MOLECULAR NEUROBIOLOGY
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2022
·Vol. 59
·期 11
·6903-6917
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IF 5.682
Zhao Maofang,Cheng Yuan,Wang Xiaoxuan,Cui Xiaoying,Cheng Xiaojing,Fu Qian,Song Yilin,Yu Peiquan,Liu Yi,Yu Yinghua
Obesity has become a public health epidemic worldwide and is associated with many diseases with high mortality including hypertension, diabetes, and heart disease. High-fat diet (HFD)-induced energy imbalance is one of the primary causes of obesity, but the underlying mechanisms are not fully elucidated. Our study showed that HFD reduced the level of hydrogen sulfide (H 2 S) and its catalytic enzyme cystathionine β-synthase (CBS) in mouse hypothalamus and plasma. We found that HFD activated mTOR, IKK/NF-κB, the main pathway regulating inflammation. Activation of inflammatory pathway promoted the production of pro-inflammatory cytokines including IL-6, IL-1β, and TNF-α, which caused cell damage and loss in the hypothalamus. The disturbance of the hypothalamic neuron circuits resulted in body weight gain in HFD-induced mice. Importantly, we also showed that restoration of H 2 S level with NaHS or activation of CBS with SAMe attenuated HFD-induced activation of mTOR, IKK/NF-κB signaling, which reduced the inflammation and the neuronal cell loss in the hypothalamus, and also inhibited body weight gain in mice. The same effects were obtained by inhibiting mTOR or NF-κB, which suggested that mTOR and NF-κB were the critical molecular factors involved in hypothalamic inflammation. Taken together, this study identified that HFD-induced hypothalamus inflammation plays a critical role in the development of obesity. Moreover, the inhibition of hypothalamic inflammation by regaining H 2 S level could be a potential therapeutic to prevent the development of obesity. Graphical abstract
研究领域:
营养学
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内分泌学
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免疫学
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分子生物学
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DOI
PubMed
高影响因子
Polymer Chemistry
·
2016
·Vol. 7
·期 33
·5312-5321
·
IF 5.687
Xiao Wang,Yuan Gao,Wenjie Wang,Anjun Qin,Jing Zhi Sun,Ben Zhong Tang
A series of poly(diphenyl substituted acetylenes) (PDSAs) were prepared through a post-polymerization modification strategy. Primary amine, tertiary amine and quaternized ammonium functionalities were successfully and efficiently attached onto the skeleton of poly(1,2-diphenylacetylene) via the precursor PDSA (P0) with activated ester moieties. The structures of the derived amine-functionalized PDSAs, the modification processes and the efficiency of the post-polymerization modification were characterized by multiple spectroscopic techniques. With the aid of the protection and de-protection of tert-butyloxyl carbonyl (P1), PDSA bearing terminal primary amine groups (P2) were obtained. The plentiful amine groups on the side-chains helped in grafting P2 onto graphene oxide (GO) and the resultant hybrids not only showed a greatly improved dispersing ability in organic solvents, but also emitted strong yellow-greenish fluorescence. The polymer bearing tertiary amine functionalities on side chains (P3) could be directly derived from reacting P0 with 3-N,N′-dimethyl-1-propylamine under mild conditions and in high yield. P3 showed evident pH-dependent fluorescence emission behaviour. Based on P3, cationic PDSA P4 was readily obtained by the transition of tertiary amine to quaternized ammonium functionalities. This transition afforded a novel fluorescent and polyelectrolytic PDSA. P4 was tried as a water soluble fluorescent probe in calf thymus DNA (ct-DNA) detection. The experimental data indicated that P4 at a low concentration of 0.1 ppm can respond to the existence of 10−11 g L−1ct-DNA in aqueous solution. The working mechanism was associated with the aggregation-induced emission enhancement. The present work, together with our previous reports, suggests that the PDSA with an activated ester precursor can be employed as a broad platform to construct different functional PDSAs.
研究领域:
高分子化学
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材料科学
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生物医学
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产品关联
DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Chao Li,Dianqiang Li,Yuchen Jiang,Lijun Zhang,Yong Huang,Bin Li,Shuang Wang,Xun Hu
CO 2 and H 2 O are commonly used oxidants for activation of carbonaceous feedstock, which are also major products in biomass pyrolysis. The heated CO 2 and H 2 O from pyrolysis might be used directly to activate biochar without cooling down. This was investigated in a reactor with dual fixed beds with biochar on the bottom and biomass feedstock (poplar sawdust, cellulose, or lignin) of the same origin on top. The CO 2 and H 2 O together with the volatiles generated at 700 °C from the top bed passed through the lower-bed biochar for activation. The results indicated that, except for CO 2 and H 2 O, the volatiles from pyrolysis of upper-bed biomass were highly reactive with the lower-bed biochar, especially for the cellulose-derived aliphatic volatiles. This formed carbonaceous deposit and enhanced the yield of biochar at expense of the volatiles (i.e. aldehydes/ketones and heavy organics of large π-conjugated structures), leading to lower yields of bio-oil. The carbonaceous deposit formed via cracking and/or polymerization filled the pores and substantially decreased the surface specific area by 99.9 % for sawdust-biochar, 87.4 % for cellulose-biochar, and 33.1 % for lignin-biochar. The volatile-char interaction, instead of the activation with CO 2 and H 2 O, dominated the pore development of biochar. Additionally, the interaction of volatiles with biochar enhanced deoxygenation, producing the carbon-rich biochar of higher heating value and energy yield.
