ChemistrySelect
·
2024
·Vol. 9
·期 40
·e202402625
·
IF 1.9
Weixing Song,Zhenxiao Zhang,Meng Hao,Xingwei Hu,Jiaqi Chai,Bo Jiang,Ying Song
Graphical Electrochromic hydrogels exhibit rapid response speed, consistent color change, excellent reversibility. The dynamic reversible borate bond formed between borax and PVA molecular chains confers the hydrogel with robust self-repairing properties. Cracking caused by aging or repeated bending can severely affect the lifetime of electrochromic devices. In this work, a self-healing electrochromic hydrogel was developed with poly (vinyl alcohol) (PVA)-sodium carboxymethyl chitosan (SCC) semi-inter transfer network as the matrix, viologen bromide (HPV 2+ 2Br − ) as the electrochromic substance, and borax as the cross-linking agent. The self-healing properties of hydrogel stem from the dynamic and reversible borate bonds between borax and PVA molecular chains. As the voltage changes, the color of the device transitions from colorless to light purple and then to dark purple. The optical contrast at 600 nm reaches approximately 51 %. At room temperature, the disconnected hydrogel can fully restore its original state after 30 minutes of contact, effectively addressing issues related to cracks and damage in flexible electrochromic devices. This research holds significant implications for enhancing the reliability and stability of flexible electrochromic devices.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Longrui Yang,Yuhang Fan,Xiaoyu Li,Xiaoyun Sun,Jiaci Chen,Juan Zhang,Xiangyi Pang,Fengchun Huang,Ailiang Chen
Simultaneous determination of Somatic Cell Count (SCC) and Total Plate Count (TPC) in raw milk reflects milk cleanliness and cow health. The luciferase was thermally unstable and required storage at −20 °C, with repeated freeze-thaw cycles reducing activity. To overcome this limitation, an inorganic hybrid nanoflower luciferase was synthesized by mixing genetically engineered free luciferase with PBS and zinc acetate, followed by incubation, centrifugation, washing, and resuspension. Transmission electron microscopy confirmed successful assembly of luciferase into nanoflower structures. The nanoflower luciferase remained stable over 75 % of its initial activity after 21 days at 4 °C, whereas free enzyme required −20 °C.Compared with genetically engineered free luciferase, the nanoflower form effectively and simultaneously detected SCC and TPC in raw milk even after 2-fold dilution. The limits of quantification were 1 × 10 4 cells/mL for SCC and 1 × 10 5 CFU/mL for TPC.
研究领域:
食品科学与技术
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酶工程
·
生物传感器
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乳品质量控制
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纳米生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS IN CIVIL ENGINEERING
·
2019
·Vol. 31
·期 11
·04019279
·
IF 1.984
Zhi Cheng,Xiaobo Pei,Hua Hou,Tao Han,Lan Liu,Huiqi Wang,Yunshan Han
This work provides a systematic analysis of the expansive and load-deformation behaviors in circular steel tube stub columns (CSTCs) of self-compacting concrete (SCC) blended with ground circulating fluidized bed (CFB) bottom ashes (BAs). A series of SCCs with different expansive properties was fabricated by adding CFB-BAs. As the dosage of CFB-BAs increased, the time-dependent circumferential and axial strains increased. The expansive and load-deformation behaviors of cured SCCs filling the CSTCs were evaluated. Time-dependent expansive strain (TDES) measurements revealed that the expansive behavior in both the circumferential and axial directions had the same variation trend. The circumferential TDES values were much larger than the axial values. The axial load-displacement relations indicated that the specimen with 30% CFB-BAs had a 34% higher ultimate load, and it had a 54% higher ultimate load when 1.5% sodium sulfate was added to the specimen. The prestress had a significant impact on the ultimate capacity of concrete-filled steel tubes (CFTs). However, the ultimate capacity still was determined by the compressive strength of the core concrete, and it was not directly proportional to the initial prestress. The specimen with a 4-mm wall thickness and 30% CFB-BAs gained the most ultimate stress, indicating that the wall thicknesses of steel tubes had a distinct influence on the load-deformation behavior.
