MICROPOROUS AND MESOPOROUS MATERIALS
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2024
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IF 4.8
Changfeng Zeng,Jie Li,Jie Gong,Lixiong Zhang,Liang Yu
ZIF-8/PVA microspheres with an even size were synthesized with the assistance of a simple microfluidic device. The ZIF-8/PVA microdroplets were first generated in a simple co-flow microfluidic device using a PVA aqueous solution dispersed with ZIF-8 nanoparticles as the dispersed phase and fatty acid methyl ester (FAME) as the continuous phase. Subsequently, the ZIF-8/PVA microdroplets were further extracted to form ZIF-8/PVA microspheres. The influence of the type of continuous phase on the sphericity of microspheres was investigated and the effect of ZIF-8 content was studied. Further studies showed that decreasing the extraction rate and using additives of NaCl in the dispersed phase could improve the sphericity of the ZIF-8/PVA microspheres. Finally, the synthesized ZIF-8/PVA microspheres were used to study the loading and release of tetracycline. The results showed that the loading of ZIF-8/PVA microspheres was more than 5 times higher than that of pure PVA microspheres. The drug release time of ZIF-8/PVA microspheres was much longer than that of the PVA microspheres and the release rate was significantly affected by the pH of the environment.
研究领域:
材料科学
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药学
✓ 已验证
产品关联
DOI
高影响因子
Applied Materials Today
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2025
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IF 6.9
Zerong Wang,Ge Yan,Yi Ning,Xiaoli Zhou,Xin Lu,Qianqian Zhou,Qiwei Tian
Transarterial embolization (TAE) is a primary clinical treatment for hepatocellular carcinoma (HCC); however, its therapeutic efficacy is limited by its functional constraints. To enhance treatment outcomes, this study aims to develop a multifunctional embolic microsphere, LUT-Fe@PVA, for the combined treatment of HCC. This approach leverages a synergistic strategy that integrates TAE, sonodynamic therapy (SDT), and chemodynamic therapy (CDT) to improve the therapeutic efficacy. The LUT-Fe@PVA microspheres were synthesized via a microemulsion crosslinking method and loaded with luteolin-iron complexes to enable ultrasound-triggered reactive oxygen species (ROS) generation and Fenton reaction for enhanced tumor destruction. In vitro results demonstrated that the combination therapy significantly kills the tumor cells. In vivo, 18 F-FDG microPET/CT imaging revealed significantly reduced uptake values, while histological analysis confirmed extensive tumor cell necrosis and apoptosis in the combined therapy group. This study presents a promising multifunctional approach for HCC treatment by integrating embolization, SDT, and CDT, offering a novel strategy for effective and selective tumor treatment with minimal side effects.
研究领域:
肿瘤学
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生物医学工程
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药剂学
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影像医学
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介入治疗学
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
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2021
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IF 8.947
Jiaojiao Li,Jihua Wang,Jianye Li,Xin Yang,Jiangling Wan,Chuansheng Zheng,Qing Du,Guofeng Zhou,Xiangliang Yang
Magnetic resonance imaging (MRI) has attracted increasing attention as a feasible alternative or adjunctive imaging modality for X-ray digital subtraction angiography because of the high tissue resolution and non-ionization radiation. In this study, a one-step electrospray method was developed to fabricate PVA microspheres encapsulated with in situ synthesized Fe 3 O 4 nanoparticles . Fe 3 O 4 @PVA microspheres were mono-dispersed black spheres with a wide range of sizes (262–958 µm). The in situ -synthesized Fe 3 O 4 nanoparticles were used as the contrast agent of MRI and the cross-linkers of PVA matrixes for the embolization purpose. In vivo evaluation of renal arteries of normal rabbits showed that Fe 3 O 4 @PVA microspheres had good embolic effect and enhanced capability of MRI. In vitro and in vivo biosafety assessment confirmed that Fe 3 O 4 @PVA microspheres had favorable biocompatibility. The DOX-loaded Fe 3 O 4 @PVA microspheres showed a typical drug-sustained release profile. These results suggest that the prepared DOX-loaded Fe 3 O 4 @PVA microspheres have the function of MRI, embolotherapy and chemotherapy. We expect our study could provide a simple and useful approach for the systematic design , fabrication, and application of a new type of magnetic microspheres as a triple-functional embolic agent for the development of MRI-guided TACE. Statement of significance Due to the low tissue resolution and hazardous ionization radiation of X-ray digital subtraction angiography, it is beneficial to study MR imaging embolic microspheres for the development of MRI-guided TACE. In this study, a one-step electrospray method was firstly developed to fabricate PVA microspheres encapsulated with in situ synthesized Fe 3 O 4 nanoparticles. Then, chemotherapeutic agent (DOX), contrast media of MRI (Fe 3 O 4 ) and embolic agent (PVA matrix) were combined together in one body (DOX-loaded Fe 3 O 4 @PVA microspheres) to achieve the triple effects of chemotherapy, MR imaging and embolization. This triple-functional embolic agent offers potential for the future development of MRI-guided TACE.
研究领域:
材料科学
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医学影像
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纳米技术
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Advances
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2022
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IF 0
Xueqing Yang,Shizhen Wang,Xiang Zhang,Changqing Ye,Shige Wang,Xiao An
The development of tissue adhesive embolization microspheres with imaging ability is one of the important methods to improve the efficacy of interventional embolization. This study reported the synthesis of iodine (I)-polyvinyl alcohol (PVA)@polydopamine (PDA) microspheres to achieve the computed tomography image, drug loading and controlled release, and the enhanced embolization of liver portal vein. The [email protected] microspheres with a diameter of 147.9 μm showed an excellent computed tomography imaging ability. Moreover, the introduction of PDA endowed the [email protected] microspheres with tissue adhesive ability and therefore the in vivo embolization effect was improved. The in vivo embolization results showed that focal necrosis of hepatocytes with necrotic cell fragments and inflammatory cell infiltration was observed in the liver tissue, proving that the [email protected] microspheres have an enhanced embolization effect than PVA particles. The [email protected] microspheres were further used to deliver and release of chemotherapeutic drugs (5-fluorouracil), which displayed an initial fast release (release amount: 29.74%) in the first 24 h and then a sustained release of 34.48% within 72 h. Moreover, as a universal platform, the [email protected] microspheres could combine with other imaging agents like Bi 2 S 3 , thus holding a great potential in the interventional treatment of different diseases.
研究领域:
医学影像
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药学
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介入放射学
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生物材料
✓ 已验证
产品关联
DOI
PubMed
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