Nature Communications
·
2023
·Vol. 14
·期 1
·1-18
·
IF 16.6
Zhong Jing,He Xiaofang,Gao Xinxin,Liu Qiaohong,Zhao Yu,Hong Ying,Zhu Weize,Yan Juan,Li Yifan,Li Yan,Zheng Ningning,Bao Yiyang,Wang Hao,Ma Junli,Huang Wenjin,Liu Zekun,Lyu Yuanzhi,Ke Xisong,Jia Wei,Xie Cen,Hu Yiyang,Sheng Lili,Li Houkai
Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of certain BA in NAFLD is poorly understood. Here we show levels of serum hyodeoxycholic acid (HDCA) decrease in both NAFLD patients and mice, as well as in liver and intestinal contents of NAFLD mice compared to their healthy counterparts. Serum HDCA is also inversely correlated with NAFLD severity. Dietary HDCA supplementation ameliorates diet-induced NAFLD in male wild type mice by activating fatty acid oxidation in hepatic peroxisome proliferator-activated receptor α (PPARα)-dependent way because the anti-NAFLD effect of HDCA is abolished in hepatocyte-specific Pparα knockout mice. Mechanistically, HDCA facilitates nuclear localization of PPARα by directly interacting with RAN protein. This interaction disrupts the formation of RAN/CRM1/PPARα nucleus-cytoplasm shuttling heterotrimer. Our results demonstrate the therapeutic potential of HDCA for NAFLD and provide new insights of BAs on regulating fatty acid metabolism.
研究领域:
肝病学
·
分子生物学
·
代谢
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DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2022
·Vol. 7
·期 7
·2101639
·
IF 8.856
Chuqiao Hu,Hao Chen,La Li,Hui Huang,Guozhen Shen
The enriched surface functional group such as OH termination and unique 2D structure of Ti 3 C 2 T x MXene provide the feasibility to form hydrogen bonds with organic photosensitive materials as van der Waals heterostructures, thus can realize the improved photoresponsivity of near infrared (NIR) photodetectors (PDs). In this work, an organic–inorganic van der Waals heterostructure-based NIR PD array is designed using Ti 3 C 2 T x MXene as conductive electrodes and RAN film as active materials (Ti 3 C 2 T x -RAN PDs). The on-off ratio of the fabricated devices shows 6.25 times higher than that of PDs using thermal evaporated Au electrode (Au-RAN PDs) under 1064 nm laser excitations. The fabricated Ti 3 C 2 T x -RAN NIR PDs also possess outstanding mechanical stability with no obvious photoresponse degradation under different bending states and high transparency with a transmittance above 70% in the visible region. Owing to the high performance of the Ti 3 C 2 T x -RAN PDs, a 1024-pixel (32 × 32) image sensor array is fabricated to achieve delicate, vivid, and higher resolution imaging of a “deer,” opening up a new avenue for the biomimetic vision and flexible wearable accurate image sensing.
研究领域:
材料科学
·
光学工程
·
电子器件
·
柔性电子
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DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2025
·
IF 3.2
Yini Cui,Jiyong Zhao,Minjie Qu,Zhipeng Wang
The toughened polyphenylene sulfide (PPS) was prepared using copolymer poly(aryl ether sulfone ketone) as the toughening agent, which was synthesized through copolycondensation of 2-phenyl-3,3-bis(4-hydroxyphenyl)phthalimide, 1,4-bis(4-fluorophenyl)butane-1,4-diketone (BFB), and bis(4-fluorophenyl)sulfone (DFS) as monomers. The properties of the copolymers were regulated by controlling the ratio of BFB and DFS. The glass transition temperature ( T g ) exceeds 210°C, and the thermal decomposition temperature ( T d 5% ) surpasses 430°C, demonstrating the copolymer's excellent thermal stability. When the mole ratio of sulfone to ketone was 8:2, the impact strength exhibited an increase of approximately 178% compared to that of neat PPS. The influences of the toughening agent and blending method on the thermal properties, rheological properties, and mechanical properties of the blends were examined. Highlights Copolymer was synthesized as a toughening agent for polyphenylene sulfide (PPS). Copolymer demonstrates good thermal stability properties. Adding copolymer and EGMA significantly improved the toughness of PPS.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2022
·Vol. 40
·期 6
·602-610
·
IF 3.815
Wei Xue-Wei,Zhao Xin-Xin,Li Yi,Meng Xiao-Yu,Zhou Qiong,Ye Hai-Mu
