RSC Advances
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2019
·Vol. 9
·期 68
·39631-39639
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IF 3.049
Jie Wang,Zixin Yu,Peihua Li,Dachuan Ding,Xuan Zheng,Chuanqun Hu,Tao Hu,Xinghou Gong,Ying Chang,Chonggang Wu
A poly(styrene-ran-cinnamic acid) (SCA) containing 6.8 mol% of CA, with a w (∼217 000) comparable to commercial polystyrene (PS), was successfully synthesised via emulsion free-radical copolymerisation as evidenced by 1744 and 1703 cm−1 infrared peak occurrences, respectively characteristic of free and dimeric carboxyl CO stretches. Upon the interchain hydrogen bond cross-linking by CA, the impact toughness of the SCA was considerably improved by 47.2% against PS, the glass transition, heat deflection and Vicat softening temperatures were significantly enhanced until 117.0, 108.0 and 118.3 °C, respectively, compared with PS (95.2, 87.6 and 96.0 °C), while the extensional viscosities were near one order-of-magnitude higher than PS by which the temperature window required for appropriate melt-strengths would be greatly broadened. Meanwhile, the SCA displayed other properties basically analogous to PS. This work presents a modified PS, SCA, with enhanced toughness, heat resistance and melt strength that potentially extend its styrofoam and commodity applications.
研究领域:
材料科学
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高分子化学
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工程学
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DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 17
·52041
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IF 3.125
Zhiyuan Song,Jie Wang,Qian Tao,Yang Yu,Hui Zhang,Chuanqun Hu,Hongyu Cen,Xuan Zheng,Tao Hu,Chonggang Wu
Zn-salt poly(styrene– ran –cinnamic acid) (SCA–Zn) ionomers were successfully synthesized via the melt neutralization of poly(styrene– ran –cinnamic acid) (SCA), which has a comparable molecular weight ( = 217,000) to commercial polystyrene (PS), with different mass fractions of ZnO (0.62, 1.6, and 3.9 wt.%) and the successful synthesis was confirmed by Fourier transform infrared spectroscopy. The mechanical properties, heat resistance, and processibility of the PS, SCA, and SCA–Zn samples were characterized. Compared to SCA, the three SCA–Zn ionomers exhibited significantly higher α cN values, with the ionomers containing 1.6 and 3.9 wt.% ZnO were 11.4% and 68.6% higher than that of SCA, respectively. Compared to commercial PS, SCA–Zn also exhibited significant improvements in heat resistance (glass transition temperature and vicat softening temperature both improved by about 20 °C) and impact toughness ( α cN values of the ionomers containing 1.6 and 3.9 wt.% ZnO were 69.6% and 156.5% higher than that of PS), while the processability of SCA–Zn was not significantly worse than that of PS. This method efficiently improves both the toughness and heat resistance of PS, providing an efficient way to expand the market application of styrenic resins.
研究领域:
高分子材料
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材料科学
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产品关联
DOI
高影响因子
ADVANCED ENGINEERING MATERIALS
·
2024
·Vol. 26
·期 22
·2401581
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IF 3.4
Li Wan,Jinyin Wang,Wen Yue,Fankai Lin,Chuanhua Gao,XianJie Liu,Xin Min,Chengbiao Wang,ZhaoHui Huang
Geothermal energy, derived from the radioactive decay of elements within the Earth's core, is a renewable and clean energy source. The extraction of geothermal energy primarily depends on ground heat exchangers. To address the issue of incompatibility between corrosion resistance, high thermal conductivity, and mechanical performance in current ground heat exchangers, this study develops composites (PEPOE/SCA@SiC) composed of high-density polyethylene (HDPE) modified with toughener polyethylene-octene copolymer elastomer (POE) and silicon carbide (SiC) crystals modified with γ-aminopropyltriethoxysilane (SCA). HDPE offers excellent corrosion resistance, SiC crystals provide efficient phonon transport, and SCA improves the interface compatibility of the composite. The thermal conductivity of PEPOE/SCA@SiC reaches 3.83 W m − 1 K − 1 , with a maximum tensile strength of 20.3 MPa, a tensile elastic modulus of up to 498 MPa, and a maximum bending stress of 22.2 MPa with a bending elastic modulus of 561 MPa. Corrosion resistance tests indicate no signs of corrosion in PEPOE/SCA@SiC when exposed to geothermal simulation fluids at 90 °C for 30 days. This study demonstrates that PEPOE/SCA@SiC composites have substantial potential for application in ground heat exchangers, offering promising prospects for advancing sustainable use of geothermal energy and environmental protection.
