COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
·
IF 2.714
Yang Li,Ke Hu,Bo Chen,Yijun Liang,Fengguo Fan,Jianfei Sun,Yu Zhang,Ning Gu
Field-assisted synthesis has been one of the common strategies of nanoparticles preparation with enhanced properties. However, most researches focused on exploring the effects of monofunctional static field on the structure and properties of synthetic nanomaterials, few researchers have applied fields with period variation as assistance. Combining medium alternating current magnetic field with most widely used method traditional chemical co-precipitation held potential in preparation high quality Fe 3 O 4 nanoparticle. In this study, Fe 3 O 4 nanoparticle clusters were prepared in alternating-current magnetic field (ACMF) by co-precipitation principle, structural and magnetic properties were also characterized. Results demonstrated that Fe 3 O 4 nanoparticle clusters prepared by co-precipitation heated in ACMF indicated a better heat production under ACMF, comparing with Fe 3 O 4 nanoparticle clusters with similar size and distribution prepared by classic co-precipitation. It might be due to the magnetic effects induced by ACMF that Fe 3 O 4 nanoparticles tend to grow along the magnetization direction. This technology might hold promise in preparation high performance magnetic nanomaterial in the future.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2015
·Vol. 16
·期 6
·13507-13527
·
IF 2.862
Arshad Mehmood Abbasi,Xinbo Guo,Xiong Fu,Lin Zhou,Youngsheng Chen,Yong Zhu,Huaifeng Yan,Rui Hai Liu
Mango (Mangifera indicaL.), also called “the king of fruits”, is one of the most popular fruits in tropical regions. Pulp and peel samples of mango cultivars were analyzed to estimate total phenolic, total flavonoid and total anthocyanin contents. Phenolic acids, hydrophilic peroxyl radical scavenging capacity (hydro-PSC) and oxygen radical scavenging capacity (ORAC)in vitrowere also determined. Total phenolics and flavonoid contents were found maximum in the peel of Xiao Tainang and Da Tainang cultivars, respectively, whereas Xiao Tainang also exhibited significant antioxidant capacity. Noteworthy, concentrations of gallic acid, protocatechuic acid, ferulic acid, chlorogenic acid and caffeic acids at 79.15, 64.33, 33.75, 27.19 and 13.62 mg/100 g fresh weight (FW) were quantified for Da Tainang, Xiao Tainang and of Jidan cultivars, respectively. Comparatively, a higher level of phenolics and significant antioxidant capacity in mango peel indicated that it might be useful as a functional food and value-added ingredient to promote human health.Keywords:mango;phenolics;flavonoids;anthocyanins;phenolic acids;ORAC;hydro-PSC
研究领域:
食品科学
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植物化学
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DOI
PubMed
高影响因子
JOURNAL OF PEPTIDE SCIENCE
·
2024
·
IF 1.8
Weimiao Dong,Haihong Yang,Min Liu,Leixia Mei,Jun Han
The fabrication of wound microenvironment-responsive peptide hydrogels with hemostatic ability, antibacterial activity, and wound healing potential remains a challenge. Herein, we constructed a multifunctional dressing by inducing the self-assembly of a peptide (Pep-1) and water-soluble new methylene blue (NMB) through electrostatic interaction. The self-assembly mechanism was demonstrated using a combination of transmission electron microscopy, circular dichroism spectrum, fluorescence spectrum, Zeta potential, and rheological analysis. The Pep-1/NMB hydrogel also exhibited a faster drug release rate in wound acidic environment. Furthermore, when Pep-1/NMB was exposed to a 635 nm laser, its antibacterial ratios increased sharply to 95.3%, indicating remarkably improved antibacterial effects. The findings from the blood coagulation and hemostasis assay indicated that Pep-1/NMB effectively enhanced the speed of blood clotting in vitro and efficiently controlled hemorrhage in a mouse liver hemorrhage model. Meanwhile, hemolytic and cytotoxicity evaluation revealed that the hydrogel had excellent hemocompatibility and cytocompatibility. Finally, the findings from the wound healing studies and H&E staining indicated that the Pep-1/NMB hydrogel had a significant impact on cell migration and wound repair. The results indicated that wound microenvironment-responsive Pep-1/NMB hydrogel had significant potential as a highly effective wound dressing platform, offering rapid hemostasis, antibacterial, and wound healing acceleration properties.
