TALANTA
·
2016
·
IF 4.035
Yonghua Xiao,Rong Xiao,Jian Tang,Qiankun Zhu,Xiaoming Li,Yan Xiong,Xuewen Wu
The molecularly imprinted polymers (MIP) were prepared via aqueous RAFT precipitation polymerization, with aristolochic acid I (AAI) as the template molecule, AA as the functional monomer , EGDMA as the cross-linker, AIBN as the chain initiator, CTP as the chain transfer agent and 80% (g/g) DMF-aqueous solution as the porogen . The differential UV–vis spectra revealed that a cooperative hydrogen-bonding complex between AAI and AA might be formed at the molar ratio of 1:3 in prepolymerized system. The synthesized MIPs were characterized by FTIR spectra, solid UV–visible absorption spectra, nitrogen adsorption-desorption isotherms and scanning electron microscope, which proved that the MIPs and NIPs have the similar chemical structures and the adding of AAI could affect the size and morphology of the microspheres . UV–visible absorption spectra and High-performance liquid chromatography (HPLC) was used to investigate the adsorption and recognition properties of the MIPs. The Scatchard isotherm model described that the binding sites independently acted. The Langmuir isotherm model suggested an excellent imprinting effect owing to the presence of a large number of specific binding sites on the MIP. The Freundlich model indicated that the AAI could be readily absorbed by MIP. Selective absorption of the template molecule was demonstrated in presence of its analogous compounds, benzoic acid and nitrobenzene . The recycling experiments implied that the MIP could be reused to further selective recognition and separation to AAI for six times at least. MIP was developed for removal of AAI from the Aristolochia manshuriensis extraction. The results indicated that 25 mg of MIP could remove the AAI below the HPLC detection limits (6.47 ng mL -1 ) from 5.0 mL of the extraction (CAAI=0.0018 mg mL -1 ) with the recovery of AAI to 91.50% (n=3, SD=4.24%). Therefore, it is clearly revealed that the MIP can be a useful tool to remove toxic compounds from natural products .
研究领域:
分析化学
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药物化学
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环境科学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2014
·Vol. 5
·期 14
·10611-10618
·
IF 3.708
Jinhua Li,Ruichen Dong,Xiaoyan Wang,Hua Xiong,Shoufang Xu,Dazhong Shen,Xingliang Song,Lingxin Chen
A facile strategy was developed to prepare magnetic molecularly imprinted microspheres (MMIMs) for the selective recognition and effective removal of 17-beta-estradiol (17β-E2) by reversible addition-fragmentation chain transfer precipitation polymerization. One-pot synthesis was employed, which could simplify the imprinting process and shorten the experimental period. The resultant MMIMs displayed fast kinetics and high binding capacity, and the adsorption processes followed Langmuir–Freundlich isotherm and pseudo-second-order kinetic models. Excellent recognition selectivity toward 17β-E2 was attained over other phenolic estrogens such as 17-alpha-E2, estriol and estrone. The magnetic property of MMIMs provided fast and simple separation, and the recycling process for magnetic solid phase extraction (MSPE) was sustainable at least five times without obvious efficiency decrease. Furthermore, the MMIMs-MSPE presented satisfactory recoveries within 71.7–108.3% with the precisions of 1.1–6.0% for spiked 17β-E2 in water, soil and food samples. The developed MMIMs-based method proved to be a convenient and practical way in sample pretreatment and targeted pollutants removal.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Lijuan Zhao,Faqiong Zhao,Baizhao Zeng
A novel water-compatible fenitrothion imprinted polymer was prepared on Au nanoparticles (AuNPs) by click chemistry and reversible addition–fragmentation chain transfer (RAFT) precipitation polymerization (RAFTPP). The RAFT chain-transfer agent was synthesized on the surface of AuNPs using click chemistry, then an imprinted polymer with hydrophilic polymer brushes was prepared on the RAFT chain-transfer agent modified AuNPs by RAFTPP, mediated by hydrophilic polyethylene glycol macromolecular cochain-transfer agent. The obtained molecularly imprinted material showed improved accessibility to fenitrothion and recognition property in water medium. When the material was immobilized on an ionic liquid functionalized graphene coated glassy carbon electrode for the electrochemical determination of fenitrothion, the resulting electrochemical sensor presented linear response in the range of 0.01−5 μM, with a sensitivity of 6.1 μA/μM mm 2 . The low limit of detection was 8 nM (S/N=3). The sensor was successfully applied to the determination of real samples and the recovery for standard added was 95−108%.
