Journal of CO2 Utilization
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2022
·
IF 8.321
Ying Wang,Kai Yan,Zi-Qing Du,Jia-Jie Long
A special magenta dye SCFX-AYRL with dichlorotriazine as reactive group, designed as one of supercritical trichromatic dyes, was successfully synthesized for sustainable coloration of natural fibers in supercritical fluid of carbon dioxide (SCF-CO 2 ). The products were characterized and tested by FT-IR, 1 H NMR, LC-MS, EA and Uv-Vis spectra. Moreover, Gaussian software was also employed to assist a theoretical design of the dye and its precursor, such as the optimization of structure conformations, the calculation of frontier molecular orbitals and parameters, and the prediction of characteristic absorption wavelength. The obtained results show that the molecular structure and color characteristics of the synthesized dye well met the expected theoretical design and calculations. Particularly, the powerfully excited molecular orbitals facilitated the first electron transition from the highest occupied orbital (HOMO) to the lowest unoccupied molecular orbital (LUMO) by contributing characteristic singlet absorption bands for the precursor and its target dye. Moreover, an energy gap (Δ E ) calculation between the LUMO and the HOMO was performed to predict color hue shift, and was well consistent with experimental detects. A successful application of the special dye on natural protein fibers was observed for eco-friendly coloration in SCF-CO 2 with high color strength, fixation efficiency over 90.0 %, as well as high brilliant color and fastness.
研究领域:
化学工程
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纺织科学
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环境科学
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR HISTOLOGY
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2025
·Vol. 56
·期 1
·1-14
·
IF 2.2
Ma Jinjie,Yan Jing,Su Nan,Qiu Zhengjun,Hou Huailong,Sun Jingxuan,Sun Xiangyu,Niu Yumei,He Lina
Facial nerve injuries lead to significant functional impairments and psychological distress for affected patients. Effective repair of these injuries remains a challenge. For longer nerve gaps, the regeneration outcomes after nerve grafting remain suboptimal due to limited sources and postoperative immune responses. Tissue engineering techniques are conventional methods for repairing peripheral nerve defects. This study explores the potential of dental pulp cells (DPCs) combined with stem cell factor (SCF) to enhance neurogenic differentiation and improve facial nerve regeneration. DPCs were isolated from rabbit dental pulp, the pluripotency of the cells was identified from three perspectives: osteogenic differentiation, adipogenic differentiation, and neurogenic differentiation. In vivo experiments involved injuring the buccal branch of the facial nerve in New Zealand white rabbits, followed by treatment with PBS, DPCs, SCF, or SCF + DPCs. Functional recovery was assessed over 12 weeks, with SCF + DPCs demonstrating the most significant improvement in whisker movement scores. Histomorphological evaluations revealed enhanced myelinated fiber density and axonal morphology in the SCF + DPCs group. RNA sequencing identified 608 differentially expressed genes, with enrichment in the TGF-β signaling pathway. In in vitro experiments, we demonstrated from multiple angles using Western blot analysis, Real-time quantitative polymerase chain reaction (QPCR) analysis, and immunofluorescence staining that SCF can promote the neurogenic differentiation of DPCs through the TGF-β1 signaling pathway. Our findings indicate that the combination of SCF and DPCs offers a promising strategy for enhancing facial nerve repair.
研究领域:
神经科学
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组织工程
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再生医学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Drug Design Development and Therapy
·
2025
·
IF 5.1
Shuting Zou,Bin Xie,Zhentao An,Fang Li,Li Cui,Zhenhai Zhang,Weiquan Bu,Dandan He
Objective The aroma of the aromatic class of traditional Chinese medicines can promote gastrointestinal peristalsis. This study aimed to explore the mechanisms by which volatile oil from Citri Reticulatae Pericarpium Viride (VOCRPV) alleviates slow-transit constipation (STC).Methods The main active ingredients in VOCRPV were determined by High-Performance Liquid Chromatography (HPLC). Due to poor stability, an olive oil solution was prepared to enhance the volatile oil’s stability. A mouse model of STC was induced using loperamide hydrochloride. The mice’s body weight was monitored weekly. The number of fecal pellets, fecal water content, and small intestinal propulsion rate were detected. The colon tissues were analyzed using HE staining. The serum content of gastrointestinal hormones was measured using the corresponding ELISA kit. The protein expressions of stem cell factor (SCF) and c-Kit in colon tissues were detected by Western blot and immunohistochemistry methods. The 16S rRNA gene sequencing was used to detect the intestinal flora.Results The contents of p-isopropyl toluene, γ-Terpinene, and d-Limonene were determined by HPLC. VOCRPV and its olive oil solution significantly enhanced body weight, increased the number of fecal pellets, improved fecal water content, and boosted small intestinal propulsion rate in mice with loperamide-induced STC, while also repairing colon mucosa damage. They also increased gastrin (Gas) and motilin (MTL) levels in treated mice, upregulated the expression of SCF and c-Kit proteins, and restored intestinal flora balance in STC mice.Conclusion VOCRPV could effectively alleviate STC, and olive oil enhances its therapeutic effect. VOCRPV alleviates STC by elevating Gas and MTL levels, activating the SCF/c-Kit signaling pathway, and modulating intestinal flora.