研究领域:
材料科学
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生物医学工程
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药学
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组织工程
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DOI
PubMed
高影响因子
JOURNAL OF PEPTIDE SCIENCE
·
2021
·Vol. 27
·期 10
·e3352
·
IF 1.905
Ruifang Li,Songlin He,Kedong Yin,Beibei Zhang,Yanjie Yi,Meng Zhang,Nanqi Pei,Liang Huang
Infections with multidrug-resistant (MDR) pathogens are increasingly concerning for public health. Synthesized antimicrobial peptide A4 (SAMP-A4), a peptide computationally designed by our research team, is a potential drug candidate. However, the antimicrobial peptide SAMP-A4 is easily degraded in serum. To obtain SAMP-A4 analogues with high biostability, chemical modifications at its N-terminus, including fatty acid conjugation, glycosylation and PEGylation, were carried out. The results showed that the introduction of hydrophobic fatty acids at the N-terminus of SAMP-A4 is better than hydrophilic glycosylation and PEGylation. With increasing fatty acid chain length, the stability of SAMP-A4 analogues in serum and trypsin solutions is significantly improved, and the activities against MDR bacteria and Candida are significantly enhanced. There is no obvious change in haemolysis even when hexanoic acid is coupled with SAMP-A4, so the resulting analogue SAMP-A4-C6, SAMP-A4 conjugated with hexanoic acid, is the most likely of the analogues to become a drug.
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DOI
高影响因子
JOURNAL OF PEPTIDE SCIENCE
·
2017
·Vol. 24
·期 1
·e3058
·
IF 1.972
Yexuan Mao,Lanlan Yu,Mengfan Mao,Chuanguo Ma,Lingbo Qu
Type 2 diabetes mellitus, a kind of conformational disease, has become an epidemic disease, which seriously endangers the quality of life and health of human beings. The deposition of human islet amyloid polypeptide (hIAPP) has been considered as one of the major pathological features of type 2 diabetes mellitus. As lipopeptides have some hydrophobic groups, which are similar to the reported aggregation inhibitors, and some lipopeptides could prevent cells from depositing of amyloid fibrils, several potential lipopeptide inhibitors have been engineered and synthesized, which have been assessed for their inhibitory effect in preventing amyloid fibrils formation of hIAPP 11-20 by using the conventional thioflavin-T fluorescence assay and new technique microscale thermophoresis (MST). The final amyloid fibrils of hIAPP 11-20 were characterized by transmission electron microscopy. Results suggested that with the increasing length of alkyl chain, the antiaggregation efficiency of lipopeptide inhibitors towards hIAPP 11-20 increased gradually. Meanwhile, the amount of arginines, which represent the head groups of lipopeptides, may also have some influence. The binding events also showed that the inhibitory efficiency of these lipopeptide inhibitors was enhanced with the increase of affinities between lipopeptides and hIAPP 11-20 , which were obtained from MST. This study demonstrated the efficiency of lipopeptides in inhibiting the aggregation of hIAPP 11-20 and proved that MST could be regarded as an appropriate and rapid method to screen potential inhibitors of hIAPP 11-20 or other amyloid proteins. This study also broadens the types of inhibitors on inhibiting amyloid formation of hIAPP.
研究领域:
生物化学
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分子生物学
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药物化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PEPTIDE SCIENCE
·
2022
·Vol. 28
·期 10
·e3411
·
IF 2.408
Shu Bai,Jie Zhang,Liyan Zhu,Xiaoxing Gong,Linling Yu,Yan Sun
Oriented immobilization of antibodies is important for the effective recognition of target antigens. In this paper, a heptapeptide ligand, HWRGWVC (HC7), was modified onto non-porous monosized poly(glyceryl methacrylate) (pGMA) microspheres (named pGMA-HC7) to explore the antibody immobilization behaviors. Characterization of the microspheres by particle size analyzer, scanning electron microscopy, Fourier transform infrared spectroscopy, and reversed-phase chromatography proved the success of each fabrication step. The capacity and activity of antibody immobilization through HC7 were studied using immunoglobulin G (IgG) as a model antibody and horseradish peroxidase (HRP) as a model antigen. Additionally, IgG immobilizations on pGMA microspheres by nonspecific adsorption and covalent coupling through carbodiimide chemistry were conducted for comparison. pGMA-HC7 exhibited an IgG adsorption capacity of 3–4 mg/g in 10 min by the specific binding of HC7 without nonspecific interactions. Notably, the ligand HC7 showed a by two orders of magnitude stronger affinity for IgG than its original hexapeptide ligand HWRGWV. Moreover, the capacity and activity of the immobilized anti-HRP antibody on pGMA-HC7 were 1.6-fold and 3-fold higher than those of the covalent coupling, respectively. The results proved the superior role of HWRGWVC in the affinity binding of antibody and the potential of pGMA-HC7-25 in immunoassay and immunodiagnostic applications.
