JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2023
·
IF 6.1
Jian Liu,Baoheng Yin,Shuang Li,Lian Mi,Guanghao Yin,Feng Li,Lingmei Zhong,Na Bai,Xue Li
Reactive oxygen species (ROS)-based photodynamic therapy (PDT) and heat-based photothermal therapy (PTT) have garnered significant attention for their non-resistant and minimally invasive characteristics in the treatment of bacterial infections. However, the excessive generation of ROS during treatment can lead to persistent levels of oxidative stress, causing irreversible damage to surrounding tissues. In this study, we successfully synthesized a multifunctional nanocomposite consisting of hollow interior and porous surface nanostructured copper sulfide (Nano CuS) loaded with Rutin, a compound known for its ROS scavenging properties. This nanocomposite effectively eliminates bacteria through PDT and PTT in the initial stage, while simultaneously releasing Rutin to clear ROS at the site of inflammation. This dual therapeutic approach provides antimicrobial and anti-inflammatory effects, making it a promising strategy for combating bacterial infections. Overall, our synthesized nanomaterial demonstrates excellent efficacy in antibacterial and anti-inflammatory applications, offering new insights for future developments in infection treatments.
研究领域:
纳米技术
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生物医学工程
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药学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
Photodiagnosis and Photodynamic Therapy
·
2022
·
IF 3.577
Ying Zhang,Peiyuan Li,Rixiang Su,Fangzhou Wen,Zhiruo Jia,Yingbin Lv,Jinyun Cai,Wei Su
Overuse of antibiotics has led to the emergence of multidrug resistant (MDR) bacteria.. Photothermal (PTT) and photodynamic therapy (PDT) have may be effective alternatives for antibiotics in the treatment of bacterial infections. In this study, based on chitosan (CS)-coated gold nanoparticles, a pH stimulus-responsive drug delivery system was developed, which can anchor to the cell membrane for photodynamic therapy and photothermal therapy, and enhance the therapeutic potential of curcumin (Cur). Release experiments showed that AuNPs/CS-Cur nanocomposites released curcumin in a pH-dependent manner, which may facilitate the drug to be delivered to the acidic bacterial infection environment. CS as the outer layer covered on gold nanoparticles could improve the dispersibility of Cur in aqueous solution, gold nanoparticles prevent rapid photobleaching of curcumin, thus ensuring the yield of singlet oxygen under irradiation, and enhance the electrostatic binding with bacteria cell membrane. Under light conditions, AuNPs/CS-Cur can produce a large amount of reactive oxygen species and heat to kill S. aureus and E. coli . Compared with free Cur-mediated PDT, the complex significantly improved the synergistic PTT/PDT photoinactivation ability against S. aureus and E. coli . In addition, AuNPs/CS-Cur had good biocompatibility. Therefore, AuNPs/CS-Cur possessed the characteristics of electrostatic targeting, photodynamic and photothermal antibacterial therapy, which would become an efficient and safe antibacterial nano-platform and provide new ideas for the treatment of bacterial infection.
研究领域:
纳米技术
·
药学
·
生物医学工程
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微生物学
·
治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wei Su,Ying Zhang,Yiqing Chen,Lini Huo,Fangzhou Wen,Jinyun Cai,Qikun Gong,Peiyuan Li
Bacterial infections impede skin wound healing, and antibacterial hydrogels have garnered significant attention in the field of wound care due to their combined therapeutic effects. In this study, an intelligent, responsive AC-Gel@Cur-Au hydrogel was developed using temperature-sensitive agarose and pH-responsive chitosan as the structural framework, infused with Gel@Cur and AuNR. The AC-Gel@Cur-Au hydrogels demonstrated excellent mechanical properties, swelling capacity, tissue adhesion, and biodegradability. Upon irradiation, the hydrogels exhibited effective photodynamic therapy (PDT), photothermal therapy (PTT), and heat-sensitive gel-sol conversion capabilities, allowing for the release of curcumin in response to temperature and pH changes. Through these synergistic effects, the AC-Gel@Cur-Au hydrogel displayed a rapid bactericidal effect against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), effectively treating persistent biofilms. In vivo studies using a full-thickness defect model of S. aureus infection demonstrated that the hydrogel possessed strong antibacterial activity and enhanced wound healing capabilities, significantly reducing inflammation. Furthermore, the hydrogel significantly promoted granulation tissue formation, collagen deposition, and angiogenesis. Importantly, all the components of the AC-Gel@Cur-Au hydrogel were found to be non-cytotoxic, indicating good biocompatibility. This safe, synergistic antibacterial hydrogel holds great promise for the treatment of bacterial infections in wound healing.
