Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 20
·5010-5017
·
IF 5.256
Kesong Miao,Heng Zhang,Lijuan Sun,Zhengtao Zhu,Li-Juan Fan
With the aim of detecting glutaraldehyde (GA) in wastewater released from hospitals and other sites, fluorescent poly(phenyleneethynylene) with pendant protonated primary amino groups (PPE-NH3+) was synthesized and characterized. The fluorescence of the conjugated polyelectrolyte PPE-NH3+ in aqueous solution changed upon addition of aldehydes. Among many commonly encountered aldehydes including formaldehyde (FA) and glutaraldehyde (GA), GA displayed the strongest quenching of the fluorescence of PPE-NH3+. The quenching efficiency reached above 85% with 1 mM of GA and the limit of detection (LOD) was 0.49 μM. The fluorescence quenching mechanism was discussed. GA, as a dialdehyde, could react with amino groups on different polymer chains simultaneously, and thus might result in more efficient chain aggregation and quenching. Finally, this sensory system was demonstrated to be very effective in detecting GA in real water samples from a water tap in our lab, a pond on the campus, Dushu lake and a river nearby a hospital.
研究领域:
环境科学
·
分析化学
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DOI
高影响因子
Nanomaterials
·
2026
·Vol. 16
·期 8
·468
·
IF 4.8
Yingying Chen,Yingchun Guo,Shouquan Sun,Peisong Tang,Takeshi Yanagihara,Bin He
Featured Application The black spherical silica developed in this study exhibits well-controlled particle size distribution (D50 ≈ 2.0 μm), low moisture content (<0.1%), high electrical insulation (volume resistivity ∼10 13 Ω·cm), and excellent dispersion stability. These properties make it suitable as a functional inorganic filler for high-frequency semiconductor packaging substrates, particularly for applications requiring both effective light-shielding capability (L* as low as 20.1) and low dielectric loss (D f ≤ 0.0017 at 1–10 GHz). The findings provide practical guidance for the design of black fillers used in copper-clad laminates for 5G/6G communication devices. This study utilized polysiloxane as the raw material to successfully prepare black spherical silica fillers with varying internal carbon content. Through different thermal treatment processes, a dense silica layer was formed on the particle surface, while the internal hydrocarbon groups were thermally decomposed into carbon. Four types of spherical silica with different carbon contents were systematically characterized in terms of particle size distribution (D50 ≈ 2.0 μm, D100 < 5 μm), scanning electron microscopy morphology, moisture content (<0.1%), specific surface area (~1.0–1.1 m 2 /g), true density (~1.90–1.97 g/cm 3 ), carbon content, blackness (L* values), and volume resistivity. The results indicate that the prepared black spherical silica exhibits a narrow particle size distribution, low moisture content, and high electrical insulation properties. Furthermore, the prepared black spherical silica was used as a filler in a polyphenylene oxide-based binder system to fabricate copper-clad laminates (CCLs), and their dielectric properties were systematically investigated. The study found that at electric field frequencies of 1 GHz and 10 GHz, the dielectric constant (D k ) and dielectric loss (D f ) of CCLs prepared with fillers containing less than 5% carbon remained largely consistent with those of carbon-free control samples. However, the D f of CCLs prepared with fillers containing 9.00% carbon increased nearly tenfold, indicating that when the internal carbon content of the filler exceeds a certain threshold, it adversely affects the high-frequency dielectric properties of the copper-clad laminate.
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DOI
PubMed
高影响因子
Frontiers in Microbiology
·
2015
·
IF 3.989
Deng Wanyan
PE/PPE family proteins, named after their conserved PE (Pro-Glu) and PPE (Pro-Pro-Glu) domains of N-terminal, are most intriguing aspects of pathologic mycobacterial genome. The roles of most members of this family remain unknown, although selected genes of this family are related to the virulence of Mycobacterium tuberculosis. In order to decipher the role of Rv1169c, the Mycobacterium smegmatis strain heterologous expressed this ORF was constructed and identified that Rv1169c was a cell wall associated protein with a novel function in modifying the cell wall fatty acids. The growth of Rv1169c expressing strain was affected under surface stress, acidic condition and antibiotics treatment. M. smegmatis expressing Rv1169c induced necrotic cell death of macrophage after infection and significantly decreased interlukin-6 production compared to controls. In general, these results underscore a proposing role of Rv1169c in virulence of M. tuberculosis, as it's role in the susceptibility of anti-mycobacteria factors caused by modified cell wall fatty acid, and the induced necrotic cell death by Rv1169c is crucial for M. tuberculosis virulence during infection.
研究领域:
微生物学
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免疫学
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分子生物学
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传染病学
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产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Meng Li,Haifei Wen,Haoxuan Li,Zhi-Chao Yan,Ying Li,Lei Wang,Dong Wang,Ben Zhong Tang
The outbreak of infectious diseases such as COVID-19 causes an urgent need for abundant personal protective equipment (PPE) which leads to a huge shortage of raw materials. Additionally, the inappropriate disposal and sterilization of PPE may result in a high risk of cross-contamination. Therefore, the exploration of antimicrobial materials possessing both microbe interception and self-decontamination effects to develop reusable and easy-to-sterilize PPE is of great importance. Herein, an aggregation-induced emission (AIE)-active luminogen-loaded nanofibrous membrane ( [email protected] ) sharing sunlight-triggered photodynamic/photothermal anti-pathogen functions are prepared using the electrospinning technique. Thanks to its porous nanostructure, [email protected] shows excellent interception effects toward ultrafine particles and pathogenic aerosols. Benefiting from the superior photophysical properties of the AIE-active dopants, [email protected] exhibits integrated properties of wide absorption in visible light range, efficient ROS generation, and moderate photothermal conversion performance. A series of antimicrobial evaluations reveal that [email protected] could effectively inactivate pathogenic aerosols containing bacteria (inhibition rate: >99%), fungi (~88%), and viruses (>99%) within only 10 min sunlight irradiation. This study represents a new strategy to construct reusable and easy-to-sterilize hybrid materials for potential bioprotective applications.
研究领域:
材料科学
·
纳米技术
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生物医学工程
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光疗
·
抗菌技术
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DOI
PubMed
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2021
·
IF 3.575
Dandan Zheng,Jinglong Wang,Genju Li,Lulu An,Ying Qu,Qinxiu Zhang,Wenhui Ye,Xin Zhao,Zhongxi Zhao
Autophagy-impairment is involved in the pathological process of chronic obstructive pulmonary disease (COPD), and relates to inflammation and emphysema in lung injury. This study aimed to elucidate the protective effect of S -Allylmercapto- N -acetylcysteine (ASSNAC) against COPD via regulating the autophagy. Firstly, porcine pancreatic elastase (PPE)-induced COPD model in A549 cells was established, and ASSNAC was verified to alleviate the autophagy-impairment from the results of western blotting analysis of LC3BⅡ/Ⅰ and monodansylcadaverine (MDC) staining of autophagosome . Secondly, Balb/c mice were stimulated by PPE to induce the COPD model in vivo . The histological analysis of lung tissues presented that ASSNAC could alleviate the lung injury induced by PPE. Thirdly, the secretions of NO , TNF- α and IL-1 β in serum and BALF were reduced by ASSNAC compared with the PPE group. Finally, the mechanism of therapeutic effects of ASSNAC against COPD through regulating the autophagy-impairment was clarified. That is, ASSNAC inhibits the phosphorylation of PI3K/Akt/mTOR signaling pathways. In a word, this research provides a reference for ASSNAC to be an effective drug for pulmonary diseases.
研究领域:
药理学
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肺病学
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分子生物学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
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