MACROMOLECULAR CHEMISTRY AND PHYSICS
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2018
·Vol. 219
·期 8
·1700558
·
IF 2.492
Hengchang Liu,Yujun Feng
Multicompartment micelles (MCMs), whose cores have at least two compartments, show potential applications in various areas, but the synthesis of polymers for preparing MCMs is usually tedious and time-consuming. In this work, two well-defined telechelic fluorocarbon-terminated triblock copolymers, F 8 -PEO 100 -PPO 65 -PEO 100 -F 8 (F 8 -F127-F 8 ) and F 8 -PEO 132 -PPO 50 -PEO 132 -F 8 (F 8 -F108-F 8 ), are synthesized via a single-step coupling reaction of Pluronics F127 or F108 with perfluoro-1-octanesulfonyl fluoride and characterized by Fourier-transform infrared and NMR spectroscopies, as well as gel permeation chromatography and surface tensiometry. Both of these fluorocarbon-terminated Pluronics can self-assemble into spherical MCMs with Janus-core in aqueous solution, as evidenced by transmission electron microscopy imaging. Since the lipophilic block (PPO) and fluorophilic segments (F 8 ) are separated by the hydrophilic blocks (PEO), these fluorocarbon-terminated Pluronics will loop to give rise to flower-like MCMs, and the calculations based on thermodynamics and dynamics support the formation of such unique aggregates. A “pre-self-assembly” mechanism is proposed to explain the formation process of flower-like MCMs with Janus-core prepared by these telechelic fluorocarbon-terminated triblock copolymers.
研究领域:
材料科学
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化学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2018
·
IF 3.52
Zi-ling Li,Sheng-feng Peng,Xing Chen,Yu-qing Zhu,Li-qiang Zou,Wei Liu,Cheng-mei Liu
The present work evaluated the feasibility of different pluronics (F127, F87 and P85) utilized as modifiers to improve the stability and bioaccessibility of curcumin liposomes (cur-Lps). Pluronics modified curcumin liposomes (cur-pluronic-Lps) were prepared by thin film evaporation combined with dynamic high pressure microfluidization. The particle size and polydispersity index of cur-pluronic-Lps was significantly lower than cur-Lps. Fourier transform infrared spectroscopy analysis revealed that curcumin was loaded in liposomes successfully and X-ray diffraction suggested that curcumin in the liposomes was in an amorphous state. In vitro release studies demonstrated that 73.4%, 63.9%, 66.7% and 58.9% curcumin released from cur-Lps, cur-F127-Lps, cur-F87-Lps and cur-P85-Lps, respectively. Compared with cur-Lps, cur-pluronic-Lps showed a slower release rate and lower cumulative release percentage for curcumin. Non-Fickian transport was the main release mechanism for cur-Lps, cur-F127-Lps and cur-F87-Lps, and typically the first-order model fitted cur-P85-Lps release. Stability studies (exposure to solutions of different pH and heat treatment) indicated that pluronics modification could enhance their pH stability and thermal stability. In vitro simulated gastrointestinal tract studies suggested that pluronics modification could significantly improve the absorption of cur-Lps. Bioaccessibility of curcumin liposomes increased in the following order: cur-Lps < cur-F87-Lps < cur-P85-Lps < cur-F127-Lps. These results may guide the potential application of pluronics modified liposomes as carriers of curcumin in nutraceutical and functional foods.
研究领域:
药剂学
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食品科学
·
生物医学工程
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DOI
高影响因子
NANOTECHNOLOGY
·
2018
·Vol. 29
·期 34
·345101
·
IF 3.404
Luping Sha,Da Wang,Yuling Mao,Wei Shi,Tianbin Gao,Qinfu Zhao,Siling Wang
In this research, a novel method was used to successfully stably coat Pluronic P123 on mesoporous silica nanoparticles (MSNs). Co-constructing a drug delivery system (DDS) with P123 and MSNs has not been previously reported. In this DDS, the coating of P123 was realized through a hydrophobic interaction with octadecyl chain-modified MSNs. The experiments found only Pluronic with an appropriate ratio of hydrophilic and lipophilic segments could keep the nanoassemblies stable. For comparison, nanoassemblies consisting of P123 and octadecyl chain-modified MSNs with or without a disulfide bond were prepared, which were denoted as PSMSNs and PMSNs, respectively. The disulfide bond was expected to endow the system with redox-responsiveness to enhance the therapeutic effect meanwhile decreasing the toxicity. A series of experiments including characterization of the nanoparticles, in vitro drug release, cell uptake and cellular drug release, in vitro cytotoxicity, cell migration and biodistribution of the nanoparticles were carried out. Compared with the PMSNs, PSMSNs displayed a redox-responsive drug release property not only in in vitro release text, but also on the cellular level. In addition, the cell migration experiments proved that the coating of P123 endowed the system with the ability of anti-metastasis. The accumulation of P123 in the tumor was enhanced after coating the MSNs by virtue of the 'EPR' effect of nanoparticles compared with the solution form.
研究领域:
药物递送系统
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纳米医学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Dongxiang Li,Xing Qian,Changshuo Lian,Rui Huang,Ziyi Hao,Ming Cheng,Shuping Li,Chunfang Li,Shahid Iqbal,Lianjie Qin,Jikuan Zhao
The critical micelle concentration (CMC) is one main parameter of surfactants , so an accurate, rapid, and convenient method for CMC determination is of great significance for surfactant applications. In this paper, three samples of carbon quantum dots (CQDs) with different fluorescence properties were developed as fluorescent probes for the CMC determination of CTAB , SDS , Triton X-100, perfluoro OBS and Pluronics® P-123. The fluorescence excitation and emission spectra of a constant amount of the CQDs in different concentrations of the surfactant solution were recorded, and then the CMC values of the surfactant were deduced from the fluorescence intensity change and the Stokes shift variation. The obtained CMC data using three samples of the CQDs agree well with those in the published literature. It is also demonstrated that in the micellization process the interaction between the CQDs and the surfactant molecules is complicated, because the fluorescence properties of the CQDs are found to be related to the characteristics of the CQDs, the head group type of ionic surfactants , the chemical structure between the hydrophobic and hydrophilic segment, and the chemical nature of the hydrophobic chains of the surfactants. So, the CQDs are demonstrated to be located at the palisade layer in the surfactant micelles due to the surface-attached polar groups on the CQDs although the CQDs are mainly hydrophobic as fluorescent probes. The fluorescent CQDs are considered to be new choices of the fluorescent probes in the facile CMC measurement of the surfactants.
研究领域:
化学
·
材料科学
·
分析化学
·
胶体科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）