Journal of Materials Chemistry B
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2024
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IF 6.1
Wan-Chun Luo,Li-N Bao,Yu Zhang,Zi-Tong Zhang,xi li,Mengmeng Pan,Jingtao Zhang,Kun Huang,Yu Xu,Li Xu
Alzheimer’s Disease (AD) heavily impacts human lives, and is becoming serious with the aging society. Inhibiting and disaggregating β-amyloid aggregates is a possible solution for AD therapy. In this study, a novel type of nanozymes based on Ru3+ chelated nanoscale metal organic frameworks (Ru3+-NMOFs), displaying strong peroxidase-like activity, was proposed as an inhibitor and disaggregater for β-amyloid aggregates. As a high concentration of hydrogen peroxide was present at the sites of β-amyloid aggregates, Ru3+-NMOFs could catalyze hydrogen peroxide to hydroxyl radicals. Thus, hydroxyl radical would attack the β-amyloid chain for oxidation, enhancing its hydrophilicity, and resulting in a decreased hydrophobic interaction and reduced aggregation degree. Ru3+-NMOFs behaved effective in inhibiting as well as disaggregating β-amyloid fibrils both in vitro and in vivo. Additionally, the reduction of β-amyloid aggregates and the attenuation of reactive oxygen species transfer led to lower levels of inflammatory factors, which would be beneficial in alleviating AD symptom. In a typical application, Ru3+-NMOFs could mitigate the paralysis of C. elegans CL2120 and increase survival rates. This study opens a new avenue for MOFs based nanozymes as a potential treatment agent for AD therapy.
研究领域:
神经科学
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生物技术
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纳米技术
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药理学
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DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
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2022
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IF 12.545
Nannan Wu,Hong Zhong,Yu Zhang,Xiaoqian Wei,Lei Jiao,Zhichao Wu,Jiajia Huang,Hengjia Wang,Scott P. Beckman,Wenling Gu,Chengzhou Zhu
Rational design and construction of electrochemical sensing platforms with high sensitivity and selectivity is one of the challenges in practical application. Although single-atom catalysts (SACs) have attracted extensive attention, atomically dispersed metal catalysts (ADCs) with multi-atom sites can further compensate for the deficiencies of SACs, which have gradually been a research hotspot in recent years. Herein, atomically dispersed Ru 3 site catalyst (Ru 3 /NC) is employed to catalyze small biomolecule oxidation , which exhibits much superior electrocatalytic ability of uric acid (UA) to Ru single-atom catalyst (Ru 1 /NC). What's more, theoretical calculations reveal that the enhanced performance is mainly derived from the dominant electronic structure of ADCs with multi-atom sites compared to SACs, leading to the more favorable adsorption of hydroxy anion groups, which can serve as one part of the active moiety and “promoter” to achieve the fast oxidation of small biomolecules. Our findings provide a new paradigm for designing promising catalysts to realize highly sensitive and selective small biomolecule detection and explore the catalytic mechanisms of small biomolecules at the atomic scale.
研究领域:
电化学
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催化
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材料科学
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分析化学
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生物分子传感
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DOI
PubMed
高影响因子
RSC Advances
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2018
·Vol. 8
·期 45
·25802-25807
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IF 2.936
Jinyu Gu,Gangbin Yan,Yuebin Lian,Qiaoqiao Mu,Huidong Jin,Zaichao Zhang,Zhao Deng,Yang Peng
Inorganic defect halide compounds such as Cs3Bi2I9 have been regarded as promising alternatives to overcome the instability and toxicity issues of conventional perovskite solar cells. However, their wide indirect bandgaps and deep defect states severely limit their photoelectronic conversion efficiency when implemented in devices. Trivalent cation substitution has been proposed by previous calculations allowing the engineering of their band structures, but experimental evidences are still lacking. Herein we use the trivalent cation Ru3+ to partially replace Bi3+ in Cs3Bi2I9, and reveal their structural and optoelectronic properties, as well as the environmental stability. The Ru-doped Cs3Bi2I9 shows a decreasing bandgap with the increasing doping levels and an overall up-shift of band structure, owing to the dopant-induced defect states and thus enhanced phonon–electron coupling. As a result, upon Ru3+ doping, the narrowed bandgap and the upward shift of the band structures might facilitate and broaden their applications in optoelectronic devices.
研究领域:
材料科学
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能源科学
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光电子学
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DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2026
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IF 3.9
Zhangxinyu Fan,Yiheng Cui,Weixiang Wang,Yi Sun,Liqian Lin,Xinxin Geng,Guo Tian,Qin Zhong,Boyang Liu
Abstract Global warming has spurred interest in CO2 utilization. Coupling reverse water–gas shift (RWGS) with hydroformylation allows olefins to react with H2/CO2 to produce valuable aldehydes, which is a profitable reaction and helps with carbon fixation. However, temperature mismatch between the two reactions and limited mechanistic understanding hinder the rational design of catalysts. Using density functional theory (DFT) calculations and experimental evaluations, we investigated the effects of different phosphine ligands and acid additives on the performance of silane-free CO2 hydroformylation. Formic acid alters the CO2 activation pathway and reduces the energy barrier, thereby improving catalytic activity and chemoselectivity. The effects of reaction conditions reveal a competitive relationship between CO2 reduction and olefin carbonylation, suggesting that balancing RWGS and hydroformylation rates enhances catalytic performance. Our work not only deepens the mechanism understanding of silane-free CO2 hydroformylation but also paves the way for the rational design of subsequent high-performance catalysts.