研究领域:
生物医学工程
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伤口愈合
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抗菌材料
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光疗
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药学科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Yanyan Zheng,Yueyue Xie,Xu Dong,Shulin Shen,Gensuo Zheng,Jiaqi Weng,Qinying Yan
Biofilms, which are dense bacterial aggregates that form protective adhesion layers on surfaces, are associated with chronic wound infections, severe acne, and various other bacterial infection sites. However, the increasing antibiotic resistance of bacteria within biofilms and the limited penetration capacity of conventional treatments pose significant therapeutic challenges. To address these issues, we engineered a freeze-drying microneedle system integrating indocyanine green-loaded ZIF-8/hyaluronic acid nanoparticles (ICG@ZIF@HA NPs) and graphene oxide (GO) for dual-modal phototherapy. Notably, the microneedles demonstrated robust mechanical strength, enabling penetration through 140 μm-thick Staphylococcus aureus biofilms. Subsequently, the disruption of the biofilm’s structural integrity facilitated the release of ICG@ZIF@HA NPs from the microneedle tips into deeper biofilm regions. Moreover, the nanoparticles exhibited pH-triggered release kinetics, with over 80% of ICG released at pH 5.5 within 2 h, and generated reactive oxygen species (ROS) under 808 nm near-infrared (NIR) irradiation. Meanwhile, the GO in the backing provided localized hyperthermia, reaching 55 °C within 500 s under NIR exposure. By combining ROS generation and bacterial membrane disruption, the microneedle system achieved a synergistic antimicrobial effect, effectively inhibiting bacterial growth and eliminating biofilms under NIR irradiation. Thus, this study establishes a robust foundation for integrating antimicrobial therapy with microneedle technology, offering a safer and more efficient strategy for biofilm eradication.
研究领域:
纳米医学
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光疗
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抗菌治疗
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药物递送系统
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生物材料
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生物膜研究
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2022
·
IF 6.76
Mengchao Ding,Xiaoying Kong,Weiyan Chen,Lei Yan,He Huang,Zunzhou Lv,Peng Jiang,Ali Mu,Congcong Huang,Jinsheng Shi
Single cancer starvation therapy (ST) strategy can’t achieve satisfactory anti-tumor effect, mainly due to the diversified nutritional sources of tumor cells. Herein, [email protected] 2 @2-Deoxy-D-glucose(2-DG)-CaCO 3 -RGD nanoparticles (CADCR NPs) were prepared for three-pathway blocking for efficient starvation therapy as well as reinforced photothermal therapy (PTT) and chemodynamic therapy (CDT). After CADCR NPs were targeted to tumor cells, CaCO 3 was ruptured in the acidic environment, releasing Ca 2+ to chelate glutamine and cutting off the glutamine metabolic pathway of the tumor. 2-DG was also released from mesoporous SiO 2 and restrained the glycolytic pathway of tumor cells. In addition, under the thermal stimulus of near-infrared irradiation, axitinib was released from CuS NPs, which inhibited the proliferation of tumor blood vessels, ultimately inhibiting the aerobic respiratory pathway of tumor cells. Interestingly, CADCR NPs also showed potential to reshape the tumor microenvironment (TME) and promoted the transformation of macrophages from M2 to M1 type, increasing the expression of CD8+ T cells in the tumor site. In conclusion, CADCR NPs achieve severe tumor starvation by simultaneously interfering with three energy metabolic pathways, and further enhance tumor treatment with the aid of PTT, CDT, and TME improvement, which exhibits great potential for clinical cancer therapy.
研究领域:
癌症治疗
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纳米技术
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生物医学工程
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药学
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肿瘤微环境
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细胞代谢
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 7
·1846-1857
·
IF 6.331
Yiyao Pu,Yuda Zhu,Zi Qiao,Nini Xin,Suping Chen,Jing Sun,Rongrong Jin,Yu Nie,Hongsong Fan
Based on widely used photoacoustic imaging (PAI) and photothermal properties of polydopamine (PDA), a multifunctional Gd–PDA-Ce6@Gd-MOF (GPCG) nanosystem with a core–shell structure and strong imaging ability was constructed. Benefitting from the metal–organic framework (MOF) structure, GPCG nanoparticles (NPs) showed enhanced magnetic resonance imaging (MRI) ability with high relaxation rates (r1 = 13.72 mM−1 s−1 and r2 = 216.14 mM−1 s−1). The MRI effect of Gd ions combined with the PAI effect of PDA, giving GPCG NPs a dual-modal imaging ability. The core, mainly composed of PDA and photodynamic photosensitizer chlorin e6 (Ce6), achieved photothermal/photodynamic therapy (PTT/PDT) synergistic performance. Besides, to overcome the unexpected release of Ce6, the MOF shell realized pH-sensitive release and a high local concentration. Through in vivo studies, we concluded that GPCG NPs show a good inhibitory effect on tumor growth. In conclusion, we successfully obtained a GPCG theranostic nanoplatform and paved the way for subsequent design of imaging guided therapeutic nanostructures based on metal-doped PDA.
