PCL) hydrogels were synthesized via in situ free radical polymerization. Poly(ethylene glycol diacrylate) (PEGDAc) and poly(ε-caprolactone diacrylate) (PCLDAc) were prepared as macrocrosslinkers. All compounds were investigated by Nuclear Magnetic Resonance (NMR) and Fourier transform-infrared spectroscopy (FT-IR). Differential Scanning Calorimetry (DSC) results showed the lower critical solution temperatures (LCSTs) of the gels were at around 31°C. The macroporous gels not only had considerable swelling ratios, but also exhibited rapid swelling kinetics and response sensitivity. Above mentioned hydrogels showed a remarkable oscillatory swelling–deswelling transition, making them have potential application in long-term drug delivery. POLYM. ENG. SCI., 55:223–230, 2015. © 2014 Society of Plastics Engineers
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2012
·
IF 3.461
Yan-Ling Luo,Li-Li Zhang,Feng Xu
Brush-like block copolymers with poly( t -butyl methacrylate) (PBMA) and poly(N-ispropylacrylamide) (PNIPAAm) as side arms, PBMA-b-PNIPAAm, were designed and synthesized via a simple free radical polymerization route. The chemical structure and molecular weight of these polymer brushes were characterized and determined by nuclear magnetic resonance ( 1 H NMR), Fourier transform infrared spectrometry (FT-IR) and gel permeation chromatography (GPC). The polymer brushes can spontaneously assembled into regularly spherical core–shell nanostructured micelles with well-dispersed individual nanoparticles in aqueous solutions, and physiochemical properties of the micelles formed were detected by a surface tension technique, nanoparticle analyzer, transmission electron microscope (TEM), dynamic light scattering (DLS) and UV–vis transmittance measurements. Low critical micelle concentration (CMC) and high zeta potentials revealed the micellar stability and the micellar particle size was in the range from 36 to 93 nm by TEM and less than 200 nm by DLS. The resulting block polymer brushes were temperature-sensitive with low critical solution temperature (LCST) about 28.80–29.40 °C. These characteristic parameters were affected by their compositional ratios and the length of hydrophilic or hydrophobic chains. The evaluation for caffeine drug release and release kinetics demonstrated that the drug release and bioavailability may be mediated or improved by the temperature-induced structural changes of the micelles and different diffusion mechanism.
研究领域:
高分子化学
·
药剂学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
POLYMER SCIENCE SERIES A
·
2012
·Vol. 54
·期 4
·270-281
·
IF 0.838
Luo Yan-Ling,Zhang Li-Li,Xu Feng
Brush-like block copolymers with poly( t -butyl methacrylate) (PBMA) and poly( N -isopropylacrylamide) (PNIPAAm) as side arms, PBMA- b -PNIPAAm, were designed and synthesized via a simple free radical polymerization route. The chemical structure and molecular weight of these polymer brushes were characterized and determined by nuclear magnetic resonance ( 1 H NMR), Fourier transform infrared spectrometry (FTIR) and gel permeation chromatography (GPC). The micellar formation by these polymer brushes in aqueous solutions were detected by a surface tension technique, and the critical micelle concentration (CMC) ranged from 1.53 to 8.06 mg L −1 . The morphology and geometry of polymer micelles were investigated by transmission electron microscope (TEM) and dynamic light scattering (DLS). The polymer micelles assume the regularly-spherical core-shell structure with well-dispersed individual nanoparticles, and the particle size was in the range from 36 to 93 nm. The PNIPAAm segments exhibited a thermoreversible phase transition, so the resulting block polymer brushes were temperature-sensitive and the low critical solution temperature (LCST) was determined by UV-vis spectrometer at about 28.82–29.40°C. The characteristic parameters of the polymer micelles such as CMC, micellar size and LCST values were affected by their compositional ratios and the length of hydrophilic or hydrophobic chains. The evaluation for caffeine drug release behavior of the block polymer micelles demonstrated that the self-assembled micelles exhibited thermal-triggered properties in controlled drug release.
