Small Methods
·
2025
·
IF 9.1
Shengdong Mu,LiLi Ji,Yao Rao,Zihao Feng,Jiatian Zhu,Ling Bai,Yue Liu,Xingxiu Zhao,Changqing Zhao,Zhifeng Zhao
Real-time and high-efficient detection of food additives is of great significance for global public health. As a popular biosensor, colorimetric detection has been widely applied in various fields, including the food industry. However, owing to the complex structure, weak ROS-catalytic activities and unclear catalytic mechanism, recently reported biocatalysts as biosensors still face major challenges in achieving high-efficient and multimodal aspects. Here, the novel design of high-efficient, robust, multimodal, and Os-based active centers on the oxygen vacancies (O v )-containing Cu 2 Cl(OH) 3 substrates (Os@TBCC-O v ) to serve as ROS-catalytic biosensors to colorimetric detection of food additives is reported. Benefiting from the highly active and excellent electronic structure of Os-single-atom sites, the synthesized Os@TBCC-O v biocatalysts exhibit superior POD-mimetic activities, thus facilitating the exceptional and exclusive detecting activities. Moreover, colorimetric studies found that the POD-mimetic biosensor of Os@TBCC-O v can provide high-efficient, wide-range and visual detection abilities of food additives, including H 2 O 2 , L-Cysteine and glucose, which is much higher efficient than that of previously reported biosensors. Meanwhile, the results of practical application further demonstrate the feasibility of Os@TBCC-O v -based biosensors in detection of food additives. It is suggested that this design will offer a novel pathway for high-efficient colorimetric detection of POD-mimetic biocatalysts in food industry and other related fields.
研究领域:
生物传感器
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食品安全
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纳米技术
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酶模拟物
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分析化学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Weiqiang Li,Xiaoyun Xu,Yang Song,Linping Fan,Jin Huang,Luyu Yang,Yang Liu,Hengyi Xu
For foodborne pathogens pose a serious threat to public health, a magnetic separation strategy and a nanozyme-based biosensor are proposed for biosensing of Listeria monocytogenes ( L. monocytogenes ). In this work, doripenem is selected as a recognized molecule for the modification of magnetic beads to capture L. monocytogenes in food and environmental samples. Furthermore, the POD-like MXene-Hemin-Au is constructed from perspective of charge transfer engineering which provides a vivid example to rational design of nanozymes. Finally, the captured L. monocytogenes is labeled with MXene-Hemin-Au@mAb, forming the sandwich complexes for quantitative determination. The current signals that generated by the complexes exhibit a good linear relationship with a limit of detection of 2.3 × 10 1 CFU/mL. The biosensor shows a satisfactory applicability in real samples with recoveries of 91.19% to 102.98%. Overall, the biosensor with integrated magnetic separation strategy presents a potential approach for high sensitivity biosensing of foodborne pathogens.
研究领域:
生物传感
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纳米技术
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食品安全
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微生物学
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分析化学
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DOI
PubMed
高影响因子
Batteries & Supercaps
·
2021
·Vol. 5
·期 1
·e202100203
·
IF 7.093
Yaqian Dong,Yaohui Zhang,Nana Wang,Guifu Zou,Qiang Zhang,Shengquan Gan,Liang He,Zhongchao Bai
Graphical Materials for better SIB anode : The synergistic effects of the one-dimensional N-doped carbon and ultra-small Fe 7 S 8 particles in the reported pod-like Fe 7 S 8 @N−C nanocomposite, improve electrical conductivity and alleviate the volume expansion of the anode of SIB during cycling. One dimensional Fe 7 S 8 @N−C nanocomposite, consisting of Fe 7 S 8 nanoparticles homogeneously embedded in N-doped carbon nanowires, was synthesized by a facile hydrothermal-annealing process. As an anode material for sodium-ion batteries, the electrode exhibited capacities of 481 mA h g −1 after 1000 cycles at 5 A g −1 and 591 mA h g −1 at 200 mA g −1 with a retention ratio of 91 %. The excellent rate performance and cycling stability can be attributed to the synergistic effects of the one-dimensional N-doped carbon and ultra-small Fe 7 S 8 particles, which will improve electrical conductivity and alleviate the volume expansion of the electrode during cycling. This work will afford a great reference for further development of iron sulfides-based anode materials towards high-performance sodium-ion batteries.
