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A novel water-soluble fluorescence probe based on ICT lighten for detecting hydrogen sulfide and its application in bioimaging

Tao Ma,Fangjun Huo,Ying Wen,Timothy E. Glass,Caixia Yin

Endogenous H 2 S, considered to be involved in many physiological processes, has attracted more attention in fluorescence detection and bioimaging. Therefore, it is necessary to design probes with good biocompatibility and high bioavailability. In this study, a novel fluorescent probe , QN-1 , based on azide group and quinoline derivatives was developed for detecting H 2 S. QN-1 can detect H 2 S specifically in aqueous phase, which indicated QN-1 has excellent water solubility. Besides, QN-1 shows excellent properties of higher selectivity and 11-fold fluorescence enhancement at 533 nm. Therefore, QN-1 with excellent properties can be used for cell imaging.