ADVANCED MATERIALS
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2023
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IF 29.4
Xiangping Song,Qiong Huang,Yuqi Yang,Liang Ma,Wenguang Liu,Chunlin Ou,Qiaohui Chen,Tianjiao Zhao,Zuoxiu Xiao,Mingyuan Wang,Yitian Jiang,Yunrong Yang,Jinping Zhang,Yang Xiao,Yayun Nan,Wei Wu,Kelong Ai
Non-invasive localization of lesions and specific targeted therapy are still the main challenges for inflammatory bowel disease (IBD). Ta, as a medical metal element, has been widely used in the treatment of different diseases because of its excellent physicochemical properties, but is still far from being explored in IBD. Here, Ta 2 C modified with chondroitin sulfate (CS) (TACS) was evaluated as a highly targeted therapy nanomedicine for IBD. Specifically, TACS was modified with dual targeting CS functions due to IBD lesion-specific positive charges and high expression of CD44 receptor. Thanks to the acid stability, sensitive CT imaging function and strong ROS elimination ability, oral TACS can accurately locate and delineate IBD lesions through non-invasive CT imaging, and specifically targeted treat IBD effectively because high levels of ROS are a central factor in the progression of IBD. As expected, TACS has much better imaging and therapeutic effects than clinical CT contrast agent and first-line drug 5-aminosalicylic acid, respectively. The mechanism of TACS treatment mainly involves protection of mitochondria, elimination of oxidative stress, inhibiting macrophage M1 polarization, protection of intestinal barrier, and restoration of intestinal flora balance. Collectively, this work provides unprecedented opportunities for oral nanomedicines to targeted therapy of IBD. This article is protected by copyright. All rights reserved
研究领域:
药理学
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纳米技术
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医学成像
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胃肠病学
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治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2022
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IF 14.224
Song Meng,Zhihao Yao,Jiawei Liu,Erjing Wang,Cao Li,Bingbing Jiang,Ziqiang Xu
Since the excess exposure to F - may induce serious issues to human health, the effective adsorption and sensitive detection of F - is essential. Therefore, carbon dots (CDs) capped CeO 2 (CeO 2 @CDs) was synthesized via hydrothermal treatment of tannic acid and CeCl 3 . Due to abundant phenolic hydroxyl are reserved and excellent hydrophilicity, CeO 2 @CDs possess high F - adsorption capacity. The partition coefficient parameters (PC) are determined to be 2.65 L/g, which is comparable with previous work. The kinetics results and adsorption isotherm are consistent with pseudo-second-order model and Freundlich model, respectively, indicating the chemisorption dominate the adsorption, mainly via the ion exchange between hydroxyl and F - . Since phenolic hydroxyl existed on the CeO 2 @CDs, synergetic effect of CDs and CeO 2 contribute to superior ROS eliminating capacity, even at acidic conditions. Moreover, due to the ROS scavenging of CeO 2 @CDs abilities can be potentiated by F - , colorimetric detection of F - can be realized via horseradish peroxidase as an indicator. The linear range is 0.3–2.1 mM with limit of detection is 0.13 mg/L. The current results imply that CeO 2 @CDs possess potential in both efficient removal and sensitive detection of F - related contamination issues and elucidation of development to address other anions related issues.
研究领域:
环境科学
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纳米技术
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分析化学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
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2023
·Vol. 13
·期 24
·16211-16221
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IF 3.9
Chunxiao Wang,Ruifu Zhao,Zhen Wang,Tingting Xu,Peng Huang
Atherosclerosis (AS), a chronic inflammatory disease, is the leading cause of death worldwide. Anti-oxidative therapy has been developed for AS therapy in light of the critical role of ROS in pathogenesis of AS, but current anti-oxidants have exhibited limited outcomes in the clinic. Herein, new ROS-eliminating liposome-like NPs (Tempol-Lips) were assembled from synthetic lipids that covalently conjugated two Tempol molecules with phosphatidylcholine by esterification reaction. The obtained Tempol-Lips can be efficiently internalized into inflammatory macrophages and attenuated inflammation via scavenging overproduced intracellular ROS. After i.v. administration, Tempol-Lips with nanoscale character accumulated in the plaques of ApoE−/− mice through passive targeting and significantly inhibited the pathogenesis of AS, compared with those treated with control drugs. The therapeutic benefits of Tempol-Lips primarily are ascribed to the reduced local and systematic oxidative stress and inflammation. Preliminary studies in vivo further demonstrated Tempol-Lips were safe and biocompatible after long-term i.v. injection. Conclusively, Tempol-Lips can be developed as a novel anti-AS nanotherapy with potential translation in the clinic.
