COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2020
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IF 3.99
Shuman Li,Ming Han,Hong-Guo Liu
Amphiphilic block copolymers can self-assemble into various aggregates in which functional inorganic nanoparticles and organic chromophores can be incorporated. A variety of fabrication methods have been developed. In this work, the liquid/liquid interface mass transfer-assisted self-assembly method was extended to fabricate composite organized structure of polystyrene-b-polyacrylic acid (PS-b-PAA) with small organic molecules, such as diamines, dopamine and dyes. It was found that long uniform nanowires , hollow spheres and foams were generated when using these organic molecules under different conditions, which correspond to worm-like micelles , vesicles and aggregates of microcapsules, respectively. The length of the nanowires reaches to several tens of micrometers. The influence of the molecular structure of the organic molecules, especially the diamines was investigated and discussed, and the formation mechanism of these aggregates was analyzed. This method may be developed to a facile and useful approach to fabricate functional composite structure of block copolymers and small molecules.
研究领域:
材料科学
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聚合物化学
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纳米技术
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2019
·
IF 7.015
Juan Cheng,Miao Xu,Panpan Cheng,Wanna Zhang,Nan Li,Yong Wang,Jingying Yang,Kaiyuan Liang,Peng Li,Haizhou Yu,Xiaoyan Qiu
As a representative amphiphilic block copolymer , polystyrene- block -poly (acrylic acid) (PS- b -PAA) has great potential in biomedical applications owing to its pH-responsiveness, antibacterial property and biocompatibility. Self-assembly of PS- b -PAA has been widely investigated with regard to micelles and thin films . Whereas, it is difficult to precipitate PS- b -PAA in water to make membrane due to the high hydrophilicity of PAA blocks. Herein, a process is described to fabricate PS- b -PAA isoporous membranes by combining self-assembly of metal-block copolymer complexes and non-solvent induced phase separation. Different antibacterial metal ions were doped in PS- b -PAA casting solution, which not only enhanced the mechanical property significantly, but also adjusted the pore size of the membranes. The membranes exhibited a pH-responsive release property and excellent separation performance based on size or charge differences. Moreover, the antifouling property was significantly enhanced through the synergistic effect of antibacterial metal ions and PAA segments.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2022
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IF 10.53
Guohao He,Mingming Li,Xin Li,Qimeng Wang,Zhiying Xie,Yali Xue,Kai Wang,Jun Yu,Gengzhi Sun,Haizhou Yu,Xiaoyan Qiu
Isoporous membranes from a process coupling the self-assembly of block copolymer with nonsolvent-induced phase separation (SNIPS) could enhance both the permeability and selectivity due to the high pore density and uniform pore sizes. Whereas, it is difficult to precipitate PAA based block copolymer in nonsolvent to make membranes because PAA blocks are hydrophilic. Herein, isoporous PS 678 - b -PAA 180 membranes were well prepared after reinforced by multiwalled carbon nanotubes decorated with silver nanoparticles (MWCNT-Ag). Such composite membranes bear not only regular channels with an effective pore diameter of ca. 18.85 nm, but also high water permeance of 1770.35 L bar −1 m −2 h −1 . With the participation of carbon nanotubes, the PS- b -PAA isoporous membrane exhibits excellent photothermal conversion properties, which endows the membrane with an efficiency of ca. 10.6 kg m −2 h −1 for light energy-driven seawater desalination and wastewater purification. Moreover, the silver particle-decorated CNTs enable the membrane to be antibacterial, which ensures reliability in long-term application.
