PHYSICA B-CONDENSED MATTER
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2025
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IF 2.8
Dongxue Luo,Ronghua Qin,Minghang Song,Lingfang Xu,Tian Liang,Yalong Ge,Changping Yang
BiFeO 3 has profuse physical properties in multiferroics. However, significant leakage current constrains its utility in practical applications. In this paper, we synergistically embed BiFeO 3 nanoparticles in a ferroelectric crystal P(VDF-TrFE) base and use barrier layers to reduce the leakage current and promote the ferroelectric performance. Our finding indicate that the multilayer BiFeO 3 /P(VDF-TrFE) composite films equipped with barrier layers exhibit a leakage current below the magnitude of microampere level, a 99 % reduction compared to single-layer films. Additionally, the effective remnant ferroelectric polarization reaches 16 μC/cm 2 , a 66 % improvement. We combined the conductive mechanism analysis by fitting I - V curves and constructing energy band structures, uncovering that the essence of the optimization characteristics is related to a Space-Charge-Limited Conduction (SCLC) mechanism in the multilayer composite films. This research offers potential film solutions for a variety of electrical devices, supported by both experimental and theoretical perspectives.
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高影响因子
Open Medicine
·
2025
·Vol. 20
·期 1
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IF 1.6
Xi Yan,Yinghao Niu,Yaojie Wang,Sisi Wei,Lina Han,Zhongyu Guo,Lianmei Zhao,Feng Gao
Purpose
This study aims to investigate the role and mechanism of p -hydroxyl cinnamaldehyde (CMSP) in triggering ferroptosis of small cell lung cancer (SCLC) cells.
Methods
The impact of CMSP on ferroptosis in H1688 and SW1271 cells was assessed through cell experiments and biological information analysis. Moreover, the expression of heme oxygenase 1 (HMOX1) in SCLC tissue was examined.
Results
Following CMSP treatment, a concentration-dependent increase in cell death was observed, and differentially expressed genes were found to be associated with ferroptosis. CMSP notably facilitated ferroptosis events, such as elevated levels of reactive oxygen species (ROS), Fe 2+ , malondialdehyde (MDA), transferrin receptor 1 (TFR1), divalent metal transporter 1 (DMT1), and decreased levels of glutathione (GSH), solute carrier family 7 member 11 (SLC7A11), and glutathione peroxidase 4 (GPX4). Furthermore, CMSP promoted mitochondrial dysfunction, manifested as reduced mitochondrial volume, increased membrane density, elevated mitochondrial ROS, and decreased mitochondrial membrane potential. Consistently, the mitochondrial-targeted antioxidant Mito-TEMPO reversed CMSP-induced ferroptosis. Expression of the HMOX1 gene was markedly increased under CMSP treatment, while lower expression was observed in cancer tissue compared to adjacent tissue.
Conclusion
CMSP triggers mitochondrial dysfunction via HMOX1 activation, leading to ferroptosis in SCLC cells, underscoring its potential as a therapeutic agent for SCLC.
研究领域:
肿瘤学
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分子生物学
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药理学
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PubMed
高影响因子
Scientific Reports
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2025
·Vol. 15
·期 1
·1-15
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IF 3.9
Xia Hong,Tai Xue-jiao,Cheng Wang,Wu Yi,He Dan,Wang Li-feng,Liu Hao,Zhang Shen-yi,Sun Yu-ting,Liu Hang-zhi,Liu Dan-dan,Zhao Hu-zi,Ji Fu-yun,Li Xi-hua
Small cell lung cancer (SCLC) is a therapeutically challenging disease. Metformin, an effective agent for the treatment of type 2 diabetes, has been shown to have antitumour effects on many cancers, including non-small cell lung cancer (NSCLC) and breast cancer. Currently, the antitumour effects of metformin on SCLC and the underlying molecular mechanisms remain unclear. CCK-8, EdU, colony formation, flow cytometry, immunofluorescence, molecular docking, western blotting, nude mouse transplanted tumour model, and immunohistochemistry experiments were conducted to analyse gene functions and the underlying mechanism involved. In vitro experiments demonstrated that metformin inhibited the growth of SCLC cells (H446, H526, H446/DDP and H526/DDP), which was confirmed in xenograft mouse models in vivo. Additionally, metformin induced cell cycle arrest, apoptosis, and autophagy in these SCLC cells. The molecular docking results indicated that metformin has a certain binding affinity for EGFR. The western blotting results revealed that metformin decreased the expression of EGFR, p-EGFR, AKT, and p-AKT, which could be reversed by EGF and SC79. Moreover, metformin activated AMPK and inactivated mTOR, and compound C and SC79 increased the levels of p-mTOR. Metformin can not only enhance the antitumour effect of cisplatin but also alleviate the toxic effects of cisplatin on the organs of xenograft model animals. In summary, the current study revealed that metformin inhibits the growth of SCLC by inducing autophagy and apoptosis via suppression of the EGFR/AKT/AMPK/mTOR pathway. Metformin might be a promising candidate drug for combination therapy of SCLC.