研究领域:
纳米技术
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生物医学工程
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诊疗学
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影像与治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Yu Chen,Zhentan Lu,Dong Wang
The combination of phototherapy and chemotherapy with superior advantages is a promising strategy for cancer therapy. However, combination therapy is generally regulated by two different wavelengths of light or other stimuli, which results in complex operations and inevitable systemic side effects, even affecting therapeutic efficacy. Herein, we design a signal NIR light-regulated nanoplatform via the self-assembly process of reactive oxygen species (ROS)-sensitive prodrug (DTD), human serum albumin (HSA), and IR780 for combined photothermal/photodynamic therapy and chemotherapy. Upon 808 nm laser irradiation, IR780 in nanoparticles generates abundant ROS and a significant photothermal effect to achieve photothermal/photodynamic therapy. Meanwhile, the generating ROS further cleans up the thioketal link to release DOX for chemotherapy. Hence, signal NIR light can effectively control the process of combination therapy. In vivo and in vitro experiment results demonstrate that the multifunctional nanoparticles exhibit excellent antitumor efficacy via the combination of phototherapy and chemotherapy controlled by a signal NIR laser. Overall, the signal NIR light-regulated nanoparticles with combination therapy performance provide a versatile platform for enhancing antitumor efficacy.
研究领域:
肿瘤学
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纳米医学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2024
·
IF 7.2
Qinqin Xu,Xiaohua Ban,Lingjie Yang,Yanrong Chen,Fang Zhang,Yu Wang,Peng Cao,Meng Yu,Xiaohui Duan
Chemodynamic therapy (CDT), which uses metal ions to covert endogenous hydrogen peroxide into highly reactive hydroxyl radicals, is an newly-developing strategy for cancer therapy. However, poor drug delivery efficiency and restricted catalytic performance hinder the therapeutic potential of CDT. Herein, we constructed an in situ injectable hydrogel incorporating Fe/Mn-polydopamine nanoparticles and the ferroptosis inducer piperazine erastin (PE) (FMPEG) for mediating tumor-specific magnetic resonance imaging-visualized photothermal therapy (PTT)/CDT. Upon exposure to near-infrared light irradiation, FMPEG treatment exerted a PTT effect, which further accelerated the drug release behavior from FMP nanoparticles in response to the acidic tumor microenvironment. The released metal ions and PE enhanced the CDT effect at the tumor site. Furthermore, a long-term antitumor effect was obtained via the immunostimulatory effect of CDT/PTT by producing tumor-associated antigens. These findings, along with the unique advantages of injectable hydrogels in immune activation, prove the great potential of FMPEG administration as an efficient strategy for the clinical prevention of distant tumor metastasis of breast cancer.
研究领域:
肿瘤学
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医学影像
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纳米技术
·
癌症治疗
·
免疫疗法
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Yang Dong,Liang Guo,Lu Song,Tingting Liu,Gang Zheng,Meizhu Zheng,Baojiang Li
Background Triple-negative breast cancer (TNBC) has a high early recurrence rate and poor prognosis. Given its insensitivity to traditional systemic chemotherapy, there is an urgent need for new therapeutic strategies for effective treatment. This paper reports the development of a novel two-dimensional MXene composite nanoplatform for efficient synergistic chemotherapy and photothermal therapy of TNBC.Results To achieve surface functionalization of MXene, we developed a surface nanopore engineering strategy, enabling the uniform coating of a thin mesoporous silica layer on the two-dimensional Ti3C2 MXene surface. This strategy endows MXenes with well-defined mesopores for on-demand drug release/delivery and enhanced hydrophilicity/dispersibility. Systematic in vitro and in vivo evaluations demonstrate that Ti3C2@MSNs have high active targeting capability upon entering tumors, and through the synergistic chemotherapy of the mesoporous shell and the photothermal therapy of the Ti3C2 MXene core, tumors can be completely eradicated with no significant recurrence.Conclusion This study provides a new strategy for developing MXene-based composite nano drug delivery systems to effectively combat TNBC.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2021
·
IF 0
Yue Duan,Han Yang,Junxiao Gao,Daohe Wei,Yue Zhang,Jian Wang,Xinhui Zhang,Jinchao Zhang,Kun Ge,Xiaoli Wu,Jin Chang
Immunotherapy has shown great potential in cancer therapeutics but has limitations of the insufficient activation of dendritic cells (DCs) and immune-suppressive microenvironment. To overcome these obstacles, a cascade synergistic immunotherapy nanosystem (denoted as CpG@PDA-FA) was designed to elevate anticancer immune response. The combination nanosystem including a photothermal agent polydopamine (PDA) and immunomodulator CpG oligodeoxynucleotides (CpG ODNs). On the one hand, polydopamine (PDA) acts as a photothermal agent to induce low-temperature PTT. It leads to immunogenic cell death (ICD), a programmed cell death pathway, which can activate DCs and enhance the antitumor immune response of T cells. On the other hand, CpG ODNs further promote maturation and migration of DCs as well as ameliorates the immunosuppression microenvironment of the tumor (TME). This paper focuses on a cancer synergistic treatment of ICD-induced immunotherapy by low-temperature PTT and ameliorates TME by immunomodulator CpG ODNs. We proved that CpG@PDA-FA NPs realized a remarkable synergistic treatment effect compared with respective single PTT or CpG therapy in the maturation of DCs and activation of T cells. In addition, CpG@PDA-FA NPs also reduced myeloid-derived suppressor cells and regulatory T cells to relieve immunosuppression. Hence, CpG@PDA-FA NPs provide a bidirectional immunotherapy strategy for tumor inhibition and highlight the cascade effects of low-temperature PTT and immunotherapy.