研究领域:
材料科学
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环境工程
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纳米技术
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Yongbin Qin,Jun Guan,Dan Xu,Chengyin Wang,Jun Sun,Zichen Zheng,Wei Gu,Kewei Liu,Carla Bittencourt,Lifeng Zhang
Alpha-Fetoprotein (AFP) is an important tumor biomarker closely associated with the early diagnosis of hepatocellular carcinoma and other diseases. To achieve rapid and highly sensitive AFP detection, this study developed a label-free electrochemical impedance immunosensor with enhanced sensitivity based on Polystyrene- block -poly acrylic acid (PS-b-PAA) thin films and a biotin-streptavidin (B-SA) amplification strategy. The sensor utilizes the unique properties of PS-b-PAA thin films, where carboxyl groups (-COOH) form covalent bonds with the amino groups (−NH 2 ) of streptavidin, combined with the B-SA system to achieve efficient antibody immobilization. The results showed that the B-SA system significantly enhanced antibody immobilization efficiency, reduced non-specific adsorption, and improved the sensitivity and specificity of electrochemical signals. As a signal amplification strategy, the biotin-streptavidin system increased the sensing signal by approximately 2.19-fold. The sensor exhibited a linear response range from 0.05 ng/mL to 300.00 ng/mL and a detection limit of 0.02 ng/mL. Moreover, the sensor's performance in real human serum samples was consistent with that of the enzyme-linked immunosorbent assay (ELISA), demonstrating excellent reproducibility and long-term stability. This study shows that the fabricated electrochemical impedance immunosensor, based on PS-b-PAA thin films and the B-SA system, exhibits excellent performance in AFP detection, providing a reliable, rapid, and efficient solution for early cancer biomarker detection.
研究领域:
生物传感器
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分析化学
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癌症诊断
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纳米材料
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电化学
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
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2017
·Vol. 295
·期 5
·817-826
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IF 1.723
Nie Xiaobo,Xu Yajun,Zhang Ying
Well-defined polymer/inorganic nanoparticle (NP) hybrids are of vital importance to the development of nanomaterials with desired optical, electric, magnetic, and many other properties. We demonstrate the efficient incorporation of n -trioctylphosphine oxide (TOPO)-coated CdSe quantum dots (QDs) into polystyrene- b -polyacrylic acid (PS- b -PAA) colloids by a “solution phase self-assembly” approach. Driven by the hydrophobic interactions, the CdSe QDs are homogeneously encapsulated in the hybrid colloids. The sizes of the hybrid colloids with different structures, i.e., simple spherical micelles and big compound micelles, are tuned from 45 to 126 nm by varying the THF content in the cosolvents of THF and DMF, as well as changing the content or addition rate of selective solvent (water). The PS- b -PAA@CdSe QD hybrid colloids, which show brightly green fluorescence, can be endocytosed into biological cells and be released from the cells evolutionally, indicating their potential applications in biological imaging, labeling, and sensing, among others.
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2020
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IF 7.1
Mengdi Lu,Hu Zhu,Ming Lin,Fang Wang,Long Hong,Jean-Francois Masson,Wei Peng
Block copolymer (BCP) brush-like layer absorbed on optical fibers are shown to address the longstanding challenge of forming dense and well-dispersed gold nanorods (AuNRs) films on highly curved surface, allowing the development of real-time localized surface plasmon resonance (LSPR) biosensors for antigen-antibody interaction. This method requires only solution-based manufacturing processes and a plasma cleaning step to self-assemble AuNRs with various aspect ratios on the optical fibers. Because AuNRs capped with cetyltrimethylammonium bromide (CTAB) have been problematic for biosensing applications due to their cytotoxicity and displacement difficulty in the construction of biosensors, citrate-stabilized AuNRs were prepared from CTAB-stabilized AuNRs via surfactant exchange. For comparison, both a poly(styrene)- b -poly(acrylic acid) (PS- b -PAA) BCP template with CTAB-stabilized AuNRs and a poly(styrene)- b -poly(4-vinyl pyridine) (PS- b -P4VP) BCP template with citrate-stabilized AuNRs were employed for the fabrication of the optical fiber biosensor. The LSPR spectral analysis results demonstrate that the sensitivity of the sensor produced by the PS- b -P4VP templating method was 1.5 times better than that of the sensor produced by the PS- b -PAA templating method, which was due to the improved surface coverage and reduced aggregation of nanoparticles. The detection limit of the PS- b -P4VP-templated sensor for human IgG was 0.6 nM. Furthermore, for citrate-stabilized AuNRs, the PS- b -P4VP templating method also led to a better surface morphology and higher sensitivity as compared to the standard particle absorption methods using alkoxysilanes or polyelectrolytes on identical fibers. The simplicity of the fabrication process and the far superior optical performance of the PS- b -P4VP-templated LSPR optical fiber sensor illustrate the ability to regulate the detection range by tuning the aspect ratios of the AuNRs, and demonstrate its application prospects as a real-time biosensor without cytotoxicity.
研究领域:
材料科学
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纳米技术
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光学传感
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生物传感器
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）