Singlet oxygen generation proportion from triplet state of porphyrin in water
The proportion of singlet oxygen ( R ) produced from the triplet state of porphyrin in aqueous solutions was investigated by substituting porphyrin molecules with the metalloporphyrin Platinum(II) meso -tetraphenylporphyrin (Pt-TPP). The feasibility of using platinum porphyrin as a substitute for porphyrin to study the photophysical properties in photodynamic therapy (PDT) was confirmed. The model of first-order decay in a water-methanol mixed solution encompasses potential deactivation processes of the excited triplet states and was built, which was confirmed by monitoring the change in the total transition rate of the T 1 state ( A 0 ) value at different water contents under anoxic environments, obtained through measuring the phosphorescence lifetime ( τ p ) of Pt-TPP. Combined with A 0 and the quenching rate constant of T 1 by O 2 ( k q ), the formula for R in relation to changes in oxygen can be deduced in pure water.
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