研究领域:
材料科学
·
药学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 10
·3214
·
IF 4.927
Yi Gao,Xuesong Yao,Qinggeng Jiang,Jianhe Liao,Yongping Chen,Rentong Yu
Microgels have unique and versatile properties allowing their use in forward osmosis areas as a draw agent. In this contribution, poly(4-vinylpyridine) (P4VP) was synthesized via RAFT polymerization and then grafted to a poly(N-Isopropylacrylamide) (PNIPAAm) crosslinking network by reverse suspension polymerization. P4VP was successfully obtained by the quasiliving polymerization with the result of nuclear magnetic resonance and gel permeation chromatography characterization. The particle size and particle size distribution of the PNIPAAm-g-P4VP microgels containing 0, 5, 10, 15 and 20 wt% P4VP were measured by means of a laser particle size analyzer. It was found that all the microgels were of micrometer scale and the particle size was increased with the P4VP load. Inter/intra-molecular-specific interactions, i.e., hydrogen bond interactions were then investigated by Fourier infrared spectroscopy. In addition, the water flux measurements showed that all the PNIPAAm-g-P4VP microgels can draw water more effectively than a blank PNIPAAm microgel. For the copolymer microgel incorporating 20 wt% P4VP, the water flux was measured to be 7.48 L∙m−2∙h−1.Keywords:microgel;forward osmosis;draw agent;P4VP
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 36
·16679-16688
·
IF 3.591
Lijuan Zhang,Dongqing Zhao,Yao Lu,Jinghan Chen,Haotian Li,Jinghan Xie,Yue Xu,Haikuan Yuan,Xijian Liu,Xueyan Zhu,Jie Lu
A highly efficient strategy was developed to fabricate a graphene oxide modified cellulose nanocrystal/PNIPAAm IPN (GO-CNC/PNIPAAm IPN) hydrogel, which was capable of effectively adsorbing cationic and anionic dyes. The adsorption of Congo red (CR) and methylene blue (MB) was investigated based on the effects of pH, adsorption isotherms, adsorption kinetics, and recycling experiments. The adsorption capacities for CR and MB of the GO-CNC/PNIPAAm IPN hydrogel adsorbent were 728.8 mg g−1 and 281.9 mg g−1, respectively, and the difference is due to complex electrostatic and chemisorption effects between the adsorbent and the dye, which could be explained using the Langmuir isotherm adsorption model and pseudo-second-order kinetics model. In addition, the GO-CNC/PNIPAAm IPN hydrogel could be used repeatedly, and the adsorption capacities for CR and MB were 84.9% and 82.4% of the original hydrogel after five re-adsorption experiments, respectively. This type of adsorbent provided the advantages of being low-cost, having simple preparation, being non-polluting, and having good adsorption effects and a long service life, which is promising for its use in dye wastewater treatment in the future.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 31
·6212-6225
·
IF 6.331
Xiao Han,Rong Yang,Xiuzhen Wan,Jie Dou,Jiang Yuan,Bo Chi,Jian Shen
Hydrogel is a potential wound dressing material due to its ability to maintain a humid environment, the strong absorptive capacity of exuded tissue fluid, and gas exchange function. Herein, poly(N-isopropyl acrylamide)/keratin double network (PNIPAAm/keratin DN) gels were fabricated through covalent and ionic double cross-linking strategy. The effects of PNIPAAm/keratin ratios on the morphology and swelling rate of gels were characterized. The DN gels could swell up from 2600% to 4600% in proportion to the keratin content, demonstrating their great ability to absorb tissue fluid. The gels possessed thermo-sensitiveness, imparting self-stripping property. Moreover, the antibacterial chlorhexidine acetate (CHX) was loaded into gels with a post-fabrication drug-loading strategy. The release behavior showed that CHX-loaded DN gels exhibited multiple responsive characteristics (temperature, pH, and ROS). Furthermore, the drug-loaded gels showed greater antibacterial activity than free CHX due to the sustained drug release effect. Meanwhile, the antioxidant efficiency of PNIPAAm/keratin DN gels was ca. 33.1%, while the PNIPAAm gel was just ca. 18.2%, indicating the strong oxidation resistance of DN gels. In the Sprague Dawley (SD) rat skin defect model, the hydrogel had better tissue regeneration ability than the commercial film. Taken together, the multifunctional PNIPAAm/keratin DN gels are potential candidates for clinical wound treatment.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Ziwei Lv,Hongxu Liu,Jingxuan Zhao,Ruijia Wang,Ting Xie,Yuchao Qi,Yang Yu,Xue Lv,Shulin Sun
In this paper, PVDF-g-PNIPAAm/GEP-PDA@ZnO composite membranes that can undergo light-induced structural response and photodegradation to achieve self-cleaning have been designed and applied to the separation and purification of dye wastewater. The membranes were prepared by blending graphene (GPE)-polydopamine (PDA)-coated zinc oxide (ZnO) core–shell particles into the PVDF-g-PNIPAAm matrix with a non-solvent induced phase separation technique. The GPE and ZnO are tightly bonded by highly adhesive PDA to form a “strawberry-like” core–shell structure. GPE absorbs light energy and converts it into heat, resulting in changes in PNIPAAm chain segments to expand the pore size for self-cleaning. While the membrane is warming up, GPE further promotes the activation of active groups on the surface of PDA@ZnO at high temperature, resulting in unique and excellent photothermal catalytic activity. As a result, the membrane achieves both self-cleaning and pollutant degradation, which results in an FRR of 99.6% after light cleaning. Moreover, the GPE-PDA@ZnO nanoparticle-modified PVDF-g-PNIPAAm membranes exhibit excellent cycling stability with a degradation flux recovery rate of more than 97% even after multiple UV cleaning. Thus, PVDF-g-PNIPAAm/GPE-PDA@ZnO composite membranes extend the versatility of PVDF-based membranes and show extraordinary potential for application in wastewater treatment.
