ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Xiaoyu Tian,Bo Zhang,YanYan Li,Junsheng Yang,Liangbo Sun,Houchang Pei,Qiang Cao,Qianqian Lin
The noble-metal-free surface-enhanced Raman scattering (SERS) substrates have gained significant attention due to their abundant sources, signal uniformity, biocompatibility, and chemical stability. However, the lack of controllable synthesis and fabrication methods for high-SERS-activity noble-metal-free substrates hinders their practical applications. In this study, we demonstrate the use of a femtosecond laser direct writing technique to precisely manipulate and modify microstructures, resulting in enhanced SERS signals from Sb2S3 nonmetal-oxide semiconductor materials. Compared with unpatterned Sb2S3 samples, the Sb2S3 microstructures exhibited up to a 16-fold increase in Raman scattering intensity. Interestingly, our results indicate that the femtosecond laser can induce a transformation in the crystalline state of Sb2S3 and significantly enhance the Raman spectrum signal within the Sb2S3 microstructures. This enhancement is also highly dependent on the period and depth of the microstructures, possibly due to the cavity effects, resulting in a stronger local field enhancement.
研究领域:
材料科学
·
光谱学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2025
·
IF 5.1
Chiyi Wei,Yanlong Li,Haijiao Xu,Molei Hao,Tianxi Wang,Weiyuan Huang,Wanlu Cao,Zihao Li,xiaoming wei,Zhongmin Yang
Chiral recognition plays a vital role in chemical, biological, and pharmaceutical studies. However, differentiating enantiomers is still challenging. This study presents a new approach to enhance the distinction between enantiomers in surface-enhanced Raman scattering (SERS) by leveraging the coupling effect of propagating surface plasmon (PSP) and localized surface plasmons (LSP). We construct a SERS substrate that integrates laser-induced periodic surface structures with chiral plasmonic nanoparticle 432 helicoid III, creating a PSP-LSP coupling mechanism. The results demonstrate that the composite substrate not only enhances the SERS signal but also effectively amplifies the disparity between enantiomers. This advancement paves a new way in chiral SERS substrate design and the research of enantiomeric disparity amplification.
研究领域:
化学
·
生物学
·
药学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2023
·Vol. 15
·期 18
·8424-8431
·
IF 6.7
Bingfang Zou,Shiyun Lou,Jie Duan,Shaomin Zhou,Yongqiang Wang
Magnetic-based microfluidic SERS biosensors hold great potential in various biological analyses due to their integrated advantages including easy manipulation, miniaturization and ultrasensitivity. However, it remains challenging to collect reliable SERS nanoprobe signals for quantitative analysis due to the irregular aggregation of magnetic carriers in a microfluidic chamber. Here, magnetic/plasmonic hybrid nanostirrers embedded with a Raman reporter are developed as capture carriers to improve the reliability of microfluidic SERS biosensors. Experimental results revealed that SERS signals from magnetic hybrid nanostirrers could serve as microenvironment beacons of their irregular aggregation, and a signal filtering method was proposed through exploring the relationship between the intensity range of beacons and the signal reproducibility of SERS nanoprobes using interleukin 6 as a model target analyte. Using the signal filtering method, reliable SERS nanoprobe signals with high reproducibility could be picked out from similar microenvironments according to their beacon intensity, and then the influence of irregular aggregation of magnetic carriers on the SERS nanoprobe could be eliminated. The filtered SERS nanoprobe signals also exhibited excellent repeatability from independent tests, which lay a solid foundation for a reliable working curve and subsequent accurate bioassay. This study provides a simple but promising route for reliable microfluidic SERS biosensors, which will further promote their practical application in biological analysis.
研究领域:
分析化学
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生物医学工程
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Guofeng Wang,Shiwei Xu,Chao Deng,Yueyue Feng,Liying Huang,Qin Guo,Yajun Wang,Min Zhang,Qian Shi,Nannan Liu
Copper ions (Cu + and Cu 2+ ) are vital for physiological functions, and their imbalance is implicated in disease progression. However, simultaneous detection of both species is challenging due to their similar properties. Here, we report a dual-functionalized glass micropipette sensor enabling independent detection of Cu + and Cu 2+ . UiO-66-NH 2 was grown in situ on the inner wall to capture Cu 2+ via amino coordination, reducing ionic current. Glutathione-functionalized carbon nanotubes (GCNTs) coated on the outer surface bind Cu + , increasing SERS signal via enhanced surface defects. The sensor exhibits a wide detection range (10 -1 –10 5 μM), a detection limit of 0.1 μM, and allows simultaneous monitoring of Cu + /Cu 2+ in the physiological range (2–10 μM). It further distinguishes copper ion levels in MCF-10A and MCF-7 cells, revealing altered copper homeostasis in cancer. This platform offers a sensitive, selective tool for studying copper in biological systems.