研究领域:
材料科学
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能源存储
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DOI
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2021
·Vol. 2022
·期 6
·e202100996
·
IF 2.524
Fagong Xu,Feiyang Zhan,Beibei Zhang,Tuanhui Li,Lei He,Liting Du,Shizhou Luo,Baishu Zheng,Ruirui Yun
Graphical A tubular core-shell catalyst of Fe/Fe 3 C-900 has been designed and synthesized which shows an excellent activity, chemo-selectivity and stability for the hydrogenation of nitroarenes under mild conditions. Recent years, tubular structure as the carrier loading nanoparticles has been reported more and more frequently which is synthesized by pyrolysis polyhedral MOFs. However, the construct mechanism has not been referred. Herein, a tubular structure has been designed by calcining modified ZIF-8 under different temperature to reveal the formation process of tubular carbon from the polyhedron. As a result, a pod-like core-shell catalyst of Fe/Fe 3 C-900 has been obtained and exhibits a high activity and excellent substituent tolerance for the reduction of nitro groups under mild conditions.
研究领域:
催化
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材料科学
·
化学
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DOI
高影响因子
POLYMER
·
2026
·
IF 5.1
Chaohua Zhang,Zhengjiang Dong,Jinghong Qiu,Zongliang Du,Xu Cheng,Haibo Wang,Xiaosheng Du
Developing flexible, form-stable phase change materials (PCMs) that simultaneously possess high photothermal conversion efficiency and robust flame retardancy is crucial for optimizing solar energy utilization. However, conventional composites typically struggle with an inherent trade-off between preventing liquid leakage and maintaining mechanical flexibility, primarily due to their rigid, continuous network structures. Inspired by natural pod structures, we report an innovative emulsion-crosslinking approach to fabricate intrinsically flexible phase change composites (MSPCFs). By establishing a stable water-in-oil emulsion, polyethylene glycol (PEG) serves as the dispersed phase encapsulated within a flexible, crosslinked organosilicon continuous matrix. This unique discrete, non-continuous morphology effectively eradicates leakage risks while imparting superior intrinsic flexibility compared to traditional porous scaffolds. To further elevate performance, a novel phosphorus-based flame retardant (DOPO-HEA) and single-layer Ti 3 C 2 T x MXene were synthesized and synergistically incorporated. The optimized MSPCFs demonstrate exceptional multifunctionality, exhibiting a 64.6% enhancement in thermal conductivity and a remarkable solar-thermal storage efficiency of 88.41%. Moreover, fire safety is significantly improved, evidenced by a 58.3% reduction in peak heat release rate. This study provides a pioneering strategy for designing safe, shape-stable, and intrinsically flexible PCMs, offering significant potential for efficient solar-thermal energy storage and advanced thermal management applications.
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DOI
高影响因子
Royal Society Open Science
·
2019
·Vol. 6
·期 9
·
IF 2.515
Shang Wang,Zhaolian Han,Tingting Di,Rui Li,Siyuan Liu,Zhiqiang Cheng
The pod-shaped TiO2 nano burst tubes (TiO2 NBTs) were prepared by the combination of electrospinning and impregnation calcination with oxalic acid (H2C2O4), polystyrene (PS) and tetrabutyl titanate. The silver nanoparticles (AgNPs) were loaded onto the surface of TiO2 NBTs by ultraviolet light reduction method to prepare pod-shaped Ag@TiO2 NBTs. In this work, we analysed the effect of the amount of oxalic acid on the cracking degree of TiO2 NBTs; the effect of the concentration of AgNO3 solution on the particle size and loading of AgNPs on the surface of TiO2 NBTs. Scanning electron microscopy and transmission electron microscopy investigated the surface morphology of samples. X-ray diffraction and X-ray photoelectron spectroscopy characterized the structure and composition of samples. Rhodamine B (RhB) solution was used to evaluate the photocatalytic activity of pod-shaped TiO2 NBTs and Ag@TiO2 NBTs. The results showed that TiO2 NBTs degraded 91.0% of RhB under ultraviolet light, Ag@TiO2 NBTs degraded 95.5% under visible light for 75 and 60 min, respectively. The degradation process of both samples was consistent with the Langmuir–Hinshelwood first-order kinetic equation. Therefore, the catalytic performance of the sample is: Ag@TiO2 NBTs > TiO2 NBTs > TiO2 nanotubes.