研究领域:
肿瘤学
·
免疫治疗
·
纳米技术
·
癌症生物学
✓ 已验证
产品关联
DOI
PubMed
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Hang Wu,Lei Xie,Liang Zhu,Tengbo Yu,Yingze Zhang
As a common malignant bone tumor in adolescents, osteosarcoma (OS) possesses a very poor prognosis and lacks effective treatments. In this study, we developed a multifunctional nanotherapeutic agent (WSe 2 /AIPH/GOx) that can combine photothermal therapy (PTT) /thermodynamic therapy (TDT) /starvation therapy (ST) against OS. The prepared WSe 2 /AIPH/GOx exhibited a high photothermal conversion efficiency of 37.3% under 808 nm near-infrared laser irradiation, which could effectively eliminate tumor cells. In addition, the local high temperature caused by photothermal heat induces the rapid release and decomposition of AIPH, generating oxygen-independent alkyl radicals that promote tumor cell death in the hypoxic microenvironment. More importantly, the introduction of GOx depletes glucose to starve tumor cells on the one hand, and on the other hand can indirectly increase the thermal sensitivity of cells. In vivo experiments have demonstrated that WSe 2 /AIPH/GOx can effectively inhibit tumor growth in mice due to the combined effects of multiple therapies. Overall, this work provides an effective strategy for potential osteosarcoma treatment based on combination therapies.
研究领域:
肿瘤学
·
纳米医学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Liang Zixing,Li Xiaofeng,Chen Xiaofang,Zhou Jiawei,Li Yanan,Peng Jianhui,Lin Zhousheng,Liu Gai,Zeng Xiancheng,Li Cheng,Hang Lifeng,Li Hailiang
Introduction: Photodynamic therapy (PDT) and photothermal therapy (PTT) are widely used in the treatment of tumors. However, their application in the treatment of clinical tumors is limited by the complexity and irreversible hypoxia environment generated by tumor tissues. To overcome this limitation, a nanoparticle composed of indocyanine green (ICG) and Fe-MOF-5 was developed.Methods: We prepared F-I@FM5 and measured its morphology, particle size, and stability. Its enzyme like ability and optical effect was verified. Then we used MTT, staining and flow cytometry to evaluated the anti-tumor effect on EMT-6 cells in vitro. Finally, the anti-tumor effect in vivo has been studied on EMT-6 tumor bearing mice.Results: For the composite nanoparticle, we confirmed that Fe-MOF-5 has the best nanozyme activity. In addition, it has excellent photothermal conversion efficiency and generates reactive oxygen species (ROS) under near-infrared light irradiation (808 nm). The composite nanoparticle showed good tumor inhibition effect in vitro and in vivo, which was superior to the free ICG or Fe-MOF-5 alone. Besides, there was no obvious cytotoxicity in major organs within the effective therapeutic concentration.Discussion: Fe-MOF-5 has the function of simulating catalase, which can promote the decomposition of excessive H2O2 in the tumor microenvironment and produce oxygen to improve the hypoxic environment. The improvement of tumor hypoxia can enhance the efficacy of PDT and PTT. This research not only provides an efficient and stable anti-tumor nano platform, but also has broad application prospects in the field of tumor therapy, and provides a new idea for the application of MOF as an important carrier material in the field of photodynamic therapy.
研究领域:
癌症治疗
·
纳米技术
·
光动力疗法
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光热疗法
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）