研究领域:
中药学
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消化系统研究
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分子生物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
·
2023
·
IF 2.8
Li Cui,Bin Zhang,Shuting Zou,Jing Liu,Pingrong Wang,Hui Li,Zhenhai Zhang
In this study we sought to elucidate the therapeutic effects of fenchone on constipation-predominant irritable bowel syndrome (IBS-C) and the underlying mechanisms. An IBS-C model was established in rats by administration of ice water by gavage for 14 days. Fenchone increased the reduced body weight, number of fecal pellets, fecal moisture, and intestinal transit rate, and decreased the enhanced visceral hypersensitivity in the rat model of IBS-C. In addition, fenchone increased the serum content of excitatory neurotransmitters and decreased the serum content of inhibitory neurotransmitters in the IBS-C rat model. Meanwhile, western blot and immunofluorescence experiments indicated that fenchone increased the expressions of SCF and c-Kit. Furthermore, compared with the IBS-C model group, fenchone increased the relative abundance of Lactobacillus , Blautia , Allobaculum , Subdoligranulum , and Ruminococcaceae_UCG-008 , and reduced the relative abundance of Bacteroides , Enterococcus , Alistipes , and Escherichia-Shigella on the genus level. Overall, fenchone ameliorates IBS-C via modulation of the SCF/c-Kit pathway and gut microbiota, and could therefore serve as a novel drug candidate against IBS-C.
研究领域:
药理学
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胃肠病学
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微生物学
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DOI
PubMed
高影响因子
CANCER SCIENCE
·
2021
·Vol. 112
·期 8
·3218-3232
·
IF 6.716
Dan-Hua He,Yu-Fei Chen,Yi-Le Zhou,Shi-Bing Zhang,Ming Hong,Xianjun Yu,Su-Fen Wei,Xiang-Zhen Fan,Si-Yi Li,Qi Wang,Yongzhi Lu,Yong-Qiang Liu
Skp2 is overexpressed in multiple cancers and plays a critical role in tumor development through ubiquitin/proteasome-dependent degradation of its substrate proteins. Drugs targeting Skp2 have exhibited promising anticancer activity. Here, we identified a plant-derived Skp2 inhibitor, betulinic acid (BA), via high-throughput structure-based virtual screening of a phytochemical library. BA significantly inhibited the proliferation and migration of non–small cell lung cancer (NSCLC) through targeting Skp2-SCF E3 ligase both in vitro and in vivo. Mechanistically, BA binding to Skp2, especially forming H-bonds with residue Lys145, decreases its stability by disrupting Skp1-Skp2 interactions, thereby inhibiting the Skp2-SCF E3 ligase and promoting the accumulation of its substrates; that is, E-cadherin and p27. In both subcutaneous and orthotopic xenografts, BA significantly inhibited the proliferation and metastasis of NSCLC through targeting Skp2-SCF E3 ligase and upregulating p27 and E-cadherin protein levels. Taken together, BA can be considered a valuable therapeutic candidate to inhibit metastasis of NSCLC.
研究领域:
肿瘤学
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药理学
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分子生物学
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癌症研究
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 53
·33450-33458
·
IF 3.108
Liu Liu,Fei Yan,Fangyuan Gai,Linghan Xiao,Lei Shang,Ming Li,Yuhui Ao
Polyetheretherketone (PEEK)/short carbon fiber (SCF)/polytetrafluoroethylene (PTFE)/graphene (GE) composites (PSPGE) with different weight fractions of GE were prepared successfully. The effect of GE on the tribological behavior of PEEK composites was investigated under different applied pressures, sliding speeds and temperatures. Characterization results revealed that the tribological performance was improved with the increase of GE loading, and 2.0 wt% GE filled PEEK/SCF/PTFE composites had the lowest friction coefficient and wear rate. The PSPGE exhibited excellent lubrication and wear resistance efficiency especially under harsh conditions. Moreover, the improved thermal conductivity of the PSPGE composites allowed friction heat to be transferred and further increased the wear resistance. Thus, this newly developed novel PSP2.0GE composite could be applied to many new fields as an advanced friction material.
