EUROPEAN POLYMER JOURNAL
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2024
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IF 5.8
Ze Xu,Jun Gao,Hongyu Zhang,Guojun Zheng,Jihong Hu,Junyao Li,Laidi Xu,Yong Kong
A thermosensitive hydrogel based on 6-deoxy-6-arginine grafted chitosan (DAC) and poloxamer 407 (P407) is prepared for wound repair. Since P407 is a thermosensitive polymer, the resultant DAC/P407-gel exhibits thermo-responsive sol–to–gel phase transition behaviors with a phase transition temperature (T sol/gel ) of ∼ 26.5 °C, making it an appropriate material for wound healing. The DAC/P407-gel has a three-dimensional (3D) network structure with large amounts of pores, and the good air permeability of the hydrogel makes it an attractive candidate as wound dressing. The introduction of DAC can not only increase the mechanical strength of the hydrogel but also significantly enhance its biological indexes including antibacterial activity, blood-clotting index (BCI) and hemocompatibility. The cytotoxicity test reveals that the developed DAC/P407-gel also shows outstanding cytocompatibility.
研究领域:
生物材料学
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医学工程
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药剂学
✓ 已验证
产品关联
DOI
高影响因子
ACS Omega
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2023
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IF 4.1
Zhijiang Sun,Zehua Yin,Mingyu Zhang,Dongli Guo,Fen Ran
At present, the design and fabrication of polymer membranes with high permeability and good retention ability are still huge challenges. In this study, the commercial Poloxamer 407 (Pluronic F127) is selected as a multifunctional additive, and polyvinylpyrrolidone is used as a pore-forming agent to modify the poly(ether sulfone) membrane by liquid–liquid phase conversion technology to prepare an ultrafiltration membrane with excellent performance. The hydrophobic poly(propylene oxide) segment in Poloxamer 407 guarantees that this copolymer can be firmly anchored to the poly(ether sulfone) matrix, and the hydrophilic poly(ethylene oxide) segments in Poloxamer 407 impart a stronger hydrophilic nature to the modified membrane surface. Therefore, the permeability and hydrophilicity of the modified membrane are significantly improved and the modified membrane also has good stability. When the amount of Poloxamer 407 added to the casting solution reached 0.6 g, the water flux of the modified membrane was as high as 368 L m–2 h–1, and the rejection rate of bovine serum albumin was close to 98%. In the test to isolate organic small molecule dyes, the retention rate of the modified membrane to Congo red is 94.27%. In addition, the modified membrane shows an excellent water flux recovery rate and antifouling ability. It performs well in subsequent cycle tests and long-term membrane life tests and can be used repeatedly. Our work has resulted in poly(ether sulfone) membranes with good performance, which show great potential in the treatment of biomedical wastewater and the removal of industrial organic dye wastewater, it provides ideas for the development and application of amphiphilic polymer materials.
研究领域:
材料科学
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膜技术
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环境工程
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Rixiang Su,Peiyuan Li,Ying Zhang,Yingbin Lv,Fangzhou Wen,Wei Su
The design and development of smart shape-adaptable wound dressings with superior antimicrobial ability remain a challenge in therapeutic and clinical application. Herein, polydopamine/tannic acid/chitosan/poloxamer 407/188 hydrogel (PTCPP) was prepared with the aim of developing an in situ -formed antibacterial wound dressing with temperature stimulation and near-infrared radiation (NIR) responsive ability. PTCPP possessed injectability, photothermal stability, sustained release properties and cytocompatibility. In vitro antibacterial results showed that the bactericidal rates of PTCPP against Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ) under NIR irradiation were 99.994 % and 99.91 %, respectively. In vivo experiments, PTCPP can adapt to shape of the wound, showing good adhesion, while promoting wound healing in bacterial infections. Therefore, PTCPP has potential application in the treatment of infectious wounds, and provides a strategic choice for developing antibacterial wound dressing combined with photothermal therapy.
研究领域:
材料科学
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生物医学工程
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
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2022
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IF 6.064
Xiaojuan Peng,Chuanbo Ding,Yingchun Zhao,Mingqian Hao,Wencong Liu,Min Yang,Fengyan Xiao,Yinan Zheng
Ginsenoside Rg3 has shown beneficial effects in various skin diseases. The current interest in designing and developing hydrogels for biomedical applications continues to grow, inspiring the further development of drug-loaded hydrogels for tissue repair and localized drug delivery. The aim of the present study was to develop an effective and safe hydrogel (Rg3-Gel), using ginsenoside Rg3, and we evaluated the wound-healing potential and therapeutic mechanism of Rg3-Gel. The results indicated that the optimized Rg3-Gel underwent discontinuous phase transition at low and high temperatures. Rg3-Gel also exhibited good network structures, swelling water retention capacity, sustainable release performance, and excellent biocompatibility. Subsequently, the good antibacterial and antioxidant properties of Rg3-Gel were confirmed by in vitro tests. In full-thickness skin defect wounded models, Rg3-Gel significantly accelerated the wound contraction, promoted epithelial and tissue regeneration, and promoted collagen deposition and angiogenesis. In addition, Rg3-Gel increased the expression of autophagy proteins by inhibiting the MAPK and NF-KB pathways in vivo . It simultaneously regulated host immunity by increasing the abundance of beneficial bacteria and the diversity of the wound surface flora. From these preliminary evaluations, it is possible to conclude that Rg3-Gel has excellent application potential in wound-healing drug delivery systems.