研究领域:
材料科学
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纳米技术
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光催化
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环境工程
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DOI
高影响因子
Signal Transduction and Targeted Therapy
·
2022
·Vol. 7
·期 1
·1-9
·
IF 38.104
Cao Changyu,Zhang Tingbo,Yang Nan,Niu Xianghong,Zhou Zhaobo,Wang Jinlan,Yang Dongliang,Chen Peng,Zhong Liping,Dong Xiaochen,Zhao Yongxiang
The current feasibility of nanocatalysts in clinical anti-infection therapy, especially for drug-resistant bacteria infection is extremely restrained because of the insufficient reactive oxygen generation. Herein, a novel Ag/Bi 2 MoO 6 (Ag/BMO) nanozyme optimized by charge separation engineering with photoactivated sustainable peroxidase-mimicking activities and NIR-II photodynamic performance was synthesized by solvothermal reaction and photoreduction. The Ag/BMO nanozyme held satisfactory bactericidal performance against methicillin-resistant Staphylococcus aureus (MRSA) (~99.9%). The excellent antibacterial performance of Ag/BMO NPs was ascribed to the corporation of peroxidase-like activity, NIR-II photodynamic behavior, and acidity-enhanced release of Ag + . As revealed by theoretical calculations, the introduction of Ag to BMO made it easier to separate photo-triggered electron-hole pairs for ROS production. And the conduction and valence band potentials of Ag/BMO NPs were favorable for the reduction of O 2 to ·O 2 − . Under 1064 nm laser irradiation, the electron transfer to BMO was beneficial to the reversible change of Mo 5+ /Mo 6+ , further improving the peroxidase-like catalytic activity and NIR-II photodynamic performance based on the Russell mechanism. In vivo, the Ag/BMO NPs exhibited promising therapeutic effects towards MRSA-infected wounds. This study enriches the nanozyme research and proves that nanozymes can be rationally optimized by charge separation engineering strategy.
研究领域:
生物医学工程
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纳米医学
·
感染性疾病
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Yu Lu,Wen-yan Wang,Fei Xue,Jing-hui Yang,Xiao-dong Qi,Zuo-wan Zhou,Yong Wang
Polymeric dielectric composites have wide applications in many fields ranging from wearable devices, sensors to energy storage. In this work, a novel kind of hybrid particles with ‘core-shell’-like structure were fabricated via the polydopamine-assisted deposition technology, in which the tetra-pod zinc oxide whisker (T-ZnOw) was the ‘core’ and the two-dimensional graphene oxide (GO) was the ‘shell’, while polydopamine (PDA) was the adhesion layer between T-ZnOw and GO . With the aid of PDA adhesion layer, the ‘core-shell’-like structure of the hybrid GO/PDA@T-ZnOw particles could be maintained in the poly(vinylidene fluoride) (PVDF) composites. Dielectric property measurements showed that the hybrid particles could be an excellent candidate to prepare the dielectric composites with excellent dielectric properties. There was a critical particle content (2.0–2.5 wt%) at which the composites exhibited the maximum dielectric constant and relatively low dielectric loss. Further results showed that GO and PDA@T-ZnOw particles had tremendous synergistic effect in enhancing the dielectric properties of the composites. The mechanisms for the largely enhanced dielectric constant were mainly related to the multiple interfaces in the composites, including the interfaces between GO and PVDF, between GO and PDA and between PDA and T-ZnOw, which provided more probability for interfacial polarization of the composites in the electrical field. This work presents a guideline to design high-performance dielectric composites with construction of the multiple interfaces.
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DOI
高影响因子
Pharmaceutics
·
2021
·Vol. 13
·期 8
·1116
·
IF 6.321
Junwei Xu,Yunxue Jia,Meili Liu,Xuenan Gu,Ping Li,Yubo Fan
Drug delivery systems (DDSs) limited to a single function or single-drug loading are struggling to meet the requirements of clinical medical applications. It is of great significance to fabricate DDSs with multiple functions such as magnetic targeting or fluorescent labeling, as well as with multiple-drug loading for enhancing drug efficacy and accelerating actions. In this study, inspired by the dual-chamber structure of rapeseed pods, biomimetic magnetic–luminescent bifunctional drug delivery carriers (DDCs) of 1.9 ± 0.3 μm diameter and 19.6 ± 4.4 μm length for dual drug release were fabricated via double-needle electrospraying. Morphological images showed that the rapeseed pod-like DDCs had a rod-like morphology and Janus dual-chamber structure. Magnetic nanoparticles and luminescent materials were elaborately designed to be dispersed in two different chambers to endow the DDCs with excellent magnetic and luminescent properties. Synchronously, the Janus structure of DDCs promoted the luminescent intensity by at least threefold compared to single-chamber DDCs. The results of the hemolysis experiment and cytotoxicity assay suggested the great blood and cell compatibilities of DDCs. Further inspired by the core–shell structure of rapeseeds containing oil wrapped in rapeseed pods, DDCs were fabricated to carry benzimidazole molecules and[email protected]nanoparticles in different chambers, realizing the sequential release of benzimidazole within 12 h and of doxorubicin from day 3 to day 18. These rapeseed pod-like DDSs with excellent magnetic and luminescent properties and sequential release of dual drugs have potential for biomedical applications such as targeted drug delivery, bioimaging, and sustained treatment of diseases.Keywords:rapeseed pod-like drug delivery system;electrospray;magnetic–luminescent bifunctional drug delivery carrier;dual drugs;sequential release
研究领域:
药学
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纳米技术
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生物医学工程
·
材料科学
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DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Xueer Lin,Jiahui Zou,Guancheng Zhu,Linfeng Pang,Yuqi Chen,Yanyan Huang
To effectively overcome the shortcomings of traditional chromatographic and enzymatic methods for detecting organophosphorus pesticides, Cu-MOFs with inherent peroxidase (POD)-like activity were constructed for direct colorimetric detection of omethoate (OMT). Benefiting from the mesoporous and benzene ring structure, Cu-MOFs demonstrated excellent OMT enrichment capability. OMT exhibited a pronounced inhibitory effect on the POD-like activity of Cu-MOFs whereas other pesticides showed negligible interference, demonstrating the specific identification of OMT by Cu-MOFs. Experimental data and theoretical calculations indicated that OMT effectively bond to Cu-MOFs through Cu 2+ coordination and ligand binding. Owning to its enrichment, identification and catalytic abilities, OMT detection was achieved and the limit of detection (LOD) was 16 μg L −1 . Furthermore, a smartphone-assisted portable detection was established with a LOD of 79 μg L −1 . Validation experiments of cabbage samples confirmed its’ reliability for practical applications. Our system integrated the enrichment, identification, and detection of OMT within a single system, improving both sensitivity and operational convenience.