研究领域:
土木工程
·
建筑材料
·
结构工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Zhangbiao Xu,Lei Xu,Junyu Lu,Yongfen Sun,Junjie Shu,Yang Xiong,Wentian Zhang
This study presents a valuable repurposing approach for spent cathode carbon, in which the aluminum electrolysis spent cathode carbon was successfully converted into graphene oxide by Hummer’s method of oxidative intercalation with synergistic ultrasonic exfoliation, and further constructed NiCoLDH/rGO-SCC composites to be used in the electrode materials of hybrid supercapacitor. The large specific surface area of graphene oxide serves as a conductive channel in the electrodes, facilitating charge transfer during the reaction process, in addition to providing NiCoLDH nanosheets with a large number of spatial sites. Electrochemical tests and density functional theory calculations confirmed that graphene oxide facilitated charge transfer during pseudocapacitive reactions. In the three-electrode system, the composite exhibited a specific capacity of 2818 F g −1 , ensuring outstanding electrochemical performance for the hybrid supercapacitor. The results showed that the assembled hybrid supercapacitor could reach an energy density of 35.93 Wh kg −1 at a power density of 375 W kg −1 , and still possesses a capacity retention rate of 85.25 % after 1000 charge/discharge cycles. Consequently, the results demonstrated the supercapacitor’s significant application prospects. This approach provides a sustainable way to recycle spent cathode carbon and develop new capacitor electrode applications.
研究领域:
材料科学
·
环境科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-19
·
IF 10.2
Zhang Peisen,Cui Yingying,Wang Jian,Cheng Junwei,Zhu Lichong,Liu Chuang,Yue Saisai,Pang Runxin,Guan Jiaoqiong,Xie Bixia,Zhang Ni,Qin Meng,Jing Lihong,Hou Yi,Lan Yue
Background Although the promising advancements of current therapeutic approaches is available for the squamous cell carcinoma (SCC) patients, the clinical treatment of SCC still faces many difficulties. The surgical irreparable disfigurement and the postoperative wound infection largely hamper the recovery, and the chemo/radiotherapy leads to toxic side effects.Results Herein, a novel pH/Hyaluronidase (HAase) dual-stimuli triggered smart nanoprobe FeIIITA@HA has been designed through the biomineralization of Fe3+ and polyphenol tannic acid (TA) under the control of hyaluronic acid (HA) matrix. With the HA residues on the outer surface, FeIIITA@HA nanoprobes can specifically target the SCC cells through the over-expressed CD44, and accumulate in the carcinoma region after intravenously administration. The abundant HAase in carcinoma microenvironment will trigger the degradation of HA molecules, thereby exposing the FeIIITA complex. After ingesting by tumor cells via CD44 mediated endocytosis, the acidic lysosomal condition will further trigger the protonation of TA molecules, finally leading to the Fe3+ release of nanoprobe, and inducing a hybrid ferroptosis/apoptosis of tumor cells through peroxidase activity and glutathione depletion. In addition, Owing to the outstanding T1 magnetic resonance imaging (MRI) performance and phototermal conversion efficiency of nanoprobes, the MRI-guided photothermal therapy (PTT) can be also combined to complement the Fe3+-induced cancer therapy. Meanwhile, it was also found that the nanoprobes can promote the recruitment of CD4+ and CD8+ T cells to inhibit the tumor growth through the cytokines secretion. In addition, the FeIIITA@HA nanoprobes can be eliminated from the body and no obvious adverse side effect can be found in histological analysis, which confirmed the biosafety of them.Conclusion The current FeIIITA@HA nanoprobe has huge potential in clinical translation in the field of precise diagnosis and intelligent synergistic therapy of superficial SCC. This strategy will promisingly avoid the surgical defects, and reduce the systemic side effect of traditional chemotherapy, paving a new way for the future SCC treatment.Graphical Abstract
研究领域:
纳米技术
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癌症治疗
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生物医学工程
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分子生物学
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免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Liming Liu,Ning Ma,Lu Wang,Yu Zhang,Yi-Zhen Wan,Tianze Wang,Weiping Qian
Fibrinolytic activity assay is particularly important for the detection, diagnosis, and treatment of cardiovascular disease and the development of fibrinolytic drugs. A novel efficacious strategy for real-time and label-free dynamic detection of fibrinolytic activity based on ordered porous layer interferometry (OPLI) was developed. Fibrin or a mixture of fibrin and plasminogen (Plg) was loaded into the highly ordered silica colloidal crystal (SCC) film scaffold to construct a fibrinolytic response interference layer to measure fibrinolytic activity with different mechanisms of action. Fibrinolytic enzyme-triggered fibrinolysis led to the migration of interference fringes in the interferogram, which could be represented by optical thickness changes (ΔOT) tracked in real time by the OPLI system. The morphology and optical property of the fibrinolytic response interference layer were characterized, and the Plg content in the fibrinolytic response interference layer and experimental parameters of the system were optimized. The method showed adequate sensitivity for the fibrinolytic activity of lumbrokinase and streptokinase, with wide linear ranges of 12–6000 and 10–2000 U/mL, respectively. Compared with the traditional fibrin plate method, it has a lower detection limit and higher linearity. The whole kinetic process of fibrinolysis by these two fibrinolytic drug models was recorded in real time, and the Michaelis constant and apparent kinetic parameters were calculated. Importantly, some other blood proteins were less interfering with this system, and it showed reliability in fibrin activity detection in real whole blood samples. This study established a better and more targeted research method of in vitro fibrinolysis and provided dynamic monitoring data for the analysis of fibrinolytic activity of whole blood.
