LANGMUIR
·
2018
·
IF 3.789
Fang Cheng,Chuanlei Zhu,Wei He,Jing Zhao,Jingping Qu
Two types of zwitterionic polymer-modified magnetic nanoparticles (NPs) are fabricated by conjugating pSBMA onto PEI-precoated NPs via either a one-step method (1S NPs) or two-step method (2S NPs). For both methods, divinyl sulfone is used as the linker molecule. Although 1S NPs were capable of resisting both IgG and BSA, 2S NPs exhibited specificity toward IgG adsorption in complex biological fluids, e.g., in a mixture of serums and IgG. The moderate interactions (Kd ≈ 1.2 μM) between IgG and 2S NPs are 3 orders of magnitude lower than IgG binding with protein A (Kd 10 nM). Through complementary characterizations and analyses, we rationalize that the surface developed herein with IgG specificity contains two key components: polyzwitterions with a short chain length and sulfone groups with a high density.
研究领域:
生物材料学
·
免疫学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Xiuhua Sun,Qi Li,Zhiren Guo,Ke Wang,Taijiang Gui,Changlu Gao
In this paper, two series of poly(sulfobetaine methacrylate)-b-poly(lauryl methacrylate) (PSBMA-b-PLMA) diblock copolymers were prepared to investigate the core–shell reversion of amphiphilic copolymers. Experimental results proved that the PSBMA-b-PLMA copolymers can be self-assembled as core–shell nanoparticles in chloroform. Moreover, 1H NMR spectra and contact angle measurements revealed that there is a transitional PSBMA/PLMA block ratio of 0.6, above which the nanoparticles are capable of switching their core and shell in aqueous solution. Consequently, nanoparticles with PSBMA/PLMA block ratios above 0.6 showed superior antifouling and antibacterial abilities to those with block ratios below 0.4. Moreover, it was also found that the block chain length plays an important role in core–shell reversion as evidenced by 1H NMR spectra, water contact angle, and antifouling tests. As a result, coatings fabricated with the PLMA100 series of nanoparticles showed better antifouling abilities than those of the PLMA150 series at the same block ratio probably because of the thinner shell of PLMA100 copolymers. PSBMA100-b-PLMA100 was proved to be the best candidate for the fabrication of antifouling coatings as it exhibited the highest efficacy in antibacterial adhesion and antiprotein adsorption. This study provided a facile method to fabricate antifouling coatings by developing amphiphilic diblock copolymers with tuned hydrophobic/hydrophilic block ratio, block chain length, etc.
研究领域:
材料科学
·
生物医学工程
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DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Qingping Xin,Tao Huang,Shuo Li,Ningning Gao,Huimin Jin,Hao Chen,Lei Zhang,Hui Ye,Hong Li,Yuzhong Zhang
The membrane separation approach has garnered considerable interest in the area of CO2 separation due to its advantages of requiring little electricity and a wide range of applications. Here, we report the preparation of pSBMA@Ti3C2Tx nanosheets functionalized with poly(amphiphilic poly(methacryloyloxyethylsulfobetaine) (pSBMA)) by precipitation distillation, weighing of pSBMA@Ti3C2Tx nanosheets with different mass ratios to be added into cross-linked poly(ethylene oxide) (XLPEO), and preparation of a continuous, thin mixed-matrix membrane (MMM). Under gas humidification, the membrane showed the best permeation performance. Due to the richness of hydrophilic organosulfate groups (−SO3–) and quaternary amine groups [−N+(CH3)3] in pSBMA, the overall water content of the MMMs is increased, which greatly improves the CO2 permeability. Enhancing the ratio of bound water augments the membrane’s capacity to segregate CO2/N2. Under coordination of water molecules, quaternary amine groups effectively promote the quick delivery of CO2 in the membrane. In the wet state, the XLPEO/pSBMA@Ti3C2Tx-0.2 membrane has a CO2/N2 selectivity of 27.5 and a CO2 permeability of 4953 barrer, an improvement of 87% and 109%, respectively, compared to those of the XLPEO pure membrane, breaking the 2008 Robeson upper limit and approaching the 2019 upper limit. We also studied the change of the gas separation performance of the membrane under different pressures.