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2022
·
IF 7.968
Mengjiao Fan,Chao Li,Yuewen Shao,Kai Sun,Lijun Zhang,Shu Zhang,Kuan Ding,Mortaza Gholizadeh,Xun Hu
In pyrolysis , the formed biochar is not an inert material as it could interact with of varied volatiles via distinct ways, modifying the composition of bio-oil and its own property. In this study, the pyrolysis of biomass with the biochar of the exactly same origin was conducted at 500 ºC with cellulose, lignin and poplar sawdust as the research objects, aiming to probe the potential involvement of biochar in pyrolysis. It has been demonstrated that, independent of feedstock, the presence of biochar decreased yields of newly formed biochar (41.0 % decrease for cellulose while 22.3 % for sawdust) via suppressing secondary condensation of volatiles. However, the biochar catalyst aided to form more bio-oil and gas via catalyzing the secondary cracking reactions such as decarboxylation and dehydrogenation reactions. In addition, during the volatile-char interaction, deposition of oxygen-containing species on surface of biochar was observed, which influenced the thermal stability, hydrophilicity, the crystallinity and regularity of the spatial arrangement of carbon crystals of the resulting biochar. The results from in-situ characterization showed that the biochar catalyst interfered with the dehydrogenation of the C-H, the dehydration of -OH and formation of the reaction intermediates with C O.
研究领域:
化学工程
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环境科学
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材料科学
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产品关联
DOI
高影响因子
TENSIDE SURFACTANTS DETERGENTS
·
2025
·
IF 1.2
Xuejiao Song,Zexiang Bi,Zimeng Wei,Xu Li,Jinxiang Dong
The branching of the hydrophobic tail has a significant impact on the performance of branched-chain surfactants, while the influence of hydrophilic headgroups on the surface properties of branched-chain anionic surfactants is rarely reported. In this work, three branched-chain anionic surfactants with the same carbon number and hydrophobic tail architecture but different hydrophilic groups, C 8 sodium branched-chain alkylsulfonate (C 8 SBCAS), C 8 sodium branched-chain alkylphosphonate (C 8 SBCAP), C 8 sodium Guerbet alcohol sulfate (C 8 SGAS) with sulfonate, phosphonate and sulfate groups, respectively, were synthesized. Their surfactant properties, including equilibrium surface tension, dynamic surface tension, wetting ability and foaming property, were thoroughly investigated. The order of the critical micelle concentration ( CMC ) is C 8 SGAS < C 8 SBCAP < C 8 SBCAS, and the equilibrium surface tension ( γ CMC ) follows the order C 8 SBCAP < C 8 SBCAS < C 8 SGAS. These results indicated that increasing the polarity of the hydrophilic headgroups and weakening the charge effect could reduce the hydrophobicity of surfactants, thereby improving their wetting ability and foaming properties. This study provides new insights into the influence of hydrophilic headgroups on the properties of branched-chain anionic surfactants to meet the specific needs of different sectors.
研究领域:
化学
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材料科学
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表面科学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Chang Liu,Jianguo Dong,Zedong Zhang,Kexin Fu,Dekun Wang,Xue Mi,Shijing Yue,Xiaoyue Tan,Yuying Zhang
The physicochemical properties of nanoparticles (NPs) significantly influence their deposition at the disease site, ultimately impacting the overall therapeutic efficacy; however, precisely assessing the effects of various factors on NP accumulation within a single cell/tumor tissue is challenging due to the lack of appropriate labeling techniques. Surface-enhanced Raman spectroscopy (SERS) tag is a powerful encoding method that has recently been intensively employed for immunodetection of biomarkers. Herein, we introduce a multiplexed SERS tracking approach for systematic investigation of size-dependent accumulation and distribution of NPs within the same tumor. Four-sized (34, 60, 108, and 147 nm) NPs encoded with different SERS “colors” were fabricated, mixed, and incubated with monolayer tumor cells, multicellular tumor spheroids, or injected into mouse models bearing xenograft solid tumors in a single dose. Multicolor SERS detection of the specimens revealed that NP accumulation in tumor cells, tumor spheroids, and solid tumors was in the order of 34 nm > 60 nm > 108 nm > 147 nm, 60 nm > 34 nm > 108 nm > 147 nm, and 34 nm > 147 nm > 108 nm > 60 nm, respectively. Inductively coupled plasma mass spectroscopy determination performed in parallel samples were in alignment with the four-color SERS probing results, demonstrating the effectiveness of this multiplexed evaluation assay. Furthermore, in combination with fluorescence labeling of specific biomolecules, this method can be applied for the colocalization of different NPs in various pathological structures and provide additional information for analysis of the possible mechanisms.