研究领域:
药剂学
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生物医学工程
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伤口愈合
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药物递送系统
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组织工程
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药理学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2014
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IF 3.785
Chenxi Li,Chunyan Li,Zheshuo Liu,Qiuhong Li,Xueying Yan,Yu Liu,Weiyue Lu
The objective of this study was to construct a new in situ gel system based on the combination of poloxamer 407 and carrageenan (carrageenan–poloxamer 407 hydrogel, CPH) for intranasal delivery of ketorolac tromethamine . CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow erosion in aqueous environment containing potassium ion at the physiological level. Loading with ketorolac tromethamine influenced erosion, drug release and thermosensitive properties of CPH. CPH containing 15% ketorolac tromethamine showed suitable gelation temperature (near 35 °C) and in vitro sustained release profiles. Pharmacokinetic study of intranasal CPH containing 15% ketorolac tromethamine in rats demonstrated enhanced absolute bioavailability (68.8 ± 23.3%) and prolonged mean residence time (8.8 ± 3.5 h) in comparison with the intranasal solution group (24.8 ± 13.8%, 3.9 ± 0.6 h). Nasal ciliotoxicity evaluation on an in situ toad palate model preliminarily showed the safety of CPH for intranasal use. All results suggested the potential of CPH as a new sustained - release platform for the intranasal delivery of ketorolac tromethamine.
研究领域:
药剂学
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药物递送系统
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药代动力学
✓ 已验证
DOI
高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2023
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IF 5
Dan Ma,Hai Zhang,Mao Zhao,An-ru Liao,Qian-rong Peng,Wen-wen Jiang,Min Yang
Combination therapy and the drug delivery in response to the tumor microenvironment can effectively improve the efficacy of anticancer therapy. Polymeric nanoparticles can increase the solubility of water-insoluble drugs and have been evaluated as carriers for anti-cancer drugs in several clinical trials . In this paper, zinc phthalocyanine-encapsulated with a boronate-linked polydopamine-poloxamers 407 nanoparticles were developed for pH response and reactive oxygen species (ROS) response release, as well as synergistic photothermal and photodynamic effects. These nanoparticles exhibited a favorable size of 75.02 ± 1.12 nm , stability within 28 days, pH and ROS release up to 57.29% within 84 h, and 73.5% inhibition of A549 cells at a concentration of 5 μg/mL. Overall, our work provides an effective strategy for the encapsulation of hydrophobic photosensitizers , combined PDT and PTT therapy.
研究领域:
纳米技术
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癌症治疗
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药物递送系统
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2016
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IF 3.994
Emmanuel Omari-Siaw,Qilong Wang,Congyong Sun,Zengquan Gu,Yuan Zhu,Xia Cao,Caleb Kesse Firempong,Rita Agyare,Ximing Xu,Jiangnan Yu
An optimized perillaldehyde-loaded liposomal nanoformulation (PAH-LNF) was successfully applied to improve the pharmacological effect of perillaldehyde (PAH) in poloxamer 407-induced hyperlipidemia . Oral administration of PAH-LNF (240 mg/kg per body weight) in rats significantly enhanced solubility and relative bioavailability (270.7%) compared to the free PAH with about 2.7-, 1.5-, 1.3-, 1.3- and 1.5-fold increase in AUC, T 1/2 , MRT, C max and T max , respectively. Tissue distribution study also revealed the accumulation of PAH in the liver, lungs, spleen, kidney, brain and heart in order of decreasing affinity. Moreover, a significant decrease in serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) with simultaneous increase in high-density lipoprotein cholesterol (HDL-C) level was observed in the chemically-induced hyperlipidemic mice which further confirmed PAH’s anti-hyperlipidemic properties. Additionally, PAH-LNF also significantly increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) with a concurrent decrease in malondialdehyde (MDA) to affirm the antioxidant and hepatoprotective effects of PAH. Thus, liposomal nanoformulation promises to be a useful drug delivery system for the development of PAH.
研究领域:
药理学
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纳米医学
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生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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