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2026
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IF 8.2
Zhe Liu,Yuanye Gao,Xuhui Guo,Siwei Li
The scaling up of proton exchange membrane (PEM) electrolyzers for green hydrogen requires proactive environmental risk assessment of catalyst materials. Ruthenium (Ru)-based catalysts are increasingly favored over iridium (Ir) due to cost advantages. However, their tendency to dissolve and release Ru3+ ions under operational conditions poses a potential but unexplored ecological threat. This study demonstrates that Ru3+ exhibits significantly higher acute toxicity than Ir3+ in zebrafish, with a 48 hpf LC50 of 55.3 mg/L. Transcriptomic analysis revealed 4,619 differentially expressed genes, predominantly enriched in neurodevelopmental and immunotoxic pathways, leading to reduced hatching, immune dysregulation, and locomotor defects. Molecular docking identified key protein targets (CASP3, DLG4, GRIN2B, and GSTO1) underlying the toxicity. These findings establish a preemptive safety benchmark for Ru3+ and underscore the necessity of incorporating ecotoxicological considerations into the sustainable design of PEM electrocatalysts. We advocate for an expanded ASC-E (Activity, Stability, Cost, Environment) paradigm that integrates environmental biosafety as a core metric.
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PubMed
高影响因子
Surfaces and Interfaces
·
2024
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IF 5.7
Liming Zeng,Yongyang Zhu,Daifeng Wu,Dongxing Wang,Qing Zhou
The hydrogen evolution reaction (HER) in alkaline medium is much sluggish than that in acidic medium due to the limited water dissociation step, thus accelerating the water dissociation kinetics is critical. Herein, we designed a MoO x species-modified ruthenium nanoparticle catalyst (MoO x /Ru/C-3) based on the unique electrostatic interaction between carboxymethylcellulose sodium salt (CMC) and metal ions , where an heterophase structure is formed between MoO x and Ru. The obvious electronic interaction between them allows the formation of synergistic promotion relationship involving the water dissociation on MoO x and the adsorbed hydrogen recombination on Ru. At a metal loading of 6.98 μg Ru cm-2 geo, the overpotential of 82 mV is just required to reach a current density of 10 mA cm −2 , exhibiting a significantly better apparent electrochemical activity than Ru/C (98 mV) without introduction of MoO x , which demonstrates superior or comparable alkaline HER activity to the recently reported Ru-based electrocatalysts . Meanwhile, the overpotential for Ru/C increased by 113 mV after 24 h of chronopotentiometric test, whereas only 61 mV elevates for MoO x /Ru/C-3, and even just 98 mV generates after 120 h. Thereof, introduction of MoO x species into Ru matrix can also markedly improve the electrochemical stability. The proposed material construction strategy in this study provides a feasible idea for the rational design of highly cost-performance alkaline hydrogen evolution catalysts.
研究领域:
材料科学
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电化学
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DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2025
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IF 4.7
Yu-Xuan Wang,Shuo-Chen Ni,Xing Li,Xunwen Xiao,Jin-Peng Xue
Precise structural engineering of coordination polymers through rational selection of metal centers and organic ligands is essential for tuning their architectures and properties. Here, three new coordination polymers, [Zn 2 (L1) 2 (L2) 2 ·1DMF] n ( 1 ), [Cd 2 (L1) 2 (L2) 2 ] n ( 2 ), and [Cd 2 (L1) 2 (L3) 3 ] n ( 3 ) (L1 = 4,4′-(anthracene-9,10-diyl)-dibenzoic acid, L2 = 1,4-bis(4-pyridyl)naphthalene, L3 = 9,10-bis(4-pyridyl)anthracene, DMF = N,N -dimethylformamide), were synthesized via solvothermal methods. Single-crystal X-ray diffraction shows that 1 and 2 are isostructural 3-fold interpenetrated frameworks with minor differences induced by the metal centers. The use of the bulkier ligand L3 in compound 3 yields a distinct 3-fold interpenetrated framework structurally related to those of 1 and 2 , stabilized by uncoordinated pyridyl groups through N–H···π interactions, but distinguished by half of the L 3 ligands featuring uncoordinated pyridyl groups that engage in N–H···π interactions to stabilize the structure. Notably, compound 2 exhibits the selectivity and sensitivity for fluorescence turn-off detection of Ru 3+ ions in water, with a detection limit of 3.44 μM. These results demonstrate that both subtle and significant framework modifications can be achieved through stepwise metal and ligand design, providing guidance for developing metal-organic frameworks with optimized ion sensing properties.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
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IF 13.273
Qinxue Yang,Ying Yan,Xiaofang Yang,Guiying Liao,Jie He,Dongsheng Wang
The possible effect of complexation of tetracycline (TC) with metal ions on the degradation of TC by homogeneous activated peroxymonosulfate (PMS) was investigated. The oxidation kinetics of TC indicated the differences in PMS activation ability by Fe 2+/3+ and Ru 3+ . Fe 2+/3+ could activate PMS to generate HO• and SO 4 - • as is known, while Ru 3+ promoted the generation of 1 O 2 from PMS, though 1 O 2 may be not the only and dominant oxidant. The stronger complex ability of Ru 3+ and Fe 3+ with TC than Fe 2+ contributed to the enhanced oxidation of TC in Fe 3+ /PMS and Ru 3+ /PMS systems. The complexation facilitated TC degradation possibly due to the electron reconfiguration of metal ions and TC, such as reduce the stability of -C–C- double bands in TC structures and made it more vulnerable. The complexation reactions were commonly occurred but ignored in metal species activated PMS systems, the findings in this study suggested that the interaction between metal ions and organic contaminants should be reconsidered and utilized in the development of AOPs.
