Rui Gao,Xiangbo Ma,Lihong Liu,Shan Gao,Xianfa Zhang,Yingming Xu,Xiaoli Cheng,Hui Zhao,Lihua Huo
The o-methoxyaniline (OMA) monomer was polymerized in-situ by vapor phase polymerization to form uniform and dense poly-o-methoxyaniline (POMA) film on the surface of ZnO nanorods array film which was pre-prepared by hydrothermal method . The as-prepared POMA/ZnO composite shows the best response at 40 min of vapor phase polymerization time. The response to 100 ppm ammonia at 25 °C is 8.88. The recovery time of 136 s has a certain advantage in the reported room temperature ammonia sensors. The lowest detectable concentration is as low as 0.01 ppm. The fast recovery time and low detection limit make the sensor have broad application prospects. In order to explore the response mechanism of POMA/ZnO composite to ammonia gas, the work function of POMA and ZnO and corresponding band gap energies were tested respectively. And the effect of the formation of p-n heterostructure on gas response was further explored. The actual application test results reflect that the sensor can effectively identify NH 3 in the mixed gas during the production, storage and transportation of NH 3 . This can provide real-time early warning of NH 3 leakage. Especially, the sensor can detect trace amount of NH 3 in the human body's exhaled breath which is expected to realize the preliminary screening of patients with kidney disease through the detection of exhaled breath in the medical field.
Z. Yang,P. Wang,X. Liu,X. Liu,Y. Shen,A. Xie,M. Zhu
For overcoming the insurmountable obstacles of the multimodal combined therapy (MCT) in anti-cancer, tumor microenvironment regulation is considered an effective method. Hence, a TME adjustable, precise-targeted and near-infrared (NIR)-laser-responsive Au nanoclusters (NCs)@poly-o-mercaptoaniline (POMA)-Fe nanoregulators (NRGs) grafting with folic acid (FA) was designed and successfully fabricated by a simple redox with coordination method. The obtained Au NCs@POMA-Fe-FA NRGs could achieve the excellent TME regulation ability via the following avenues: the Fe 3+ ions are released by the acidic TME from the POMA-Fe-FA shell to transform the hydrogen peroxide (H 2 O 2 ) into O 2 for overcoming the hypoxia of TME. Further, the massive Fe 3+ ions are reduced by the excessive glutathione (GSH) in TME into Fe 2+ ions, which further react with H 2 O 2 to produce the hydroxyl radical (·OH) by Fenton reaction, realizing the chemodynamic therapy (CDT) to tumor. Moreover, the Au NC cores and the POMA-Fe-FA shell endow the nanoregulators with outstanding photodynamic and photothermal abilities triggered by NIR laser respectively. In addition, the consumption of GSH enhances the photodynamic therapy (PDT) and CDT synergistically. More importantly, the FA-induced targeting and NIR guided photothermal imaging grant the obtained nanoregulators outstanding selectivity for the precise tumor treatment and minimized side effect. The in vivo experimental results displayed that the tumor inhibition of the prepared Au NCs@POMA-Fe-FA NRGs could reach as high as about 84%. Obviously, the synthesized Au NCs@POMA-Fe-FA NRGs pave a new path for the design and preparation of novel multi-mode therapy for cancer with regulatory effects to TME.
危险品化学品经营许可证（带存储）