研究领域:
材料科学
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可再生能源
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环境工程
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产品关联
DOI
高影响因子
Stem Cell Research & Therapy
·
2026
·Vol. 17
·期 1
·123
·
IF 7.8
Du Mengxian,Guo Fengyi,Liu Xinna,Zhang Shiqi,Zhang Di,Qiu Leyi,Zhang Jingyang,Li Baoqiang,Yuan Huiping
Background Normal tension glaucoma (NTG) causes progressive retinal ganglion cell (RGC) loss without elevated intraocular pressure, and currently lacks effective neuroprotective therapies. OPTN(E50K) mutation, a pathogenic gene of NTG, compromises paracrine trophic capacity in bone marrow (BM) stem cells. Allogeneic young BM stem cells can provide trophic support and exhibit therapeutic potential; however, their clinical application is limited by immunogenic rejection and tumorigenic risks, prompting a renewed interest in rejuvenate autologous BM stem cells strategy. Methods To address these challenges, we developed a composite chitosan-rapamycin (RAPA) carbon dots (CRCD) to restore the reparative potential of autologous BM stem cells. BM stem cells from aged OPTN(E50K) mice were isolated, clustered and treated with CRCD before validated their changes of neurotrophic factors expression as well as oxidative stress and autophagy indicators. Then we assessed their impact on co-cultured retinas in vitro. Transplantation were performed into lethally irradiated age-matched OPTN(E50K) hosts with CRCD-pretreated autologous BM stem cells via tail vein injection, and generated stable chimeric models. Neurotrophic factors and neuron apoptosis analyses were performed, followed by the visual behavioral tests. Results Our results demonstrated that CRCD pretreatment enhanced autophagy, reduced oxidative stress, and augmented paracrine neurotrophic release. In vitro, these cells reduced retinal ganglion cell apoptosis and promoted neurotrophic factor expression in co-cultured retinal explants. In vivo, comparative analysis revealed that CRCD intervention significantly elevated neurotrophic factor expression in retinal tissues compared to RAPA-treated and untreated chimeras. Functional assessments further confirmed superior visual performance in CRCD-Sca-1 + chimeras, correlating with improved RGC survival. Conclusion These findings suggest that CRCD improved paracrine neurotrophic support of autologous BM stem cells by enhancing their autophagy and paracrine functions, leading to structural and functional rescue of the glaucomatous retina. This approach offered a clinically relevant strategy for NTG, providing sustained neuroprotection while avoiding the risks of allogeneic transplantation and repeated intravitreal drug delivery. Graphical The alternative text for this image may have been generated using AI.
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DOI
高影响因子
CONSTRUCTION AND BUILDING MATERIALS
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2026
·
IF 8.9
Xiang Tian,Yan Zhan,Jie Wu,Shanchang Yi,Tianyong Jiang,Lei Wang
Silane coupling agents (SCAs) are widely recognized for improving the mechanical performance and crack resistance of geopolymers. However, previous studies have primarily focused on strength enhancement, while the influence of SCAs on crack mode evolution and micro-damage development remains poorly quantified. This study investigates the fracture regulation and damage evolution of methyltrimethoxysilane (MTMS)-modified metakaolin-based geopolymers through an integrated analysis of mechanical behavior, acoustic emission (AE), digital image correlation (DIC), and convolutional neural networks (CNNs). MTMS was incorporated at dosages ranging from 0 to 0.4 wt%, and CNN-based crack mode identification model was developed using a balanced AE dataset containing 1200 tensile and shear cracking signals. The results show that MTMS regulates both strength and fracture behavior in a dosage-dependent manner. The optimum strength enhancement was achieved at 0.2 wt% MTMS, increasing compressive and flexural strengths by 22.9% and 30.8%, respectively, while 0.3 wt% MTMS produced the highest peak displacement and longest time to peak load. AE analysis revealed a transition from instantaneous brittle damage to progressive energy-dissipating fracture with increasing MTMS dosage, whereas excessive MTMS induced defect-related brittleness recovery. The 2D-CNN achieved a validation accuracy of 96.67%, enabling reliable quantification of tensile and shear cracking evolution. CNN classification showed that 0.2 wt% MTMS promoted mixed-mode fracture by reducing tensile crack dominance and increasing shear-related damage activity. Combined DIC-AE analysis identified three fracture stages, including microcrack initiation, stable crack propagation, and unstable fracture. This study provides an intelligent framework for quantitatively linking SCA-induced fracture regulation with micro-damage evolution in geopolymers.
