RSC Advances
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2025
·Vol. 15
·期 20
·15639-15650
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IF 4.6
Zicheng Wan,Dongyang Li,Yang Zhou,Tun Wang,Benyin Zhu,Changhai Du,Yimin Li,Chang Shu
This study presents a preliminary investigation of porous nickel-titanium (NiTi) materials with controllable porosity fabricated through metal injection molding combined with the powder space-holder method (MIM-PSH). The thermosensitive hydrogel Pluronic F-127 was utilized as a drug carrier to load the anti-proliferative drug rapamycin, resulting in porous NiTi-hydrogel composite materials for controlled drug release. By tuning the NiTi matrix porosity (0%, 20%, and 40%), the system achieved precise modulation of drug loading capacity and release kinetics. Notably, the 40% porous NiTi composite exhibited a threefold increase in the drug-loading capacity and sustained release over 17 days. This hybrid design leveraged the thermoresponsive properties of the hydrogel and the tailored pore architecture to enable spatiotemporal control of rapamycin delivery, effectively inhibiting human aortic smooth muscle cell proliferation and mitigating in vivo vascular tissue hyperplasia. This study provides a foundational framework for the development of multifunctional biomaterial systems for vascular therapy.
研究领域:
生物医学工程
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材料科学
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药理学
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产品关联
DOI
PubMed
高影响因子
CYTOKINE
·
2024
·
IF 3.7
Chenggang Huang,Jiajia Teng,Wei Liu,Junzhe Wang,An Liu
Background Impaired wound healing in traumatic skin injuries remains a severe clinical challenge due to impaired re-vascularization, harmful bacteria infection, and inflammation dysregulation. Macrophages are recognized as prominent immune cells in tissue regeneration and wound healing. Consequently, the modulation of macrophages provides a promising therapeutic target for wound healing disorders. Here, we aimed to explore whether a novel constructed combination of thermosensitive hydrogel Pluronic F-127 (PF-127) and phillyrin (PH, the main active compound of forsythia suspensa) could improve skin wound healing. Methods Firstly, the biological effects of pH on the phenotype and inflammation of macrophages were assessed by flow cytometry and ELISA. The biocompatibility of the PF-127 plus PH combination was investigated on keratinocytes and red blood cells. The biological effect of PF-127/PH hydrogel on the migratory ability of keratinocytes in vitro was evaluated using the scratch and transwell migration assays. In addition, S. aureus and E. coli were employed to test the antibacterial properties of the PF-127 plus PH combination. Finally, PF-127 plus PH scaffold was applied to the full-thickness skin defect in mice. Histomorphological evaluation and immunochemistry were performed to explore the wound-healing activity of PF-127/PH hydrogel. Results PH can promote the polarization of macrophages from the M1 (pro-inflammatory) phenotype to the M2 (anti-inflammatory) phenotype. The PF-127/PH hydrogel was highly biocompatible and showed a potent stimulative effect on the migration of keratinocytes in vitro. The combination of PF-127 and PH exerted a pronounced antibacterial activity on S. aureus and E. coli in vitro. PF-127/PH hydrogel potently accelerates the healing of full-thickness skin defects by promoting skin cell proliferation, accelerating angiogenesis, and inhibiting inflammation. Conclusions Our study suggests that PF-127/PH hydrogel has excellent potential for treating traumatic skin defects.
研究领域:
医学
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生物材料学
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免疫学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Lianlong Zhan,Wei Lu,Qin Xiang,Zhiping Chen,Wenlu Luo,Cailin Xu,Renting Huang,Shuagnfei Wang,Hui He
Using biomass for the production of low-energy regenerative carbon capture materials represents an effective strategy to advance carbon dioxide capture and storage technologies. In this study, a low-energy regenerative bagasse-based CO 2 capture material is synthesized through a one-step, rapid crosslinking strategy. In this method, epichlorohydrin is used to crosslink bagasse with temperature sensitive Pluronic® F-127 and polyethyleneimine, thereby addressing the challenge of simultaneously incorporating multiple functional groups into the biomass matrix. The resulting material with abundant amino adsorption sites demonstrates a high adsorption capacity of 4.52 mmol/g. Interestingly, the temperature-sensitive response of the material facilitates the grafted amine chain segments on bagasse to stretch and shrink reversibly within a narrow temperature range of 25 °C for adsorption and 55 °C for desorption. The shrinkage state is conducive to the CO 2 desorption process, resulting in an ultralow regeneration temperature of 55 °C. Additionally, the water contained in the material enhances its cyclic stability in extreme environments, such as pure CO 2 atmosphere at high temperature. Overall, this research not only provides new ideas for enhancing the long-term stability and economic viability of CO 2 capture materials but also offers feasible solutions for combating climate change and promoting sustainable development.