研究领域:
生物医学工程
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纳米技术
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癌症研究
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分子生物学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2024
·
IF 5.3
Mengwei Wang,Olivia Aalling-Frederiksen,Anders Ø. Madsen,Kirsten M.Ø. Jensen,Mads R.V. Jørgensen,Junbo Gong,Thomas Rades,Inês C.B. Martins
The influence of different preparation methods on the physicochemical properties of amorphous solid forms have gained considerable attention, especially with recent publications on pharmaceutical poly a morphism. In the present study, we have investigated the possible occurrence of poly a morphism in the drug celecoxib (CEL) by investigating the thermal behavior, morphology, structure, molecular mobility and physical stability of amorphous CEL obtained by quench-cooling (QC), ball milling (BM) and spray drying (SD). Similar glass transition temperatures but different recrystallization behaviors were observed for CEL-QC, CEL-BM and CEL-SD using modulated differential scanning calorimetry analysis. A correlation between the different recrystallization behaviors of the three CEL amorphous forms and the respective distinct powder morphologies, was also found. Molecular dynamics simulations however, reveal that CEL presents similar molecular conformational distributions when subjected to QC and SD. Moreover, the obtained molecular conformational distributions of CEL are different from the ones found in its crystal structure and also from the ones found in the lowest-energy structure obtained by quantum mechanical calculations. The type and strength of CEL hydrogen bond interactions found in CEL-QC and CEL-SD systems are almost identical, though different from the ones presented in the crystal structure. Pair distribution function analyses and isothermal microcalorimetry show similar local structures and structural relaxation times, respectively, for CEL-QC, CEL-BM and CEL-SD. The present work shows that not only similar physicochemical properties (glass transition temperature, and structural relaxation time), but also similar molecular conformational distributions were observed for all prepared CEL amorphous systems. Hence, despite their different recrystallization behaviors, the three amorphous forms of CEL did not show any signs of poly a morphism.
研究领域:
药剂学
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材料科学
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DOI
PubMed
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2021
·Vol. 99
·期 1
·169-177
·
IF 2.326
Cheng Ming,Liu Wensheng,Yao Shuwei,Wang Juan,Ma Yunzhu
Phase transformation is essentially important for the microstructures and properties of sol–gel prepared alumina fiber and powders. In this study, alumina precursor fiber and xerogels were prepared using the same aluminum carboxylate sol. The phase transformation and microstructure evolution of the precursor fibers and xerogels were investigated using TG-DSC, XRD, TEM, and SEM methods. The alumina precursor fiber and xerogels have similar chemical structures and Al(III) species. After preheated at 600 °C, most of the free water molecules, hydroxyl groups, nitrate acid radical, formic acid radicals, and acetic acid radicals are removed from the alumina precursor fiber and xerogels. The preheated fiber and xerogels exhibit amorphous phases. From the TG-DSC curves, the transformation temperature from γ-Al 2 O 3 to α-Al 2 O 3 in the preheated fiber is 30 °C lower than that in the preheated xerogels. The TEM results suggest that the fiber calcined at 1000 °C for 1 h can be completely transformed into α-Al 2 O 3 phase, while the xerogels need to be calcined at 1100 °C for 1 h to completely convert into the α-Al 2 O 3 phase. The difference in the phase transformation of the alumina fiber and xerogels was discussed in this paper.
研究领域:
材料科学
·
陶瓷学
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2022
·
IF 8.008
Shuangtian Dong,Dongyang Wang,Xuwen Gao,Li Fu,Jingna Jia,Yuqi Xu,Bin Zhang,Guizheng Zou
All commercial chemiluminescence (CL) assays are conducted with either glow or flash CL of eye-visible waveband from chemical luminophores. Herein, glow and flash, as well as waveband adjustable CL from the same nanoparticle luminophore of thiol-capped CuInS2@ZnS nanocrystals (CIS@ZnS-Thiol), are proposed via extensively exploiting the differed redox nature of CL triggering reagents. Taking thiosalicylic acid (TSA) as the model thiol-capping agent, the electron-injection-initiated charge transfer between CIS@ZnS-TSA and reductant can bring out efficient glow CL while the hole-injection-initiated charge transfer between CIS@ZnS-TSA and oxidant can give off obvious flash CL under optimum conditions. The maximum emission wavelength for CL of CIS@ZnS-TSA is adjustable from 730 nm to 823 nm via employing different triggering agents. Promisingly, the coexistent reductant of N2H4·H2O and oxidant of H2O2 can be employed as dual triggering reagents to trigger eye-visible and highly efficient flash CL from CIS@ZnS-TSA. The maximum emission intensity for flash CL of CIS@ZnS-TSA/N2H4–H2O2 is 101-fold greater than the glow CL of CIS@ZnS-TSA/N2H4 and 22-fold greater than the flash CL of CIS@ZnS-TSA/H2O2, respectively. The flash CL from CIS@ZnS-TSA/N2H4–H2O2 is qualified for highly sensitive and selective CL immunoassay in a commercialized typical procedure with the entire operating process manually terminated within 35 min.