研究领域:
材料科学
·
环境工程
·
光催化技术
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR RESEARCH
·
2011
·Vol. 19
·期 12
·1287-1295
·
IF 1.639
Xu Feng,Yan Ting-Ting,Luo Yan-Ling
The thermo-sensitive amphiphilic block copolymer poly( N -isopropylacrylamide)- block -poly( D,L -lactide) (PNIPAAm- b -PLA) was synthesized using a simple free radical copolymerization route based on a bifunctional initiator, 2,2-azobis(2-methylpropion amidine) dihydrochloride followed by the ring-opening polymerization of D,L -actide in the presence of a Sn(Oct) 2 catalyst. The chemical structure of the PNIPAAm- b -PLA copolymers was verified using Fourier transform-infrared spectrophotometry and nuclear magnetic resonance, and the molecular weight and polydispersity index were examined using gel permeation chromatography. The amphiphilic PNIPAAm- b -PLA block copolymers could self-assemble into spherically shaped micelles in an aqueous solution with a transmission electron microscopy diameter range of 40–56 nm and a dynamic laser scattering hydrodynamic diameter of 90–200 nm. This behavior depends on the environmental temperature, the hydrophobic interactions among PNIPAAm molecular chains, the intermolecular hydrogen bonding between the PNIPAAm chains and water molecules, and the intramolecular hydrogen bonding between the -CONH 2 groups. The copolymers held a critical micellization concentration of 4.93–7.21 mg·L −1 and a low critical solution temperature of 31.15–32.62 °C being more or less affected by their compositions, PLA or PNIPAAm block length, and polymerization temperature. The as-prepared PNIPAAm- b -PLA block polymers are anticipated to be applied as candidate drug release carriers.
研究领域:
高分子化学
·
药物递送系统
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2020
·
IF 7.182
Zhicai Yu,Jinru Liu,Hualing He,Shengnan Ma,Jinyin Yao
A novel fire-preventing triple-network (TN) hydrogel was prepared and laminated on cotton fabric to improve fire-resistant performance of cellulose fabric. The TN hydrogel composed of Poly (N-isopropylacrylamide) (PNIPAAm)/sodium alginate (SA)/ Poly (vinyl alcohol) (PVA) exhibited excellent swelling ratio, swelling-deswelling behavior and antibacterial property. Results indicated that introduction of SA could improve water retention capabilities of TN hydrogels. Thermogravimetric experiments showed that the thermal stability of hydrogels was best at a SA: PVA ratio of 2:1. Furthermore, the obtained hydrogel-cotton fabric laminates displayed efficient flame retardancy. Compared to original fabric, hydrogel-fabric laminates were nearly undamaged when exposed to fire for 12 s. This result is attributed to energy absorption as water is heated and evaporates in the hydrogel. The present work provides a new concept to prepare fire-resistant polymer fabric, which may be used in fire-protective clothing to protect the skin from burn injuries.
研究领域:
材料科学
·
高分子化学
·
消防工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2013
·
IF 2.108
Yan-Ling Luo,Rui-Juan Huang,Li-Li Zhang,Feng Xu,Ya-Shao Chen
A thermo- and pH-stimuli-responsive brush-shaped graft copolymer based on macromonomers acrylate terminated PMAA–CH=CH 2 and PNIPAAm–CH=CH 2 was synthesized, which is composed of poly(methacrylic acid) (PMAA) and poly( N -ispropylacrylamide) (PNIPAAm) as graft brushes, named PMAA- b -PNIPAAm. The copolymers can self-assemble to form spherically-shaped core-shell nanostrucrued micelles in different media, with the critical micelle concentration (CMC) in aqueous solution from 9.24 to 32.81 mg L −1 , and the hydrodynamic diameters varying with pH and temperature, from 120 to 195 nm. The resultant nanoscale copolymer micelles exhibited pH-triggered thermoresponsive behavior, with low critical solution temperature (LCST) about 38.2–47.5 °C. The polymer micelle nanoparticles were observed to be stable under simulated physiological conditions. The cytotoxicity studies by MTT assay and in vitro prednisone drug release demonstrated that the PMAA- b -PNIPAAm copolymer micelles were not directly toxic to L929 mouse embryonic fibroblasts and the in vitro release behavior under various physiological environments depended upon pH and temperature change. Therefore the as-prepared brush-shaped graft copolymer micelle nanoparticles may serve as a promising “intelligent” drug delivery carrier.
研究领域:
材料科学与工程
·
生物医学工程
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）