Co-crystallization of different monomeric units fundamentally contributes to the versatile and tunable performance of random copolymers. At present, the crystallization manners of random binary copolymers have been divided into three categories: isomorphism, isodimorphism and comonomer exclusion. Each category, however, has its own advantages and disadvantages. Therefore, it is challenging to design and prepare random copolymer sharing the advantages of isomorphism and isodimorphism through a new co-crystallization manner beyond the ones already exist. On the basis of previous study on poly(alkylene succinate- ran -alkylene fumarate) whose co-crystallization can be extensively and finely regulated by simply varying the chemical structure of alkylene, random copolymers of poly(propylene succinate- ran -propylene fumarate) (PPSF) are synthesized using 1,3-propanediol as the diol source. The thermal properties and crystal structure of PPSF are investigated, and, intriguingly, it is proved that PPSF is an isodimorphism system while displays similar composition-dependent thermal properties and crystallinity as isomorphism. That is, PPSF exhibits a novel co-crystallization behavior that has rarely been discovered, which would combine the advantages of both isomorphism and isodimorphism. Consequently, PPSF could be termed as a new-type, special composition-dependent polymorphism. Besides, the altering of PPS-like to PPF-like crystal structure of PPSF when changing chain composition has been proved to originate from the shift of dominant inter-segment interaction from van der Waals forces to strong hydrogen-bonding interaction. This work enriches the co-crystallization manner of random copolymers, leading to more diverse performance design of polymer materials.
研究领域:
高分子化学
·
材料科学
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产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2025
·
IF 5.4
Juan Torres-Rodríguez,Ricardo A. Pérez-Camargo,Yunxiang Shi,Kaojin Wang,Yong-Guang Jia,X. X. Zhu,Alejandro J. Müller
Poly(ε-caprolactone-ran-ω-pentadecalactone) (PCLx-PPDLy) copolymers were synthesized by using ring-opening polymerization with Candida antarctica lipase B as a catalyst across various compositions. The aim was to study their crystallization behavior and ascertain whether they are isomorphic or isodimorphic. Differential scanning calorimetry, polarized light optical microscopy, in situ wide- and small-angle X-ray scattering, and Fourier-transform infrared spectroscopy were employed to assess the crystallization mode. Various crystallization conditions were used to investigate their influence on the comonomer inclusion/exclusion balance. The copolymers exhibited pseudoeutectic behavior across all compositions, crystallizing in either PPDL-type or PCL-type unit cells and conformations, independent of crystallization conditions. This indicates that they are isodimorphic, contrary to previous reports. Self-nucleation tests showed that the Domain II width decreases with increasing comonomer content, supporting isodimorphism. The pseudoeutectic point was observed at CL contents above 83%, which explains the previously unrecognized isodimorphic character of these copolyesters.
研究领域:
高分子化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL IMMUNOPHARMACOLOGY
·
2025
·
IF 4.7
Zhiqiang Wang,Man Li,Shuming Guo,Chen Deng,Beiyang Wang,Fang Gao,Junqiao Lv,Lin Sun
Ischemia and hypoxia near the injury site following spinal cord injury (SCI) lead to early lactate accumulation. Reactive astrocytes polarize and migrate to the lesion site, sealing it off and restricting immune cell infiltration. However, the specific mechanisms through which lactate influences astrocyte polarization remain poorly understood. In this study, we found that lactate can promote astrocyte proliferation, migration and differentiation into A2 after oxygen-glucose deprivation/reoxygenation (OGD/R). Inhibiting signal transducer and activator of transcription 3 (STAT3) nuclear transport reversed lactate-driven astrocyte polarization both in vivo and in vitro. Moreover, lactylome analysis identified nonhistone protein Ran as a target of lactylation at lysine 123 (K123). Ran silencing or mutation at K123 reversed the effects of lactate on STAT3 nuclear transport and astrocyte polarization. We also found that Ran lactylation is regulated by SIRT1. Taken together, our results show that lactate promotes astrocyte polarization via Ran lactylation-dependent regulation of STAT3 nuclear transport.