研究领域:
生物化学
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生物技术
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材料科学
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免疫学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PEPTIDE SCIENCE
·
2023
·Vol. 29
·期 11
·e3497
·
IF 2.1
Ruifang Li,Pu Hao,Kedong Yin,Qingpeng Xu,Shiming Ren,Yingyuan Zhao,Lan Zhang,Beibei Zhang
Antimicrobial peptides and their analogues have become substitutes for antibiotics in recent years. The antimicrobial peptide analogue SAMP-A4-C8 ( n -octanoic-VRLLRRRI) with high antimicrobial activity was found in our lab. We speculate that it may kill pathogens by some lethal mechanism of action. In the present investigation, the microbicidal activities of SAMP-A4-C8 and its mechanism of action were investigated. The results demonstrated that SAMP-A4-C8 had lethal activities against Staphylococcus aureus and Candida albicans by cell disruption. Based on its microbicidal activities, we believe that it is worth further research for its potential as drug candidate. The results showed that SAMP-A4-C8, with low propensity to induce the resistance of S. aureus and C. albicans , could kill the persister cells of S. aureus and C. albicans , exhibited biofilm forming inhibition activity and preformed biofilm eradication ability against S. aureus and C. albicans , and displayed therapeutic potential on pneumonia in S. aureus -infected mice by reducing lung inflammation. The present study provided a promising drug candidate in the war against multidrug resistance.
研究领域:
微生物学
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药理学
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感染病学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 34
·期 52
·2411183
·
IF 18.5
Song Yin,Xuewei Jiao,Xudong Liu,Mingxuan Liu,Bingshun Xu,Na Li,Yonghao Lu,Shaopeng Yang,Weiguang Kong
The role of MA in FAMA mixed perovskite remains far from being fully understood, due to the intricate chemical evolutions in the precursor solutions. Adjusting the content of MA in FAMA mixed perovskite arbitrarily remains a great challenge. This study elucidates a synergistic effect between H + and I − oxidation which helps to reduce the content of MA in FA-dominated perovskite. Briefly, excessive H + boosts the balanced and rapid assembly of MA and FA components in FA-dominated perovskite and hampers unfavorable chemical evolution induced by nucleophilic reaction between MA and FA in the precursor solution, while I − oxidation accelerates the in situ crystallization of perovskite. Leveraging this synergistic effect, centimeter-scaled FA x MA (1-x) PbI 3 single crystals with arbitrarily adjustable values of x are successfully fabricated. In addition, peroxyacetic acid is introduced as the additive, enabling the blade-coated FA 0.9 MA 0.1 PbI 3 perovskite solar cells (PSCs) to achieve an impressive efficiency of 23.7%. The efficiency achieved here is among the highest values for blade-coated PSCs with FA content exceeding 90% so far. The optimized solution developed in this study achieved exceptional stability, allowing it to be stored under air conditions for over 2 months without significant degradation in cell efficiency. This outcome satisfies the requirements for commercialization.
研究领域:
材料科学
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能源技术
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化学工程
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产品关联
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Shuang Liu,Jiayi Lian,Zhengming Xu,Yue Ning,Minyu Shi,Zhengang Zhao,Zhanying Zhang
Betanin is a high-value health-promoting food ingredient. However, the bioavailability of betanin is constrained by its low stability. In this study, for the first time, betanin was stabilized and delivered using chitosan-coated nanoliposomes (CC-NLs). The CC-NLs were firstly synthesized and characterized. The results showed that increasing chitosan concentration from 0% to 1.0% increased particle size of CC-NLs from 156.4 nm to 217.2 nm. With the use of CC-NLs prepared with 0.6% chitosan, it was found that increasing pH from 1.5 to 9.0 reduced zeta potential of CC-NLs from 8.62 mv to-9.65 mv while the average size of CC-NLs of 221.40 nm peaked at pH 5.5. In aqueous solution, 29.0% of loaded betanin was released from NLs compared to 15.8% from CC-NLs. The in vitro digestion analysis indicated that uncoated NLs and CC-NLs had similar stabilities and relatively stable in oral and gastric fluids. However, in intestinal fluid, the average size of both NLs and CC-NLs were significantly reduced due to bile salt and trypsin. Furthermore, in vitro antioxidant activity assay results showed that betanin delivered by CC-NLs had the highest ORAC and PSC values. This study demonstrated that betanin could be efficiently delivered by CC-NLs with improved stability and bioavailability. The information generated from this study is very useful for the applications of betanin in functional food, pharmaceutical and cosmetics industry.
