CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Tian Huang,Jing Zhao,Haijun Li,Wei Zhou,Jintao Wang,Jianliang Shen,Jicai Chen,Xiangwen Liao
Infections caused by methicillin-resistant Staphylococcus aureus ( MRSA ) are a significant public health challenge, necessitating the development of innovative antibacterial strategies. Nanomaterials are recognized for their ability to serve as photothermal conversion agents, transforming light energy into heat for antibacterial applications. These materials act as biological enzymes capable of generating reactive oxygen species (ROS), leveraging their catalytic activity to combat infections. While they show considerable promise, enhancing their ROS-generating efficiency and overall catalytic performance remains a critical challenge. In this work, a high catalytic bimetallic nanoplatform was developed, building on “large electronegativity difference induction/etch-assisted/diffusion termination” mechanism to improve antibacterial efficacy. The synthesized nanoparticles were found to exhibit exceptional photothermal conversion efficiency and surface defects, enabling efficient bacterial eradication. Both in vitro and in vivo experiments demonstrated that H-Pt 3 Sn nanoparticles effectively eliminated MRSA while significantly inhibiting and disrupting biofilms formed by the pathogen. The nanoparticles also facilitated tissue repair by modulating macrophage-related molecular markers. In conclusion, this study presents a promising photothermal synergistic nanosystem with high catalytic functionality for advanced anti-infective applications.
研究领域:
生物医学工程
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材料科学
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抗菌研究
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Wanchao Zuo,Zhipeng Ding,Haodong Zhao,Xiangming Meng,Jiaren Song,Qing Yang,Siqi Zeng,Tianye Fang,Jianjun Dai,Feng Xue,Yanmin Ju
Early detection of pathogenic bacterial infections is crucial for mitigating risks, yet conventional assays face limited adoption due to their dependence on laborious protocols, specialized instruments/personnel, and slow turnaround times. While colorimetric lateral flow immunoassays (CLFIA) offer an efficient and convenient alternative, their sensitivity remains insufficient for detecting early-stage bacterial contamination primarily constrained by inadequate colorimetric signal intensity. Here, we integrate defect-rich intermetallic Pt 3 Sn nanocrystals ( D -Pt 3 Sn NCs) as colorimetric signal amplifiers to develop an enzyme-accelerated signal enhancement (EASE)-based CLFIA for the detection of early-stage bacterial contamination. D -Pt 3 Sn NCs exhibit enhanced peroxidase-like activity than Pt 3 Sn NCs without surface depressions, and superior tolerance and stability under extreme environments relative to natural horseradish peroxidase. Upon integration with the EASE-based CLFIA platform, D -Pt 3 Sn NCs enable sensitive immunochromatographic analysis of Escherichia coli O157:H7 ( E. coli O157:H7) with a visual detection sensitivity of 10 CFU/mL. Besides, proof-of-concept assays for detecting E. coli O157:H7 in cabbage and beef samples validate the anti-matrix interference capability and practicality of this platform. Overall, defect-rich intermetallic nanocrystals hold promise as versatile catalytic colorimetric signal amplifiers, enabling highly-sensitive immunochromatographic detection of trace-level analytes in complex matrices.
研究领域:
纳米技术
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生物传感器
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分析化学
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食品安全
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免疫诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 6
·1143-1151
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IF 7.779
Qian Di,Xixia Zhao,Wenjing Zhu,Yiliang Luan,Zhen Hou,Xiaokun Fan,Yan Zhou,Shutao Wang,Zewei Quan,Jun Zhang
This article proposes a general approach for the preparation of intermetallic nanoparticles of Pt3Sn, PtSn, PtSn2, and PtSn4, triggered by hexamethyldisilazane (HMDS) in conjunction with SnCl2. The ethanol oxidation reaction (EOR) tests demonstrate the improved specific activity of PtxSny intermetallic nanoparticles (PtxSny), due to the lower binding energy between carbon monoxide (CO) and PtxSny, the oxidation state of Sn, and the presence of Pt–Sn bonds on the surface. Strikingly, PtSn with an optimized Pt : Sn ratio of 1 : 1 holds superior EOR performance and stability to other PtxSny intermetallics. In addition, PtxSny intermetallic nanoparticles including PtSn, PtSn2, and even the most Sn-rich PtSn4 hold a higher specific current density than the commercial Pt/C after a long-term test, showing the enhanced stability for the EOR. Furthermore, this method was also successfully extended to the synthesis of other Sn-containing intermetallic nanoparticles, such as Ag3Sn and Cu6Sn5.
研究领域:
材料科学
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电化学
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）