研究领域:
分析化学
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纳米技术
·
环境科学
·
生物传感器
·
农药检测
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Peiye Liu,Jing Shen,Jiankang Cao,Weibo Jiang
Novel p -coumaric acid (pCA)-loaded nanoliposomes were prepared by the thin-film hydration method, assisted with ultrasonic treatment, and optimized by the response surface methodology. The characterization showed that the fabricated pCA-loaded liposomes were nanosized spherical vesicles (83.55 ± 0.34 nm), exhibiting favorable dispersibility and encapsulation efficiency (55.70 ± 0.10 %). Fourier transform infrared spectroscopy analysis indicated that pCA was encapsulated into phospholipid bilayer through hydrophobic interaction and hydrogen bonding. Tests of temperature stability and centrifugal stability suggested that pCA-loaded nanoliposomes were less sensitive to aggregation and fusion during storage. Incubation experiments revealed that pCA-loaded nanoliposomes had a good inhibitory effect on the expansion of disease area on fresh pod pepper fruit caused by Botrytis cinerea . Additionally, pCA-loaded nanoliposomes effectively extended shelf life of fresh pod peppers by reducing weight loss and naturally-infected decays. The findings presented a viable strategy for designing liposomal encapsulation technology to efficiently enhance antimicrobial activity of pCA in food preservation.
研究领域:
纳米技术
·
食品科学
·
药学
·
农业科学
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产品关联
DOI
PubMed
高影响因子
DIAMOND AND RELATED MATERIALS
·
2026
·
IF 5.2
Lu Sun,Jie Wei,Qing Hu,Xiuquan Xu,Jing Wu,Yaoyao Cao,Yao Zhang,Haoyan Wu
A Fe/V-CN nanozyme with synergistically enhanced POD-like activity was rationally designed. • A sensitive cascade colorimetric platform for detecting gastric cancer-related D-amino acids was successfully constructed. • The assay supports reliable quantification of D-amino acids in complex human saliva matrices. The development of a practical and reliable cascade colorimetric method for detecting D-amino acids (DAAs) provides a promising tool for the prevention and preliminary diagnosis of gastric cancer. Herein, a bimetallic Fe V supported on graphitic carbon nitride (Fe/V-CN) nanozyme was rationally designed and synthesized via a simple annealing strategy. The atomic dispersion of Fe and V species, along with their coexisting multivalent states (Fe 2+ / 3+ , V 4+ / 5+ ) synergistically boosted the intrinsic peroxidase-like (POD) activity to Fe/V-CN, which were characterized by a high substrate affinity ( K m of 0.078 and 0.083 mM for TMB and H 2 O 2 ) and an accelerated catalytic turnover ( V max of 4.94 × 10 −7 and 7.76 × 10 −7 M·s −1 , respectively). Leveraging this improved activity, a cascade colorimetric sensing system was developed by integrating Fe/V-CN with D-amino acid oxidase (DAAO) for the specific detection of DAAs. The platform exhibited favorable analytical performance for D-proline (D-Pro) and D-alanine (D-Ala), offering wide linear ranges of 0–200 μM and 0–160 μM and low detection limits of 0.93 μM and 1.45 μM, respectively, combined with acceptable selectivity against common interferents. For real-sample analysis, the platform was successfully implemented in determine DAAs in human saliva, delivering satisfactory recoveries (95.8–105.7%) and good precision (RSD < 3.5%). This work presented a synergistic Fe/V bimetallic nanozyme and a practical sensing strategy, demonstrating the feasibility of DAAs detection in complex biological matrices. Download: Download high-res image (70KB) Download: Download full-size image
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高影响因子
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