研究领域:
材料科学
·
环境工程
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产品关联
DOI
高影响因子
Colloid and Interface Science Communications
·
2018
·
IF 0
Jindan Wu,Chong Zhang,Shuting Xu,Xiaoyu Pang,Guoqiang Cai,Jiping Wang
Recently, antibacterial textiles have gained interest from scientists due to their potential to provide protection and high-quality life to people. In this study, zwitterionic poly(sulfobetaine methacrylate) (pSBMA) brushes were grafted onto cotton fabrics via reactive dye intermediate reaction and surface-initiated atom transfer radical polymerization (SI-ATRP) technology. Two bacterial species (Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli ) was used for bacterial attachment experiments. The capability of resisting nonspecific protein adhesion, short-term bacterial attachment (24 h) and long-term biofilm formation (120 h) of pSBMA-grafted cotton fabrics were studied. The results suggested that the pSBMA-grafted cottons exhibited an excellent non-fouling performance. Different from the studies on two-dimensional surfaces, our study provides an insight into the long-term biofilm resisting properties of porous textiles grafted with zwitterionic polymers.
研究领域:
材料科学
·
生物学
·
纺织工程
✓ 已验证
产品关联
DOI
Acta Biomaterialia
·
2016
·
IF 6.008
Jiang Wu,Zecong Xiao,Chaochao He,Jingjing Zhu,Guanglong Ma,Guangzhi Wang,Hongyu Zhang,Jian Xiao,Shengfu Chen
Nonfouling materials such as neutral poly(ethylene glycol) (PEG) and zwitterionic poly(sulfobetaine methacrylate) (pSBMA) are ideal biocompatible materials for drug, especially protein drug delivery. The interaction behavior of protein between the nonfouling materials could cause great impact on their future applications, such as controlled release drug delivery systems. In this work, we investigated the diffusion behavior of the fluorescence-labeled model proteins (bovine serum albumin (BSA) and lysozyme (LYZ)) in nonfouling PEG, pSBMA and mixed PEG-SBMA hydrogels (SBMA:PEG 4:1, SBMA:PEG 1:4). It was observed that these four hydrogels showed varied diffusion behavior for either negatively charged BSA or positively charged LYZ due to protein-polymer interaction and the free water content in hydrogel matrix. The relatively stronger interaction between protein-PEG than protein-pSBMA could increase protein loading efficiency and control release rate by changing ratio of PEG to SBMA in the hybrid hydrogel. Moreover, it is further demonstrated the free water (freezable water) content in low cross-linked hydrogel, not the equilibrium water content (EWC), is a more accurate parameter to reflect the diffusion behavior of protein molecules . Thus, these results together provide new insights of the interactions between protein molecules and nonfouling polymers as well as the bio applications of the nonfouling polymeric hydrogels. Statement of Significance This work shows that the relative stronger interaction between protein-PEG than protein-pSBMA could increase protein loading efficiency and control release rate by the change ratio of PEG to SBMA in the hydrogel, while the free water (freezable water) content in low cross-linked hydrogel, not the equilibrium water content (EWC), is a more accurate parameter to reflect the diffusion behavior of protein molecules. The impact of this work (i) gains some new insights of the interactions between protein molecules and nonfouling polymer matrixes for protein drug delivery; (ii) prompts to apply the weak PEG-protein interactions to protein drug loading and release; (iii) provides a new fundamental understanding of free water in hydrogel for protein diffusion.
研究领域:
生物材料学
·
药物递送系统
·
生物化学
✓ 已验证
DOI
高影响因子
ACTA PHYSICO-CHIMICA SINICA
·
2015
·Vol. 31
·期 10
·1905-1913
·
IF 0.852
ZHANG Jia-Han,GUO Gui-Bao,AN Sheng-Li,HAO Yan,ZHANG Dong,YAN Kai-Bo
Poly(vinylidene fluoride)-graft-poly(sulfobetaine methacrylate) (PVDF-g-PSBMA) proton exchange membranes were synthesized via single-step grafting sulfobetaine methacrylate (SBMA) onto PVDF. Benzoyl peroxide (BPO) was the initiator, and the PVDF was initially modified by tetramethylammonium
hydroxide (TMAH) in the liquid phase. Microstructure morphologies and sulfur distributions in the membrane were characterized by Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM-EDX), respectively. The PVDF formed C=C
double bonds following dehydrofluorination by TMAH. SBMA was grafted onto the modified PVDF backbones, forming a homogeneous sulfur distribution in the interior and exterior of the membrane. Proton conductivities and methanol permeabilities of PVDF-g-PSBMA membranes increased with the increasing
of the TMAH mass fraction in methanol. When the mass fraction was 20%, the proton conductivity of the membrane was 0.0892 S·cm-1 at 20 , and the methanol permeability was 4.04 × 10-7 cm2·s-1 at ambient temperature, respectively.
The membrane exhibited good thermal stability up to 270 , as verified by thermogravimetric analysis (TGA). With this membrane, the peak power density of a direct methanol fuel cell (DMFC) was 17.06 mW·cm-2.