研究领域:
分析化学
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环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Lijuan Zhao,Faqiong Zhao,Baizhao Zeng
A novel brucine imprinted polymer was prepared on multi-walled carbon nanotubes by reversible addition–fragmentation chain transfer (RAFT) precipitation polymerization. The polymer was further grafted with hydrophilic poly(glycerol monomethacrylate) brushes to improve its water-compatibility. The obtained molecularly imprinted material showed enhanced accessibility to brucine and improved selective recognition property in water medium. When the material was supported on an ionic liquid functionalized graphene coated glassy carbon electrode for the electrochemical determination of brucine, the resulting electrochemical sensor presented good analytical performance. Under the optimized conditions, the peak current was linear to brucine concentration in the ranges of 0.006−0.6 μM and 0.6−5.0 μM with sensitivities of 15.3 μA/μM mm 2 and 5.4 μA/μM mm 2 , respectively; the detection limit was 2 nM ( S / N =3). The sensor was successfully applied to the determination of brucine in practical samples and the recovery for the standards added was 94−104%.
研究领域:
分析化学
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材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2021
·Vol. 222
·期 17
·2100145
·
IF 2.527
Qiaoge Fu,Nana Chen,Guanyu Wang,Ruili Guo
The poly (ethylene glycol dimethacrylate- co -vinylphenylboronic acid) P(EGDMA- co -VPBA) adsorbents are prepared via reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization with 4-vinylphenylboronic acid (VPBA) as the functional monomer, and used for selective adsorption of steviol glycosides (SGs). The boron content and pore structure of the P(EGDMA- co -VPBA) adsorbent are adjusted by changing the polymerization conditions. The adsorption results show that the pore structure of the P(EGDMA- co -VPBA) affects the adsorption capacity to SGs, the presence of boric acid functional groups shows favorable adsorption selectivity for stevioside (STV), and the adsorption selectivity is proportional to the content of boric acid in P(EGDMA- co -VPBA) adsorbents. The adsorption performance of P(EGDMA- co -VPBA) toward SGs is the best when the ratio of monomer to cross-linker is 1:50 and the solvent is acetonitrile. In the SG solution (6.0 mg mL −1 , C STV / C RA = 1:1), the adsorption capacities and adsorption selectivity ( α STV/RA ) of P(EGDMA- co -VPBA) to SGs are 113.20 mg g –1 and 4.99, respectively. The adsorption kinetics and isotherm data obey pseudo-second-order kinetic model and Langmuir isotherm model, respectively. The boric acid copolymers with VPBA as the monomer prepared by the one-step method can become a promising material for efficient separation and purification of SGs.
研究领域:
化学工程
·
食品科学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Yaqiong Yang,Zhengzheng Wang,Hui Niu,Huiqi Zhang
A facile and efficient one-pot approach for the synthesis of quantum dot (QD)-labeled hydrophilic molecularly imprinted polymer (MIP) nanoparticles for direct optosensing of folic acid (FA) in the undiluted bovine and porcine serums is described. Hydrophilic macromolecular chain transfer agent-mediated reversible addition-fragmentation chain transfer (RAFT) precipitation polymerization was used to implement the molecular imprinting of FA in the presence of CdTe quantum dots (QDs). The resulting FA-imprinted polymer nanoparticles with surface-grafted hydrophilic poly(glyceryl monomethacrylate) brushes and QDs labeling not only showed outstanding specific molecular recognition toward FA in biological samples, but also exhibited good photostability, rapid binding kinetics , and obvious template binding-induced fluorescence quenching . These characteristics make them a useful fluorescent chemosensor for directly and selectively optosensing FA in the undiluted bovine and porcine serums, with its limit of detection being 0.025 μM and average recoveries ranging from 98% to 102%, even in the presence of several interfering compounds. This advanced fluorescent MIP chemosensor is highly promising for rapid quantification of FA in such applications as clinical diagnostics and food analysis.
研究领域:
材料科学
·
纳米技术
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分析化学
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生物技术
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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