研究领域:
肿瘤学
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分子生物学
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药理学
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PubMed
高影响因子
SLAS Discovery
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2024
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IF 2.7
Cui Lin,Yijie Wang,Tao Peng,Pengpeng Liu,Yuanyuan Liang,Wencheng Kang,Xiaoping Yu,Yang Song,Xuping Shentu
Neuron-specific enolase (NSE) is currently the most reliable biomarker for small cell lung cancer (SCLC), which is important for disease monitoring, clinical evaluation and diagnosis. However, traditional methods suffer from various disadvantages, including instability, complexity, time-consuming operations, and the necessity for standards. In this study, we developed a calibration-free concentration analysis (CFCA) method based on surface plasmon resonance (SPR) technology, to accurately quantify the active concentration of NSE without relying on any standards. Based on the principle of CFCA, the active concentration of NSE can be calculated by observing binding rate variations at two flow rates under partial mass transport limitation and combining it with the known diffusion coefficient of the NSE. Using the method of CFCA, the active concentration of NSE was determined was only 0.48 mg/mL with an intra-day repeatability of 4.75%. The method has the advantages of simplicity, rapidity, realistic analysis and ease of implementation of high-throughput automated detection. Therefore, the method is expected to become the main measurement method for protein active concentration, which will be beneficial for the development of active protein standards.
研究领域:
肿瘤学
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生物标志物研究
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分析化学
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生物物理学
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PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
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2024
·Vol. 130
·期 6
·1-15
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IF 2.5
Zia Layiq,Saleem Farwa,Jaffari G. Hassnain,Hussain Mozaffar,Shah S. Ismat
Magnetoelectric composite materials, which exhibit both ferroelectric and ferromagnetic properties simultaneously, have attracted considerable interest for their potential in various applications such as microelectronics, memory devices, and spintronics. In this study, we investigated the synthesis, structural, morphological, electrical, and magnetic properties of multiferroic CoFe 2 O 4 /0.65BiFeO 3 -0.35PbTiO 3 (CFO/65BF-35PT) composite thin films. These films were prepared using a high ferroelectric, morphotropic phase boundary (MPB) composition, 65BF-35PT, combined with a high magnetostrictive compound, CFO. Multilayered CFO/65BF-35PT composite films were spin-coated onto fluorine-doped tin oxide (FTO)/glass substrates using the sol-gel method, with variation in the solution molarity to achieve different layer thicknesses. Structural analysis revealed a perovskite phase for 65BF-35PT and a spinal structure for CFO, with the presence of rhombohedral and tetragonal polymorphs confirming MPB composition. Scanning electron microscope images demonstrated uniform growth of 1 μm thick composite films. Ferroelectric hysteresis loops exhibited considerable leakage current at room temperature, increasing with higher CFO content, while current versus voltage plots revealed ohmic conduction at low applied fields and space charge limited current (SCLC) conduction at high fields in all composite films. The crossover field between ohmic and SCLC conduction decreased with increasing CFO content. Moreover, room-temperature magnetic hysteresis loops showed a decrease in saturation and coercive field with increasing CFO concentration, and the temperature-dependent magnetization response indicated a monotonic decrease, with magnetization vanishing around 800 K, confirming the magnetic order of CFO. Our findings demonstrate that stable ferroelectric and ferromagnetic phases can be achieved at low temperatures by depositing composite films containing CFO/MPB on a low-cost FTO substrate.
研究领域:
材料科学
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电气工程
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物理学
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纳米技术
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自旋电子学
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微电子学
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