Pharmaceutics
·
2020
·Vol. 12
·期 7
·675
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IF 4.421
Chun Chu,Zhihong Bao,Meng Sun,Xiaowei Wang,Hongyan Zhang,Weiguo Chen,Yang Sui,Ji Li,Yuanyuan Zhuang,Dongkai Wang
The combination of chemotherapy and phototherapy has attracted increasing attention for cancer treatment in recent years. In the current study, porous PdPt bimetallic nanoparticles (NPs) were synthesized and used as delivery carriers for the anti-cancer drug doxorubicin (DOX).[email protected]NPs were modified with thiol functionalized hyaluronic acid (HA-SH) to generate[email protected]@HA NPs with an average size of 105.2 ± 6.7 nm. Characterization and in vivo and in vitro assessment of anti-tumor effects of[email protected]@HA NPs were further performed. The prepared[email protected]@HA NPs presented a high photothermal conversion efficiency of 49.1% under the irradiation of a single 808 nm near-infrared (NIR) laser. Moreover, NIR laser irradiation-induced photothermal effect triggered the release of DOX from[email protected]@HA NPs. The combined chemo-photothermal treatment of NIR-irradiated[email protected]@HA NPs exerted a stronger inhibitory effect on cell viability than that of DOX or NIR-irradiated[email protected]NPs in mouse mammary carcinoma 4T1 cells in vitro. Further, the in vivo combination therapy, which used NIR-irradiated[email protected]@HA NPs in a mouse tumor model established by subcutaneous inoculation of 4T1 cells, was demonstrated to achieve a remarkable tumor-growth inhibition in comparison with chemotherapy or photothermal therapy alone. Results of immunohistochemical staining for caspase-3 and Ki-67 indicated the increased apoptosis and decreased proliferation of tumor cells contributed to the anti-tumor effect of chemo-photothermal treatment. In addition,[email protected]@HA NPs induced negligible toxicity in vivo. Hence, the developed nanoplatform demonstrates great potential for applications in photothermal therapy, drug delivery and controlled release.Keywords:PdPt bimetallic nanoparticles;drug delivery;chemo-photothermal therapy;anti-tumor effect
研究领域:
纳米医学
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肿瘤学
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生物材料
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 9
·2006-2011
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IF 4.726
Na Li,Yaoguang Wang,Wei Cao,Yunhui Zhang,Tao Yan,Bin Du,Qin Wei
The excellent catalytic activity of a novel nanomaterial was introduced to ultrasensitive sandwich-type electrochemical immunosensor applications for detection of carcinoembryonic antigen (CEA). Amino-functionalized multi-walled carbon nanotube (MWCNT-NH2) supported PdPt nanocages were used as catalytic labels of secondary anti-CEA. PdPt nanocages with hollow interiors and porous walls could efficiently enhance electrocatalysis for reduction of H2O2. Meanwhile, with good dispersion, large specific surface area and amino groups, MWCNT-NH2 can immobilize a large amount of PdPt nanocages to improve the sensitivity and amplify the signal of the immunosensor. For the immobilization of primary antibodies, 3-aminopropyltriethoxysilane functionalized graphene sheets were used as transducing materials to modify glassy carbon electrodes and to enhance the electron transfer efficiently. Under the optimal conditions, the electrochemical immunosensor exhibited a wide linear range of 0.001–20 ng mL−1 with a low detection limit of 0.2 pg mL−1 for CEA. The proposed sensing strategy enriches electrochemical immunoassays and may have a promising application in bioassay analysis.
研究领域:
生物医学工程
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分析化学
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产品关联
DOI
PubMed
高影响因子
Journal of Food Measurement and Characterization
·
2024
·
IF 2.9
Liao Diyan,Zhao Yong,Zhou Yi,Yi Yinhui,Weng Wenchuan,Zhu Gangbing
The extensive usage of organophosphate pesticides (OPs) has posed severe harm to human health and environmental system, but achieving highly effective and on-site detection is still a great challenge. In this work, a novel nanozyme Nb 2 CT x MXene/bimetallic PdPt (Nb 2 CT x @PdPt) was synthesized firstly through a simple self-reduction method, and the results show that the as-prepared Nb 2 CT x @PdPt nanozyme exhibits outstanding peroxidase-like activity. Interestingly, the nanozyme activity of Nb 2 CT x @PdPt is restrained remarkably in the presence of acetylcholine chloride and acetylcholinesterase while it can be restored through the addition of OPs (selecting glyphosate as a model). Based on this phenomenon, a sensitive colorimetric assay coupled with hydrogel and smartphone for OPs was then constructed. After optimizing various conditions, the designed sensing platform can achieve stable, rapid, and sensitive on-site detection for OPs, showing superior sensing performances: a wide linearity of 1.0 ng mL −1 –1.0 µg mL −1 and low detection limit of 0.419 ng mL −1 .