研究领域:
材料科学
·
能源工程
✓ 已验证
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2025
·
IF 5.1
Weiqi Liang,Ning Xu,Changyong Mo,Guanjie Li,Youhao Liao,Weishan Li
Utilizing high-capacity lithium anodes becomes the most effective strategy to enhance the energy density of lithium metal batteries (LMBs). The associated safety issues can be effectively addressed by employing gel polymer electrolytes (GPEs). Although traditional polyethylene oxide (PEO) based GPE exhibits good compatibility with lithium anodes, its lower oxidative decomposition potential (< 4 V) restricts its application in 4.2 V LMBs. To extend the oxidative stability of PEO, we propose a PEO blended GPE that incorporates the water-soluble zwitterionic polymer, poly(sulfobetaine methacrylate) (PSBMA), synthesized via free-radical polymerization. The blended polymer membrane was fabricated using electrospinning with water as the solvent. The environmentally friendly membrane with porous fiber structure shows the increased ionic conductivity of 1.8 × 10 ‐3 S cm ‐1 for PPA25-GPE (PEO: PSBMA = 75 %: 25 %), compared to 1.0 × 10 ‐3 S cm ‐1 for PEO based GPE. Furthermore, the oxidative potential of PPA25-GPE is extended to 5 V vs Li/Li + . The superior film-forming ability and wettability properties of PSBMA, attributed to its zwitterionic groups, improve the interfacial compatibility between GPE and electrodes, contributing to the cyclic performance of the assembled battery. A Li||Li symmetric cell delivers a stable lifespan of over 2500 h at 0.5 mA cm ‐2 with a fixed areal capacity of 0.5 mAh cm ‐2 , while the LiNi 0.8 Co 0.15 Al 0.05 O 2 /Li cell exhibits excellent cycling stability and rate capability up to 4.5 V. Consequently, the environmentally friendly nature and electrochemical stability of GPE facilitates the further development of high-energy density LMBs.
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2026
·Vol. 26
·期 7
·e70228
·
IF 4.2
Jiale Cao,Xinzhong Song,Xiangkuan Zhang,Maocheng Ji,Jianyong Li,Jia Man
With the increasing demand for blood‐contacting medical devices, surface‐related limitations of conventional materials, including high friction, nonspecific adhesion, and insufficient long‐term stability, have become critical challenges for clinical safety. To address these issues while retaining zwitterions’ inherent advantages, this study proposes a “penetration–crosslinking–entanglement” strategy to fabricate an integrated pure poly sulfobetaine methacrylate (PSBMA) zwitterionic hydrogel coating on thermoplastic polyurethane (TPU). This process enables covalent bonding between PSBMA chains and the TPU matrix, together with extensive physical entanglement of long PSBMA chains, resulting in a robust coating–substrate integrated architecture. The positive and negative charge groups in PSBMA molecules strongly adsorb water molecules through electrostatic interactions, laying the foundation for the formation of a stable hydration layer. It renders the modified TPU surface superhydrophilic, with water contact angles below 20°, and significantly reduces the friction coefficient to below 0.03 while maintaining stable lubrication under various loads and shear rates. In addition, the coating effectively suppresses protein adsorption as well as blood cell adhesion and activation. Overall, this simple and scalable strategy achieves a synergistic enhancement of surface lubricity, anti‐adhesion, stability, and blood compatibility of TPU, offering a promising solution for blood‐contacting medical devices such as interventional catheters. A novel penetration–crosslinking–entanglement strategy enables the fabrication of an integrated pure zwitterionic PSBMA coating on TPU. The coating forms a robust hydration layer that provides ultra‐low friction, suppresses protein and blood adhesion, and maintains long‐term stability, advancing the design of multifunctional surfaces for blood‐contacting biomedical devices.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2014
·
IF 5.684
Yichuan Hu,Guang Yang,Bo Liang,Lu Fang,Guanglong Ma,Qin Zhu,Shengfu Chen,Xuesong Ye
A well-controllable electrochemically mediated surface-initiated atom transfer radical polymerization (e-siATRP) method for the fabrication of superlow protein absorption zwitterionic hydrogel coatings based on poly(sulbetaine methacrylate) (pSBMA) was developed in this work. The effects of the electric condition on polymerization as well as its antifouling performances both in vitro and in vivo were also investigated. Different potentials (−0.08 V, −0.15 V and −0.22 V) and polymerization times (from 8 to 48 h) were chosen to study the polymerization procedure. X-ray photoelectron spectroscopy, atomic force microscopy and ellipsometry measurements were used to characterize the properties of the polymer layers. Ellipsometry measurements showed that a higher potential provided faster polymerization and thicker polymer layers; however, the protein absorption experiments showed that the best polymerization condition was under a constant potential of −0.15 V and 32 h, under which the protein absorption was 0.8% in an enzyme-linked immunosorbent assay (compared to a bare gold electrode). The electrodes with a pSBMA coating effectively deduced the current sensitivity decay both in undiluted serum and in vivo. The usage of the commercially available polymerization monomer of SBMA, the simple convenient synthesis process regardless of the presence of oxygen and the excellent controllability of e-siATRP make it a very promising and universal technique in the preparation of zwitterionic polymer coatings , especially in the development of biocompatible material for implantable devices such as neural and biosensor electrodes.