研究领域:
神经科学
·
细胞生物学
·
分子生物学
·
代谢学
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产品关联
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2018
·Vol. 29
·期 6
·1684-1696
·
IF 2.137
Xiaoyu Chen,Xiaomeng Wu,Zhongyong Fan,Qinghua Zhao,Qing Liu
The macroinitiator of poly(1,3-trimethylene carbonate) (PTMC) with number-average molecular weight ( ) of 9.6 × 10 3 g mol −1 was synthesized by ring-opening polymerization at 120°C. Then, the novel terpolymer P(TMC- b -( L LA- ran -GA)) consisting of PTMC homopolymer segment attached with various monomer molar ratios of L -lactide ( L LA) and glycolide (GA) random copolymerization block was prepared with about 5.0 × 10 4 g mol −1 by ring-opening polymerization in bulk at 140°C. The tailored molecular structures of P(TMC- b -( L LA- ran -GA)) were characterized by 1 H nuclear magnetic resonance, 13 C NMR, FTIR, and gel permeation chromatography, and chain microstructure analysis was performed in detail with 13 C NMR spectroscopy. The effect of GA units on the thermal and crystallization behaviors, mechanical properties, as well as biodegradability of terpolymers was investigated by differential scanning calorimetry, wide-angle X-ray diffraction, stress-strain measurements, and in vitro tests in comparison with corresponding poly(trimethylene carbonate- block - L -lactide) copolymer P(TMC- b - L LA). The results show that amorphous PTMC segments have a significant effect on condensed state behavior of the terpolymers, and the incorporation of GA units strongly decreases the crystallinity and crystallization ability of L LA segment within terpolymers because of more random L LA-GA sequence and shorter average L LA block length. Meanwhile, the toughness of materials is greatly improved, and in vitro degradation is also accelerated. Peripheral vascular stents were 3D printed for the first time and met the requirements for application. The results show totally biodegradable terpolymers with unique molecular structure, and modifiable properties are promising new biomaterials with advanced performance for biomedical application.
研究领域:
生物材料学
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高分子化学
·
医学工程
✓ 已验证
DOI
高影响因子
MACROMOLECULES
·
2019
·
IF 5.997
Hai-Mu Ye,Jing Wang,Cai-Shui Wang,Hong-Fang Li
Poly(decamethylene succinate-ran-decamethylene fumarate)s (PDSFs) were synthesized, and their structure and crystallization behavior were systematically studied. All polyesters possess high crystallizability irrespective of composition and display the widest pseudoeutectic region that has been reported to date. Nevertheless, both melting point– and crystallization temperature–composition relationships demonstrate PDSFs display off-V-shaped behavior, indicating particular pseudoeutectic behavior. PDSF57 and PDSF37 located in the pseudoeutectic region are studied in detail. DF-rich crystals form first due to the assembly of fumarate-related preordered structure in the PDSF57 melt; then DS-rich crystals appear through plausible epitaxial crystallization. PDSF37 is proven to be located in the boundary of the pseudoeutectic region. DF-rich ordered structure forms first but cannot crystallize itself, which plays the role of the “soft epitaxial” substrate for DS-rich crystal formation; meanwhile, the DF-rich form crystallizes with the assistance of DS-rich crystals. The particular crystallization process of PDSF37 induces tightly attached structures between the two types of crystals and results in a fantastic and abrupt melting point jump.
研究领域:
高分子科学
·
材料化学
·
聚合物热性能
·
晶体学
·
聚合物结晶
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DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 5
·1739-1751
·
IF 3.4
Na Ni,Tiantang Fan,Wuyou Ye,Qi Xia,Dongyang Liu,Jingwen Qin,Zhongyong Fan,Qing Liu
Poly( L -lactic acid) (PLLA) is a biocompatible material and has found its application in bioresorbable vascular stents (BVS). However, the crystallization of pure PLLA makes it brittle as a medical implant device. In this work, the biodegradable poly(1,3-trimethylene carbonate- b -( L -lactide- ran -glycolide acid)) (PTLG) terpolymers with improved mechanical performance were developed and processed into peripheral vascular stents by a novel 3D 4-axial printing technology. The PTLG terpolymers were successfully synthesized by ring-opening copolymerization of L -lactic acid (LLA), 1,3-trimethylene carbonate (PTMC) and glycolide acid (GA) units. The crystallinity and mechanical properties of the PTLG terpolymers with various degradation rate depends on the chain sequence structure and the component contents. Compared with the stent prepared by laser engraving, the peripheral vascular stent prepared by the 3D 4-axial printing technology exhibit a finer structure and smoother strut surface. It was found that both the strut diameters and the molecular weight of PTMC affect the radial force of the stents and that the apparent activation energy of thermal decomposition of the stents is mainly influenced by the molecular weight of PTMC and the component ratio. Therefore, the addition of the PTMC segment can effectively improve the flexibility of the PTLG terpolymer stent and the 3D printed PTLG terpolymer-based stent. Furthermore, CCK-8 and live/dead staining suggested that the stents have good biocompatibility.