研究领域:
环境科学
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生物医学工程
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分析化学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
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IF 8.456
Gaojie Li,Xiaohong Wang,Liuming Yan,Yan Wang,Zhanying Zhang,Jiaqiang Xu
Bimetallic nanoparticles (NPs) usually exhibit some novel properties due to the synergistic effects of the two distinct metals, which is expected to play an important role in the field of gas sensing. PdPt bimetal NPs with Pd-rich shell and Pt-rich core were successfully synthesized and used to modify SnO2 nanosheets. The 1P-PdPt/SnO2-A sensor obtained by self-assemblies of PdPt NPs exhibited temperature-dependent dual selectivity to CO at 100 °C and CH4 at 320 °C. Furthermore, the sensor possessed good long term stability and antihumidity interference. The activation energy of adsorption for CO and CH4 were estimated by the temperature-dependent response process modeled using Langmuir adsorption kinetics, which proved that the lower activation energy of adsorption corresponded to better sensing performance. The gas-sensing mechanism based on the diffusion depth of the tested gas in the sensing layer was discussed. The dramatically improved sensing performance could be ascribed to the high catalytic activity of PdPt bimetal, the electron sensitization of PdO, and Schottky barrier-type junctions at the interface between SnO2 and PdPt NPs. Our present results demonstrate that bimetal NPs with special structure and components can significantly improve the gas-sensing performance of metal oxide semiconductor and the obtained sensor has great potential in monitoring coal mine gas.
研究领域:
材料科学
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化学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 29
·4561-4567
·
IF 5.047
Lihua Jin,Yanan Sun,Lulu Shi,Cong Li,Yehua Shen
In this study, we found that PdPt bimetallic alloy nanowires (Pd/Pt NWs) exhibited excellent oxidase-like activity in acidic media. Their oxidase-like activity could be readily tailored by a well-defined Pd/Pt ratio, while the nanowires with Pd/Pt ratio of 1 : 3 (defined as Pd/Pt-1 : 3 NWs) proved to exhibit the most efficient catalytic oxidation activity. By using their excellent oxidase-like activity, we developed a simple colorimetric assay to detect the activity of acid phosphatase (ACP) based on its catalytic hydrolysate, ascorbic acid (AA), which effectively inhibited the action of the Pd/Pt-1 : 3 NW-mediated TMB-oxidized chromogenic reaction. Good linearity between the absorbance change and activity of ACP was obtained in the range of 0.17–2.67 U L−1, with the limit of detection as low as 0.06 U L−1. Moreover, the proposed method was also adopted to determine the ACP activity in mimicking physiological sample solutions with satisfactory results, illustrating its great potential for biological analysis.
研究领域:
生物化学
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纳米材料科学
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分析化学
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产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Jinwu Hu,Ran Li,Xin Wang,Shaozhen Wang,Caihong Fang
Constructing an appealing architecture is of great significance to improving the electrocatalytic activity and stability of Pt-based nanocatalysts. In this work, we successfully synthesized porous Pd@PdPt core/shell nanocrystals via a facile one-pot method, which possess several architectural and compositional advantages, involving porous outer, ultrathin branches, an open mesoporous skeleton, a core/shell structure, and an alloyed composition. These morphological features and the synergistic effect between different components in the alloy endow the Pd@PdPt nanostructures with abundant active sites, effective mass transfer, strain in the particle, and the electronic coupling effect. The Pd@PdPt nanoalloy therefore exhibits excellent electrocatalytic performances in alcohol oxidation reactions. Impressively, the Pd5Pt4 nanocubes exhibit a higher mass/specific activity of 3.225 A mgPt+Pd–1/34.49 A m–2 for the ethanol oxidation reaction, which is even 4.00-/2.39-fold as high as that of commercial Pt/C. Moreover, the Pd5Pt4 nanocubes also show a superior mass activity of 2.824 A mgPt+Pd–1/37.66 A m–2 toward the methanol oxidation reaction, which is up to 4.20/2.40 times that of the commercial Pt/C. The Pd@PdPt also has enhanced electrocatalytic stability. More importantly, the porous Pt5Pd4 nanocubes still demonstrate superior electrocatalytic activities of 0.259, 1.19, 2.65, and 2.76 A mgPt+Pd–1 for the oxidation of glucose, isopropyl alcohol, glycerol, and ethylene glycol, respectively. We therefore believe that these universal electrocatalysts have the potential to promote practical applications in fuel cells.