研究领域:
生物化学
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分析化学
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医学
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Chunyuan Song,Boyue Yang,Yu Zhu,Yanjun Yang,Lianhui Wang
With years of outrageous mercury emissions, there is an urgent need to develop convenient and sensitive methods for detecting mercury ions in response to increasingly serious mercury pollution in water. In the present work, a portable, ultrasensitive SERS sensor is proposed and utilized for detecting trace mercury ions in water. The SERS sensor is prepared on an excellent sliver nanorods array SERS substrate by immobilizing T-component oligonucleotide probes labeled with dye on the 3′-end and –SH on the 5′-end. The SERS sensor responses to the specific chemical bonding between thymine and mercury ions, which causes the previous flexible single strand of oligonucleotide probe changing into rigid and upright double chain structure. Such change in the structure drives the dyes far away from the excellent SERS substrate and results in a SERS signal attenuation of the dye. Therefore, by monitoring the decay of SERS signal of the dye, mercury ions in water can be detected qualitatively and quantitatively. The experimental results indicate that the proposed optimal SERS sensor owns a linear response with wide detecting range from 1 pM to 1 μM, and a detection limit of 0.16 pM is obtained. In addition, the SERS sensor demonstrates good specificity for Hg 2+ , which can accurately identify trace mercury ions from a mixture of ten kinds of other ions. The SERS sensor has been further executed to analyze the trace mercury ions in tap water and lake water respectively, and good recovery rates are obtained for sensing both kinds of water. With its high selectivity and good portability, the ultrasensitive SERS sensor is expected to be a promising candidate for discriminating mercury ions in the fields of environmental monitoring and food safety.
研究领域:
环境科学
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分析化学
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材料科学
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纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Xiaoyan Ma,Huiting Wang,Yaxian Chen,Longfei Fu,Jie Zhou,Ling Zhang,Zhiqiang Xing,Qian Zhang,Lixin Xia
Utilizing hydrothermal synthesis, TiO 2 and g-C 3 N 4 were grown on cotton fabric. Subsequently, Ag NPs were uniformly deposited on their surfaces to produce a Ag@g-C 3 N 4 /TiO 2 cotton fabric substrate (AGTC) with dual-functionalilites of photocatalytic reusability and SERS signal amplification. The introduction of TiO 2 and g-C 3 N 4 nanocomposites significantly enhances the SERS signal on the AGTC substrate for malachite green (MG) detection. The SERS signal on the AGTC substrate is 2.28 times stronger than that on the bare silver-modified cotton fabric, with a reduced detection limit of 6.74 × 10 −13 M. Additionally, the Local Surface Plasmon Resonance (LSPR) effect induced by Ag NPs facilitates electron transfer among substrate components, markedly enhancing photocatalytic capability for degrading organic pollutants under visible light. Consequently, under visible light, the substrate rapidly degrades pollutants and reverts to a reusable state. Experimental results demonstrate the substrate's capability to continuously detect various concentrations and types of target substances, while maintaining high sensitivity. Leveraging the flexibility of cotton fabric, convenient wipe detection and self-cleaning experiments were conducted on the surfaces of different fish species, validating AGTC's outstanding sensitivity in real sample analysis. Therefore, as a flexible and reusable SERS substrate, AGTC exhibits broad potential applications in both SERS detection and photocatalytic degradation of pollutants.
研究领域:
材料科学
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环境科学
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分析化学
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产品关联
DOI
高影响因子
Journal of Physical Chemistry C
·
2020
·
IF 4.189
Jing-Yun Yang,Ye Zhang,Xia Ji,He-Fang Wang
Surface-enhanced Raman scattering (SERS) has been widely investigated in recent years. The subtle design and synthesis of SERS substrates, including the semiconductor–metal composites, are the key but difficult points. To date, only the short-lived semiconductors are involved, and no research has been conducted concerning the long-lived ones although the persistent luminescence semiconductors have great potential of charge transfer in relatively long durations. Herein, we present a concept of afterglow-assistant SERS (AASERS) on the long-lived gold shell-capped Cr3+-doped ZnGa2O4 (CZGO@Au) substrate. The normal SERS, AASERS acquired immediately after 2 min illuminating of a 633 nm laser, AA-1 min SERS acquired 1 min after 2 min illuminating of a 633 nm of the typical analytes on CZGO@Au, ZnGa2O4@Au (ZGO@Au), and gold nanostars (GNSs) with the same UV–vis absorption wavelength are systematically compared. The CZGO@Au owns the SERS signals that are 1.8 times of ZGO@Au and 3.4 times of GNSs. A higher AASERS than the corresponding SERS (1.65 times) is only observed on CZGO@Au, and the AASERS on CZGO@Au is 2.8 times of that on ZGO@Au and 5.2 times of that on GNSs. Because of the afterglow decay of CZGO@Au, the AA-1 min SERS on CZGO@Au returns to its SERS. These data demonstrate that the AASERS on long-lived substrates is a promising way for further enhancing SERS signals just by laser illuminating the substrates, and thus affords alternatives for reducing the difficulties in the complicated synthesis of the exquisite substrates. The AASERS mechanism and the application of CZGO@Au in SERS imaging of living U87MG cells are also discussed.