研究领域:
材料科学
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机械工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2020
·Vol. 31
·期 23
·21325-21334
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IF 2.22
Liu Houbao,Fu Renli,Su Xinqing,Wang He,Wu Binyong,He Qinjiang
With the development of electronic components towards high power, high packaging density, and miniaturization of device size, heat dissipation and the electromagnetic interference problems between the electronic components are emerging. In order to solve the undesirable electromagnetic wave and heat emissions produced by electronic device simultaneously, the electronic packaging materials with high thermal conductivity and anti-electromagnetic interference are highly expected. In this work, NiFe 2 O 4 -modified short carbon fibers (SCF) were designed and prepared. NiFe 2 O 4 were in situ grown on the surface of SCF by hydrothermal method. The chemical structure and morphology of SCF-NiFe 2 O 4 were characterized by X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The microwave absorbing performance test shows that SCF-NiFe 2 O 4 possess superior microwave absorbing performance, where the minimum reflection loss is − 20.7 dB. Finally, SCF-NiFe 2 O 4 /epoxy resin composites were prepared by introducing SCF-NiFe 2 O 4 as thermal conductive filler into epoxy resin. The surface-modified SCF with NiFe 2 O 4 is more easily infiltrated by resin and exhibits strong interfacial interaction with the matrix. With the increase of the content of SCF-NiFe 2 O 4 , the thermal conductivity of the composites increases obviously. When the content of SCF-NiFe 2 O 4 reaches 20 vol%, the composites show better thermal conductivity, and the thermal conductivity reaches 1.03 W/m K.
研究领域:
材料科学
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电子工程
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DOI
高影响因子
POLYMER COMPOSITES
·
2022
·Vol. 43
·期 3
·1476-1484
·
IF 3.531
Zheng Li,Kexin Wang,Xudong Liu,Jiaoli Hu,Jie Zhang,Guorui Yang,Ruihang Xie,Jialiang Zhang,Yuhui Ao
To enhance the interfacial adhesion of short carbon fiber (SCF) reinforced polypropylene (PP) composites, a new modified chlorinated polypropylene resin (g-CPP) was synthesized and utilized to manufacture the sizing agent for SCF. The findings of thermogravimetric analysis and differential scanning calorimetry showed that g-CPP had high thermal characteristics, with its glass transition temperature (Tg) raised by 11°C.The g-CPP sizing agent that has been developed has increased storage stability (particle size was 109.8 nm). The contact angle of SCF was reduced from 81.52° to 60.04° after sizing, and the surface free energy was raised from 29.31 mN/m soared to 47.13 mN/m. The SCF/PP composites with 1 wt% sizing agent demonstrated the best interfacial adhesion, with improvements in flexural and tensile strengths of 54% and 39%, respectively. The interfacial reinforcement mechanism of sizing agent to improve interfacial adhesion was investigated. This work proposes an attractive way for the future preparation of high-performance SCF/PP composites.
研究领域:
材料科学
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化学工程
✓ 已验证
DOI
高影响因子
COMPOSITES COMMUNICATIONS
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2020
·
IF 4.915
Houbao Liu,Xinqing Su,Renli Fu,Binyong Wu,Xudong Chen
The flexible heat dissipation material with high thermal conductivity and electrical insulation is ideal for highly integrated flexible electronic devices. In this study, the flexible polymer composite films were prepared by spin coating process, the thermal conductivity and electrical insulation of the composite film are significantly enhanced by adding short carbon fibers (SCF) and boron nitride (BN) particles to PDMS matrix. SCF and BN particles construct an effective thermal conduction path in the PDMS matrix, while highly insulating BN particles inhibit the formation of conductive paths. The thermal conductivity of 15%SCF/20%BN/PDMS film achieved 2.29 W/m·K when 15 wt% SCF and 20 wt% BN were loaded, which was 990% enhancement compared to pure PDMS. And its volume electrical resistivity and breakdown strength reached 2.11 × 1014 Ω·cm and 12.5 KV/mm respectively, showing excellent electrical insulation property.