研究领域:
材料科学
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化学
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DOI
高影响因子
Analytical Methods
·
2024
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IF 2.7
Huanxin Xiao,Weiguang Chen,Mingxia Lin,Shilin Jiang,Xiping Cui,Suqing Zhao
Cervical cancer (CC) remains one of the most severe global health challenges affecting women, primarily due to persistent infection with high-risk human papillomavirus (HPV) subtypes, particularly with HPV16 and HPV 18. Effective detection of these high-risk HPV strains is crucial for CC prevention. Current screening programs for HPV DNA include PCR and in situ hybridization, which are accurate and sensitive. However, these approaches demand a high level of expertise, along with expensive instruments and consumables, thus hindering their widespread use. Therefore, there is a compelling demand to develop an efficient, straightforward, and cost-effective method. Herein, we propose a lateral flow immunoassay (LFIA) method based on Au@PdPt nanoparticles for the simultaneous detection and genotyping of HPV16 and HPV18 within 15 min. This innovative approach allows for qualitative assessment by the naked eye and enables semi-quantitative detection through a smartphone. In this study, under optimal conditions, the qualitative visual limits of detection (vLOD) for HPV16 and HPV18 reached 0.007 nM and 0.01 nM, respectively, which were 32-fold and 20-fold more sensitive than conventional AuNPs-LFIA for HPV16 and HPV18, respectively. Meanwhile, semi-quantitative limits of detection (qLOD) for HPV16 and HPV18 were 0.05 nM and 0.02 nM, respectively. In conclusion, our formulated approach represents a significant step forward in HPV detection and genotyping, with the potential to enhance accessibility and effectiveness in the early diagnosis of CC at the point of care and beyond.
研究领域:
医学诊断
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纳米技术
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癌症研究
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即时检测
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2023
·
IF 10
Yi Lu,Xinni Pan,Cheng Cao,Shanshan Fan,Haisong Tan,Shengsheng Cui,Yanlei Liu,Daxiang Cui
As one of the most widely used drugs, acetaminophen, is the leading cause of acute liver injury. In addition, acetaminophen-induced liver injury (AILI) has a strong relationship with the overproduced reactive oxygen species, which can be effectively eliminated by nanozymes. To address these challenges, mesoporous PdPt@MnO 2 nanoprobes (PPM NPs) mimicking peroxide, catalase, and superoxide dismutase-like properties are synthesized. They demonstrate nontoxicity, high colloidal stability, and exceptional reactive oxygen species (ROS)-scavenging ability. By scavenging excessive ROS, decreasing inflammatory cytokines, and inhibiting the recruitment and activation of monocyte/macrophage cells and neutrophils, the pathology mechanism of PPM NPs in AILI is confirmed. Moreover, PPM NPs’ therapeutic effect and good biocompatibility may facilitate the clinical treatment of AILI.