研究领域:
生物医学工程
·
材料科学
·
聚合物化学
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产品关联
DOI
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2023
·
IF 2.9
Sili Zheng,Dongning Zhang,Bailu Duan,Guoyan Mo,Jingjing Li,Hailing Huang,Shanshan Wang,Yan Ye,Zhuang Huang,Ping Huang,Fengyun Zhang,Fang Huang,Lintao Han
Acute enteritis (AE) is a type of digestive disease caused by biochemical factors that irritate the intestinal tract or pathogenic bacteria that infect it. In China, Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) have been applied against diarrhea caused by AE and bacillary dysentery for many years, but the underlying mechanisms of their beneficial effects are not known. In the present study, network pharmacology and metabolomics were performed to clarify the active ingredients of MMRAC and explore the specific mechanism of MMRAC on AE mice. A total of 43 active components of MMRAC with 87 anti-AE target genes were identified, and these target genes were enriched in IL-17 and HIF-1 signaling pathways. Integration analysis revealed that purine metabolism was the critical metabolic pathway by which MMRAC exerted its therapeutic effect against AE. Specifically, MAPK14, MMP9, PTGS2, HIF1A, EGLN1, NOS2 were the pivotal targets of MMRAC for the treatment of AE, and Western blot analysis revealed MMRAC to decrease protein levels of these pro-inflammatory signaling molecules. According to molecular docking, these key targets have a strong affinity with the MMRAC compounds. Collectively, MMRAC relieved the colon inflammation of AE mice via regulating inflammatory signaling pathways to reduce hypoxia and improved energy metabolism.
研究领域:
药理学
·
代谢组学
·
炎症
·
胃肠病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2023
·
IF 4.6
Yingchia Hung,Wangkai Xiang,Zongjun Zou,Yuanhua Zhang,Bao Wang,Chengtao Yu,Ying Zheng,Pengju Pan
Minor comonomer units can enter the crystalline phase of isodimorphic copolymers as defects, and affect their chain conformation and packing. However, the effects of minor comonomer inclusion on the crystalline structure and crystal transitions of aliphatic copolycarbonates are still unclear. Herein, we synthesized the poly(octamethylene- ran -decamethylene carbonate) with various compositions and systematically studied their crystallization behavior and crystal transitions upon cooling and heating. The random copolycarbonates exhibit isodimorphic crystallization behavior, showing the pseudo-eutectic region at octamethylene carbonate fraction ( f C8 ) of 0.64–0.79. The octamethylene carbonate (C8)-rich copolycarbonates ( f C8 ≥ 0.79) show reversible solid-solid crystal transitions as poly(octamethylene carbonate) (PC8) homopolymer upon cooling and heating, which are temperature- and composition-dependent. With f C8 decreasing, the δ-α transition is observed at a high temperature with more inclusion of comonomer defects, and the crystals are conformational disordered with development of more gauche conformation in methylene segments at a low temperature when compared to PC8 homopolymer. At a high temperature, the chain conformation in methylene segments of C8-rich copolycarbonates are analogous as that of PC8 homopolymer, thus the α-β transition temperature remains unchanged.
研究领域:
材料科学
·
高分子化学
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产品关联
DOI
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 68
·39631-39639
·
IF 3.049
Jie Wang,Zixin Yu,Peihua Li,Dachuan Ding,Xuan Zheng,Chuanqun Hu,Tao Hu,Xinghou Gong,Ying Chang,Chonggang Wu
A poly(styrene-ran-cinnamic acid) (SCA) containing 6.8 mol% of CA, with a w (∼217 000) comparable to commercial polystyrene (PS), was successfully synthesised via emulsion free-radical copolymerisation as evidenced by 1744 and 1703 cm−1 infrared peak occurrences, respectively characteristic of free and dimeric carboxyl CO stretches. Upon the interchain hydrogen bond cross-linking by CA, the impact toughness of the SCA was considerably improved by 47.2% against PS, the glass transition, heat deflection and Vicat softening temperatures were significantly enhanced until 117.0, 108.0 and 118.3 °C, respectively, compared with PS (95.2, 87.6 and 96.0 °C), while the extensional viscosities were near one order-of-magnitude higher than PS by which the temperature window required for appropriate melt-strengths would be greatly broadened. Meanwhile, the SCA displayed other properties basically analogous to PS. This work presents a modified PS, SCA, with enhanced toughness, heat resistance and melt strength that potentially extend its styrofoam and commodity applications.
研究领域:
材料科学
·
高分子化学
·
工程学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）