研究领域:
心血管疾病
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纳米医学
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药学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2023
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IF 13.3
Xiaotong Chen,Lianying Zhang,Haifeng Zeng,Wei Meng,Guijiang Liu,Wenhua Zhang,Pei Zhao,Qun Zhang,Ming Chen,Jinxiang Chen
Rheumatoid arthritis (RA) is a chronic autoimmune disease commonly associated with the accumulation of hyperactive immune cells (HICs), particularly macrophages of pro-inflammatory (M1) phenotype, accompanied by the elevated level of reactive oxygen species (ROS), decreased pH and O 2 content in joint synovium. In this work, an immunomodulatory nanosystem (IMN) is developed for RA therapy by modulating and restoring the function of HICs in inflamed tissues. Manganese tetraoxide nanoparticles (Mn 3 O 4 ) nanoparticles anchored on UiO-66-NH 2 are designed, and then the hybrid is coated with Mn-EGCG film, further wrapped with HA to obtain the final nanocomposite of UiO-66-NH 2 @Mn 3 O 4 /Mn-EGCG@HA (termed as UMnEH). When UMnEH diffuses to the inflammatory site of RA synovium, the stimulation of microwave (MW) irradiation and low pH trigger the slow dissociation of Mn-EGCG film. Then the endogenously overexpressed hydrogen peroxide (H 2 O 2 ) disintegrates the exposed Mn 3 O 4 NPs to promote ROS scavenging and O 2 generation. Assisted by MW irradiation, the elevated O 2 content in the RA microenvironment down-regulates the expression of hypoxia-inducible factor-1α (HIF-1α). Coupled with the clearance of ROS, it promotes the re-polarization of M1 phenotype macrophages into anti-inflammatory (M2) phenotype macrophages. Therefore, the multifunctional UMnEH nanoplatform, as the IMN, exhibits a promising potential to modulate and restore the function of HICs and has an exciting prospect in the treatment of RA.
研究领域:
纳米技术
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免疫学
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风湿病学
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治疗学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Tissue Engineering and Regenerative Medicine
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2023
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IF 3.6
Ye Yuanjian,Zhong Haobo,Huang Shoubin,Lai Weiqiang,Huang Yizhi,Sun Chunhan,Zhang Yanling,Zheng Shaowei
Background: Implantation of bone marrow mesenchymal stem cells (BMSCs) is a potential alternative for promoting bone defects healing or osseointegration in osteoporosis. However, the reactive oxygen species (ROS) accumulated and excessive inflammation in the osteoporotic microenvironment could weaken the self-replication and multi-directional differentiation of transplanted BMSCs. Methods: In this study, to improve the hostile microenvironment in osteoporosis, Poloxamer 407 and hyaluronic acid (HA) was crosslinked to synthetize a thermos-responsive and injectable hydrogel to load MnO 2 nanoparticles as a protective carrier (MnO 2 @Pol/HA hydrogel) for delivering BMSCs. Results: The resulting MnO 2 @Pol/HA hydrogel processed excellent biocompatibility and durable retention time, and can eliminate accumulated ROS effectively, thereby protecting BMSCs from ROS-mediated inhibition of cell viability, including survival, proliferation, and osteogenic differentiation. In osteoporotic bone defects, implanting of this BMSCs incorporated MnO 2 @Pol/HA hydrogel significantly eliminated ROS level in bone marrow and bone tissue, induced macrophages polarization from M1 to M2 phenotype, decreased the expression of pro-inflammatory cytokines (e.g . , TNF-α, IL-1β, and IL-6) and osteogenic related factors (e.g., TGF-β and PDGF). Conclusion: This hydrogel-based BMSCs protected delivery strategy indicated better bone repair effect than BMSCs delivering or MnO 2 @Pol/HA hydrogel implantation singly, which providing a potential alternative strategy for enhancing osteoporotic bone defects healing.
研究领域:
生物医学工程
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组织工程
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再生医学
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纳米技术
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骨科
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干细胞研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）