研究领域:
生物材料
·
医学工程
·
表面科学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Jianwen Hu,Haotian Gao,Wenqing Xie,Junjie Fan,Shuai Zhang,Shuangqing Sun,Songqing Hu,Yonglin Zhong
Enhancing heavy oil recovery is crucial to ensuring stable crude oil production. The development of stimulus-responsive Janus Pickering emulsifiers tailored for a reservoir environment has garnered significant attention in the field of reservoir production, emerging as a promising alternative to traditional surfactants. In this study, silica-based Janus nanosheets with temperature-responsive properties (OH-SiO2–PSBMA JNs) are synthesized using sol–gel process and atom transfer radical polymerization (ATRP) method. Experimental observations reveal that OH-SiO2–PSBMA JNs (0.1 wt %) can effectively reduce the interfacial tension (IFT) between heavy oil and water to 23.24 mN/m. Additionally, these nanosheets exhibited excellent emulsifying ability, forming stable emulsions with an average particle size of only 35 μm at a mass fraction of 1 wt % and demonstrating good salt tolerance (Salinity value: 1.51 × 104 mg/L). Furthermore, OH-SiO2–PSBMA JNs exhibited a temperature response that is well-suited for the reservoir environment, effectively stabilizing heavy oil emulsion at a high temperature (65 °C) and facilitating oil–water separation at a lower temperature (25 °C). These excellent properties of nanosheets contributed to obtaining an additional 13.2% recovery rate at low concentration (0.03 wt %). These results indicated that OH-SiO2–PSBMA JNs had the potential for enhanced oil recovery (EOR) application.
研究领域:
石油工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Jicui Dai,Yichao Dong,Cong Yu,Yaxin Liu,Xiangguo Teng
A novel N115-g-PSBMA membrane containing zwitterionic groups was successfully prepared by grafting the zwitterionic SBMA (sulfobetaine methacrylate) onto Nafion 115 (N115) via SI-ATRP (surface-initiated atom transfer radical polymerization) technique. The N115-g-PSBMA membrane has shown higher hydrophilicity , lower vanadium permeability, higher coulombic efficiency and energy efficiency than that of commercial N115 membrane for VRB (vanadium redox flow battery) application. At the current density of 40–80 mA cm −2 , the average energy efficiency of the VRB with N115-g-PSBMA membrane has reached up to 87.3%, which is 2.6% higher than that of the VRB with N115 membrane at the same current densities. The method is expected to present a new direction to prepare novel separators with both excellent performances and low cost for VRB application.
研究领域:
能源材料
·
高分子科学
·
电化学储能
✓ 已验证
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 4
·2081-2091
·
IF 3.049
Jiajia Shen,Miao Du,Ziliang Wu,Yihu Song,Qiang Zheng
Biological fouling, where marine microorganisms attach densely to various submerged surfaces, has been a serious economic problem worldwide. Different from most antifouling approaches based on stiff and solid materials or coatings, a soft and wet coating composed of zwitterionic polymer was prepared in this paper. With the combination of the anti-polyelectrolyte effect of poly-N-(3-sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium betaine (PSBMA) and the typical polyelectrolyte effect of polyacrylic acid (PAA), a bicomponent hydrogel coating with weak swelling in saline solution was achieved, which could avoid peeling from solid substrates. The bicomponent hydrogel coating showed strong tensile properties and good compression performance and slipperiness. Although the large Young's modulus of the coating relatively weakens the drag reduction effect, entering the mixed lubrication region in low sliding rate is easy and a low friction coefficient at a high rate could thus be obtained. With the aid of silane coupling agent and weak deformation in water and saline solution, the hydrogel coating could be bound tightly on solid surfaces. After strong sandy water abrasion, the bicomponent hydrogel coating could maintain its original state without any cracks and peeling. The hydrogel coating exhibits good anti-bacterial adhesion and anti-protein adsorption. The bicomponent zwitterionic hydrogel coating reported here provides a new strategy for marine antifouling and drag reduction studies.
研究领域:
材料科学
·
海洋生物学
·
表面化学
·
高分子科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）