研究领域:
环境科学
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化学工程
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产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2024
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IF 6.1
Xuwen Da,Yunli Xu,Lei Wang,Xiulian Liu,Yatong Peng,Yao Wu,Wanpeng Zhou,Wentao Wang,Xuesong Wang,Qian-Xiong Zhou
Traditional photodynamic therapy (PDT) is almost ineffective against deeply seated tumors due to the limited penetration depth of external light. The development of chemiexcited PDT is promising to address this issue, but it is still challenging to construct simple, efficient and targeted chemiexcited PDT systems. In this work, CPPO (bio(3,5,6-trichloro-2-n-pentyloxycarbonylphenyl) oxalate) and [Ru(phen)2(PIP-OCH3)](PF6)2 (Ru3, where phen = 1,10-phenanthroline, PIP-OCH3 = 2-(4-methoxy phenyl)-1Himidazo[4,5-f][1,10]phenanthroline) with efficient photo-catalytic NADH oxidation were co-encapsulated with DSPE-PEG 2000 to form Ru3/CPPO@PEG nanoparticles (NP3). Once internalized by cancer cells, Ru3 can be excited by the chemical energy produced by the reaction between CPPO and endogenous H2O2. The subsequent oxidation of intracellular NADH and generation of H2O2 in situ by excited Ru3 will further promote the sustained occurrence of chemical reaction, realizing a self-enhanced chemiexcited PDT. NP3 could effectively deplete intracellular NADH, inhibit ATP synthesis, increase H2O2 content, and produce reactive oxygen species (ROS) within cancer cells, thus exhibited efficient chemiexcited PDT activity against various cancer cells. Notably, minimal cytotoxicity was observed towards normal cells. Good therapeutic effects against subcutaneously implanted and lung metastatic tumors were also observed for NP3. The current findings may provide new sights for development of novel chemiexcited PDT.
研究领域:
光动力疗法
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癌症研究
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纳米技术
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生物化学
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药学
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产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 11
·2544-2556
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IF 7.779
Xuwen Da,Zhanhua Wang,Yao Jian,Chao Zhang,Yuanjun Hou,Yishan Yao,Xuesong Wang,Qianxiong Zhou
The bottleneck problems of chemodynamic therapy (CDT) are the dependence on an acidic pH (2.0–4.0), insufficient H2O2 level in tumor tissues, and potential systematic toxicity of inorganic nanomaterials-based CDT agents. In this study, the new tricks of two old compounds, i.e. [Ru(phen)2(PIP-OCH3)](PF6)2 (Ru3, phen = 1,10-phenanthroline, PIP-OCH3 = 2-(4-methoxy phenyl)-1H-imidazo[4,5-f][1,10]phenanthroline) and Fe(tpy)Cl3 (tpy = 2,2′:6′,2′-terpyridine), were harnessed to construct an ideal CDT system. Ru3 was able to efficiently photo-catalyze NADH oxidation accompanied by the production of H2O2in situ with a high yield of 73.2%, which can be converted into cytotoxic hydroxyl radicals by the biocompatible Fe(tpy)Cl3 at a neutral pH. By loading both Ru3 and Fe(tpy)Cl3 in tumor-targeting bovine serum albumin (BSA), the obtained BSA@Fe/Ru nanoparticles exhibited a highly efficient, selective, and photo-controlled CDT activity both in vitro and in vivo. This work may provide new sights for overcoming the issues confronted in CDT.
研究领域:
纳米技术
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癌症治疗
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光催化
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生物医学工程
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产品关联
DOI
高影响因子
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