研究领域:
纳米技术
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药理学
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肝病学
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生物化学
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治疗学
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产品关联
DOI
PubMed
高影响因子
Carbon Energy
·
2023
·Vol. 5
·期 12
·e367
·
IF 20.5
Xi-Lai Liu,Yu-Chuan Jiang,Jiang-Tao Huang,Wei Zhong,Bin He,Pu-Jun Jin,Yu Chen
Small-molecule electrooxidation-boosted water electrolysis (WE) is an energy-saving method for hydrogen (H 2 ) production. Herein, PdPt bimetallenes (PdPt BMLs) are obtained through the simple galvanic replacement reaction. PdPt BMLs reveal 2.93-fold enhancement in intrinsic electroactivity and 4.53-fold enhancement in mass electroactivity for the formate oxidation reaction (FOR) with respect to Pd metallenes (Pd MLs) at 0.50 V potential due to the synergistic effect. Meanwhile, the introduction of Pt atoms also considerably increases the electroactivity of PdPt BMLs for hydrogen evolution reaction (HER) with respect to Pd MLs in an alkaline medium, which even exceeds that with the use of commercial Pt nanocrystals. Inspired by the outstanding FOR and HER electroactivity of bifunctional PdPt BMLs, a two-electrode FOR-boosted WE system (FOR-WE) is constructed by using PdPt BMLs as the cathode and the anode. The FOR-WE system only requires an operational voltage of 0.31 V to achieve H 2 production, which is 1.48 V lower than that (ca. 1.79 V) with the use of the traditional WE system.
研究领域:
材料科学
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电化学
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产品关联
DOI
高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2021
·
IF 5.455
Dan Yu,Yufei Feng,Jing Jin,Qian Liu,Lu Tao,Junshuang Zhou,Li Hou,Faming Gao
A bstract One-dimensional (1D) Pt-based nanotubes (NTs) are widely studied as a promising class of ORR electrocatalysts . A rational porosity for wall of nanotubes could lead to higher atomic utilization and better mass transportation. To confirm this speculation, we prepare a novel class of PdPt porous nanotubes with sub-nano Pt-shell. Their ESCA of 95 m 2 g −1 and mass activity of 2.29 A mg Pt −1 are distinctly greater than that of the Pt nanotubes with perfect wall (91.45 m 2 g −1 and 2.09 A mg Pt −1 ), and are 14.3 and 9.6 times higher than those of commercial benchmark Pt/C catalyst, respectively. The prolonged electrocatalytic durability is also shown. The improved performance can be ascribed to a combination of alloying and unique geometry (one dimension and nanotubes with porous walls).
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Keda Bao,Siyi Qiu,Wentian Wang,Chao Yang,Wei Wang,Xiaoli Wang,Qijun Wang,Jiawen Yin,Qinghui Jin,Jiawen Jian,Jie Zou
The new palladium nanoparticles (Pd NPs) based carrier-free catalytic combustion hydrogen (H 2 ) sensor presents a promising potential for H 2 energy vehicle due to excellent vibration and low power consumption. However, the sintering of the Pd NPs at elevated temperatures decreases the sensitivity, limiting the applications of these sensors. To enhance the durability of Pd NPs based carrier-free catalytic combustion H 2 sensor, palladium-platinum alloy nanoparticles (PdPt NPs) was fabricated on the filament by a co-electrodeposition method. The impact of morphology and composition of PdPt NPs on the sensing performance was systematically investigated. The results indicated that Pt atoms in the alloy can restrict the mobility of Pd atoms, which may reduce the sintering between particles at elevated temperatures. Compared to a pure Pd NPs H 2 sensor, the PdPt NPs H 2 sensor demonstrated superior sensitivity and linearity and their low power consumption and durability were significantly improved.
研究领域:
材料科学
·
传感器技术
·
能源工程
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产品关联
DOI
高影响因子
NANO
·
2017
·
IF 1.025
Meiling Peng,Tao Wang,Zhenzhen Jiang,Sheng Wang
In this work, a synthesis method of residue-free PdPt nanodendrites on reduced graphene oxide (rGO) is reported. Using UV light as an energy trigger and methanol as the reducing agent, PdPt nanodendrites are synthesized with clean, residue-free surfaces (e.g., surfactant and polymer). In comparison with commercial Pd/C and Pt/C catalysts, the as-prepared PdPt nanodendrites on rGO have a large electrochemically active surface area, enhanced catalytic activity, high stability, and tolerance toward the ethanol oxidation reaction in alkaline media. Among the nanodendrite composites prepared, those containing a Pd:Pt ratio of 1:2 on rGO exhibit the best stability and durability, and their mass activity is 2.0 and 2.4 times greater than those of commercial Pt/C and Pd/C catalysts, respectively. This strategy presents an environmentally friendly way to fabricate other noble metal catalysts with improved catalytic activity and stability for use in direct alcohol fuel cells.
研究领域:
材料科学
·
电化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）