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DOI
高影响因子
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
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2026
·Vol. 1870
·期 11
·130988
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IF 2.9
Jingxian Han,Lei Hua,Siqi Zhang,Bin Yang,Zhiying Li,Xiangguang Meng
Background Heart failure (HF) remains a leading cause of death worldwide. Stem cells represent a promising strategy for myocardial regeneration due to their differentiation potential and paracrine effects. This study investigated the effect of human pericardial fluid Sca-1 + /Nanog + cells Conditioned Medium (hPFCs-CM) on doxorubicin (DOX)-induced damage to AC16 cardiomyocytes using transcriptomic analysis. Methods Human AC16 cardiomyocytes were divided into Control (CON), DOX, DOXh, and hPFCs groups. Cell viability, cytotoxicity (LDH release), reactive oxygen species (ROS) levels, and apoptosis were assessed. Transcriptomic sequencing was performed on CON, DOX, and DOXh groups. MYH3 and IFI16 genes were knocked down using siRNA, followed by Western blot analysis of apoptosis. Results DOX significantly increased ROS and apoptosis compared with CON group ( P < 0.05), while hPFCs-CM attenuated these effects ( P < 0.05). RNA-seq identified 52 differentially expressed genes between DOX and DOXh groups (adj P < 0.05). Three target genes ( MYH3 , IFI16 , and KCTD14 ) were selected for RT-qPCR validation. Further functional assays revealed that MYH3 knockdown significantly potentiated the anti-apoptotic activity of hPFCs-CM ( P < 0.05), whereas IFI16 knockdown showed no significant effect. Conclusion hPFCs-CM effectively attenuated DOX-induced AC16 cardiomyocyte damage through MYH3, providing potential molecular targets for future mechanistic studies in myocardial injury treatment.
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DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2022
·
IF 1.366
Qian Tao,Jie Wang,Zhiyuan Song,Hui Zhang,Yang Yu,Chuanqun Hu,Hongyu Cen,Xuan Zheng,Tao Hu,Chonggang Wu
Poly(styrene-ran-cinnamic acid) (SCA) Zn-salt ionomers (SCA‒Zn) bearing increasing contents (0, 0.23, 0.55, 1.3, 3.0, and 5.5 mol%) of Zn2+ ions were successfully synthesized by solution neutralization of the SCA with Zn2+ ions at room temperature. As the ion content of the SCA‒Zn increased from 0 to 5.5 mol%, the size and the aggregation number of the ionic aggregates did not change significantly, because the increase in ion content led to a monotonic increase in the number density of ionic aggregates, while the number of ions participating in the aggregates to form ionic aggregates was essentially fixed. Furthermore, the Tg values of the SCA‒Zn increased slowly as the Zn2+ ion content increased, and the linear increase rate with Zn2+ ion content was ∼0.8 °C mol−1, which was quite different from the reported increase rate in the Tg values of the matrix phase with Na+ ion content of 3–6 °C mol−1. This appeared to be caused by the steric hindrance effect of the adjacent groups of –COO− ions in the SCA and the long-distance electrostatic attraction. In addition, the degree of ionization of the SCA‒Zn was too low to cause large changes in thermal stability.
研究领域:
高分子化学
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材料科学
·
物理化学
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DOI
高影响因子
MEASUREMENT
·
2024
·
IF 5.2
Bin Yin,Zhuxuan Jiang,Shilin Liu,Guofeng Sang,Yanzhi Lv,Muguang Wang,Shiying Xiao,Beilei Wu,Qichao Wang,Li Pei,Songhua Wu
A composite Fabry-Perot (F-P) fiber optic sensor based on the vernier effect is fabricated, and experiments confirmed that it can be used to simultaneously measure underwater temperature and pH. The fiber optic sensor fabricated with single mode fiber (SMF) − multi mode fiber (MMF) − seven core fiber (SCF) − quartz capillary tube (QCT) − no core fiber (NCF) structures has contained a silane coupling agent-polyvinyl alcohol/graphene oxide (SCA-PVA/GO) hybrid multilayer film to enhance the sensor performance. Two types of sensors are fabricated, one with a plane end face and another with a tapered end surface, which named as sensor 1 and sensor 2, respectively. Their performance are experimentally demonstrated. Within the temperature range of 15°C-35°C and the pH range of 7.55–9.21, the sensitivities of sensor 1 to temperature and pH are 82.94 pm/°C and 1.16 dB/pH, while the corresponding values of sensor 2 are 39.26 pm/°C and 0.4 dB/pH. Experimental results demonstrated that the sensitivities of sensor 1 to temperature and pH are higher than that of sensor 2. But compared with sensor 2, sensor 1 has higher values of crosstalk and random error. By contrast, sensor 2 maintain a good linear relationship with the environmental dual parameters, allowing for the simultaneous measurement of underwater temperature and pH. Moreover, both sensors demonstrate good stability and reversibility when the temperature and pH are varied. Furthermore, the pH response times of the two sensors are less than 0.5 s, with a recovery time of 2 s. Thus, the proposed sensors with outstanding stability, reversibility, repeatability, and rapid response times will have a broad range of applications in the fields of marine environment monitoring, water quality detection, and food and medical device safety testing.
研究领域:
海洋环境监测
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水质量检测
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光学传感
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材料科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）