研究领域:
生物医学工程
·
心血管疾病
·
药物开发
·
干涉测量
·
纤溶
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xinwei Fu,Shan Du,Jie Liang,Bo Wang,Yingqi Liu,Yunlong Yu,Liqun Xu,Peng Xue,Bin Wang,Yuejun Kang
Ion interference therapy (IIT) represents an intervention strategy aimed at modulating the intracellular distribution of functional ions to mitigate bacterial biofilm infections (BBI). However, bacteria tend to activate protective pathways to alleviate the damage induced by ion interference under stress conditions, substantially diminishing the long-term therapeutic efficacy of IIT. Herein, we proposed an antibiofilm strategy of the photodynamic therapy (PDT)-mediated hypoxia-enhanced copper ion interference therapy (PHCIIT). The double-layered microneedles (CuIA@SCC MN) were synthesized by integrating the novel copper-coordinated polymeric nanorods (CuIA NRs) with sodium copper chlorophyllin (SCC) on the surface of hydrogel microneedles. Compared to conventional copper ion therapy, treatment with CuIA@SCC MN resulted in the PDT-mediated hypoxic microenvironment, enhancing the copper toxicity by inhibiting the protective mechanisms of bacteria, including down-regulation of multicopper oxidase activity and the enhanced accumulation of monovalent copper ions. Furthermore, the sustained release of therapeutic copper ions from CuIA NRs within the micro-acidic biofilm would further aggravate copper overload. The efficacy of the PHCIIT strategy was validated using diabetic wounds infected with E. coli biofilm. Following PHCIIT intervention, macrophages in the infected tissues exhibited polarization towards the M2-like phenotype, which could expedite wound healing. It is believed that the PHCIIT-based strategy is highly significant in advancing conventional IIT.
研究领域:
生物医学工程
·
微生物学
·
材料科学
·
治疗学
·
伤口愈合
✓ 已验证
DOI
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Yu Zhang,Lu Wang,Ning Ma,Yizhen Wan,Xueyi Zhu,Weiping Qian
Nonspecific adsorption (NSA) seems to be an impregnable obstacle to the progress of the biomedical, diagnostic, microelectronic, and material fields. The reaction path of bioconjugation can alter the surface charge distribution on products and the interaction of bioconjugates, an ignored factor causing NSA. We monitored exacerbated NSA introduced by a 1-ethyl-3-(3-(dimethylamino)propyl) carbodiimide (EDC) addition reaction, which cannot be resistant to bovine serum albumin (BSA) or polyethylene glycol (PEG) antifouling coating and Tween-20. And the negative effects can be minimized by adding as low as 7.5 × 10–6 M N-hydroxysulfosuccinimide (sulfo-NHS). We applied ordered porous layer interferometry (OPLI) to sensitively evaluate the NSA that is difficult to measure on individual particles. Using the silica colloidal crystal (SCC) film with Fabry–Perot fringes as in situ and real-time monitoring for the NSA, we optimized the surface chemistry to yield a conjugate surface without variational charge distribution. In this work, we propose a novel approach from the perspective of the reaction pathway to minimize the NSA of solely EDC-induced chemistry.
研究领域:
生物医学工程
·
材料科学
·
分析化学
·
表面化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Tianze Wang,Lu Wang,Ning Ma,Yu Zhang,Liming Liu,Yizhen Wan,Lele Zhou,Weiping Qian
Colloidal crystal nanomaterials have been proven to be valuable substrates for optical-based biosensing due to their ordered macroporous nanostructure and brilliant optical properties. In this work, silica colloidal crystal (SCC) thin films, as well as polystyrene–SCC composite films and inverse opal (IO) polystyrene films fabricated using SCC as templates, are investigated for their application as substrate materials in optical interferometric biosensors. The SCC films formed by the self-assembly of silica colloidal crystals have the most densely packed nano-3D structure, also known as the opal structure. IO films are fabricated by filling the opal pores of SCC with polystyrene and then removing the template, resulting in an interconnected nano-3D ordered macroporous structure, as indicated by the name inverse opal. The performance of the three materials was compared and discussed based on an ordered porous layer interferometry optical platform, focusing on refractive index response, protein adsorption response, and biomolecular interaction response. These results could potentially offer innovative material support for the advancement of label-free optical biosensors, which can be used for more biological/biochemical/biomolecular reaction monitoring studies.
研究领域:
材料科学
·
纳米技术
·
光学
·
生物传感
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）