研究领域:
食品科学
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药学
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生物技术
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产品关联
DOI
高影响因子
Science China-Materials
·
2022
·Vol. 66
·期 2
·485-492
·
IF 8.64
Yan Furi,Duan Jialong,Guo Qiyao,Zhang Qiaoyu,Yang Xiya,Yang Peizhi,Tang Qunwei
The colloidal nature of perovskite precursor solution highly determines the quality of perovskite film and the photovoltaic performance of a perovskite solar cell (PSC). Herein, we demonstrate a facile method to fabricate a high-quality all-inorganic CsPbIBr 2 film by regulating the temperature of the precursor solution. After characterization, stable microcrystals with a size up to 1 have been formed under high temperatures, more suitable for preferable crystallization by spontaneous nucleation than the precursor solution at room temperature. Consequently, rapid charge transfer across enlarged crystal grain rather than intragranular charge recombination is achieved within the perovskite film because of reduced defects, promoting the efficiency as high as 11.12% for carbon-based PSC, which is higher than that of a control device with 8.51% efficiency. Moreover, the optimal device shows improved stability under air atmosphere and high-temperature conditions.
研究领域:
材料科学
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光伏技术
·
化学
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产品关联
DOI
高影响因子
Journal of Materials Chemistry A
·
2024
·Vol. 12
·期 34
·23067-23075
·
IF 10.7
Hui Li,Jialong Duan,Naimin Liu,Linzheng Ma,Jie Dou,Xinyu Zhang,Qiyao Guo,Yuanyuan Zhao,Benlin He,Qunwei Tang
Defects in perovskite films not only challenge the efficiency and stability improvement of perovskite solar cells (PSCs), but also serve as electronic dopants that impact interface energetics and charge-transfer kinetics. To address this issue, herein, we introduced a natural additive into a perovskite precursor to improve the inorganic CsPbI2Br film quality. Arising from the strong interaction between passivation molecules and undercoordinated Pb2+ in the perovskite, the reduction in defects results in effective n-type de-doping of the inorganic CsPbI2Br perovskite surface, concomitantly forming an n/n− homojunction at the top perovskite/carbon interface for accelerating charge extraction and suppressing carrier nonradiative recombination in a carbon-based PSC. Consequently, a cutting-edge efficiency as high as 15.0% was achieved with reduced hysteresis in addition to significantly improved long-term stability for a 65 days storage period in the air (94.74% efficiency retention rate) and persistent light irradiation for over 230 hours in N2 (∼82% efficiency retention rate).
研究领域:
材料科学
·
太阳能
·
光伏技术
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2016
·
IF 4.052
Huailing Wang,Xinbo Guo,Xiaodan Hu,Tong Li,Xiong Fu,Rui Hai Liu
Numerous reports have demonstrated that the consumption of fruits and vegetables is beneficial for the human health. Blueberries, in particular, are rich in phytochemicals including free and bound forming. Phytochemical profiles of 14 varieties of blueberry were compared in this study. 12 compounds were analyzed and had significant changes in blueberry fruits. Total antioxidant activities in different blueberry varieties varied about 2.6 times by oxygen radical absorbance capacity (ORAC) assay, and 2 times by peroxyl radical scavenging capacity (PSC) assay. The cellular antioxidant activities (CAA) in different varieties varied about 3.9 times without phosphate buffer saline (PBS) wash, and 4.7 times with PBS wash by CAA assay. Blueberry extracts had potent antiproliferative activities against HepG2 human liver cancer cells, indicating the potential protective benefits associated with their use as functional foods. The anti-proliferative activity was observed to be dose-dependent in blueberry extracts.
研究领域:
营养学
·
食品科学
·
植物学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）