研究领域:
材料科学
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分析化学
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纳米技术
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生物医学工程
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 11
·期 2
·441-451
·
IF 7.571
Imran Mahmood Khan,Sobia Niazi,Imran Pasha,Muhammad Kashif Iqbal Khan,Lin Yue,Hua Ye,Ali Mohsin,Muhammad Shoaib,Yin Zhang,Zhouping Wang
Fluorescent gold (Au) nanostructures have emerged as burgeoning materials to fabricate nanomaterial assemblies which play a vital role in improving the detection sensitivity and specificity for various biomolecules. In this work, a fluorescence labelled (Rhodamine-B-Isothiocyanate) silica shell with Au metal core (AuNPs@PVP@RITC@SiO2) and a graphene–Au nanostar nanocomposite (rGO–AuNS) are presented as a metal enhanced fluorescence (MEF) material and Raman signal enhancer, respectively. Their composite (AuNPs@PVP@RITC@SiO2NPs/rGO–AuNS) was employed as a dual-mode fluorescence (FL) and surface-enhanced Raman scattering (SERS) nanoprobe for selective and sensitive detection of T-2 toxin. To comprehend the dual-modality, a core–shell nanostructure, AuNPs@PVP@RITC@SiO2, was functionalized with an aptamer (donor) and adsorbed on the surface of rGO–AuNS through electrostatic forces and π–π stacking which act as a FL quencher and SERS signal enhancer. When exposed to T-2 toxin, the apt-AuNPs@PVP@RITC@SiO2NPs move away from the surface of rGO–AuNS, resulting in the restoration of FL and reduction of the SERS signal. There was distinct linearity between the T-2 toxin concentration and the dual FL and SERS signals with lower limits of detection (LOD) of 85 pM and 12 pM, as compared to the previous methods, respectively. The developed FL and SERS aptasensor presented excellent recovery ratio and RSD in wheat and maize, respectively, as compared with the standard ELISA method. The complementary performances of the developed stratagem revealed a high correlation between the FL and SERS sensing modes with exquisite detection properties.
研究领域:
分析化学
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毒理学
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纳米技术
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食品安全
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环境科学
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产品关联
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2023
·Vol. 7
·期 6
·1100-1109
·
IF 7
Suyang Li,Junjie Chen,Wanbing Xu,Biao Sun,Jiechen Wu,Qiang Chen,Pei Liang
Bimetallic gold core–silver shell (Au@Ag) surface-enhanced Raman scattering tags draw broad interest in the fields of biological and environmental analyses. Herein, an efficient hybrid microfluidic chip was designed to prepare uniform Au@Ag core–shell nanoparticles, and DTNB was used as the internal standard tag molecule to prepare Au@DTNB@Ag for SERS detection. Homogeneous core–shell nanoparticles with a particle size of 90 nm were prepared by mixing a silver precursor and a gold core in a microfluidic chip. The relative standard deviation (RSD) of the particle size distribution was close to 10%, and the detection limit of 4-MBA was as low as 10-10 M. In order to solve the influence of SERS signal fluctuation, a uniform Au@DTNB@Ag core–molecule–shell structure was synthesized in a microfluidic chip, and the characteristic peak of the analyte was corrected by the relative intensity of the DTNB characteristic peak (1335 cm−1). The experimental results showed that the SERS detection was achieved with high reproducibility, and the SERS peak intensity had a good linear correlation with the concentration. The homogeneous SERS substrate prepared using a microfluidic chip has potential for sensitive and reliable detection of environmental chemical contaminants.
研究领域:
纳米技术
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分析化学
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环境科学
·
材料科学
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产品关联
DOI
高影响因子
Aggregate
·
2024
·
IF 13.9
Yu Yang,Hao Lu,Dan Fang,Yuyuan Zhang,Yuteng Tang,Songsong Zhao,Jun Yan,Xiaojie Qin,Jianlei Shen,Fan Yang
Solid bubbles have expanded the SERS assay toolbox, but their detection performance in biofluids is still hampered by the irrational design of the plasmonic sensing interface. A plasmonic bubble aggregate-driven DNA-encoded SERS assay is reported here that enables simultaneous, ultrasensitive, and specific detection of multiple miRNAs in blood samples for accurate cancer diagnosis. In this assay, the buoyancy of plasmonic bubbles allows them to self-aggregate at a droplet apex for SERS reconfiguration, form single-layer bubble aggregates with plasmonic nanogaps, and prevent the coffee ring effect during evaporation assembly. Furthermore, DNA-encoded plasmonic bubbles seamlessly couple with dual-color catalytic hybridization assembly to amplify the specific miRNA-responsive Raman signal, and function as both an analyte concentrator and a Raman signal aggregator without external forces. Using these merits, this magnet-free, portable assay achieves femtomolar dual-miRNA quantitation with single-base resolution, simultaneous miRNA detection across four cell lines, and accurate cancer diagnosis (AUC = 1) via analyzing 40 blood samples with machine learning, thus providing a promising tool for clinical diagnosis.
研究领域:
生物医学工程
·
纳米技术
·
癌症研究
·
分析化学
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）