研究领域:
纳米技术
·
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2016
·Vol. 3
·期 8
·1082-1090
·
IF 4.532
Min Li,Xiaoyang Liu,Li Liu,Bing Ma,Benxian Li,Xudong Zhao,Wenming Tong,Xiaofeng Wang
A series of Yb3+/Tm3+ co-doped β-NaYF4 (β-NaYF4:Yb,Tm) crystals have been successfully synthesized via the molten salt synthesis (MSS) method. A unique strong green emission of Tm3+ was observed, which cannot be obtained by any other method. The red, green and blue (RGB) light emissions have been obtained simultaneously in the presence of a single activator (Tm3+). The influencing factors of crystal growth have been studied in detail, in order to understand the change of the transition probabilities of Tm3+. Subsequent studies indicate that the RGB light emissions of Tm3+ can be effectively tuned by varying the concentration of sensitizers (Yb3+ and Mn2+) and the reaction time. Consequently, the effective multicolor upconversion (UC) luminescence was obtained, especially a strong white light, which was not obtained in the β-NaYF4:Yb,Tm system earlier. To our knowledge, it is the first time that the UC properties in the β-NaYF4:Yb,Tm system have been investigated by altering the transition probabilities at the same energy level of Tm3+.
研究领域:
材料科学
·
光学
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DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Jie Zhang,Siheng Zhang,Jianda Niu,Zhixian Dong,Jinbao Xu,Tingting Cui,Caihong Lei
With the increasing demands on healthy and environmental issues in modern society, green chemistry and atomic economics have become the consensus of researchers and manufacturers, forcing us to explore much simpler approaches to producing widely utilized biodegradable and biocompatible polyesters. In this context, 4-(hydroxymethyl) benzoic acid (4-HBA), an organic weak acid involving carboxyl and hydroxyl groups, was selected to proceed the ROP of various cyclic monomers, such as ε -caprolactone (CL), δ -valerolactone (VL), l-lactide (LA) and trimethylene carbonate (TMC), as catalyst and initiator in the same molecule (CINICAT) to give α -carboxyl- ω -hydroxyl polymers with controlled molar mass and narrow dispersity (around 1.15). MALDI-TOF, 2D-NMR and other characterizations were applied to confirm the structure of the produced polymers, while density of functional theory simulation ( DFT) calculation was carried out to study the structural influence of CINICAT on the polymerizations as well as the polymerization mechanism.
研究领域:
材料科学
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2024
·
IF 5.6
Zihan Zeng,Zheng Zhang,Bangjie Yin,Min Zhang
Taylor dispersion analysis (TDA) is a rapid and precise method for determining the hydrodynamic radius ( R H ) of various substances. We present a versatile TDA system with a flow-through sample injection device, two compact 3-in-1 detectors, and a high-voltage power supply. The 3D-printed detectors combine fluorimetry (FD), photometry (AD@255 nm), and contactless conductometry (C 4 D) in a single head, enabling simultaneous detection at one capillary window. Using bovine serum albumin (BSA) as a model analyte, we compare TDA with different detection methods. BSA labeled with fluorescein isothiocyanate (FITC) is analyzed in both pulse mode and capillary electrophoresis (CE) TDA. FD and AD detection yield similar R H values, except when FITC binds with small ions in the buffer. In phosphate buffer, C 4 D underestimates R H values by approximately 18 % due to BSA self-association. In Tris-based buffers, C 4 D values are 87%–96 % of AD values in pulse mode. With CE-TDA using Tris-CHES buffer, no statistical difference is found across all detections. The system is also applied to CE-TDA of various compounds, particularly charged saccharides. CE-TDA improves the accuracy of TDA results from C 4 D. We demonstrate the resolution of mixed C 4 D-TDA signals with assistance from FD and AD signals, successfully resolving gluconate peaks fully covered by another compound. The versatile system with 3-in-1 detection offers a powerful tool for TDA of mixtures and enhances sample throughput.
研究领域:
分析化学
·
生物技术
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）