研究领域:
材料科学
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环境科学
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生物质工程
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2020
·
IF 3.557
Guohong Ren,Xichen Zhang,Zhicheng Zhang,Ying Liang,Shishan Wu,Jian Shen
Pt-based nanomaterials have been proven to be effective catalysts for direct alcohol fuel cells (DAFCs). Specifically, the ternary nanoalloys (NAs) composed of Pt with other noble metals and transition metals can not only reduce the component of Pt but also enhance the electrocatalytic property and durability for alcohol oxidation. Herein, ternary PdPtCu NAs were synthesized through the solvothermal method using ethylene glycol as the solvent and reducing agent. The morphology and composition of PdPtCu NAs can be effectively controlled via selecting suitable surfactants and adjusting the proportion of precursors. The three-dimensional (3D) PdPtCu NAs with spiny rambutan-like morphology were obtained using the triblock copolymer Pluronic F-127 (PF-127) as the surfactant and adding three precursors with an equal molar ratio. The unique structure of PdPtCu NAs and the synergistic effect between the components significantly improved the electrocatalytic activity toward ethanol oxidation. Compared with different atomic ratio binary or ternary nanomaterials, 3D PdPtCu NAs manifested the best electrocatalytic performance.
研究领域:
材料科学
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电化学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
MATERIALS LETTERS
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2023
·
IF 3
Zhe Chen,Yu Han,Pengfei Cai,Xiumei Mo,Yunlong Zhang,Jinglei Wu,Binbin Sun
Clinical applications of soft tissue using 3D bio-printing have been limited due to the difficulty of forming bio-ink materials. In this study, we propose a simple and feasible gel suspension printing system with high printing accuracy using a temperature-sensitive material, Pluronic F-127. The detailed printing parameters of the printing system were confirmed. A heart organ model was successfully fabricated using this printing system, and in vitro cell experiments have demonstrated its good biocompatibility. The results showed that the printing system has the practical ability to prepare soft tissues for application.
研究领域:
生物医学工程
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再生医学
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组织工程
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产品关联
DOI
高影响因子
International Journal of Bioprinting
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2023
·
IF 8.4
Xue Yang,Shuai Li,Xin Sun,Ya Ren,Lei Qiang,Yihao Liu,Jinwu Wang,Kerong Dai
Engineered vasculature is widely employed to maintain the cell viability within in vitro tissues. A variety of fabrication techniques for engineered vasculature have been explored, with combination of additive manufacturing with a sacrifice-based technique being the most common approach. However, the size deformation of vasculature caused by the swelling of sacrificial materials remains unaddressed. In this study, Pluronic F-127 (PF-127), the most widely used sacrificial material, was employed to study the deformation of the vasculature. Then, a thermoresponsive hydrogel comprising poly(N-isopropylacrylamide) (PNIPAM) and gelatin methacrylate (GelMA) was used to induce volume shrinkage at 37°C to compensate for the deformation of vasculature caused by the swelling of a three-dimensional (3D)-printed sacrificial template, and to generate vasculature of a smaller size than that after deformation. Our results showed that the vasculature diameter increased after the sacrificial template was removed, whereas it decreased to the designed diameter after the volume shrinkage. Human umbilical vein endothelial cells (HUVECs) formed an endothelial monolayer in the engineered vasculature. Osteosarcoma cells (OCs) were loaded into a hierarchical vasculature within the thermoresponsive hydrogel to investigate the interaction between HUVECs and OCs. New blood vessel infiltration was observed within the lumen of the engineered vasculature after in vivo subcutaneous implantation for 4 weeks. In addition, engineered vasculature was implanted in a rat ischemia model to further study the function of engineered vasculature for blood vessel infiltration. This study presents a small method aiming to accurately create engineered vasculature by additive manufacturing and a sacrificebased technique.
研究领域:
组织工程
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生物医学工程
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材料科学
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细胞生物学
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产品关联
DOI
PubMed
高影响因子
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