研究领域:
材料科学
·
柔性电子
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materiomics
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2025
·
IF 9.6
Jin Cheng,Hongye Wang,Xinwei Xu,Naichao Chen,Zhan Zeng,Xiaoyu Li,Biao Guo,Binfeng Zhao,Hong Wang
To meet the demands of miniaturization and integration in modern electronic packaging, developing materials with low coefficient of thermal expansion (CTE) is essential to reduce thermal stress and enhance device reliability. In this study, the dense negative thermal expansion ceramic ScF 3 was prepared with a CTE of –8.86×10 –6 /°C. The ScF 3 ceramic was cold sintered at 150 °C, exhibiting a low permittivity of 5.3 and a high quality factor ( Q × f ) of 14,700 GHz. By incorporating ScF 3 to the hexagonal boron nitride (BN) ceramic, the CTE of ScF 3 -BN composite ceramic was adjusted to 3.36×10 –6 /°C, establishing compatibility with silicon-based chips. And finite element simulations verified that ScF 3 -BN composite significantly reduces thermal stress compared to Li 2 MoO 4 or Al 2 O 3 ceramics. Furthermore, this work demonstrates the potential of cold-sintered ScF 3 to regulate thermal expansion in packaging substrates, paving the way for improved performance in next-generation electronic devices.
研究领域:
材料科学
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电子工程
·
陶瓷学
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热管理
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微电子封装
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功能材料
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固态物理
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2026
·Vol. 19
·期 18
·3966
·
IF 3.7
Zhe Tong,Xinghao Song,Wenxing Lei,Yajun Zhang,Jiaojiao Li,Li Zhao
The incorporation of various types of fillers is critical to enhancing the starved oil lubrication performance of PEEK matrix composites. In this work, PEEK composites reinforced with h-BN and SCFs were fabricated via a hot-pressing method, and the friction and wear behaviors under dry sliding and starved oil lubrication were systematically investigated. Surface oil wettability and Vickers hardness were characterized, and tribological tests were conducted on a ball-on-disk reciprocating tribometer. Worn surface topography and wear mechanisms were elucidated through laser scanning confocal microscopy and scanning electron microscopy. The results show that h-BN effectively reduces the friction coefficient through its solid lubrication effect, while SCFs significantly improve the hardness and load-bearing capacity of the PEEK matrix. Under dry sliding conditions, the PEEK composite containing h-BN and SCFs achieves the lowest wear rate of 10.3 × 10−5mm3/(N·m), which is 74.6% lower than that of pure PEEK, indicating a synergistic anti-wear effect. Under starved oil lubrication, PEEK/h-BN maintains the smoothest and lowest friction, and the presence of SCFs further improves wear resistance of PEEK composites despite a slight increase in friction. In addition, the fillers’ incorporation reduces the surface oil wettability of the PEEK composites; the dominant wear mechanism hence transforms from severe adhesive wear and plastic deformation in pure PEEK to mild abrasive wear.
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DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2022
·
IF 9.879
Xun Fan,Qiang Gao,Yu Zhang,Jianbin Qin,Yongsheng Zhao,Xuetao Shi,Guangcheng Zhang
Carbon aerogel shows great potential in electromagnetic interference shielding (EMI) application and is generally strengthened by epoxy impregnation for harsh working environment. However, it is still challenging to simultaneously achieve high mechanical robustness and EMI performance, especially taking low-cost and light-weight feature into account. In this work, a “gelation-press drying-impregnation & micro-foaming” method was systematically reported to target microcellular epoxy foam containing hybrid reduced graphene oxide (rGO)/short-carbon-fiber (SCF) aerogel . Herein, aerogel morphology was transformed from isotropic honey-comb structure into anisotropic corrugated structure by controllable press air-drying. A further supercritical carbon dioxide (scCO 2 ) foaming process was implemented for density reduction. Moreover, the anisotropic microcellular epoxy(m-EP)/rGO-SCF foam (D = ∼0.48 μm, N f = 5.02 × 10 12 cell/cm 3 ) shows low density (1.14 g/cm 3 ), high electrical conductivity (2365.0 S/m), enhanced compressibility (σ b = 243.0 MPa, ε b = ∼45%) and outstanding EMI shielding effectiveness (95.5 dB) with a low thickness (2.0 mm) within X band (8.2–12.4 GHz). Therefore, our work provides a universal step-by-step and industrial-friendly approach to fabricate light-weight carbon-aerogel-based foams with anisotropic carbon structure and outstanding EMI performance.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）